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Thai Perilla frutescens fruit oil alleviates carbon tetrachloride-induced hepatotoxicities in rats

Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 101-110页

作者： Narisara Paradee Duangta Kanjanapothi tawat taesotikul Sarawut Kongkarnka Adchara Prommaban PimpisidKoonyosying Somdet Srichairatanakool Department of Biochemistry Faculty of MedicineChiang Mai UniversityChiang MaiThailand Faculty of Pharmacy Payap University(Maekhao Campus)Chiang MaiThailand Department of Pathology Faculty of MedicineChiang Mai UniversityChiang MaiThailand

Objective:To study the effect of perilla fruit oil against carbon tetrachloride(CCl4)-induced liver damage in ***:Perilla fruit oil was analyzed in terms of fatty acids,tocopherols and tocotrienols using ***-chronic toxicity of perilla fruit oil was investigated in rats for 90 d followed by a 28 d recovery ***,biochemical and pathological parameters were *** evaluate hepatoprotection,rats were divided into five groups and orally administered with Tween 80 for 10 d;Tween 80,silymarin,perilla fruit oil(0.1 mL/200 g)and perilla fruit oil(1 mL/200 g)for 10 d together with subcutaneous injection of CCl4(2 mL/200 g)on days 9 and *** enzymes and pathological parameters were ***:Perilla fruit oil containedα-linolenic acid(56.55%of total fatty acid),β-tocopherol(49.50 mg/kg)andγ-tocotrienol(43.65 mg/kg).Rats showed significant changes in the percentage of monocytes and platelet indices following perilla fruit oil consumption for 90 d;in the percentage of neutrophils and lymphocytes,and RBC indices in the recovery period when compared with the deionized water *** protein and creatinine levels were increased while alkaline phosphatase and aspartate aminotransferase levels were decreased(P<0.05).Organ weight index and pathological indicators did not change *** liver of CCl4-induced rats showed remarkable centrilobular fatty changes,which was ameliorated by perilla fruit oil *** aminotransferase,alanine aminotransferase and alkaline phosphatase levels were decreased(P<0.05)in rats given perilla fruit ***:Perilla fruit oil is rich inα-linolenic acid,β-tocopherol andγ-tocotrienol and improves blood biomarker levels and protects against CCl4-induced *** studies are required before supporting its use for the treatment of hepatitis.

关键词： Perilla frutescens Perilla oil Carbon tetrachloride Fatty change Liver injury

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