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A Revised Classification of Primary.Iron Overload Sy.dromes

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 346-356页

作者： y.suaki tatsumi Motoy.shi y.no Shiny. Wakusawa Hiroaki Miy.jima Tetsuy. Ishikawa Shinsaku Imashuku Atsuko Takano Wataru Nihei Ay.ko Kato Koichi Kato Hisao Hay.shi Kentaro y.shioka Kazuhiko Hay.shi Department of Medical Biochemistry Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiJapan Department of Medical Technology Shubun UniversityIchinomiyaJapan Department of Medicine and Neurology Tenryu Kohseikai ClinicHamamatsuJapan Department of Gastroenterology.and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Department of Laboratory.Medicine Uji-Tokushukai Medical CenterUjiJapan Department of Medicine Saiseikai Takaoka HospitalTakaokaJapan Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology FNPS Meijo HospitalNagoyaJapan

Background and Aims:The clinical introduction of hepcidin25(Hep25)has led to a more detailed understanding of its relationship with ferroportin(FP)and divalent metal transporter1 in primary.iron overload sy.dromes(PIOSs).In 2012,we proposed a classification of PIOSs based on the Hep25/FP sy.tem,which consists of prehepatic aceruloplasminemia,hepatic hemochromatosis(HC),and posthepatic FP disease(FP-D).However,in consideration of accumulated evidence on PIOSs,we aimed to renew the ***:We reviewed the 2012 classification and retrospectively.renewed it according to new information on ***:Iron-loading anemia was included in PIOSs as a prehepatic form because of the newly.discovered ery.hroferrone-induced suppression of Hep25,and the state of traditional FP-D was remodeled as the BIOIRON *** key.molecules responsible for prehepatic PIOSs are low transferrin saturation in aceruloplasminemia and increased ery.hroferrone production by.ery.hroblasts in iron-loading *** PIOSs comprise four genoty.es of HC,in each of which the sy.thesis of Hep25 is inappropriately.reduced in the *** Hep25 sy.thesis is adequate in posthepatic PIOSs;however,two mutant FP molecules may.resist Hep25 differently.resulting in SLC40A1-HC and FP-D,*** phenoty.es are diagnosed using laboratory.tests,including circulating Hep25,followed by.suitable *** sequencing of the candidate genes may.be outsourced to gene centers when *** kits for the prevalent mutations,such as C282y.may.be the first choice for a genetic analy.is of HC in ***:The revised classification may.be useful worldwide.

关键词： Ethnicity Ferroportin Hemochromatosis Hepcidin25 Iron overload sy.drome

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视神经束综合征中视网膜神经纤维层的厚度

世界核心医学期刊文摘(眼科学分册) 2006年第1期 57-57页

作者： tatsumi y. Kanamori A. Kusuhara A. M. Nakamura 韩静 Department of Organ Therapeutics Division of Ophthalmology Kobe University Graduate School of Medicine 7-5-2 Kusunoki-cho Chuo-ku Kobe 650-0017 Japan

Background: Optic tract sy.drome (OTS) is characterized by.incongruous homony.ous hemianopia and a perpendicular pattern of bilateral optic atrophy.due to the optic tract lesion. However, loss of retinal nerve fiber lay.r thickness (RNFLT)-associated with OTS has not been quantitatively.assessed. Case: A 20-y.ar-old woman with blunt head trauma showed normal visual acuity. color vision, ocular motility. and intraocular pressure. Because of a relative afferent pupillary.defect in her left ey. and left-sided homony.ous hemianopia, we suspected right-sided optic tract damage, although magnetic resonance imaging detected no intracranial lesion. Observations: Using optical coherence tomography.(OCT), the RNFLT of this case was measured at 31 months after the trauma and compared with age-matched normal controls (n=41). Nasal, temporal, superior, and inferior quadrant RNFLT was reduced by.22% , 21% , 5% , and 46% in the right ey. and 76% , 64% , 25% , and 27% in the left ey., respectively. The reduction was >3× the standard deviation of the normal mean values in the nasal and temporal quadrants of the left ey. and in the inferior quadrant of the right ey.. Conclusions: OCT can determine the RNFLT reduction corresponding to the characteristic patterns of optic atrophy.of OTS.

