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Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.Jacobson Brandon J.Vilarello Tiana m.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.Gary David A.Gudis Paule V.Joseph D.P.Devanand Terry E.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(od)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent od predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent od beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent od in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for od evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived od,74.5%had confirmed psychophysical od at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical od(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:od persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

Im-EDRD from Retinal Fundus Images Using multi-Level Classification Techniques

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Intelligent Automation & Soft Computing 2023年第1期35卷 567-580页

作者： m.P.Karthikeyan E.A.mary Anita Department of Computer Science and Engineering R.M.K.Engineering CollegeChennai601206India Department of Computer Science and Engineering School of Engineering and TechnologyChrist UniversityBengaluru560029India

In recent years,there has been a significant increase in the number of people suffering from eye illnesses,which should be treated as soon as possible in order to avoid *** Fundus images are employed for this purpose,as well as for analysing eye abnormalities and diagnosing eye *** can be recognised as bright lesions in fundus pictures,which can be thefirst indicator of diabetic *** that in mind,the purpose of this work is to create an Integrated model for Exudate and Diabetic Retinopathy Diagnosis(Im-EDRD)with multi-level *** model uses Support Vector machine(SVm)-based classification to separate normal and abnormal fundus images at thefirst *** input pictures for SVm are pre-processed with Green Channel Extraction and the retrieved features are based on Gray Level Co-occurrence matrix(GLCm).Furthermore,the presence of Exudate and Diabetic Retinopathy(DR)in fundus images is detected using the Adaptive Neuro Fuzzy Inference System(ANFIS)classifier at the second level of *** detection,blood vessel extraction,and Optic Disc(od)detection are all processed to achieve suitable ***,the second level processing comprises morphological Component Analysis(mCA)based image enhancement and object segmentation processes,as well as feature extraction for training the ANFIS classifier,to reliably diagnose ***,thefindings reveal that the proposed model surpasses existing models in terms of accuracy,time efficiency,and precision rate with the lowest possible error rate.

关键词： Retinal fundus images exudate diabetic retinopathy SVm ANFIS morphological component analysis

An Orbit Determination Using SGP4 Propagator and Doppler Shifts for CubeSats

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第3期35卷 472-482页

作者： Wesam m.Elmahy Zhang Xiang Lu Zhengliang Liao Wenhe School of mechanical engineering Nanjing university of science and technology Nanjing 210094 P. R. China

The two line elements(TLEs),released by the North American Aerospace Defense Command(NORAD),are chosen for CubeSats' mission ***,they have errors and other accompanied problems,which cause large deviations in the in-track *** a TLE value is available at a certain epoch,the dominant error is the angular *** is proposed to correct the angular error by solving-for the mean argument of latitude at the desired epoch.A batch least squares technique and range rate measurements are used for the correction *** the assistance of satellite tool kit(STK)software and matlab,a simulation to verify the orbit determination(od)technique is *** paper provides an angular correction low cost od method and presents a complete analysis for various test *** approach maintains high accuracy in cross-track and radial and makes great improvement in in-track at the same time,but it is exclusive for circular *** it is applied to an elliptical orbit,the error will be ***,the angular error is corrected using the longitude of periapsis which totally mitigates the error at the epoch under *** inclinations less than 20 o,the mean longitude is preferred for the angular correction as it provides more accuracy compared with the mean argument of latitude.

关键词： CubeSat low earth orbit(LEO) orbit determination doppler shift two line elements(TLEs)

Homogenization in clay barriers and seals:Two case studies

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Journal of Rock mechanics and Geotechnical Engineering 2013年第3期5卷 191-199页

作者： A.Gens B.Valleján m.T.Zandarín m.Sánchez Department of Geotechnical Engineering and Geosciences Universitat Politècnica de Catalunya Zachry Department of Civil Engineering Texas A&M UniversityCollege Station

