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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 957-961页

作者： Franelyne Pataueg Casuga Agnes Llamasares castillo Mary Jho-Anne Tolentino Corpuz The Graduate School University of Santo Tomas Faculty of Pharmacy University of Santo Tomas Research Center for Natural and Applied Sciences University of Santo Tomas

Objective: To investigate and characterize the chemical composition of the different crude extracts from the leaves of Broussonetia luzonica(Blanco)(Moraceae)(B. luzonica), an endemic plant in the ***: The air dried leaves were powdered and subjected to selective sequential extraction using solvents of increasing polarity through percolation, namely, n-hexane,ethyl acetate and methanol to obtain three different extracts. Then, each of the extracts was further subjected to gas chromatography–mass ***: Qualitative determination of the different biologically active compounds from crude extracts of B. luzonica using gas chromatography–mass spectrometry revealed different types of high and low molecular weight chemical entities with varying quantities present in each of the extracts. These chemical compounds are considered biologically and pharmacologically important. Furthermore, the three different extracts possess unique physicochemical characteristics which may be attributed to the compounds naturally present in significant quantities in the leaves of B. ***: The three extracts possess major bioactive compounds that were identified and characterized spectroscopically. Thus, identification of different biologically active compounds in the extracts of B. luzonica leaves warrants further biological and pharmacological studies.

关键词： Broussonetia luzonica(Blanco) Selective sequential extraction GC–MS analysis Endemic Percolation

Exploiting Deep Learning Techniques for Colon Polyp Segmentation

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Computers, Materials & Continua 2021年第5期67卷 1629-1644页

作者： Daniel Sierra-Sosa Sebastian Patino-Barrientos Begonya Garcia-Zapirain Cristian castillo-Oleam Adel Elmaghraby Department of Computer Science and Engineering University of LouisvilleLouisvilleKYUSA Centro de Computacion Cientifica Apolo at Universidad EAFIT MedelinColombia eVida Research Group University of DeustoBilbaoSpain

As colon cancer is among the top causes of death, there is a growinginterest in developing improved techniques for the early detection of colonpolyps. Given the close relation between colon polyps and colon cancer,their detection helps avoid cancer cases. The increment in the availability ofcolorectal screening tests and the number of colonoscopies have increasedthe burden on the medical personnel. In this article, the application of deeplearning techniques for the detection and segmentation of colon polyps incolonoscopies is presented. Four techniques were implemented and evaluated:Mask-RCNN, PANet, Cascade R-CNN and Hybrid Task Cascade (HTC).These were trained and tested using CVC-Colon database, ETIS-LARIBPolyp, and a proprietary dataset. Three experiments were conducted to assessthe techniques performance: (1) Training and testing using each databaseindependently, (2) Mergingd the databases and testing on each database independently using a merged test set, and (3) Training on each dataset and testingon the merged test set. In our experiments, PANet architecture has the bestperformance in Polyp detection, and HTC was the most accurate to segmentthem. This approach allows us to employ Deep Learning techniques to assisthealthcare professionals in the medical diagnosis for colon cancer. It is anticipated that this approach can be part of a framework for a semi-automatedpolyp detection in colonoscopies.

关键词： Colon polyps deep learning image segmentation

Multiorgan retrieval and preservation of the thoracic and abdominal organs in Maastricht III donors

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World Journal of Transplantation 2022年第5期12卷 83-87页

作者： Daniel Casanova Federico castillo Eduardo Miñambres Department of Surgery University Hospital Marqués de Valdecilla University CantabriaSantander 39008CantabriaSpain Intensive Care Unit Transplant OfficeUniversity Hospital Marques de Valdecilla University of Cantabria Medical SchoolSantander 39008CantabriaSpain

This editorial describes the indications and technical aspects of the simultaneous retrieval of thoracic and abdominal organs in Maastricht III donors as well as the preservation of such organs until their implantation.

关键词： Multiorgan retrieval Abdominal organs Thoracic organs Maastricht III Preservación Transplantation

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普雷贾马城堡的厕所血案

环球人文地理 2024年第1期 109-109页

作者：冬冬熊 J.Ossorio castillo

如今我们看到的普雷贾马城堡，是后人修缮后的成果，但不管怎么说，它仍是一座自然与人工完美融合的佳作，更是一处宝贵的建筑遗产。悬崖、洞穴、蝙蝠、骑士……这些与普雷贾马城堡相关的关键词，无疑暗示着它的奇特与神秘，但真正让这...

