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Significant influence of self-possessed moisture of limonitic nickel laterite on sintering performance and its action mechanism

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Journal of Iron and Steel Research(International) 2022年第9期29卷 1368-1380页

作者： Yu-xiao Xue De-qing zhu Jian Pan Zheng-qi Guo Hong-yu Tian Gen Li qing-zhou Huang Liao-ting Pan Xue-zhong Huang School of minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Guangxi Beibu Gulf New material Co. Ltd.Beihai 536000GuangxiChina

In consideration of the abundant moisture of limonitic nickel laterite mined,it is essential to determine whether the selfpossessed moisture of limonitic nickel laterite after pre-dried is appropriate for ***,based on the characterization of limonitic nickel laterite,the influence of its self-possessed moisture on sintering performance was expounded by sinter pot tests and the relevant mechanism was revealed by the systematical analyses of the granulation properties of sinter mixture,thermodynamic conditions during sintering and mineralogy of product *** results indicate that the selfpossessed moisture of limonitic nickel laterite indeed has significant infuence on its sintering *** the optimum self-possessed moisture of 21 mass%,sinter indices are relatively better with tumble index,productivity and solid fuel rate of 48.87%,1.04 t m^(-2) h^(-1)and 136.52 kg t^(-1),respectively,due to the superior granulation properties of sinter mixture and thermodynamic conditions during sintering,relatively large amount of silico-ferrite of calcium.a.d alumina and tighter sinter ***,sintering performance of limonitic nickel laterite is still much poorer than that of ordinary iron *** is feasible to strengthen limonitic nickel laterite sintering by inhibiting the over-fast sintering speed and improving the thermodynamic conditions during sintering.

关键词： Limonitic nickel laterite Self-possessed moisture Sintering performance Action mechanism:Stainless steel

Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis

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药学学报:英文版 2023年第6期13卷 2464-2482页

作者： Lingling zhu Xianzhe Yu Ting Cao Hanyu Deng Xiaojun Tang qing Lin qinghua Zhou Lung Cancer Center/Lung Cancer Institute West China Hospital&West China School of PharmacyKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan ProvinceSichuan UniversityChengdu 610065China Department of Gastrointestinal Surgery Chengdu Second People's HospitalChengdu 610065China Laboratory of Infectious Diseases and Vaccine West China HospitalSichuan UniversityChengdu 610065China

metastasis is the leading cause of cancer-related *** extensive treatment,the prognosis for patients with metastatic cancer remains *** addition to conventional surgical resection,radiotherapy,immunotherapy,chemotherapy,and targeted therapy,various nanobiomaterials have attracted attention for their enhanced antitumor performance and low off-target ***,nanomedicines exhibit certain limitations in clinical applications,such as rapid clearance from the body,low biological stability,and poor targeting *** methods utilize the natural biomembrane to mimic or hybridize nanoparticles and circumvent some of these *** the involvement of immune cells in the tumor microenvironment of the metastatic cascade,biomimetic methods using immune cell membranes have been proposed with unique tumor-homing ability and high *** this review,we explore the im.a.t of immune cells on various processes of tumor ***,we sum.a.ize the synthesis and applications of immune cell membrane-based nanocarriers increasing therapeutic efficacy against cancer metastases via immune evasion,prolonged circulation,enhanced tumor accumulation,and immunosuppression of the tumor ***,we describe the prospects and existing challenges in clinical translation.

关键词： Biomimetic nanoparticles Cancer metastasis Tumor microenvironment Immune system Immune cell membrane Tumor-homing Biocom.a.ibility

A FEm-DFN model for the interaction and propagation of multi-cluster fractures during variable fluid-viscosity injection in layered shale oil reservoir

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Petroleum Science 2022年第6期19卷 2796-2809页

作者： Chu-Hao Huang Hai-Yan zhu Jian-Dong Wang Jian Han Guang-qing Zhou Xuan-He Tang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanPR China Petroleum Engineering Technology Research Institute Shengli Oilfield CompanySINIOPECDongying257000ShandongPR China Chongqing Gas Field Southwest Oil and Gas Field CompanyPetro ChinaChongqing400021PR China