The paper presents two case studies that provide information on the process of homogenization of initially heterogeneous clay barriers and seals. The first case is the canister retrieval test performed in the Asp0 Hard Rock Laboratory （Sweden）. The heterogeneity arises from the use of a combination of blocks and pellets to construct the engineered barrier. The degree of homogenization achieved by the end of the tests is evaluated from data obtained during the dismantling of the test. To assist in the interpretation of the test, a fully coupled thermo-hydro-mechanical （Thm） analysis has been carried out. The second case involves the shaft sealing test performed in the HADES underground research laboratory （URL） in mol （Belgium）. Here the seal is made up of a heterogeneous mixture of bentonite pellets and bentonite powders. In addition to the full scale test, the process of homogenization of the mixture has also been observed in the laboratory using X-ray tomography. Both field test and laboratory tests are successfully modelled by a coupled hydro-mechanical （hm） analysis using a double structure constitutive law. The paper concludes with some considerations on the capability of highly expansive materials to provide a significant degree of homogenization upon hydration.

关键词： Nuclear waste disposal Clay barriers Clay seals Heterogeneity Compacted soils Coupled analyses Unsaturated soils

Assessing the response of dryland barley yield to climate variability in semi-arid regions,Iran

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Journal of Arid Land 2021年第9期13卷 905-917页

作者： mohammad KHEIRI Jafar KAmBOUZIA Reza DEIHImFARD Saghi m mOGHADDAm Seyran ANVARI Department of Agroecology Environmental Sciences Research InstituteShahid Beheshti UniversityTehran ***Iran Faculty of Environmental Sciences Czech University of Life Sciences PraguePrague 16500Czech Republic

Precipitation and temperature are the most abiotic factors that greatly impact the yield of crop,particularly in ***,as the main cereal is predominantly cultivated in dryland and the livelihood of smallholders depends on the production of this crop,particularly in arid and semi-arid *** study aimed to investigate the response of the grain yield of dryland barley to temperature and precipitation variations at annual,seasonal and monthly scales in seven counties of East and West Azerbaijan provinces in northwestern Iran during *** index(HI)was calculated and its relationship with dryland barley yield was evaluated at annual and monthly *** results showed that the minimum,maximum and mean temperatures increased by 0.19℃/a,0.11℃/a and 0.10℃/a,respectively,while annual precipitation decreased by 0.80 mm/a during *** in study area has become drier by 0.22/a in annual HI during the study *** effects of increasing temperature on the grain yield of dryland barley were more severe than the positive effects of increasing ***,weather variations in April and may were related more to the grain yield of dryland barley than those in other *** grain yield of dryland barley was more drastically affected by the variation of annual minimum temperature comparing with other weather ***,our findings illustrated that the grain yield of dryland barley increased by 0.01 t/hm^(2) for each unit increase in annual HI during ***,any increase in the monthly HI led to crop yield improvement in the study area,particularly in the drier counties,i.e.,myaneh,Tabriz and Khoy in Iran.

关键词： humidity index crop yield spatiotemporal variation temperature precipitation

Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates

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Neuroscience Bulletin 2015年第6期31卷 705-713页

作者： Arun Singh Claire A.Gutekunst Subramaniam Uthayathas John P.m.Finberg Klaus mewes Robert E. Gross Stella m.Papa Yair Feld Neuropharmacology and Neurologic Diseases Yerkes National Primate Research Center Department of Neurosurgery Emory University School of Medicine molecular Pharmacology Department Rappaport Faculty of Medicine Department of Neurology Emory University School of Medicine Gene Grafts Ltd

Recent studies have shown that fibroblast transplantation can modify the activity of basal ganglia networks in models of Parkinson＇s disease. To determine its effects on parkinsonian motor symptoms, we performed autologous dermal fibroblast transplantation into the internal pallidum （GPi） in two parkinsonian rhesus monkeys with stable levodopa- induced dyskinesias （LIDs）. Levodopa responses were assessed every week after transplantation for three months. A reduction of between 58% and 64% in total LIDs on the contralateral side was observed in both animals. No clear LID changes were observed on the ipsilateral side. These effects lasted the entire 3-month period in one monkey, but declined after 6-8 weeks in the other. The antiparkinsonian effects of levodopa did not diminish, The results of this pilot study indicate that fibroblast transplantation into the GPi may have beneficial effects on LIDs and warrant further investigation for potential therapeutic use.

