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Inverse Calculation and Regularization Process for the Solar Aspect System(SAS) of HXI Payload on ASO-S Spacecraft

Research in Astronomy and Astrophysics 2024年第4期24卷 13-34页

作者： Ji-Rui Yu Ping Ruan Yang Su Ying-Hong He Jin-you tao Zhe Zhang Song Guo Bin Xue Jian-Feng Yang Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of Sciences Xi'an 710119China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 20034China School ofAstronomy and Space Science Universityof Science and Technology of ChinaHefei 230026China

For the ASO-S/HXI payload, the accuracy of the flare reconstruction is reliant on important factors such as the alignment of the dual grating and the precise measurement of observation orientation. To guarantee optimal functionality of the instrument throughout its life cycle, the Solar Aspect System (SAS) is imperative to ensure that measurements are accurate and reliable. This is achieved by capturing the target motion and utilizing a physical model-based inversion algorithm. However, the SAS optical system’s inversion model is a typical ill-posed inverse problem due to its optical parameters, which results in small target sampling errors triggering unacceptable shifts in the solution. To enhance inversion accuracy and make it more robust against observation errors, we suggest dividing the inversion operation into two stages based on the SAS spot motion model. First, the as-rigid-aspossible (ARAP) transformation algorithm calculates the relative rotations and an intermediate variable between the substrates. Second, we solve an inversion linear equation for the relative translation of the substrates, the offset of the optical axes, and the observation orientation. To address the ill-posed challenge, the Tikhonov method grounded on the discrepancy criterion and the maximum a posteriori (MAP) method founded on the Bayesian framework are utilized. The simulation results exhibit that the ARAP method achieves a solution with a rotational error of roughly±3 5 (1/2-quantile);both regularization techniques are successful in enhancing the stability of the solution, the variance of error in the MAP method is even smaller—it achieves a translational error of approximately±18μm (1/2-quantile) in comparison to the Tikhonov method’s error of around±24μm (1/2-quantile). Furthermore, the SAS practical application data indicates the method’s usability in this study. Lastly, this paper discusses the intrinsic interconnections between the regularization methods.

关键词： methods:data analysis Sun:flares Sun:X-rays gamma rays

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang Jia Wang tao you Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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布地格福调节c-Jun表达抑制肺泡巨噬细胞NR8383氧化应激损伤的机制研究

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中国临床药理学杂志 2024年第4期40卷 534-538页

作者：张孝侠吴友涛济宁医学院医学检验实验室山东济宁272067 济宁市第二人民医院急诊科山东济宁272049

目的研究布地格福对SD大鼠NR8383氧化应激损伤保护机制。方法将大鼠肺泡巨噬细胞NR8383分为5组:空白组给予无血清K12培养基,不作任何处理;脂多糖组(LPS组)给予2.29μg·mL^(-1) LPS标准品溶液;布地格福组、c-Jun抑制药组(AS601245)、... 详细信息

目的研究布地格福对SD大鼠NR8383氧化应激损伤保护机制。方法将大鼠肺泡巨噬细胞NR8383分为5组:空白组给予无血清K12培养基,不作任何处理;脂多糖组(LPS组)给予2.29μg·mL^(-1) LPS标准品溶液;布地格福组、c-Jun抑制药组(AS601245)、布地格福+c-Jun抑制药组(Budesonide+AS601245)在LPS组基础上分别给予布地格福28.0μL、c-Jun抑制药AS601245 2.50μg、布地格福28.0μL+c-Jun抑制药AS601245 2.50μg。5组细胞均置于无血清K12培养基恒温培养24 h。以细胞计数试剂盒-8(CCK-8)法检测24 h细胞凋亡率,以实时荧光定量聚合酶链反应(q-PCR)检测c-Jun mRNA表达,以酶联免疫吸附实验(ELISA)法检测氧化应激损伤因子活性氧(ROS)、8-羟基脱氧鸟苷(8-OHdG)、谷胱甘肽过氧化物酶(GSH-Px)、硫氧还蛋白(TRX-1)表达,以蛋白质印迹(Western Blot)法检测各组c-Jun信号通路蛋白的表达。结果与LPS组(29.88±5.98)%相比,布地格福组、c-Jun抑制药组、布地格福+c-Jun抑制药组、空白组24 h细胞凋亡率显著下降[(20.15±6.66)%、(15.39±3.54)%、(12.11±2.55)%和(8.52±1.27)%],在统计学上差异均有统计学意义(均P<0.05)。布地格福组、c-Jun抑制药组、布地格福+c-Jun抑制药组、LPS组、空白组ROS浓度分别为(3.16±0.19)、(4.15±0.33)、(2.21±0.21)、(6.52±0.36)和(1.06±0.23) U·g^(-1);8-OHdG分别为(10.55±1.23)、(11.14±1.06)、(9.55±1.00)、(15.66±1.99)和(8.27±1.13)ng·mL^(-1);GSH-Px分别为(188.52±12.33)、(200.52±27.97)、(144.52±20.55)、(335.14±30.10)和(126.55±12.52)U·mL^(-1);TRX-1分别为(40.11±6.66)、(50.55±10.07)、(60.25±10.55)、(115.36±20.03)和(16.55±2.33)ng·mL^(-1);c-Jun mRNA相对表达水平分别为0.56±0.03、0.44±0.11、0.25±0.04、0.89±0.12和0.08±0.01;c-Jun/GAPDH蛋白相对表达水平为3.15±0.22、2.36±0.14、1.55±0.13、4.02±0.22和0.88±0.12;与LPS组相比,布地格福组、c-Jun抑制药组、布地格福+c-Jun抑制药组指标差异均显著下降,在统计学上差异均有统计学意义(均P<0.05)。结论布地格福显著增加NR8383细胞的存活率,并显著降低氧化损伤代表因子ROS、GSH-Px、8-OHdG、TRX-1的浓度,其氧化损伤保护机制可能与调控c-Jun蛋白相关。