To investigate the height growth of multi-cluster fractures during variable fluid-viscosity fracturing in a layered shale oil reservoir,a two-dimensional finite element method(FEm)-discrete fracture network(DFN)model coupled with flow,stress and damage is proposed.A traction-separation law is used to describe the mixed-mode response of the damaged adhesive fractures,and the cubic law is used to describe the fluid flow within the *** rock deformation is controlled by the in-situ stress,fracture cohesion and fluid pressure on the hydraulic fracture *** coupled finite element equations are solved by the explicit time difference *** effects of the fracturing treatment parameters including fluid viscosity,pumping rate and cluster spacing on the geometries of multifractures are *** results show that variable fluid-viscosity injection can improve the complexity of the fracture network and height of the main fractures *** pumping rate of15 m^(3)/min,variable fluid-viscosity of 3-9-21-36-45 m.a.s with a cluster spacing of 7.5 m is the ideal treatment *** field application shows that the peak daily production of the application well with the optimized injection procedu re of variable fluid-viscosity fracturing is 171 tons(about 2.85 times that of the adjacent well),which is the highest daily production record of a single shale oil well in China,marking a strategic breakthrough of commercial shale oil production in the Jiyang Depression,Shengli *** variable fluid-viscosity fracturing technique is proved to be very effective for improving shale oil production.

关键词： Shale oil reservoir FEm-DFN model Fracture propagation Variable fluid-viscosity injection Bedding planes

基于NLRP3/caspase-1/GSDmD信号通路介导的细胞焦亡探讨大黄糖络丸对糖尿病肾脏疾病的干预效应

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中国药理学通报 2024年第8期40卷 1552-1558页

作者：薛春霞张媛媛杨霞章溥苏蓓蓓朱向东梁建庆甘肃中医药大学基础医学院甘肃兰州730000 甘肃天水市中医院内分泌科甘肃天水741000 宁夏医科大学中医学院宁夏银川750004

目的探讨大黄糖络丸(Dahuang Tangluo pills,DHTL)对糖尿病肾脏疾病(diabetic kidney disease,DKD)db/db小鼠NOD样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)/半胱氨酸天冬氨酸蛋白水解酶-1(cystein-asparate protease-1,caspase-1)/消皮素D(gasdermin D,GSDmD)通路介导的细胞焦亡的干预效应及机制。方法将8只db/m小鼠作为空白对照组,将40只db/db小鼠造模成功后随机分为模型组,DHTL低剂量组、中剂量组、高剂量组,达格列净组,每组各8只。空白组和模型组给予等体积生理盐水灌胃,DHTL低、中、高剂量组分别给予DHTL溶液0.9、1.8、3.6 g·kg^(-1),达格列净组给予达格列净片溶液1.5 mg·kg^(-1),6组小鼠均每日灌胃1次,连续给药10周,给药期间每日检测小鼠体质量并调整灌胃剂量。给药结束后分别检测各组小鼠空腹血糖(fasting blood glucose,FBG)及体质量;采用全自动生化分析仪检测小鼠24 h尿总蛋白(24 h urine protein,24h-UTP)、血肌酐(creatinine,Scr)及尿素氮(blood urea nitrogen,BUN)水平;采用ELISA测定小鼠肾组织中IL-1β、IL-6、IL-18、TNF-α水平;HE染色观察小鼠肾组织病理改变;TUNEL染色观察小鼠肾组织细胞DNA的损伤情况;采用RT-PCR和Western blot检测小鼠肾组织NLRP3、caspase-1、GSDmD mRNA及蛋白表达。结果与空白组比较,模型组小鼠FBG、体质量、24h-UTP、IL-1β、IL-6、IL-18、TNF-α均明显升高(PmD mRNA及蛋白表达明显增加(PmD mRNA及蛋白表达均明显下降(PmD通路抑制细胞焦亡,缓解DKD小鼠的炎症反应。

关键词：糖尿病肾脏疾病大黄糖络丸 NLRP3/caspase-1/GSDmD 细胞焦亡炎症反应

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Berberine improves central memory formation of CD8^(+)T cells:Implications for design of natural product-based vaccines

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2259-2268页

作者： mingyan Li Yaling Wang Lingzhi Zhang Changxing Gao Jing JLi Jiandong Jiang qing zhu State Key Laboratory of Bioactive Substance and Function of Natural medicines and Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Chinese materia medica and Yunnan Key Laboratory of Southern medicinal Utilization Yunnan University of Chinese MedicineYunnan 650500China

Berberine(BBR)as one of the most effective natural products has been increasingly used to treat various chronic diseases due to its immunosuppressive/tolerogenic ***,it is unknown if BBR can be applied without abrogating the efforts of *** we show that priming of CD8^(+)T cells in the presence of BBR lead to improved central memory formation(Tcm)with substantially reduced effector proliferation,primarily orchestrated through activation of AmPK and *** derived from vaccinated mice fed with BBR were able to adoptively transfer protective immunity to naIve *** of BBR-fed mice conferred better memory protection against infection without losing immediate effector efficacy,suggesting appreciable benefits from using BBR in ***,our study may help to lay the groundwork for mechanistic understanding of the immunomodulatory effects of natural products and their potential use as adjuvant that allows the design of novel vaccines with more desirable properties.