关键词： globus pallidum autologous levodopa antiparkinsonian monkeys

基于器械的高血压试验的优先终点:win ratio法

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中华高血压杂志(中英文) 2021年第8期29卷 799-799页

作者： Kandzari DE Hickey GL Pocock SJ Weber mA B■hm m Cohen SA Fahy m Lamberti G mahfoud F 周卫练桂丽

具有不同临床相关性的多个终点可用于确定基于器械治疗的疗效。考虑到高血压试验中血压测量和药物变化之间的差异,研究者在一项假手术对照随机试验中,对未控制高血压患者(尽管服用了常用的抗高血压药物)的经皮经导管去肾交感神经术(rena... 详细信息

具有不同临床相关性的多个终点可用于确定基于器械治疗的疗效。考虑到高血压试验中血压测量和药物变化之间的差异,研究者在一项假手术对照随机试验中,对未控制高血压患者(尽管服用了常用的抗高血压药物)的经皮经导管去肾交感神经术(renal denervation,RDN)结果进行win ratio法分析。研究者提出一种新的优先终点框架,来确定RDN与假手术对照组相比的治疗效果。方法和结果:研究者使用由24h平均动态收缩压、

关键词：高血压收缩压 win ratio

Comparison of structural diversity of tree-crop associations in Peripheral and Buffer zones of Gachabari Sal forest area,Bangladesh

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Journal of Forestry Research 2007年第2期18卷 23-26页

作者： m.m. Rahman H. Vacik F. Begum A. Nishad K.K. Islam Institute of Silviculture University of Natural Resources and Applied Life SciencesViennaAustria Department of Agronomy Bangladesh Agricultural UniversityMymensingh-2202. Bangladesh IUCN Bangladesh Department of Agroforestry Bangladesh Agricultural UniversityMymensingh-2202. Bangladesh

The structural diversity of different tree-crop associations were studied at Gachabari Sal forest area of madhupur Garh on Buffer and Peripheral Zone during 2006. The total density, basal area of trees in the Buffer and Peripheral Zone were 155.5 trees·hm^(-2), 795.4 trees·hm^(-2) and 3.9 m2·hm-2, 5.8 m^2·hm^(-2), respectively. No regeneration and natural trees were found in Peripheral Zone and the Zone is totally occupied by exotic species where the Buffer Zone comprised of both natural and exotic trees. The Peripheral Zone belonged to younger and smaller trees whereas the Buffer Zone belonged to mixture of smaller, taller, younger and mature trees simultaneously. For the practicing of different agroforestry systems both Zones have lost their original characters of Sal forest.

关键词： Structural diversity Tree-crop associations Sal Peripheral and Buffer Zone.

在鼓泡塔中平板电极和扩张金属电极上的质量传递

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氯碱工业 1989年第5期25卷 23-27页

作者： S.PIOVANO O.N.CAVATORTA U.Bhm 金丽华锦西化工研究所

本文测定了置于鼓泡塔中心处的平板电极和扩张金属电极上的质量传递速率,在电解液物理性质不同和改变气体速度的条件下,对不同类型的扩张金属进行了研究,在有些情况下,得出传质系数的增量超过平板电极值的100%。不同体系、均存在无量纲... 详细信息

本文测定了置于鼓泡塔中心处的平板电极和扩张金属电极上的质量传递速率,在电解液物理性质不同和改变气体速度的条件下,对不同类型的扩张金属进行了研究,在有些情况下,得出传质系数的增量超过平板电极值的100%。不同体系、均存在无量纲关系。术语A 平板网眼孔径 D 扩散系数Dc 塔直径 g 重力加速度Ga 加利略数 gl^3/υ~2 Gr 格拉肖夫数 gΔQL^3/QL^2K 传质系数 L 电极高度r 径向位置 R 塔半径Re 雷诺数 RhVs/γ Rh 液压半径ε/(?)Sc 施密特数 L/D Sh 西尔乌得数 KL/DVs 表面速度 C 气泡空隙百分数εm 扩张金属孔隙率υ动态粘度Q 密度 (?)单位体积上的电极面积ψ单位网面积上的电极面积1、绪论多年来,在化学工业中,已经把鼓泡塔用作吸收器、分离器、反应器和电化学电解槽等。

关键词：鼓泡塔电解槽电极质量传递