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Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects

Neural Regeneration Research 2014年第9期9卷 901-906页

作者： tarek h.mouhieddine Firas h.Kobeissy Muhieddine Itani Amaly Nokkari Kevin K.W.Wang Faculty of Medicine American University of Beirut Medical Center Center for Neuroproteomics and Biomarkers Research Department of Psychiatry Gainesville Division of Addiction Medicine Department of Psychiatry University of Florida Faculty of Medicine Saint George University of London Department of Biochemistry and Molecular Genetics American University of Beirut

The prevalence of neurodegenerative diseases and neural injury disorders is increasing worldwide. Research is now focusing on improving current neurogenesis techniques including neural stem cell therapy and other biochemical drug-based approaches to ameliorate these disorders. Unfortunately, we are still facing many obstacles that are rendering current neurotherapies ineffective in clinical trials for reasons that are yet to be discovered. That is why we should start by fully understanding the complex mechanisms of neurogenesis and the factors that affect it, or else, all our suggested therapies would fail since they would not be targeting the essence of the neurological disorder but rather the symptoms. One possible paradigm shift is to switch from neuroprotectant therapies towards neurodegeneration/neurorestorative approaches. In addition, other and our laboratories are increasingly focusing on combining the use of pharmacological agents（such as Rho-associated kinase（ROCK） inhibitors or other growth factors（such as brain-derived neurotrophic factor（BDNF）） and stem cell treatment to enhance the survivability and/or differentiation capacity of transplanted stem cells in neurotrauma or other neurodegeneration animal models. Ongoing stem cell research is surely on the verge of a breakthrough of multiple effective therapeutic options for neurodegenerative disorders. Once, we fully comprehend the process of neurogenesis and its components, we will fully be capable of manipulating and utilizing it. In this work, we discuss the current knowledge of neuroregenerative therapies and their associated challenges.

关键词： neural stem cells neurodegeneration neuroinjury TBI rho-associated kinase(ROCK) inhibitor BDNF growth factors stem cell therapy

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A hybrid machine-learning model for solar irradiance forecasting

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Clean Energy 2024年第1期8卷 100-110页

作者： Ameera M.Almarzooqi Maher Maalouf tarek h.M.El-Fouly Vasileios E.Katzourakis Mohamed S.El Moursi Constantinos V.Chrysikopoulos Department of Industrial and Systems Engineering Khalifa UniversityAbu DhabiPO Box 127788UAE Electrical Engineering and Computer Science Department Khalifa University Abu DhabiUAE Department of Civil Infrastructure and Environmental Engineering Khalifa UniversityAbu DhabiPO Box 127788UAE School of Chemical and Environmental Engineering Technical University of CreteChaniaGreece

Nowcasting and forecasting solar irradiance are vital for the optimal prediction of grid-connected solar photovoltaic(PV)power *** plants face operational challenges and scheduling dispatch difficulties due to the fluctuating nature of their power *** the generation capacity within the electric grid increases,accurately predicting this output becomes increasingly essential,especially given the random and non-linear characteristics of solar irradiance under variable weather *** study presents a novel prediction method for solar irradiance,which is directly in correlation with PV power output,targeting both short-term and medium-term forecast *** proposed hybrid framework employs a fast trainable statistical learning technique based on the truncated-regularized kernel ridge regression *** proposed method excels in forecasting solar irradiance,especially during highly intermittent weather periods.A key strength of our model is the incorporation of multiple historical weather parameters as inputs to generate accurate predictions of future solar irradiance values in its scalable *** evaluated the performance of our model using data sets from both cloudy and sunny days in Seattle and Medford,USA and compared it against three forecasting models:persistence,modified 24-hour persistence and least *** on three widely accepted statistical performance metrics(root mean squared error,mean absolute error and coefficient of determination),our hybrid model demonstrated superior predictive accuracy in varying weather conditions and forecast horizons.

关键词： solar power generation kernel ridge regression hybrid model forecasting

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A critical review towards the causes of the iron-based catalysts deactivation mechanisms in the selective oxidation of hydrogen sulfide to elemental sulfur from biogas

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Journal of Energy Chemistry 2024年第3期90卷 388-411,I0010页

