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Science China(Life Sciences) 2014年第4期57卷 403-411页

作者： taylor chanel j HE RongQiao BARTLETT Perry F Queensland Brain Institute The University of QueenslandBrisbane Institute of Biophysics Chinese Academy of Sciences

New neurons are continuously generated from resident pools of neural stem and precursor cells(NSPCs)in the adult *** are multiple pathways through which adult neurogenesis is regulated,and here we review the role of the N-methyl-D-aspartate receptor(NMDAR)in regulating the proliferation of NSPCs in the adult ***-dependent learning tasks,enriched environments,running,and activity-dependent synaptic plasticity,all potently up-regulate hippocampal NSPC *** first consider the requirement of the NMDAR in activity-dependent synaptic plasticity,and the role the induction of synaptic plasticity has in regulating NSPCs and newborn *** address how specific NMDAR agonists and antagonists modulate proliferation,both in vivo and in vitro,and then review the evidence supporting the hypothesis that NMDARs are present on *** believe it is important to understand the mechanisms underlying the activation of adult neurogenesis,given the potential that endogenous stem cell populations have for repopulating the hippocampus with functional new *** conditions such as age-related memory decline,neurodegeneration and psychiatric disease,mature neurons are lost or become defective;as such,stimulating adult neurogenesis may provide a therapeutic strategy to overcome these conditions.

关键词： adult neurogenesis stem cell precursor cell NMDA receptor hippocampus synaptic plasticity long-term potentiation(LTP)

Inter-signal interaction and uncertain information in anuran multimodal signals

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Current Zoology 2011年第2期57卷 153-161页

作者： Ryan C. taylor Barrett A. KLEIN Michael j. RYAN Department of Biological Sciences Salisbury University Salisbury MD 21801 USA Section of Integrative Biology University of Texas at Austin Austin TX 78712 USA Smithsonian Tropical Research Institute P.O. Box 0843-03092 Balboa Ancon Republic of Panama

Disentangling the influence of multiple signal components on receivers and elucidating general processes influencing complex signal evolution are difficult tasks. In this study we test mate preferences of female squirrel treefrogs Hyla squirella and female tungara frogs Physalaemus pustulosus for similar combinations of acoustic and visual components of their multimodal courtship signals. In a two-choice playback experiment with squirrel treefrogs, the visual stimulus of a male model significantly increased the attractivness of a relatively unattractive slow call rate. A previous study demonstrated that faster call rates are more attractive to female squirrel treefrogs, and all else being equal, models of male frogs with large body stripes are more attractive. In a similar experiment with female tungara frogs, the visual stimulus of a robotic frog failed to increase the attractiveness of a relatively unattractive call. Females also showed no preference for the distinct stripe on the robot that males commonly bear on their throat. Thus, features of conspicuous signal components such as body stripes are not universally important and signal function is likely to differ even among species with similar ecologies and communication systems. Finally, we discuss the putative information content of anuran signals and suggest that the categorization of redundant versus multiple messages may not be sufficient as a general explanation for the evolution of multimodal signaling. Instead of relying on untested assumptions concerning the information content of signals, we discuss the value of initially collecting comparative empirical data sets related to receiver responses.

关键词： Inter-signal interaction Multimodal signaling Signal detection Signal weighting Squirrel treefrog Hyla squirella Tfingara frog Physalaemus pustulosus Vocal sac

Post Locoregional Therapy Treatment Imaging in Hepatocellular Carcinoma Patients:A Literature-based Review

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journal of Clinical and Translational Hepatology 2018年第2期6卷 189-197页

作者： Shamar Young Andrew j.taylor Tina Sanghvi Department of Radiology University of MinnesotaMinneapolisMNUSA

Imaging plays a crucial role in the diagnosis of hepatocellular carcinoma(HCC)as well as in determining treatment efficacy,or complications,following *** other cancers,HCC is most commonly treated by locoregional therapies(LRTs)such as thermal ablation,transarterial chemoembolization,and transarterial *** treatments can lead to changes on imaging that make determination of residual/recurrent disease *** literature-based review dis-cusses the expected postimaging findings following LRT.

