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Clinical and Pathological Value of MACC-1 Expression in Gastric Carcinoma

Journal of Cancer Therapy 2019年第7期10卷 609-618页

作者： Abeer Hafez tarek el-Gohary Fouad Abutaleb Pathology Department Zagazig University Hospitals Zagazig Egypt Medical Oncology and Hematology Department Zagazig University Hospitals Zagazig Egypt

Background: Gastric adenocarcinoma is known to be a markedly invasive disease with high potential for metastasis. Hepatocyte growth factor (HGF)/HGF receptor (MET) signaling pathway activation is an assumed mechanism of malignant transformation and metastatic potential of tumors. Metastasis associated with colon cancer-1 (MACC-1) has been identified as a key regulator of HGF/MET signaling. However, its role in gastric cancer is not well understood. Aim of this study is to assess the expression of MACC-1 in gastric cancer, its relation to other clinical and pathologic parameters and its impact on progression free and overall survival. Patient and Methods: Evaluation of MACC-1 protein expression by immune-histochemistry was done on paraffin-embedded tissues obtained from 46 patients with gastric cancer, where samples were taken from the tumor and adjacent normal mucosa. Results: MACC-1 was predominantly localized in the cytoplasm or membrane of the primary cancer cells. High MACC-1 expression was found in 63.1% (29/46) of tumor samples, while MACC-1 expression was not detected in normal mucosa (P 0.01). Expression of MACC-1 was significantly associated with older age, larger tumor size, deeper tumor invasion, presence of lymph node metastasis, distant metastasis and advanced clinical stage (p 0.05), while no relation was found with gender, tumor location or histologic classification (p > 0.05). Progression free and overall survival were significantly higher in patients with low MACC-1 expression compared to patients with high expression (Log Rank test, p = 0.02 and 0.04, consequently). Conclusion: Our study found that MACC-1 expression is strongly related to gastric cancer stage and both progression free and overall survival, suggesting that MACC-1 promotes tumorigenesis and its expression may

关键词： Gastric Cancer MACC-1 HGF/MET Signaling

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Effect of Aging on the Toughness of Austenitic and Duplex Stainless Steel Weldments

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Journal of Materials Science & Technology 2010年第9期26卷 810-816页

作者： Omyma Hassan Ibrahim Ibrahim Soliman Ibrahim tarek Ahmed Fouad Khalifa Metallurgy Dept. Nuclear Research CentreAtomic Energy Authority(Egypt) Nuclear Safety Centre Atomic Energy Authority(Egypt) Shoubra Faculty of Engineering Benha University

In the present study,the effect of aging heat treatment at 650,750,and 850？C on the impact toughness of 316L austenitic stainless steel,2205 duplex stainless steel and their weldments has been *** process was conducted using the TIG（tungsten inert gas） welding *** impact testing,at room temperature,was employed to determine the effect of aging treatment on the impact properties of investigated *** treatment resulted in degradation in the impact toughness as demonstrated by the reduction in the impact fracture energy and deformation parameters（strain hardening capacity,fracture deffection,and crack initiation and propagation energy）.The degree of embrittlement was more noticeable in duplex stainless steel parent and weld-metal than in 316L stainless steel and became greater with the increase of aging *** degradation in impact toughness was discussed in relation to the observed precipitation of the intermetallic sigma phase in the microstructure of the stainless steel weldments and the corresponding fracture surface morphology.

关键词： Austenitic and duplex stainless steels Aging Instrumented impact Toughness

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Glycogenic hepatopathy

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Hepatobiliary & Pancreatic Diseases International 2018年第2期17卷 113-118页

作者： Johad Khoury Yaniv Zohar Naim Shehadeh tarek Saadi Internal Medicine B Rambam Health Care Campus and Rappaport Faculty of Medicine Technion-Israel Institute of Technology Liver Unit Rambam Health Care Campus and Rappaport Faculty of Medicine Technion-Israel Institute of Technology Department of Pathology Rambam Health Care Campus and Rappaport Faculty of Medicine Technion-Israel Institute of Technology Meyer Children's Hospital of Haifa Rambam Health Care Campus and Rappaport Faculty of Medicine Technion-Israel Institute of Technology Institute of Diabetes Endocrinology and Metabolism Rambam Health Care Campus and Rappaport Faculty of Medicine Technion-Israel Institute of Technology Department of Gastroenterology Rambam Health Care Campus and Rappaport Faculty of Medicine Technion-Israel Institute of Technology