作者： Mostafa tarek Janaina S.Santos Victor Márquez Mohammad Fereidooni Mohammad Yazdanpanah Supareak Praserthdam Piyasan Praserthdam Center of Excellence on Catalysis and Catalytic Reaction Engineering(CECC) Department of Chemical EngineeringFaculty of EngineeringChulalongkorn UniversityBangkok 10330Thailan high-Performance Computing Unit(CECC-hCU) Center of Excellence on Catalysis and Catalytic Reaction Engineering(CECC)Chulalongkorn UniversityBangkok 10330Thailand

hydrogen sulfide(h_(2)S) not only presents significant environmental concerns but also induces severe corrosion in industrial equipment,even at low *** various technologies,the selective oxidation of hydrogen sulfide(SOh_(2)S) to elemental sulfur(S) has emerged as a sustainable and environmentally friendly *** to its unique properties,iron oxide has been extensively investigated as a catalyst for SOh_(2)S;however,rapid deactivation has remained a significant *** causes of iron oxide-based catalysts deactivation mechanisms in SOh_(2)S,including sulfur or sulfate deposition,the transformation of iron species,sintering and excessive oxygen vacancy formation,and active site loss,are thoroughly examined in this *** focusing on the deactivation mechanisms,this review aims to provide valuable insights into enhancing the stability and efficiency of iron-based catalysts for SOh_(2)S.

关键词： Selective oxidation of h_(2)S Iron-based Catalysts Mechanism of deactivation Sulfur or sulfate deposition Transformation of iron species Sintering SDG 7

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Building Custom Spreadsheet Functions with Python: End-User Software Engineering Approach

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Journal of Software Engineering and Applications 2024年第5期17卷 246-258页

作者： Tamer Bahgat Elserwy Atef Tayh Nour El-Din Raslan tarek Ali Mervat h. Gheith Department of Software Engineering Faculty of Graduate Studies for Statistical Research (FGSSR) Cairo University Giza Egypt Department of Information Systems Higher Institute of Advanced Studies Giza Egypt

End-user computing empowers non-developers to manage data and applications, enhancing collaboration and efficiency. Spreadsheets, a prime example of end-user programming environments widely used in business for data analysis. however, Excel functionalities have limits compared to dedicated programming languages. This paper addresses this gap by proposing a prototype for integrating Python’s capabilities into Excel through on-premises desktop to build custom spreadsheet functions with Python. This approach overcomes potential latency issues associated with cloud-based solutions. This prototype utilizes Excel-DNA and IronPython. Excel-DNA allows creating custom Python functions that seamlessly integrate with Excel’s calculation engine. IronPython enables the execution of these Python (CSFs) directly within Excel. C# and VSTO add-ins form the core components, facilitating communication between Python and Excel. This approach empowers users with a potentially open-ended set of Python (CSFs) for tasks like mathematical calculations, statistical analysis, and even predictive modeling, all within the familiar Excel interface. This prototype demonstrates smooth integration, allowing users to call Python (CSFs) just like standard Excel functions. This research contributes to enhancing spreadsheet capabilities for end-user programmers by leveraging Python’s power within Excel. Future research could explore expanding data analysis capabilities by expanding the (CSFs) functions for complex calculations, statistical analysis, data manipulation, and even external library integration. The possibility of integrating machine learning models through the (CSFs) functions within the familiar Excel environment.

关键词： End-User Software Engineering Custom Spreadsheet Functions (CSFs)

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Synthesized graphene oxide and fumed aerosil 380 dispersion stability and characterization with partially hydrolyzed polyacrylamide

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Chinese Journal of Chemical Engineering 2021年第6期34卷 307-322页

作者： Najeebullah Lashari tarek Ganat Department of Petroleum Engineering Universiti Teknologi PETRONAS32610 Seri IskandarPerak Darul RidzuanMalaysia Department of Petroleum and Gas Engineering Dawood University of Engineering&TechnologyM.A Jinnah RoadKarachi 74800Pakistan

hydrolyzed polyacrylamide(hPAM)is a commonly used polymer for the chemicals,mining and refining processes of hydrocarbon but suffers from a persistent high-temperature instability *** contrast,the nanoparticle suspension remains a technical challenge because of the strong interactions of van der Waal forces within nanoparticles,which always encourage *** research sought to improve nanoparticles(NP)stability and polymer(hPAM)rheological properties to improved hydrocarbon recovery by utilizing synthesized graphene oxide(GO)nanosheets and fumed Aerosil 380 Silica oxide(SiO_(2)).The aqueous nanocomposites based on hPAM-GO and hPAM-SiO_(2) in aqueous polymeric solutions have been developed,and its viscoelastic and static behaviour is *** results imply that by adding fumed silica NP,the viscoelastic behaviour of hPAM is marginally improved,particularly in high temperatures and salinity,however,the inclusion of GO's significantly improves the viscosity and stability of the base polymer fluid at high *** Fourier data for the transformation of the infrared spectrum confirmed that the hydrogen bonding formed between hPAM carbonyl groups and silica NP surface silanol functionality and covalent interlinking of electrostatic h-bonding between hPAM and functional GO contributed to the improved stabilization and improved rheological performance that helps to recover high salinity and temperature hydrocarbons.