关键词： Berberine CD8^(+)T cell T cell priming Central memory AmPK Stat5 Vaccine design Naturally occurring compound

某燃气轮机电厂启动全过程无硝黄烟排放操作方法

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南方能源建设 2024年第4期11卷 144-155页

作者：张石凯程硕黄庆周建朱为东唐寅中国华能集团南京燃机发电有限公司江苏南京210034

[目的]某燃气轮机电厂的GE-PG9351FA型燃气轮机发电机组,目前采用DLN2.0+燃烧器,设计NO_(x)(氮氧化物)排放浓度为50 mg/m^(3),启动过程中大量排放黄色烟雾,已无法满足《火电厂大气污染物排放标准》(GB 13223—2011)要求,频繁遭到周围居... 详细信息

[目的]某燃气轮机电厂的GE-PG9351FA型燃气轮机发电机组,目前采用DLN2.0+燃烧器,设计NO_(x)(氮氧化物)排放浓度为50 mg/m^(3),启动过程中大量排放黄色烟雾,已无法满足《火电厂大气污染物排放标准》(GB 13223—2011)要求,频繁遭到周围居民举报。根据江苏环保排放新规,自2023年1月1日起,NO_(x)折算排放全程小时均值均小于30 mg/m^(3)。针对该种型号燃烧器进一步降低NO_(x)且解决启动过程中硝黄烟排放的需求,电厂采用余热锅炉烟道SCR脱硝改造技术,且对启动过程各指标控制进行数据模拟推演、分析总结,提炼出合理的启动操作方法。[方法]为验证该操作方法的可行性,电厂进行了多次调峰启动过程操作试验,并根据实际NO_(x)排放特性修正操作方法中的启动时刻、燃气轮机负荷控制、SCR脱硝系统投入节点,形成最优化操作法。[结果]试验结果表明:在优化电厂SCR脱硝系统投入时刻、燃气轮机启动时刻、并网后暖机负荷后,NO_(x)折算排放全程小时均值均小于30 mg/m^(3),且硝黄烟排放现象消失。[结论]该操作策略是基于燃气轮机启动过程NO_(x)与硝黄烟排放特性而得出,后期通过数据推演和大量试验验证,可为同类型燃气轮机启动过程降低氮氧化物与硝黄烟现象提供直接指导,并为燃气轮机电厂调峰运行的NO_(x)排放控制提供分析借鉴思路。

关键词：燃气轮机电厂氮氧化物硝黄烟模拟推演启动时刻暖机负荷排放控制

超高效液相色谱-三重四极杆质谱法同时测定消肿膏中6种乌头型生物碱含量

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中国临床药理学杂志 2024年第9期40卷 1341-1344页

作者：夏天利赵德萍薛傲金美玲朱紫悦李卿张宁雷霞佳木斯大学药学院黑龙江佳木斯154007 黑龙江中医药大学中医药研究所黑龙江哈尔滨150040 无锡市中医医院江苏省中医退行性骨关节病临床医学创新中心江苏无锡214071

目的用超高效液相色谱-三重四极杆质谱串联(UPLC-TQD-mS)法同时测定消肿膏中乌头碱、新乌头碱、次乌头碱、苯甲酰乌头原碱、苯甲酰新乌头原碱、苯甲酰次乌头原碱的含量。方法用ACQUITY UPLC BEH C18柱(50 mm×2.1 mm,1.7μm),流动相为0... 详细信息

目的用超高效液相色谱-三重四极杆质谱串联(UPLC-TQD-mS)法同时测定消肿膏中乌头碱、新乌头碱、次乌头碱、苯甲酰乌头原碱、苯甲酰新乌头原碱、苯甲酰次乌头原碱的含量。方法用ACQUITY UPLC BEH C18柱(50 mm×2.1 mm,1.7μm),流动相为0.1%甲酸水(A)-乙腈(B),梯度洗脱,柱温为40℃,流速为0.3 mL·min^(-1),进样量5μL;用电喷雾离子源正离子模式(ESI+)和多反应监测模式(mRm)进行质谱分析。结果乌头碱、新乌头碱、次乌头碱、苯甲酰乌头原碱、苯甲酰新乌头原碱、苯甲酰次乌头原碱的质量浓度均在1.0~100.0 ng·mL^(-1)呈良好线性关系,平均加样回收率为98.62%~101.24%。3个批样品中,6个成分的质量分数分别为0.18、0.33、0.38、0.43、0.28、0.06μg·g^(-1)。结论该方法可用于检测消肿膏中6种乌头型生物碱含量,为消肿膏的质量评价及临床安全用药提供参考。