关键词：布地格福肺泡巨噬细胞慢性阻塞性肺疾病 c-Jun蛋白氧化应激细胞凋亡

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Effective transmittance of Fabry–Perot cavity under non-parallel beam incidence

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Chinese Physics B 2024年第1期33卷 449-457页

作者：吕寅生谢品华徐晋李友涛张华荣 School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Key Laboratory of Environment Optics and Technology Anhui Institute of Optics and Fine MechanicsHFIPSChinese Academy of SciencesHefei 230031China University of Chinese Academy of Sciences Beijing 100049China

The Fabry–Perot(FP) resonant cavity is widely used in laser and spectroscopic measurements due to its unique interference transfer function(ITF). In the ideal case of parallel incident light, the ITF of the FP resonant cavity can be expressed by the Airy function. However, in reality, it is difficult to achieve perfect parallelism with collimated beams. In this article, a theoretical model is established for non-parallel light incidence, which assumes that the non-parallel incident light is a cone-shaped beam, and the cone angle is used to quantify the non-parallelism of the beam. The transmittance function of the FP resonant cavity under non-parallel light incidence is derived. The accuracy of the model is experimentally verified. Based on this model, the effects of divergence angle, tilt angle and FP cavity parameters(reflectivity, cavity length)on the ITF are studied. The reasons for the decrease in peak value, broadening and asymmetry of the interference peak under non-parallel light incidence are explained. It is suggested that a fine balance between the interference peak and the collimation effect of the incident light should be considered in the design and application of FP resonant cavities, especially for tilted applications such as angle-scanned spectroscopy. The research results of this article have certain significance for the design and application of FP resonant cavities.

关键词： Fabry–Pérot(FP)resonant cavity interference transfer function Airy function non-parallel beam incidence

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Boundedness in a chemotaxis system with nonlinear signal production

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Applied Mathematics(A Journal of Chinese Universities) 2016年第4期31卷 379-388页

作者： LIU Dong-mei tao you-shan College of Information Science & Technology Dong Hua University Department of Applied Mathematics Dong Hua University

This work deals with the zero-Neumann boundary problem to a fully parabolic chemotaxis system with a nonlinear signal production function f（s） fulfilling 0 〈 f（s）〈 Ksα for all s 〉 0, where K and α are positive parameters. It is shown that whenever 0 〈 α 〈 2/n （where n denotes the spatial dimension） and under suitable assumptions on the initial data, this problem admits a unique global classical solution that is uniformly-in-time bounded in any spatial dimension. The proof is based on some a priori estimate techniques.

关键词： Keller-Segel model nonlinear signal production prevention of blow-up.

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基于SAR阻抗匹配的WPT最大效率跟踪控制方法

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电子器件 2024年第1期47卷 188-193页

作者：郑宏尤涛许奕然杨亮江苏大学电气信息工程学院江苏镇江212013 中国矿业大学(徐州)电气与动力工程学院江苏徐州221116

无线电能传输(WPT)技术因其安全、便捷、非接触等优点而备受关注。最大效率传输是WPT系统中一个重要课题。传统的最大效率跟踪方法通常设定系统在固定耦合条件进行负载阻抗匹配,然而,耦合系数会在初级和次级线圈相对位置变化时不可避免... 详细信息

无线电能传输(WPT)技术因其安全、便捷、非接触等优点而备受关注。最大效率传输是WPT系统中一个重要课题。传统的最大效率跟踪方法通常设定系统在固定耦合条件进行负载阻抗匹配,然而,耦合系数会在初级和次级线圈相对位置变化时不可避免地发生变化。提出基于耦合系数辨识与半有源整流(SAR)阻抗匹配的最大效率跟踪控制方法,该方法利用SAR结合耦合系数识别进行阻抗匹配,开关控制电容(SCC)补偿其阻抗虚部,避免了整流电路中非线性因素的影响。同时系统响应较快且控制方法便于实现。仿真和实验结果表明,耦合系数和等效负载变化时,都可以准确估计耦合系数并跟踪至最大效率点和输出恒压。

关键词：无线电能传输(WPT) 最大效率跟踪 SAR阻抗匹配耦合系数辨识

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High resolution radar target adaptive detector and performance assessment