关键词： Aggregation Composites Chemical enhance oil recovery hydrocarbons Nanoparticles Polymer

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Impact Assessment and Mitigation Techniques for high Penetration Levels of Renewable Energy Sources in Distribution Networks:Voltage-control Perspective

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 450-458页

作者： Ahmed S.A.Awad Dave Turcotte tarek h.M.El-Fouly Natural Resources Canada Can-metENERGYVarennesCanadaon leave from the Electrical Power and Machines DepartmentFaculty of EngineeringAin Shams UniversityCairo 11566Egyp Natural Resources Canada CanmetENERGYVarennesCanada Advanced Power and Energy Center Khalifa UniversityAbu DhabiUnited Arab Emirates

The integration of renewable distributed generation(RDG)into distribution networks is promising and increasing ***,high penetration levels of distributed generation(DG)are often limited as they may have an adverse effect on the operation of distribution *** of the operation challenges is the interaction between DG and voltage-control equipment,e.g.,an under-load tap changer(ULTC),which is basically designed to compensate for voltage changes caused by slow load *** integration of variable DGs leads to rapid voltage fluctuations,which can negatively affect the tap operation of *** paper investigates the impact of high penetration levels of RDG on the tap operation of ULTC in distribution networks through *** mitigation techniques that can alleviate this impact are also *** these techniques,constant power-factor mode is regarded as the best trade-off between the simplicity and effectiveness of minimizing the number of tap *** are performed on a Canadian benchmark rural distribution feeder using OpenDSS software.

关键词： Renewable energy distributed generation(DG) voltage regulator load tap changer distribution network.

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Maize response to elevated plant density combined with lowered N-fertilizer rate is genotype-dependent

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The Crop Journal 2015年第2期3卷 96-109页

作者： Ahmed Medhat M.Al-Naggar Reda A.Shabana Mohamed M.M.Atta tarek h.Al-Khalil Agronomy Department Faculty of Agriculture Cairo University

Increasing plant density and improving N fertilizer rate along with the use of high density-tolerant genotypes would lead to maximizing maize(Zea mays L.) grain productivity per unit land area. The objective of this investigation was to match the functions of optimum plant density and adequate nitrogen fertilizer application to produce the highest possible yields per unit area with the greatest maize genotype efficiency. Six maize inbred lines differing in tolerance to low N and high density(D) [three tolerant(T); L-17, L-18, L-53,and three sensitive(S); L-29, L-54, L-55] were chosen for diallel crosses. Parents and crosses were evaluated in the 2012 and 2013 seasons under three plant densities: low(47,600),medium(71,400), and high(95,200) plants ha-1and three N fertilization rates: low(no N addition), medium(285 kg N ha-1) and high(570 kg N ha-1). The T × T crosses were superior to the S × S and T × S crosses under the low N–high D environment in most studied traits across seasons. The relationships between the nine environments and grain yield per hectare(GYPh) showed near-linear regression functions for inbreds L54, L29, and L55 and hybrids L18 × L53 and L18 × L55 with the highest GYPh at a density of47,600 plants ha-1and N rate of 570 kg N ha-1and a curvilinear relationship for inbreds L17, L18, and L53 and the rest of the hybrids with the highest GYPh at a density of95,200 plants ha-1combined with an N rate of 570 kg N ha-1. Cross L17 × L54 gave the highest grain yield in this study under both high N–high-D(19.9 t ha-1) and medium N–high-D environments(17.6 t ha-1).

关键词： Quadratic regression Appropriate N rate high-density tolerant maize Unit area productivity

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Review of analytical methods for stress and deformation analysis of buried water pipes considering pipe-soil interaction

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Underground Space 2023年第6期13卷 205-227页

作者： Yingxu huo Sherif Mohsen Mohamed hassan Gomaa tarek Zayed Mohamed Meguid Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China Department of Building and Real Estate The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China Structural Engineering Department Faculty of EngineeringMansoura UniversityMansoura 35516Egypt Department of Civil Engineering McGill UniversityMontrealQuebec H3A 0G4Canada

Buried water pipelines are vulnerable to fail or break due to excessive loading or ground *** evaluation of pipe performance and serviceability relies on the proper understanding of pipe-soil interactions(PSI).Analytical methods are important approaches to studying ***,a systematic and thorough literature review to analyze the existing research trends,technological achievements and future research opportunities is not *** work investigates analytical methods that analyze the stress and deformation of pipes in terms of cross-sectional,transverse and longitudinal PSI ***,scientometric analysis is performed to acquire relevant research works from online databases and analyze the existing data of influential authors,productive research sources and frequent key word occurrence in the fields of ***,a qualitative discussion is performed in the three categories of PSI:(1)cross-sectional,including ovalization and circumferential behaviours;(2)transverse,including seismic fault crossing,weak soil zones,ground settlement and pipe uplift;and(3)***,six research opportunities are discussed,including the role of friction in cross-sectional deformation,combined effects of bending and compression,choice of soil reaction models and calibration of key parameters,effect of pipe flaws,soil spatial variability and behaviours of curved *** study helps beginners familiarize themselves with PSI analytical methods and provides experienced researchers with ideas for future research directions.

