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Neural Regeneration Research 2018年第8期13卷 1350-1351页

作者： Olga Kopach tatyana Pivneva Department of Clinical and Experimental Epilepsy Institute of NeurologyUniversity College London London UK Department ot Sensory Signalling Bogomoletz Institute oI Physiology KyivUkraine State Institute of Genetic and Regenerative Medicine Kyiv Ukraine

The restricted neurogenesis limits the brain ability to overcome neuronal cell death following ischemic lesion：Failure of the damaged brain to regenerate following cerebral ischemia results in functional deficits those are most often irreversible and can further deteriorate,causing mortality and severe disability,progressive memory loss and cognitive impairments,known as dementia.

关键词： neurophysiological insights into stem progenitor cell neurogenesis within a host environment

Ketogenic diet versus ketoacidosis： what determines the influence of ketone bodies on neurons？

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Neural Regeneration Research 2018年第12期13卷 2060-2063页

作者： Sergei V.Fedorovich Polina P.Voronina tatyana V.Waseem Institute of Biophysics and Cell Engineering Minsk Belarus Department of Pharmacology University of Oxford Oxford UK

Glucose is the main energy substrate for neurons, however, at certain conditions, e.g. in starvation, these cells could also use ketone bodies. This approach is used in clinical conditions as the ketogenic diet. The ketogenic diet is actually a biochemical model of fasting. It includes replacing carbohydrates by fats in daily meal. Synthesis of ketone bodies β-hydroxubutirate, acetoacetate and acetone begins once glycogen stores have depleted in the liver. The ketogenic diet can be used to treat clinical conditions, primarily epilepsy. The mechanism of neuroprotective action of ketogenic diet is not very clear. It is shown that ketone bodies influence neurons at three different levels, namely, metabolic, signaling and epigenetic levels. Ketone bodies are not always neuroprotective. Sometimes they can be toxic for the brain. Ketoacidosis which is a very dangerous complication of diabetes mellitus or alcoholism can be taken as an example. The exact mechanism of how neuroprotective properties of ketone bodies reverse to neurotoxic is yet to be established.

关键词： β-hydroxybutirate epilepsy diabetes mellitus alcoholism metabolism hydroxyl-carboxylic acid receptor epigenetics acidosis

Strengthening biological security after COVID-19:Using cartoons for engaging life science stakeholders with the Biological and Toxin Weapons Convention(BTWC)

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Journal of Biosafety and Biosecurity 2022年第1期4卷 68-74页

作者： tatyana Novossiolova Simon Whitby Malcolm Dando Lijun Shang The Law Program of the Center for the Study of Democracy Bulgaria Division of Peace Studies University of Bradford BradfordUnited Kingdom School of Human Sciences London Metropolitan UniversityLondonUnited Kingdom Biological Security Research Centre London Metropolitan UniversityLondonUnited Kingdom

The devastating effects of the COVID-19 pandemic have acutely shown the need for maintaining robust international and national systems for biological security and ensuring that life sciences are used only for peaceful *** science stakeholders can play an important role in safeguarding scientific and technological advances in biology and related fields against accidental or deliberate misuse,not least because they are on the frontlines of driving *** this paper,we argue that enhancing awareness and understanding of the risk of deliberate disease is essential for effective biological *** first discuss the issue of‘dual use’in science and technology as it relates to disarmament and non-proliferation of weapons of mass ***,we review how scientist engagement with dual-use risks has been addressed in the context of the Biological and Toxin Weapons Convention(BTWC).Third,we report on the development of an innovative awarenessraising tool,a cartoon series,that can be used for engaging life science stakeholders with BTWC ***,we outline a set of practical considerations for promoting sustainable life science engagement with the BTWC.