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Journal of Systems Engineering and Electronics 2011年第2期22卷 212-218页

作者： tao Jian you He Feng Su Changwen Qu Dianfa Ping Research Institute of Information Fusion Naval Aeronautical and Astronautical University Yantai 264001 P. R. China

The high resolution radar target detection is addressed in the non-Gaussian clutter. An adaptive detector is derived for range-spread target based on a novel covariance matrix estimator. It is proved that the new detector is constant false alarm rate （CFAR） to both of the clutter covariance matrix structure and power level theoretically for match cases. The simulation results show that the new detector is almost CFAR for mismatch cases, and it outperforms the existing adaptive detector based on the sample covariance matrix. It also shows that the detection performance improves, as the number of pulses, the number of secondary data or the clutter spike increases. In addition, the derived detector is robust to different subsets, estimated clutter group sizes and correlations of clutter. Importantly, the number of iterations for practical application is just one.

关键词： non-Gaussian clutter adaptive detection range-spread target performance assessment.

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Squeezing in the Thermal Jaynes-Cummings Model

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Chinese Physics Letters 1996年第6期13卷 432-435页

作者： XIE Rui-hua ZOU you-tao LIU Dun-huan Department of Physics Nanjing UniversityNanjing 210008 Department of Physics Wuhan UniversityWuhan 430072 National Laboratory of Solid State Microstructures Institute for Solid State Physics Center for Advanced Studies in Science and Technology of Microstructures Nanjing UniversityNanjing 210008

We have studied the influence of thermal photons on the symmetry between the field and atomic squeezing(SFAS)exposed in the resonant vacuum-field Jaynes-Cummings model with an initially coherent *** have shown that when the number of thermal photons(Nav)is less than 0.01,the SFAS is not sensitive to the presence of thermal photons;when Nav≥0.01,the broken SFAS can be seen;when Nav≥0.1,the squeezed atom cannot radiate a squeezed field any ***,we have discussed the possibility of detection of the boken symmetry in superconducting maser cavity.

关键词： symmetry Cummings resonant

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Nutrient Release from Weathering of Purplish Rocks in the Sichuan Basin,China

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Pedosphere 2008年第2期18卷 257-264页

作者： ZHU Bo WANG tao you Xiang GAO Mei-Rong Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 （China）

Purplish soils having high fertility with mineral nutrients inherited from the parent rock are widely distributed in the hills along the Yangtze River,especially in the Sichuan *** and field weathering experiments were conducted to mimic rock weathering and nutrient release processes in order to better understand soil fertility and nutrient compensation. Three types of purplish rock formations formed in the Jurassic period,Shaximiao(J_2s),Suining(J_3s),and Penglaizhen (J_3p),as well as one type formed in the Cretaceous period,the Chengqiangyan group(K_1c),were used in this study. Results showed that the soil formation rate was in the range from 11.2 to 19.6 mm every year,and rock weathering was in the order of J_3s>J_3p>J_2s>K_*** more rock surface was exposed to sunlight and rainfall in field conditions,pot weathering was slower than field *** release rates increased with rock weathering and was in the order similar to that of rock weathering:J_3p>J_3s>J_2s>K_*** release was the most important in all rocks;after 2 years of weathering,19.4% to 46.9% of K was released from the initial parent rocks,which suggested that K release from weathering could meet most of the crop K requirement in purplish ***,rapid release of nutrients from weathering of purplish rocks was key to nutrient replenishment and fertility of purplish soils.

关键词： nutrient release purplish rock soil formation weathering

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Crowdsourcing intelligent design

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Frontiers of Information Technology & Electronic Engineering 2018年第1期19卷 126-138页

作者： Wei XIANG Ling-yun SUN Wei-tao you Chang-yuan YANG State Key Lab of CAD & CG Zhejiang University Hangzhou 310058 China Modern Industrial Design Institute Zhejiang University Hangzhou 310027 China International User Experience Business Unit Alibaba Group Hangzhou 310000 China

Design intelligence,namely,artificial intelligence to solve creative problems and produce creative ideas,has improved rapidly with the new generation artificial ***,existing methods are more skillful in learning from data and have limitations in creating original ideas different from the training *** offers a promising method to produce creative designs by combining human inspiration and machines' computational *** propose a crowdsourcing intelligent design method called ‘flexible crowdsourcing design'.Design ideas produced through crowdsourcing design can be unreliable and inconsistent because they rely solely on selection among participants' submissions of *** contrast,the flexible crowdsourcing design method employs a cultivation procedure that integrates the ideas from crowd participants and cultivates these ideas to improve design quality at the same *** introduce a series of studies to show how flexible crowdsourcing design can produce original design ideas ***,we will describe the typical procedure of flexible crowdsourcing design,the refined crowdsourcing tasks,the factors that affect the idea development process,the method for calculating idea development potential,and two applications of the flexible crowdsourcing design ***,it summarizes the design capabilities enabled by crowdsourcing intelligent *** method enhances the performance of crowdsourcing design and supports the development of design intelligence.

关键词： Crowdsourcing Flexible crowdsourcing design Design intelligence

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