关键词： Hepatocellular carcinoma(HCC) Transarterial chemoembolization(TACE) Thermal ablation Transarterial radioembolization(TARE) Magnetic resonance imaging(MRI)

Strategies towards statistically robust interpretations of in situ U-Pb zircon geochronology

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Geoscience Frontiers 2016年第4期7卷 581-589页

作者： Christopher j.Spencer Christopher L.Kirkland Richard j.M.taylor The Institute of Geoscience Research(TIGeR) Department of Applied GeologyWestern Australian School of MinesCurtin UniversityWA 6102Australia Centre for Exploration Targeting-Curtin Node Department of Applied GeologyWestern Australian School of MinesCurtin UniversityWA 6102Australia Australian Research Council Centre of Excellence for Core to Crust Fluid SystemsPerthWA 6102Australia

Zircon U-Pb geochronology has become a keystone tool across Earth science, arguably providing the gold standard in resolving deep geological time. The development of rapid in situ analysis of zircon （via laser ablation and secondary ionization mass spectrometry） has allowed for large amounts of data to be generated in a relatively short amount of time and such large volume datasets offer the ability to address a range of geological questions that would otherwise remain intractable （e.g. detrital zircons as a sedi- ment fingerprinting method）. The ease of acquisition, while bringing benefit to the Earth science com- munity, has also led to diverse interpretations of geochronological data. In this work we seek to refocus U -Pb zircon geochronology toward best practice by providing a robust statistically coherent workflow. We discuss a range of data filtering approaches and their inherent limitations （e.g. discordance and the reduced chi-squared; MSWD）. We evaluate appropriate mechanisms to calculate the most geologically appropriate age from both 238U/206pb and 207pb/206pb ratios and demonstrate the cross over position when chronometric power swaps between these ratios. As our in situ analytical techniques become progressively more precise, appropriate statistical handing of U-Pb datasets will become increasingly pertinent.

关键词： Zircon Geochronology U-Pb Geostatistics MSWD

Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

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Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery L.Miller Nathan K.Evanson j.Michael taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh june 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

Sperm retrieval and intracytoplasmic sperm injection outcomes in men with cystic fibrosis disease versus congenital bilateral absence of the vas deferens

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Asian journal of Andrology 2021年第2期23卷 140-145页

作者： j Abram McBride taylor P Kohn Daniel j Mazur Larry I Lipshultz R Matthew Coward Scott Department of Urology Baylor College of MedicineHoustonTX 77030USA Department of Urology UNC School of MedicineChapel HillNC 27599USA UNC Fertility RaleighNC 27617USA

Recent data suggest that cystic fibrosis transmembrane conductance regulator(CFTR)gene alterations negatively impact male fertility beyond *** sought to compare gene alterations,sperm retrieval rates,and intracytoplasmic sperm injection(ICSI)outcomes among men with cystic fibrosis(CF)disease and congenital bilateral absence of the vas deferens(CBAVD)*** retrospectively evaluated all men who underwent surgical sperm retrieval at two academic,high-volume andrology centers from 2010 to *** men with documented CFTR alterations and obstructive azoospermia from either CBAVD or CF were *** between groups for CFTR abnormality,sperm retrieval,and ICSI outcomes were statistically ***,39 patients were included with 10 in the CF and 29 in the CBAVD *** sperm retrieval rates were significantly lower in the CF group for sperm concentration(14.8×10^(6)ml^(-1)vs 61.4×10^(6)ml^(−1),P=0.02)and total motile sperm count(2.9 million vs 11.4 million,P=0.01).This difference was only predicted by homozygous delta F508 CFTR mutations(P<0.05).The CF group also demonstrated a significantly higher rate of rescue testicular sperm extraction(70.0%vs 27.6%,P<0.03)and lower fertilization rate with ICSI(32.5%vs 68.9%,P<0.01).In conclusion,those with CF demonstrated lower sperm quality,greater difficulty with sperm retrieval,and worse ICSI outcomes compared with CBAVD-only *** delta F508 CFTR mutations appear to significantly impair spermatogenesis and sperm function.

关键词： congenital bilateral absence of the vas deferens cystic fibrosis intracytoplasmic sperm injection outcomes male infertility obstructive azoospermia

Code modernization and modularization of APEX and SWAT watershed simulation models

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International journal of Agricultural and Biological Engineering 2015年第3期8卷 81-94页

作者： Robin A.j.taylor jaehak jeong Michael White jeffrey G.Arnold Blackland Research&Extension Center Texas A&M AgriLife ResearchTempleTexas 76502USA Grassland Soil&Water Research Laboratory USDA-ARS TempleTexas 76502USA

