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Linking restless legs syndrome with Parkinson’s disease:clinical,imaging and genetic evidence

Translational Neurodegeneration 2012年第1期1卷 30-35页

作者： tasneem peeraully Eng-King Tan Department of Neurology Singapore General HospitalOutram RoadSingapore 169608Republic of Singapore

Restless legs syndrome(RLS)and Parkinson’s disease(PD)are both common neurological *** has been much debate over whether an etiological link between these two diseases exists and whether they share a common *** pointing towards a link includes response to dopaminergic agents in PD and RLS,suggestive of underlying dopamine dysfunction in both *** extrastriatal dopaminergic system,in particular altered spinal dopaminergic modulation,may be variably involved in PD patients with RLS *** addition,there is now evidence that the nigrostriatal system,primarily involved in PD,is also affected in ***,an association of RLS with the parkin mutation has been *** prevalence of RLS has also been reported to be increased in other disorders of dopamine ***,clinical association studies and functional imaging have produced mixed *** accounts of emergence of RLS and improvement in RLS symptoms after deep brain stimulation(DBS)also contribute to the uncertainty surrounding the *** the strongest arguments against a common pathophysiology is the role of iron in RLS and *** elevated iron levels in the substantia nigra contribute to oxidative stress in PD,RLS is a disorder of relative iron deficiency,with symptoms responding to replacement *** ultrasonography studies have suggested that,despite overlapping clinical features,the mechanisms underlying idiopathic RLS and RLS associated with PD may *** this review,we provide a concise summary of the clinical,imaging and genetic evidence exploring the link between RLS and PD.

关键词： Parkinson’s disease Restless-legs syndrome Pathophysiology Dopaminergic dysfunction

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