Background: Glycogenic hepatopathy(GH) is a disorder associated with uncontrolled diabetes mellitus,most commonly type 1, expressed as right upper quadrant abdominal pain, hepatomegaly and increased liver enzymes. The diagnosis may be difficult, because laboratory and imaging tests are not pathognomonic. Although GH may be suggested based on clinical presentation and imaging studies, the gold standard for diagnosis is a liver biopsy, showing a significant accumulation of glycogen within the hepatocytes. GH may be diagnosed also after elevated liver enzymes in routine blood tests. GH usually regresses after tight glycemic control. Progression to end-stage liver disease has never been reported. This review aims to increase the awareness to this disease, to suggest a pathway for investigation that may reduce the use of unnecessary tests, especially invasive *** sources: A Pub Med database search(up to July 1, 2017) was done with the words "glycogenic hepatopathy", "hepatic glycogenosis", "liver glycogenosis" and "diabetes mellitus-associated glycogen storage hepatopathy". Articles in which diabetes mellitus-associated liver glycogen accumulation was described were included in this ***: A total of 47 articles were found, describing 126 patients with GH. Hepatocellular disturbance was more profound than cholestatic disturbance. No synthetic failure was ***: GH may be diagnosed conservatively, based on corroborating medical history, physical examination, laboratory tests, imaging studies and response to treatment, even without liver biopsy. In case of doubt about the diagnosis or lack of clinical response to treatment, a liver biopsy may be *** is no role for noninvasive tests like fibroscan or fibrotest for the diagnosis of GH or for differentiation of this situation from nonalcoholic fatty liver disease.

关键词： Glycogenic hepatopathy Diabetes mellitus Hepatic glycogenosis Mauriac syndrome

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Centrifuge modeling of PGD response of buried pipe

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Earthquake Engineering and Engineering Vibration 2005年第1期4卷 69-73页

作者： Michael O'Rourke Vikram Gadicherla tarek Abdoun Department of Civil and Environmental Engineering Rensselaer Polytechnic Institute Troy New York USAProfessorHance Engineering Solutions Hyderabad IndiaEngineerDepartment of Civil and Environmental Engineering Rensselaer Polytechnic Institute Troy New York USA Assistant Professor

A new centrifuge based method for determining the response of continuous buried pipe to PGD is presented. The physical characteristics of the RPI's 100 g-ton geotechnical centrifuge and the current lifeline experiment split-box are described: The split-box contains the model pipeline and surrounding soil and is manufactured such that half can be offset, in flight, simulating PGD. In addition, governing similitude relations which allow one to determine the physical characteristics, (diameter, wall thickness and material modulus of elasticity) of the model pipeline are presented. Finally, recorded strains induced in two buried pipes with prototype diameters of 0.63 m and 0.95 m (24 and 36 inch) subject to 0.6 and 2.0 meters (2 and 6 feet) of full scale fault offsets and presented and compared to corresponding FE results.

关键词： earthquakes buried pipe permanent ground deformation centrifuge models fault crossings lifeline earthquake engineering

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Editorial on“Laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients:a propensity score matching analysis”

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 580-582页

作者： Jean Gugenheim tarek Debs Department of Digestive Surgery and Liver Transplant Unit University Côte d’AzurCHU de NiceNiceFrance

We read with great interest the article of Delvecchio et *** in a recent issue of HPB journal(1).The authors compared short-and long-term outcomes of laparoscopic and open liver resection(OLR)in elderly patients with ... 详细信息

关键词： patients hepatocellular al.

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Feasibility of 0.02% Nb-Based Microalloyed Steel for the Application of One-Step Quenching and Partitioning Heat Treatment

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Materials Sciences and Applications 2021年第8期12卷 374-387页

作者： Basem tarek Eman el-Shenawy Ahmed el-Sabbagh Mohamed A. Taha Design and Production Engineering Department Faculty of Engineering Ain Shams University Cairo Egypt Plastic Deformation Department Central Metallurgical R&D Institute (CMRDI) Cairo Egypt

To attain an enhanced combination of mechanical properties for low alloyed steel, the current study has been made to fulfill that growing need in the industry. Its results are introduced within this paper. One step Quenching and Partitioning (Q&P) heat treatment has been applied on Niobium-based microalloyed steel alloy with 0.2 %C, in the form of 2 mm thickness sheets. The target of this study is to investigate the viability of applying that significantly recommended, results-wise, heat treatment on the highly well-suited alloy steel samples, to achieve the main target of enhanced properties. A single temperature of 275°C was used as quenching and Partitioning temperature. Four Partitioning periods (30, 200, 500, and 1000 Seconds) were used for soaking at the same temperature. The results were analyzed in the light of microstructural investigation and mechanical testing. All applied cycles did not enhance the strength but moderately improved the ductility and toughness, mainly caused by the slightly high soaking temperature used. Niobium impact of grain refining was apparent through all cycles. The cycle of 500 Seconds Partitioning time obtained optimum values at that particular temperature. The 1000 Seconds Cycle obtained the worst combination of properties. A set of recommendations are set. More research is required at this point, where a lower Partitioning temperature is advised. In the light of the applied combination of parameters, the Partitioning period at such temperature is advised to be between 500 and 1000 Seconds. A high probability that periods closer to 500 than 1000 Seconds will produce better results. More research is needed between those two values of Partitioning time to precisely determine the optimum time at that temperature on that specific alloy.