如今我们看到的普雷贾马城堡，是后人修缮后的成果，但不管怎么说，它仍是一座自然与人工完美融合的佳作，更是一处宝贵的建筑遗产。悬崖、洞穴、蝙蝠、骑士……这些与普雷贾马城堡相关的关键词，无疑暗示着它的奇特与神秘，但真正让这座城堡闻名于世的，是一场荒诞的“厕所血案”。

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Global Optimization of Nonlinear Blend-Scheduling Problems

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Engineering 2017年第2期3卷 188-201页

作者： Pedro A.castillo castillo Pedro M.Castro Vladimir Mahalec Department of Chemical Engineering McMaster UniversityHamiltonON L8S 4L8Canada Center for Mathematics Fundamental Applications and Operations ResearchFaculty of SciencesUniversity of LisbonLisbon 1749-016Portugal

The scheduling of gasoline-blending operations is an important problem in the oil refining industry. Thisproblem not only exhibits the combinatorial nature that is intrinsic to scheduling problems, but alsonon-convex nonlinear behavior, due to the blending of various materials with different quality *** this work, a global optimization algorithm is proposed to solve a previously published continuous-timemixed-integer nonlinear scheduling model for gasoline blending. The model includes blend recipe optimi-zation, the distribution problem, and several important operational features and constraints. The algorithmemploys piecewise McCormick relaxation （PMCR） and normalized multiparametric disaggregation tech-nique （NMDT） to compute estimates of the global optimum. These techniques partition the domain of oneof the variables in a bilinear term and generate convex relaxations for each partition. By increasing the num-ber of partitions and reducing the domain of the variables, the algorithm is able to refine the estimates ofthe global solution. The algorithm is compared to two commercial global solvers and two heuristic methodsby solving four examples from the literature. Results show that the proposed global optimization algorithmperforms on par with commercial solvers but is not as fast as heuristic approaches.

关键词： Global optimization Nonlinear gasoline blending Continuous-time scheduling model Piecewise linear relaxations

A retrospective analysis of gender among patients admitted to a clinical decision unit at risk for acute coronary syndrome

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World Journal of Emergency Medicine 2023年第2期14卷 133-137页

作者： Joby Thoppil Lauren Kraut Collin Montgomery Wilfrido castillo Robert Silverman Sanjey Gupta Frederick Davis Department of Emergency Medicine University of Texas Southwestern Medical CenterTexas 75002USA Department of Emergency Medicine Long Island Jewish Medical CenterQueens NY 11040USA Department of Emergency Medicine South Shore HospitalBay Shore NY 11706USA

INTRODUCTION Chest pain is a common chief complaint and encompasses nearly 5.2% of all patients seen in emergency departments(ED). In the United States, this accounts for approximately six million annual visits.[1-4]The evaluation of patients with chest pain in the ED is a time-consuming and challenging process because the physician must identify those with life-threatening cardiac chest pain, while avoiding unnecessary and costly evaluations of those with non-cardiac chest pain.

关键词： admitted consuming patients

Abundance of White-fronted Parrots and diet of an urban parrot assemblage(Aves:Psittaciformes)in a green Neotropical city

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Avian Research 2022年第1期13卷 36-42页

作者： CristelAlvarez-castillo Ian MacGregor-Fors Stefan LArriaga-Weiss Claudio Mota-Vargas Diego Santiago-Alarcon Biología y Conservación de Vertebrados Instituto de EcologíaA.C.-CONACYTXalapaMexico Biological and Environmental Sciences University of HelsinkiLahtiFinland División Académica de Ciencias Biológicas Universidad Juárez Autónoma de TabascoVillahermosaMexico Biología Evolutiva Instituto de EcologíaA.C.-CONACYTXalapaMexico Department of Integrative Biology University of South FloridaTampaUSA

Urban ecosystems are evolutionarily recent novel environments acting as biodiversity *** birds are considered successful urban adapters mainly due to their generalist feeding and opportunistic behavior,allowing them to occupy environments from cold temperate to dry xeric ***,it is important to understand how these species interact in the urban *** studied the interannual(2013–2016)abundance of the White-fronted Parrot(Amazona albifrons)in the Neotropical cities of Xalapa and Coatepec,in Central Veracruz,Mé***,we studied the feeding ecology during 13 months of 6 parrot species detected in the city of *** abundance of the White-fronted Parrot was significantly higher in Xalapa than in Coatepec,and it was homogeneous across ***-native plants represented 30–41%of Psittacidae diets in Xalapa,where seeds were the most commonly consumed *** recorded the highest Psittacidae species richness and highest diet overlap among species by the end of the dry season(April–May).The White-fronted Parrot had the highest plant richness in its diet,followed by the Monk Parakeet(Myiopsitta monachus)and the Green Parakeet(Psittacara holochlorus);yet,the White-fronted Parrot had a specialized diet dominated by two plant species(Grevillea robusta and Ficus aurea).The diet overlap among the three above-mentioned parrot species was not significantly different to a null model,where the White-fronted Parrot and the Monk Parakeet overlapped during the months of February,April,June,and *** White-fronted Parrot is an urban adapter that has successfully expanded its geographic range via natural means and by human *** invasive Monk Parakeet is currently restricted to one park in Xalapa,and it has remained in that stage for many years(i.e.,pre-expansion phase).Exotic plant species in Xalapa represent∼55%of the woody vegetation,some of which have longer flowering and fruiting periods that may have aided the s

关键词： Biological invasions Feeding ecology Population biology Psittacidae Urban ecology

An origin of the along-arc compositional variation in the Izu-Bonin arc system

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Geoscience Frontiers 2020年第5期11卷 1621-1634页

