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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-yuan Hu Ding Ding yu Song Ya-Feng Deng Cheng-Ming Zhang tao yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng yu-tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Unified Limits and Large Deviation Principles forβ-Laguerre Ensembles in Global Regime

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Acta Mathematica Sinica,English Series 2023年第7期39卷 1271-1288页

作者： yu tao MA School of Mathematical Sciences&Laboratory of Mathematics and Complex Systems of Ministry of Education Beijing Normal UniversityBeijing 100875China

Let(λ_(1),...,λ_(n)) be β-Laguerre ensembles with parametersβ,p,n and μ_(n):=1/n∑^(n)_(i=1)δ_(Xi) with for 1≤i≤*** this paper,asβvaries and satisfies lim_(n→∞)log n/βn=0,we offer a modified Marchenko-Pastur,law or semicircle law as the weak limits for the sequence μ_(n) when lim_(n→∞)n/p=γ∈(0,1]or lim_(n→∞)n/p=0,*** recovers some well-known ***,we give a full large deviation principle of μ_(n) with speed βn^(2) and good rate function I_(γ) under the same condition to characterize the speed of the *** minimizer of I_(γ) is a modified Marchenko-Pastur law forγ∈(0,1]and the semicircle law forγ=0.

关键词： β-Laguerre ensemble large deviation principle empirical measure semicircular law Marchenko–Pastur law

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Limit Theorems and Large Deviations forβ-Jacobi Ensembles at Scaling Temperatures

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Acta Mathematica Sinica,English Series 2023年第10期39卷 2054-2074页

作者： yu tao MA School of Mathematical Sciences&Laboratory of Mathematics and Complex Systems of Ministry of Education Beijing Normal UniversityBeijing 100875P.R.China

Letλ=(λ_(1),...,λ_(n))beβ-Jacobi ensembles with parameters p_(1),p_(2),n andβwhileβvarying with ***γ=lim_(n→∞)n/p_(1)andσ=lim_(n→∞)p_(1)/p_(2).In this paper,supposing lim_(n→∞)log_(n)/β_(n)=0,we prove that the empirical measures of different scaledλconverge weakly to a Wachter distribution,a Marchenko–Pastur law and a semicircle law corresponding toσγ>0,σ=0 orγ=0,*** also offer a full large deviation principle with speedβn^(2)and a good rate function to precise the speed of these *** an application,the strong law of large numbers for the extremal eigenvalues ofβ-Jacobi ensembles is obtained.

关键词： β-Jacobi ensemble large deviation principle semi-circle law Marchenko-Pastur law Wachter law

Plasmonic molecular assays： Recent advances and applications for mobile health

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Nano Research 2018年第10期11卷 5439-5473页

作者： tao yu Qingshan Wei Department of Chemical and Biomolecular Engineering North Carolina State University 911 Partners Way Campus Box 7905Raleigh NC 27695 USA

Plasmonics-based biosensing assays have been extensively employed for biomedical applications. Significant advancements in use of plasmonic assays for the construction of point-of-care （POC） diagnostic methods have been made to provide effective and urgent health care of patients, especially in resource- limited settings. This rapidly progressive research area, centered on the unique surface plasmon resonance （SPR） properties of metallic nanostructures with exceptional absorption and scattering abilities, has greatly facilitated the development of cost-effective, sensitive, and rapid strategies for disease diagnostics and improving patient healthcare in both developed and developing worlds. This review highlights the recent advances and applications of plasmonic technologies for highly sensitive protein and nucleic acid biomarker detection. In particular, we focus on the implementation and penetration of various plasmonic technologies in conventional molecular diagnostic assays, and discuss how such modification has resulted in simpler, faster, and more sensitive alternatives that are suited for point-of-use. Finally, integration of plasmonic molecular assays with various portable POC platforms for mobile health applications are highlighted.