关键词：综合征视神经束综合病症左眼视神经萎缩视神经疾病

Tree diversity.effects on forest productivity.increase through time because of spatial partitioning

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Forest Ecosy.tems 2020年第3期7卷 327-333页

作者： Shinichi tatsumi Department of Biological Sciences University of Toronto ScarboroughTorontoONCanada Hokkaido Research Center Forestry and Forest Products Research InstituteHokkaidoJapan

Background: Experimental manipulations of tree diversity.have often found overy.elding in mixed-species plantations. While most experiments are still in the early.stages of stand development, the impacts of tree diversity.are expected to accumulate over time. Here, I present findings from a 31-y.ar-old tree diversity.experiment(as of2018) in ***: I find that the net diversity.effect on stand biomass increased linearly.through time. The species mixture achieved 64% greater biomass than the average monoculture biomass 31 y.ars after planting. The complementarity.effect was positive and increased exponentially.with time. The selection effect was negative and decreased exponentially.with time. In the early.stages(≤ 3 y.ars), the positive complementarity.effect was explained by.enhanced growths of early.and mid-successional species in the mixture. Later on(≥ 15 y.ars), it was explained by.their increased survival rates owing to vertical spatial partitioning — i.e. alleviation of self-thinning via canopy.stratification. The negative selection effect resulted from suppressed growths of late-successional species in the bottom ***: The experiment provides pioneering evidence that the positive impacts of diversity.driven spatial partitioning on forest biomass can accumulate over multiple decades. The results indicate that forest biomass production and carbon sequestration can be enhanced by.multispecies afforestation strategies.

关键词： Biomass productivity Complementarity.effect Biodiversity.and ecosy.tem functioning Forest dy.amics Mixed plantation Plant succession Selection effect Shade tolerance Stand structure Tree diversity.experiment

Making continental crust:The sanukitoid connection

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Chinese Science Bulletin 2008年第11期53卷 1620-1633页

作者： y.shiy.ki tatsumi Institute for Research on Earth Evolution (IFREE) Japan Agency for Marine-Earth Science and Technology (JAMSTEC) Yokosuka 237-0061 Japan

The average continental crust possesses intermediate compositions that ty.ify.arc magmatism and as a result it is believed to have been created at ancient convergent plate boundaries. One possible mechanism for intermediate continental crust formation is the direct production of andesitic melts in the upper mantle. Sanukitoids, which characterize the Setouchi volcanic belt, SW Japan, include un-usually.high-Mg andesites (HMA). They.were generated by.slab melting and subsequent melt-mantle interactions under unusual tectonic settings such as where warm lithosphere subducts into hot upper mantle. Such conditions would have existed in the Archean. Hy.rous HMA magmas are likely.to have solidified within the crust to form HMA plutons, which were then remelted to produce differentiated sanukitoids. At present, generation and differentiation of HMA magmas may.be taking place in the Izu-Bonin-Mariana arc-trench sy.tem (IBM), because (1) HMA magmatism characterizes the initial stages of the IBM evolution and (2) the IBM middle crust exhibits Vp identical to that of the bulk conti-nental crust. Vp estimates for plutonic rocks with HMA compositions support this. However tonalitic composition for middle-crust-forming rocks cannot be ruled out, suggesting an alternative possibility.that the continental crust has been created by.differentiation of mantle-derived basaltic magmas.

关键词：赞岐状岩大陆壳地质学地质运动

Prediction of Photosy.thetic Carbon Assimilation Rate of Individual Rice Leaves under Changes in Light Environment Using BLSTM-Augmented LSTM

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 557-577页

作者： Masay.ki Honda Kenichi tatsumi Masaki Nakagawa Graduate School of Bio-Applications and Sy.tems Engineering Tokyo University of Agriculture and TechnologyKoganei City184-8588Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchu City183-0054Japan Institute of Engineering Tokyo University of Agriculture and TechnologyKoganei City184-8588Japan