关键词： Nb-Based Microalloyed Steel Advanced High Strength Steel Quenching and Partitioning Retained Austenite Martensite Transformation Automotive Applications

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Energy-Efficient UAVs Coverage Path Planning Approach

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 3239-3263页

作者： Gamil Ahmed tarek Sheltami Ashraf Mahmoud Ansar Yasar Computer Engineering Department Interdisciplinary Research Center of Smart Mobility and LogisticsKing Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia Transportation Research Institute(IMOB) Hasselt UniversityHasselt3500Belgium

Unmanned aerial vehicles(UAVs),commonly known as drones,have drawn significant consideration thanks to their agility,mobility,and flexibility *** play a crucial role in modern reconnaissance,inspection,intelligence,and surveillance *** path planning(CPP)which is one of the crucial aspects that determines an intelligent system’s quality seeks an optimal trajectory to fully cover the region of interest(ROI).However,the flight time of the UAV is limited due to a battery limitation and may not cover the whole region,especially in large ***,energy consumption is one of the most challenging issues that need to be *** this paper,we propose an energy-efficient coverage path planning algorithm to solve the CPP *** objective is to generate a collision-free coverage path that minimizes the overall energy consumption and guarantees covering the whole *** do so,the flight path is optimized and the number of turns is reduced to minimize the energy *** proposed approach first decomposes the ROI into a set of cells depending on a UAV camera ***,the coverage path planning problem is formulated,where the exact solution is determined using the CPLEX *** small-scale problems,the CPLEX shows a better solution in a reasonable ***,the CPLEX solver fails to generate the solution within a reasonable time for large-scale ***,to solve the model for large-scale problems,simulated annealing forCPP is *** results show that heuristic approaches yield a better solution for large-scale problems within amuch shorter execution time than the CPLEX ***,we compare the simulated annealing against the greedy *** results show that simulated annealing outperforms the greedy algorithm in generating better solution quality.

关键词： Coverage path planning MILP CPLEX solver energy model optimization region of interest area of interest

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Potential Assessment Multi-Repeating Abiotic/Biotic Motivation Coincide Biofertilizers to Optimize Black Cumin (<i>Nigella sativa</i>L.) Seed Yield Production and Quality

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Agricultural Sciences 2021年第2期12卷 69-83页

作者： tarek elsayed S.A el Sayed S.A Radioisotopes Department Nuclear Research Center Egyptian Atomic Energy Authority Cairo Egypt

Black cumin (Nigella sativa L.) the highly aggregate valuable medicinal plant was field cultivated for two subsequent seasons (2018, 2019) designed as factorial split plot based on randomized complete block with 3 replications. The main factors 4 elicitors: salicylic acid, (SA) Nano-selenium (NPs), yeast (YS) chitosan (CH) and (E0), control. Whereas, the sub-main plot 4 biofertilizers, dray Moringa leaves extract, (MLE), neem dray leaves extract (NME), humic acid (HA) and traditional (NPK) chemical fertilizer as control. Allied statistical analysis of variance revealed that biotic and abiotic elicitors coincide biofertilizer and NPK chemical fertilizer actuated significant positive impacts, dray seed, seed fixed oil, seed essential oil yield production. Also, significantly amelioration bioactive major fatty acids content of seed fixed oil (linolenic > carvone) dihydrolenoleic > oleic) as well as major terpens content of seed essential oil (P-cymene > thnymoquione > Penine). Consequently, multi-repeating elicitation cod be considered reliable strategy achieve sustainable development for N-sativa under, biotic elicitor coincide biofertilizers that excel abiotic elicitors coincide biofertilizer which excel biotic or abiotic elicitors coincide NPK traditional chemical fertilizer.

关键词： Blacke Cumin Medicinal Plant elicitation Salicylic Acid Chitosan Nano-Selenium Yeast Biofertilizers Essential Oil

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Building Custom Spreadsheet Functions with Python:End-User Software Engineering Approach

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Journal of Software Engineering and Applications（软件工程与应用） 2024年第5期 246页

作者： Tamer Bahgat elserwy Atef Tayh Nour el-Din Raslan tarek Ali Mervat H.Gheith

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Enhancing Data Analysis and Automation: Integrating Python with Microsoft Excel for Non-Programmers

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Journal of Software Engineering and Applications（软件工程与应用） 2024年第6期 530页

作者： Osama Magdy Ali Mohamed Breik tarek Aly Atef Tayh Nour el-Din Raslan Mervat Gheith

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