关键词： Cartoon Life sciences Biological security Biological and Toxin Weapons Convention Awareness Engagement

A Host KH RNA-Binding Protein Is a Susceptibility Factor Targeted by an RXLR Effector to Promote Late Blight Disease

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Molecular Plant 2015年第9期8卷 1385-1395页

作者： Xiaodan Wang Petra Boevink Hazel McLellan Miles Armstrong tatyana Bukh-arova Zhiwei Qin Paul R.J. Birch Horticultural College Northeast Agricultural University No. 59 Mucai Road Harbin 150030 China Cell and Molecular Sciences James Hutton Institute Errol Road Invergowrie Dundee DD2 5DA UK Division of Plant Sciences College of Ufe Sciences University of Dundee (at JHI) Errol Road Invergowrie Dundee DD2 5DA UK Virus-free Seedling Research Institute of Heilongjiang Academy of Agricultural Sciences No. 368 Xuefu Road Harbin 150086 China These authors contributed equatly to this article.

Plant pathogens deliver effector proteins that alter host processes to create an environment conducive to colonization. Attention has focused on identifying the targets of effectors and how their manipulation facil- itates disease. RXLR effector Pi04089 from the potato blight pathogen Phytophthora infestans accumu- lates in the host nucleus and enhances colonization when transiently expressed in planta. Its nuclear local- ization is required for enhanced P. infestans colonization. Pi04089 interacts in yeast and in planta with a putative potato K-homology （KH） RNA-binding protein, StKRBPI. Co-localization of Pi04089 and StKRBP1, and bimolecular fluorescence complementation between them, indicate they associate at nuclear speckles. StKRBP1 protein levels increased when it was co-expressed with Pi04089. Indeed, such accumu- lation of StKRBP1 was observed also on the first day of leaf colonization by the pathogen. Remarkably, overexpression of StKRBP1 significantly enhances P. infestans infection. Mutation of the nucleotide- binding motif GxxG to GDDG in all three KH domains of StKRBP1 abolishes its interaction with Pi04089, its localization to nuclear speckles, and its increased accumulation when co-expressed with the effector. Moreover, the mutant StKRBP1 protein no longer enhances leaf colonization by P. infestans, implying that nucleotide binding is likely required for this activity. We thus argue that StKRBP1 can be regarded as a sus- ceptibility factor, as its activity is beneficial to the pathogen.

关键词： effector-triggered susceptibility oomycete plant disease late blight

Superchiral near fields detect virus structure

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Light(Science & Applications) 2020年第1期9卷 103-112页

作者： Tarun Kakkar Chantal Keijzer Marion Rodier tatyana Bukharova Michael Taliansky Andrew J.Love Joel J.Milner Affar S.Karimullah Laurence D.Barron Nikolaj Gadegaard Adrian J.Lapthorn Malcolm Kadodwala School of Chemistry Joseph Black BuildingUniversity of GlasgowGlasgow G128QQUK Institute of Molecular Cell and Systems Biology and School of Life SciencesUniversity of GlasgowG128QQ GlasgowUK James Hutton Inst Cell&Mol SciDundee DD25DAUK Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS Moscow 117997Russia School of Engineering Rankine BuildingUniversity of GlasgowGlasgow G128LTUK

Optical spectroscopy can be used to quickly characterise the structural properties of individual ***,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component *** insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical *** limits potential routes to rapid high-throughput portable detection appropriate for point-of-care ***,we demonstrate that chiral electromagnetic(EM)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus ***,they can detect both the presence and relative orientation of a bound virus *** illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum.

关键词： chiral detect fields

Fungal diversity notes 491–602: taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2017年第2期83卷 1-261页