关键词： Pipeline Analytical methods Pipe-soil interactions Seismic fault Settlement Uplift Buckling Tunnelling

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Availability,sustainability and accessibility of agro crop residue production and solar radiation in Egypt for producing highly chemical products through pyrolysis processes

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Clean Energy 2023年第3期7卷 654-670页

作者： Saad A.El-Sayed Mohamed A.Ismail Mohamed E.Mostafa Emad h.Noseir tarek M.Khass Mechanical Power Engineering Department Faculty of EngineeringZagazig UniversityAl-SharkiaEgypt Mechanical Engineering Department College of EngineeringKing Faisal UniversityAl-AhsaSaudi Arabia Environmental Engineering Department Faculty of EngineeringZagazig UniversityAl-SharkiaEgypt

This study examines the large amount of agricultural waste produced in Egypt between 2010 and 2019 by analysing data from various departments within the Agriculture *** also provides a comprehensive database on the biomass available from agricultural waste in Egypt and its potential applications for producing power,heat and chemical *** biomass-pyrolysis systems powered by solar energy are used,research demonstrates the potential to convert agricultural waste into a variety of chemical *** approach utilizes solar energy,a clean and renewable source,and has wide-ranging industrial and power generation *** Egypt’s reliance on agriculture,the country currently utilizes little biomass for energy production and has not previously used it as a source for creating chemical products,which could potentially save on the imported oil used in these *** findings of the study are graphically presented using histograms,pie charts,*** overall production of residues reached the 30-Mt level in *** it contains the most rice-cultivated land,Dakahlia(Lower Egypt region)produces the highest percentage of the total residue(37.17%).Qena governorate(Upper Egypt region)produces 1.14 metric tons of residues,with sugarcane accounting for 20.3%of the total.

关键词： biomass agro-residue solar radiation pyrolysis chemical products sustainability

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Wearable,epidermal devices for assessment of swallowing function

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npj Flexible Electronics 2023年第1期7卷 1-19页

作者： tarek Rafeedi Abdulhameed Abdal Beril Polat Katherine A.hutcheson Eileen h.Shinn Darren J.Lipomi Department of NanoEngineering University of CaliforniaSan Diego 9500 Gilman DriveMail Code 0448La JollaCA 92093-0448USA Department of Mechanical and Aerospace Engineering University of CaliforniaSan Diego 9500 Gilman DriveMail Code 0448La JollaCA 92093-0448USA Department of head and Neck Surgery Division of SurgeryDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterUnit 14451515 Holcombe StreetHoustonTX 77030-4009USA Department of Behavioral Sciences The University of Texas MD Anderson Cancer CenterUnit 13301155 Pressler StreetHoustonTX 77230-1439USA

Swallowing is an ensemble of voluntary and autonomic processes key to maintaining our body’s homeostatic *** swallowing(dysphagia)can cause dehydration,malnutrition,aspiration pneumonia,weight loss,anxiety,or even mortality—especially in older adults—by airway *** prevent or mitigate these outcomes,it is imperative to regularly assess swallowing ability in those who are at risk of developing dysphagia and those already diagnosed with ***,current diagnostic tools such as endoscopy,manometry,and videofluoroscopy require access to clinical experts to interpret the *** results are often sampled from a limited examination timeframe of swallowing activity in a controlled ***,there is some risk of periprocedural complications associated with these *** contrast,the field of epidermal sensors is finding non-invasive and minimally obtrusive ways to examine swallowing function and *** this review,we summarize the current state of wearable devices that are aimed at monitoring swallowing function and detecting its *** pay particular attention to the materials and design parameters that enable their *** examine a compilation of both proof-of-concept studies(which focus mainly on the engineering of the device)and studies whose aims are biomedical(which may involve larger cohorts of subjects,including patients).Furthermore,we briefly discuss the methods of signal acquisition and device assessment in relevant wearable ***,we examine the need to increase adherence and engagement of patients with such devices and discuss enhancements to the design of such epidermal sensors that may encourage greater enthusiasm for athome and long-term monitoring.

关键词： function enable proof

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