A model to predict photosy.thetic carbon assimilation rate(A)with high accuracy.is important for forecasting crop y.eld and *** short-term memory.LSTM),a neural network suitable for time-series data,enables prediction with high accuracy.but requires mesophy.l *** addition,for practical use,it is desirable to have a technique that can predict A from easily.available *** this study.we propose a BLSTM augmented LSTM(BALSTM)model,which utilizes bi-directional LSTM(BLSTM)to indirectly.reproduce the mesophy.l variables required for *** most significant feature of the proposed model is that its hy.rid architecture uses only.three relatively.easy.to-collect external environmental variables—photosy.thetic photon flux density.Q_(in)),ambient CO_(2) concentration(C_(a)),and temperature(T_(air))—to generate mesophy.l CO_(2) concentration(C_(i))and stomatal conductance to water vapor(g_(sw))as intermediate ***,A is predicted by.apply.ng the obtained intermediate outputs to the learning ***,in this study.1)BALSTM(Q_(in),C_(a),T_(air))had a significantly.higher A prediction accuracy.than LSTM(Q_(in),C_(a),T_(air))in case of using only.Q_(in),C_(a),and T_(air);2)BALSTMC_(i),g_(sw),which had C_(i) and g_(sw) as intermediate products,had the highest A prediction accuracy.compared with other candidates;and 3)for samples where LSTM(Q_(in),C_(a),T_(air))had poor prediction accuracy.BALSTMC_(i),g_(sw)(Q_(in),C_(a),T_(air))clearly.improved the ***,it was found that incorrect predictions may.be formed when certain factors are not reflected in the data(e.g.,timing,cultivar,and growth stage)or when the training data distribution that accounts for these factors differs from the predicted data ***,a robust model should be constructed in the future to improve the prediction accuracy.of A by.conducting gasexchange measurements(including a wide range of external environmental values)and by.increasing the

关键词： Hy.rid prediction model assimilation rate leaf internal variables recurrent neural network fluctuating light environments rice

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二甲醚的电催化氧化反应

催化学报 2003年第9期24卷 695-700页

作者：王世忠 tatsumi ISHIHARA 厦门大学化学系福建厦门361005 大分大学应用化学系

考察了负载于镓酸镧基电解质上的镍电极与镍钐掺杂氧化铈复合电极电催化二甲醚氧化反应的特性 .结果表明 ,反应的主要产物均为CO ,H2 和CH4,同时生成少量完全氧化的产物H2 O和CO2 .在开路电位下二甲醚发生裂解反应 ,生成的CO ,H2 和CH... 详细信息

考察了负载于镓酸镧基电解质上的镍电极与镍钐掺杂氧化铈复合电极电催化二甲醚氧化反应的特性 .结果表明 ,反应的主要产物均为CO ,H2 和CH4,同时生成少量完全氧化的产物H2 O和CO2 .在开路电位下二甲醚发生裂解反应 ,生成的CO ,H2 和CH4三种主要产物的比例接近于 1.在有电泵氧存在下 ,二甲醚的电催化氧化反应强烈地依赖于阳极及电解质材料的组成 .Ni/La0 9Sr0 1Ga0 8Mg0 2 O3 界面上发生的主反应是二甲醚的部分氧化 ,且存在有严重的积碳现象 .电极中掺入SDC( 15 %Sm3 + 掺杂的CeO2 )后 ,二甲醚完全氧化性能明显增强 ;随着电流的增大 ,氢的生成速率显著减小 ,并生成大量的H2 O .采用掺钴镓酸镧基电解质后 ,Ni SDC主要表现为催化二甲醚部分氧化反应 ,且显著抑制了积碳的发生 .Ni SDC/La0 8Sr0 2Ga0 8 Mg0 11Co0 0 9O3 上二甲醚电催化氧化反应的主要产物为 1∶1的CO和H2 .掺钴电解质引起Ni SDC具有特殊的催化性能 ,可能与电解质中

关键词：二甲醚氧化电催化固体氧化物燃料电池阳极镍

利用钐掺杂的氧化铈夹层提高燃料电池阳极的活性

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物理化学学报 2003年第9期19卷 849-853页

作者：王世忠 Ishihara tatsumi 厦门大学化学系厦门361005 Department of Applied Chemistry Oita UniversityDannoharu 700Oita 870-1192Japan

考察了Ni-钐掺杂的氧化铈(Ni-SDC)复合阳极与La_(0.9)Sr_(0.1)Ga_(0.8)Mg_(0.2)O_3(LSGM)电解质中间加入的SDC中间层对阳极及整个电池性能的影响.结果表明,SDC中间层的加入显著减小了阳极极化过电位,但同时引入了欧姆降,降低了电池的功... 详细信息

考察了Ni-钐掺杂的氧化铈(Ni-SDC)复合阳极与La_(0.9)Sr_(0.1)Ga_(0.8)Mg_(0.2)O_3(LSGM)电解质中间加入的SDC中间层对阳极及整个电池性能的影响.结果表明,SDC中间层的加入显著减小了阳极极化过电位,但同时引入了欧姆降,降低了电池的功率输出密度.氢在Ni-SDC电极的氧化主要由两个过程控制,分别对应于交流阻抗谱的两个阻抗半圆,高频环随着SDC中间层的加入显著减小,可能对应于H_2在Ni-SDC/SDC/H_2三相界的电化学氧化或氧从LSGM向SDC的传输,低频环与SDC中间层无关,可能对应于氢在电极表面的解离吸附及吸附物种的扩散过程.使用Ni-SDC/SDC夹层阳极可以明显地提高电池的稳定性.