作者： Kathryn Durkin Paterno R.castillo Susanne M.Straub Natsue Abe Yoshihiko Tamura Quanshu Yan Scripps Institution of Oceanography UCSD9500 Gilman DriveLa JollaCA92093-0212USA Lamont-Doherty Earth Observatory Columbia Univ.61 US-9WPalisadesNY10964USA Japan Agency for Marine-Earth Science and Technology(JAMSTEC) 2-15 Natsushima-choJapan Key Laboratory of Marine Sedimentary and Environmental Geology The First Institute of OceanographyState Oceanic AdministrationQingdao 266061China

The Izu-Bonin arc system is sediment-poor(~400 m thick with no accretionary prism)and,therefore,the influence of the altered oceanic crust(AOC)is most likely the source of the documented along-arc lava compositional variations,especially in Pb ***-Bonin arc lava geochemistry suggests an influx of subduction component from an Indian-type ***,samples drilled from the western Pacific geochemical reference site at Integrated Ocean Drilling Program Site 1149 implies subduction of a Pacific-type *** solve the apparent discrepancy of slab input versus arc output in this arc system,samples of the AOC were dredged from vertical fault scarps of the subducting Pacific Plate along a transect from 27.5°N to 34.50 *** range from tholeiitic to mildly alkalic mid-ocean ridge basalts as well as trachybasalts,basaltic trachyandesites,tephrites,and *** ratios also exhibit a range of values(87Sr/86Sr=0.70282-0.70673,143 Nd/144 Nd=0.512552-0.513174,206Pb/204 Pb=18.43-20.00,207 Pb/204 Pb=15.40-15.67,208Pb/204Pb=37.75-39.55).Our results suggest that there is a geochemical variation in the AOC that is neither completely due to seawater or hydrothermal alteration,nor to petrogenetic ***,this variation is the result of the Pacific-Izanagi Ridge system tapping into a heterogeneous,plume-polluted mantle source during the Mid-Cretaceous volcanic *** observed Pacific-type AOC is not responsible for the Indian-type Pb isotopic signature of Izu-Bonin arc *** leads us to propose an alternative scenario where the Izu-Bonin arc lava Indian-type Pb isotopic signature originates from slab-derived fluids interacting and adsorbing Pb from an Indian-type mantle wedge through zone-refining.

关键词： Izu-Bonin AOC Pb-isotopes Indian-type Zone-refining

Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences

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World Journal of Gastroenterology 2010年第25期16卷 3091-3102页

作者： Carmen Berasain Saioa Gońi Josefa castillo Maria Ujue Latasa Jesús Prieto Matias A Avila Division of Hepatologyand Gene Therapy CIMA University of Navarra Pamplona31008 Spain

Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies.

关键词： Cell signalling Hepatocarcinogenesis PremRNA splicing Splicing factors Targeted anticancer therapy

Sudden cardiac death in anabolic androgenic steroids abuse: case report and literature review

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Forensic Sciences Research 2019年第3期4卷 267-273页

作者： Ana Isabel Hernández-Guerra Javier tapia Luis Manuel Menéndez-Quintanal Joaquín S.Lucena Histopathology Service National Institute of Toxicology and Forensic Sciences(NITFS)Canary Islands DepartmentTenerifeSpain Forensic Pathology Service Institute of Legal Medicine and Forensic Sciences(ILMFS)Las Palmas de Gran CanariaSpain Chemistry Service NITFSCanary Islands DepartmentTenerifeSpain Forensic Pathology Service ILMFSSevilleSpain

Anabolic androgenic steroids (AAS) have several adverse effects on the cardiovascular system that may lead to a sudden cardiac death (SCD).We herein report a case involving a 24-year-old male,AAS abuser with intramuscular delivery in the 6 months before,who suffered a cardiorespiratory arrest at home's bathtub when returning from New Year's party.A forensic autopsy was performed according to the guidelines of the Association for European Cardiovascular Pathology (AECVP).The body showed hypertrophy of skeletal musculature,with low amount of subcutaneous fat and no signs of injury (body mass index,BMh 26.8 kg/m^(2)).On internal examination,there were multiorgan congestion,acute pulmonary edema,and cardiomegaly (420 g) with severe coronary atherosclerosis and superimposed acute occlusive thrombosis at the left main trunk and left anterior *** of scarring were located at the intersection between the posterior wall and the posterior third of the septum (postero-septal).At histology,acute myocardial infarction at the anterior third of the septum and the anterior wall,and subacute myocardial infarction at apical septum and apical posterior wall were *** findings were small intramyocardial vessel disease and myocytes *** analysis in blood showed ethanol ((0.90 ±0.05) g/L),stanazolol (11.31 μg/L),nandrolone (2.05μg/L) and testosterone (<1.00μg/L).When confronted with a sudden death in a young athlete we must pay attention to the physical phenotype that may suggest AAS abuse and perform a detailed examination of the *** analysis is a key to establish the relationship between SCD and AAS abuse.

关键词： Forensic sciences forensic pathology anabolic androgenic steroids(AAS) sudden cardiac death autopsy cardiac pathology toxicology