关键词： plasmonics molecular assay point-of-care diagnostics mobile health imaging sensing

Efficient and selective extraction of uranium from seawater based on a novel pulsed liquid chromatography radionuclide separation method

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Nuclear Science and Techniques 2023年第2期34卷 13-27页

作者： Jian‑Hua Ye tao yu State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

The novel pulsed liquid chromatography radionuclide separation method presented here provides a new and promising strategy for the extraction of uranium from *** this study,a new chromatographic separation method was proposed,and a pulsed nuclide automated separation device was developed,alongside a new chromatographic *** length of this chromatographic column was 10 m,with an internal warp of 3 mm and a packing size of 1 mm,while the total separation units of the column reached 12,*** most favorable conditions for the separation of nuclides were then obtained through optimizing the separation conditions of the device:Sample pH in the column=2,sample injection flow rate=5.698 mL/min,chromatographic column heating temperature=60℃.Separation experiments were also carried out for uranium,europium,and sodium ions in mixed solutions;uranium and sodium ions in water samples from the Ganjiang River;and uranium,sodium,and magnesium ions from seawater *** separation factors between the different nuclei were then calculated based on the experimental data,and a formula for the separation level was *** experimental results showed that the separation factor in the mixed solution of uranium and europium(1:1)was 1.088,while achieving the initial separation of uranium and europium theoretically required a 47-stage *** the separation factor of 1.50for the uranium and sodium ions in water samples from the Ganjiang River,achieving the initial separation of uranium and sodium ions would have theoretically required at least a 21-stage ***,for the seawater sample separation experiments,the separation factor of uranium and sodium ions was 1.2885;therefore,more than 28 stages of sample separation would be required to achieve uranium extraction from *** novel pulsed liquid chromatography method proposed in this study was innovative in terms of uranium separation and enrichment,while expanding the possibilities

关键词： Pulsed liquid chromatography Nuclide separation Seawater uranium extraction Uranium enrichment

STRUCTURE AND RESTRUCTURING OF BEIJING-TIANJIN-HEBEI MEGALOPOLIS IN CHINA

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Chinese Geographical Science 2006年第1期16卷 1-8页

作者： yu tao-fang School of Architecture Tsinghua University Beijing 100084 P. R. China

Scott proposes to use the term global city-regions to designate the phenomena that bear some resemblance to the "world cities" firstly identified by Hall and Friedmann and Wolff, and to the "global cities" of Sassen but whose essential social logic and contextual characteristics have evolved considerably since these pioneering studies were published. In simple geographical terms, a global city-region can be refered to comprise any major metropolitan area or any contiguous set of metropolitan areas together with a surrounding hinterland of variable extent-itself a locus of scattered urban settlements-whose internal economic and political affairs are bound up in intricate ways in intensifying and far-flung extra-national relationships. Scott refers to these extra-national relationships as a symptom of "globalization". As economic motors and political actors, the global city regions have been regarded as crucial parts of development strategies in China. In the "Eleventh Five-year Plan" issued by the National Development and Reform Commission of P. R. China, the Beijing-Tianjin-Hebei Province (Jing-Jin-Ji) region, one of the typical megalopolises or global city regions in the East Coastal China is paid more attention. This paper first analyzes the regional structure of the Jing-Jin-Ji region based on data of the fifth national population census of China. And then through the changes of the population growth, the dynamic process and mechanisms of the regional restructuring in the Jing-Jin-Ji is explored and discussed.

关键词： regional structure regional restructuring Beijing-Tianjin-Hebei (Jing-Jin-Ji)

Essentially Commuting Truncated Toeplitz Operators

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2453-2480页

作者： Xi ZHAO tao yu School of Mathematics and Science Hebei GEO University Shijiazhuang 050031P.R.China School of Mathematical Sciences Dalian University of Technology Dalian 116024P.R.China

A model space is a subspace of the Hardy space which is invariant under the backward shift,and a truncated Toeplitz operator is the compression of a Toeplitz operator on some model *** this paper we prove a necessary ... 详细信息

关键词： Truncated Toeplitz operator model space commutator maximal ideal space compact operator

Operators on the orthogonal complement of the Dirichlet space (Ⅱ)

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Science China Mathematics 2011年第9期54卷 2005-2012页

作者： yu tao Department of Mathematics Zhejiang Normal University Jinhua 321004 China

In this paper we first prove that a dual Hankel operator Rφ on the orthogonal complement of the Dirichlet space is compact for φ ∈ W^1,∞（D）, and then that a semicommutator of two Toeplitz operators on the Dirichlet space or two dual Toeplitz operators on the orthogonal complement of the Dirichlet space in Sobolev space is compact. We also prove that a dual Hankel operator Re with φ ∈ W^1,∞（D） is of finite rank if and only if Be is orthogonal to the Dirichlet space for some finite Blaschke product B, and give a sufficient and necessary condition for the semicommutator of two dual Toeplitz operators to be of finite rank.

关键词： Sobolev space Dirichlet space dual Toeplitz operator dual Hankel operator Toeplitz operator

A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-Qi yu tao yu Jian-Hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)