SWAT(Soil and Water Assessment Tool)and APEX(Agricultural Policy/Environmental eXtender)are respectively large and small watershed simulation models derived from EPIC(Environmental Policy Integrated Climate),a field-scale agroecology simulation *** three models are coded in Fortran and have evolved over several *** are widely used to analyze anthropogenic influences on soil and water quality and *** of the original Fortran code has been retained even though Fortran has been through several cycles of *** now provides functionality originally restricted to languages like C,designed to communicate directly with the operating system and *** can now use an object-oriented style of programming in Fortran,including inheritance,run-time polymorphism and *** order to enhance their utility in research and policy-making,the models are undergoing a major revision to use some of the new Fortran *** these new programming paradigms the developers of SWAT,APEX,and EPIC are working to make communication between the two models *** paper describes the ongoing revision of these models that will make them easier to use,maintain,modify and *** is intended that they will converge as they continue to evolution,while maintaining their distinctive features,capabilities and identities.

关键词： code modernization modularization object-oriented programming Fortran 2008 landscape-scale models APEX EPIC SWAT

Diversity in global gene expression and morphology across a watercress (Nasturtium officinale R. Br.) germplasm collection: first steps to breeding

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Horticulture Research 2015年第1期2卷 175-182页

作者： Adrienne C.Payne Graham j.j.Clarkson Steve Rothwell Gail taylor Centre for Biological Sciences Institute for Life SciencesUniversity of SouthamptonSouthamptonSO171BJUK Vitacress Salads Ltd Lower Link FarmSt Mary BourneAndoverHampshireSP116DBUK

Watercress(Nasturtium officinale ***.)is a nutrient intense,leafy crop that is consumed raw or in soups across the globe,but for which,currently no genomic resources or breeding programme *** morphological,biochemical and functional genomic variation was identified for the first time in a newly established watercress germplasm collection,consisting of 48 watercress accessions sourced from contrasting global *** length,stem diameter and anti-oxidant(AO)potential varied across the *** variation was used to identify three extreme contrasting accessions for further *** in global gene expression was investigated using an Affymetrix Arabidopsis ATH1 microarray gene chip,using the commercial control(C),an accession selected for dwarf phenotype with a high AO potential(dwarfAO,called‘Boldrewood’)and one with high AO potential alone.A set of transcripts significantly differentially expressed between these three accessions,were identified,including transcripts involved in the regulation of growth and development and those involved in secondary *** particular,when differential gene expression was compared between C and dwarfAO,the dwarfAO was characterised by increased expression of genes encoding glucosinolates,which are known precursors of phenethyl isothiocyanate,linked to the anti-carcinogenic effects well-documented in *** study provides the first analysis of natural variation across the watercress genome and has identified important underpinning information for future breeding for enhanced anti-carcinogenic properties and morphology traits in this nutrient-intense crop.

关键词： breeding dwarf germplasm

Synthesis of a-SnWO_4 thin-film electrodes by hydrothermal conversion from crystalline WO_3

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Chinese Chemical Letters 2015年第4期26卷 474-478页

作者： Kayla j.Pyper taylor C.Evans Bart M.Bartlett Department of Chemistry University of Michigan

Thin film electrodes of the orthorhombic form of tin tungstate （α-SnWO4） were prepared using a hydrothermal method to convert thin films of WO3 in aqueous SnCI2. The pH dependence of the growth mechanism was identified by scanning electron microscopy （SEM） and X-ray diffraction （XRD）. The XRD patterns show complete conversion of WO3（s） to SnWO4（s） at pH 1, 4, and 7. SEM images reveal a morphology change from sponge-like platelets to sharp nanowires as the pH increases from 1 to 7. The α-SnWO4 thin films were reddish brown in color, and display an indirect band gap of 1.9 eV by diffuse reflectance UV-vis spectroscopy. α-SnWO4 is therefore solar-responsive, and a chopped light linear sweep voltammogram recorded under 100 mW/cm2 AM1.5 simulated solar illumination in a pH 5 0.1 mol/L KPi buffer show a visible light response for photoelectrochemical water oxidation, producing 32 μA/cm2 at 1.23 V vs. RHE.

关键词： Alpha tin tungstateHydrothermal conversionMicrostructureHydrothermal method

Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism

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World journal of Stem Cells 2016年第10期8卷 306-315页

作者： taylor C Peak Nora M Haney William Wang Kenneth j DeLay Wayne j Hellstrom Department of Urology School of MedicineTulane University

The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation.

关键词： Stem cell therapy Leydig cells Primary hypogonadism Stem Leydig cells Testosterone Bone marrow-derived stem cells Adipose-derived mesenchymal stem cells