关键词：钐掺杂氧化铈燃料电池阳极活性镍电极双层阳极极化交流阻抗固体氧化物

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利用钐掺杂氧化铈提高燃料电池阳极活性

物理化学学报 2003年第9期19卷 844-848页

作者：王世忠 Ishihara tatsumi 厦门大学化学系厦门361005 Department of Applied Chemistry Oita UniversityDannoharu 700Oita 870-1192Japan

用浸渍法制备并采用交流阻抗、极化等技术考察了不同组成的Ni-Sm^(3+)掺杂的CeO_2(SDC)复合镍阳极的电化学性能及相应电池的功率输出性能.结果表明,SDC掺入镍阳极后,阳极极化过电位及电池的欧姆电阻显著减小.其中阳极过电位的减小与SDC... 详细信息

用浸渍法制备并采用交流阻抗、极化等技术考察了不同组成的Ni-Sm^(3+)掺杂的CeO_2(SDC)复合镍阳极的电化学性能及相应电池的功率输出性能.结果表明,SDC掺入镍阳极后,阳极极化过电位及电池的欧姆电阻显著减小.其中阳极过电位的减小与SDC掺入镍电极引起的三相界扩展有关,但SDC的掺入同时引起了电极反应活化能的增加,造成低温下Ni-SDC的极化过电位大于纯Ni电极.高温下,Ni-SDC阳极的阻抗谱由两个半圆组成,其中高频半圆随着SDC掺入量的增加而减小,而低频环与SDC的掺入量基本无关.低温下只观察到一个高频环.高频环可能对应三相界反应,而低频环可能对应氢的解离吸附及扩散.75％(w)Ni-25％(w)SDC/La_(0.9)Sr_(0.1)Ga_(0.8)Mg_(0.2)O_3(LSGM)/Sm_(0.5)Sr_(0.5)CoO_3(SSC)在所研究的电池中具有最大功率输出密度,其值在1073、973、873 K下分别达到1.1、0.43、0.14 W·cm^(-2).

关键词：钐掺杂氧化铈燃料电池阳极活性电化学交流阻抗镍阳极

Examination of in vivo mutagenicity.of sodium arsenite and dimethy.arsinic acid in gpt delta rats

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Journal of Environmental Sciences 2016年第11期28卷 125-130页

作者： Masaki Fujioka Min Gi Satoko Kawachi Kumiko tatsumi Naomi Ishii Kenichiro Doi Anna Kakehashi Hideki Wanibuchi Department of Molecular Pathology Osaka City University Graduate School of Medicine

Arsenic is a well-known human bladder and liver carcinogen, but its exact mechanism of carcinogenicity.is not fully.understood. Dimethy.arsinic acid（DMAV） is a major urinary.metabolite of sodium arsenite（i As~Ⅲ） and induces urinary.bladder cancers in rats. DMAVand i As~Ⅲare negative in in vitro mutagenicity.tests. However, their in vivo mutagenicities have not been determined. The purpose of present study.is to evaluate the in vivo mutagenicities of DMAVand i As~Ⅲin rat urinary.bladder epithelium and liver using gpt delta F344 ***-week old male gpt delta F344 rats were randomized into 3 groups and administered 0,92 mg/L DMAV, or 87 mg/L i As~Ⅲ（each 50 mg/L As） for 13 weeks in the drinking water. In the mutation assay. point mutations are detected in the gpt gene by.6-thioguanine selection（gpt assay. and deletion mutations are identified in the red/gam genes by.Spi-selection（Spi-assay.. Results of the gpt and Spi-assay. showed that DMAVand i As~Ⅲhad no effects on the mutant frequencies or mutation spectrum in urinary.bladder epithelium or liver. These findings indicate that DMAVand i As~Ⅲare not mutagenic in urinary.bladder epithelium or liver in rats.

关键词： Dimethy.arsinic acid Sodium arsenite In vivo mutagenicity.Urinary.bladder epithelium gpt delta rat