作者： Saowaluck Tibpromma Kevin D.Hyde Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Jian-Kui Liu D.Jayarama Bhat E.B.Gareth Jones Eric H.C.McKenzie Erio Camporesi Timur S.Bulgakov Mingkwan Doilom AndreLuiz Cabral Monteiro de Azevedo Santiago Kanad Das Patinjareveettil Manimohan Tatiana B.Gibertoni Young Woon Lim Anusha Hasini Ekanayaka Benjarong Thongbai Hyang Burm Lee Jun-Bo Yang Paul M.Kirk Phongeun Sysouphanthong Sanjay K.Singh Saranyaphat Boonmee Wei Dong K.N.Anil Raj K.P.Deepna Latha Rungtiwa Phookamsak Chayanard Phukhamsakda Sirinapa Konta Subashini C.Jayasiri Chada Norphanphoun Danushka S.Tennakoon Junfu Li Monika C.Dayarathne Rekhani H.Perera Yuanpin Xiao Dhanushka N.Wanasinghe Indunil C.Senanayake Ishani D.Goonasekara N.Ide Silva Ausana Mapook Ruvishika S.Jayawardena Asha J.Dissanayake Ishara S.Manawasinghe K.W.Thilini Chethana Zong-Long Luo Kalani Kanchana Hapuarachchi Abhishek Baghela Adriene Mayra Soares Alfredo Vizzini Angelina Meiras-Ottoni Armin Mesic Arun Kumar Dutta Carlos Alberto Fragoso de Souza Christian Richter Chuan-Gen Lin Debasis Chakrabarty Dinushani A.Daranagama Diogo Xavier Lima Dyutiparna Chakraborty Enrico Ercole Fang Wu Giampaolo Simonini Gianrico Vasquez Gladstone Alves da Silva Helio Longoni Plautz Jr Hiran A.Ariyawansa Hyun Lee Ivana Kusan Jie Song Jingzu Sun Joydeep Karmakar Kaifeng Hu Kamal C.Semwal Kasun M.Thambugala Kerstin Voigt Krishnendu Acharya Kunhiraman C.Rajeshkumar Leif Ryvarden Margita Jadan MdIqbal Hosen Michal Miksık Milan C.Samarakoon Nalin N.Wijayawardene Nam Kyu Kim Neven Matocec Paras Nath Singh Qing Tian R.P.Bhatt Rafael JoseVilela de Oliveira Rodham E.Tulloss S.Aamir Saithong Kaewchai Sayali D.Marathe Sehroon Khan Sinang Hongsanan Sinchan Adhikari Tahir Mehmood Tapas Kumar Bandyopadhyay tatyana YuSvetasheva Thi Thuong Thuong Nguyen Vladimır Antonın Wen-Jing Li Yong Wang Yuvraj Indoliya Zdenko Tkalcec Abdallah M.Elgorban Ali H.Bahkali Alvin M.C.Tang Hong-Yan Su Huang Zhang Itthayakorn Promputtha Jennifer Luangsa-ard Jianchu Xu Jiye Yan Kang Ji-Chuan Marc Stadler Pete Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani” Via Roma 18Forlı`Italy A.M.B.Circolo Micologico“Giovanni Carini” C.P.314BresciaItaly Societa`per gli Studi Naturalistici della Romagna C.P.144BagnacavalloRAItaly Formerly Department of Botany Goa UniversityTaleigaoGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa VelhaIndia 33 B St.Edwards Road Southsea Hants Hampshire PO53DHUK Landcare Research Manaaki Whenua Private Bag 92170AucklandNew Zealand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Division of Applied Science College of International EducationThe Hong Kong Baptist UniversityHong Kong SARChina PostGraduate Program in Biology of Fungi Department of MycologyFederal University of PernambucoAv.Nelson Chavess/nRecifePE 50670-420Brazil Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Environmental Microbiology Lab Division of Food TechnologyBiotechnology&AgrochemistryCollege of Agriculture and Life SciencesChonnam National UniversityYongbong-Dong 300Buk-GuGwangju 61186Korea Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China Yunnan Institute of Food Safety Kunming University of Science&TechnologyKunming 650500YunnanPeople’s Republic

This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and *** addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ***ever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever *** on 112 fungal taxa are compiled in this paper including Biatriosporaceae and Roussoellaceae,Didysimulans ***.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph *** new species are Amanita cornelii,***,Angustimassarina alni,***,***,***,***,Ascochyta italica,***,Austroboletus appendiculatus,Barriopsis thailandica,Berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,***,***,***,***,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,Dacrymyces chiangraiensis,Didysimulans italica,***,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,***,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,***nae,Hysterium centramurum,Inflatispora caryotae,Inocybe brunneosquamulosa,***,***,Keissleriella cirsii,Lepiota cylindrocystidia,***,***,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,***tata,***,Panus subf

关键词： Agaricomycetes Ascomycota Basidiomycota Dacrymycetes Dothideomycetes Eurotiomycetes New combination Mucoromycotina New genus New records New species Pezizomycetes Phylogeny Sordariomycetes Taxonomy