关键词：消肿膏乌头型生物碱超高效液相色谱-三重四极杆质谱法含量测定

禁渔初期长江宜昌-城陵矶江段鱼类资源时空分布特征

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水生生物学报 2024年第4期48卷 546-557,I0001页

作者：史银魁俞立雄周雪高雷朱峰跃杨锦毅陈大庆王珂段辛斌中国水产科学研究院长江水产研究所国家农业科学重庆观测实验站/农业农村部长江中上游渔业资源环境科学观测实验站武汉430223 上海海洋大学水产科学国家级实验教学示范中心上海201306

研究于2022年7月(丰水期)和2023年1月(枯水期)使用SImARD EY60回声探测仪对长江中游宜昌-城陵矶江段的鱼类资源进行了调查,并结合网捕调查结果,评估了长江十年禁渔初期该江段鱼类资源的时空分布特征。结果显示,禁渔初期宜昌-城陵矶江段... 详细信息

研究于2022年7月(丰水期)和2023年1月(枯水期)使用SImARD EY60回声探测仪对长江中游宜昌-城陵矶江段的鱼类资源进行了调查,并结合网捕调查结果,评估了长江十年禁渔初期该江段鱼类资源的时空分布特征。结果显示,禁渔初期宜昌-城陵矶江段丰水期和枯水期的鱼类密度分别为128.69和38.43 ind./1000 m^(3),目标强度(TS)均值分别为–57.54和–60.18 dB,转换后鱼类体长均值为5.22和3.85 cm。丰水期和枯水期鱼类密度和TS值均存在显著性差异。在水平方向上,鱼类分布不均匀,蜿蜒曲折处鱼类密度高于平直江段。两次调查鱼类密度最大江段分别为公安-石首和枝江-荆州江段;在垂直方向上,不同水层间鱼类平均密度表现为底层>中层>表层,两时期各水层之间鱼类密度均存在极显著性差异。结合网捕数据及历年历史调查数据,宜昌至城陵矶江段鱼类资源以鲤科、鲿科鱼类为主。禁渔初期鱼类资源有所恢复,但仍以小个体鱼类为主。长江中游鱼类资源的时空分布与生活习性、水域生态环境等因素相关。相关成果将为后续进一步开展禁渔效果评估提供数据支撑。

关键词：长江中游水声学鱼类资源时空分布禁渔初期

Surface‑Alloyed Nanoporous Zinc as Reversible and Stable Anodes for High‑Performance Aqueous Zinc‑Ion Battery

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Nano-micro Letters 2022年第8期14卷 58-71页

作者： Huan meng qing Ran Tian-Yi Dai Hang Shi Shu-Pei Zeng Yong-Fu zhu Zi Wen Wei Zhang Xing-You Lang Wei-Tao Zheng qing Jiang Key Laboratory of Automobile materials(Jilin University) Ministry of EducationSchool of Materials Science and Engineeringand Electron Microscopy CenterJilin UniversityChangchun 130022People’s Republic of China State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022People’s Republic of China

metallic zinc(Zn)is one of the most attractive multivalent-metal anode materials in post-lithium batteries because of its high abundance,low cost and high theoretical ***,it usually suffers from large voltage polarization,low Coulombic efficiency and high propensity for dendritic failure during Zn stripping/plating,hindering the practical application in aqueous rechargeable zinc-metal batteries(AR-ZmBs).Here we demonstrate that anionic surfactant-assisted in situ surface alloying of Cu and Zn remarkably improves Zn reversibility of 3D nanoporous Zn electrodes for potential use as high-performance AR-ZmB anode *** a result of the zincophilic ZnxCuy alloy shell guiding uniform Zn deposition with a zero nucleation overpotential and facilitating Zn stripping via the ZnxCuy/Zn galvanic couples,the self-supported nanoporous ZnxCuy/Zn electrodes exhibit superior dendrite-free Zn stripping/plating behaviors in ambient aqueous electrolyte,with ultralow polarizations under current densities up to 50 mA cm^(‒2),exceptional stability for 1900 h and high Zn *** enables AR-ZmB full cells constructed with nanoporous ZnxCuy/Zn anode and K_(z)mnO_(2)cathode to achieve specific energy of as high as~430 Wh kg^(‒1)with~99.8%Coulombic efficiency,and retain~86%after long-term cycles for>700 h.

关键词： Nanoporous metal Zinc-based alloy anode Aqueous zinc-ion batteries Surface alloying