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Utilizing interpretable stacking ensemble learning and NSGA-Ⅲ for the prediction and optimisation of building photo-thermal environment and energy consumption

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Building Simulation 2024年第5期17卷 819-838页

作者： Yeqin Shen Yubing Hu Kai Cheng Hainan yan Kaixiang Cai Jianye Hua Xuemin fei Qinyu Wang School of Arts Jiangsu UniversityZhenjiang212013China School of Architecture and Urban Planning Nanjing UniversityNanjing210093China School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang212013China

This study develops an approach consisting of a stacking model integrated with a multi-objective optimisation algorithm aimed at predicting and optimising the ecological performance of *** integrated model consists of five base models and a meta-model,which significantly improves the prediction ***,the R2 value was improved by 9.19% and the error metrics MAE,MSE,MAPE,and CVRMSE were reduced by 69.47%,79.88%,67.32%,and 57.02%,respectively,compared to the single prediction *** to the research on interpretable machine learning,adding the SHAP value gives us a deeper understanding of the impact of each architectural design parameter on the *** the multi-objective optimisation part,we used the NSGA-Ⅲ algorithm to successfully improve the energy efficiency,daylight utilisation and thermal comfort of the ***,the optimal design solution reduces the energy use intensity by 31.6 kWh/m^(2),improves the useful daylight index by 39%,and modulated the thermal comfort index,resulting in a decrement of 0.69℃ for the summer season and an enhancement of 0.64℃ for the winter season,***,this study provides building designers and decision makers with a tool to make better design decisions at an early stage to achieve a better combination of energy efficiency,daylight utilisation and thermal comfort optimisation in an integrated manner,providing an important support for achieving sustainable building design.

关键词： building ecological performance ensemble learning multi-objective optimisation sustainable design explainable machine learning

An Overview of Sequential Approximation in Topology Optimization of Continuum Structure

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 43-67页

作者： Kai Long Ayesha Saeed Jinhua Zhang Yara Diaeldin feiyu Lu tao tao Yuhua Li Pengwen Sun Jinshun yan State Key Laboratory of Alternate Electrical Power Systemwith Renewable Energy Sources North China Electric Power UniversityBeijing102206China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100124China New Energy and Energy Storage Division China Southern Power Grid Technology Co.Ltd.Guangzhou510080China School of Mechanical Engineering Inner Mongolia University of TechnologyHohhot010051China College of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot010051China

This paper offers an extensive overview of the utilization of sequential approximate optimization approaches in the context of numerically simulated large-scale continuum *** structures,commonly encountered in engineering applications,often involve complex objective and constraint functions that cannot be readily expressed as explicit functions of the design *** a result,sequential approximation techniques have emerged as the preferred strategy for addressing a wide array of topology optimization *** the past several decades,topology optimization methods have been advanced remarkably and successfully applied to solve engineering problems incorporating diverse physical *** comparison to the large-scale equation solution,sensitivity analysis,graphics post-processing,etc.,the progress of the sequential approximation functions and their corresponding optimizersmake sluggish ***,particularly novices,pay special attention to their difficulties with a particular ***,this paper provides an overview of sequential approximation functions,related literature on topology optimization methods,and their *** from optimality criteria and sequential linear programming,the other sequential approximate optimizations are introduced by employing Taylor expansion and intervening *** addition,recent advancements have led to the emergence of approaches such as Augmented Lagrange,sequential approximate integer,and non-gradient approximation are also *** highlighting real-world applications and case studies,the paper not only demonstrates the practical relevance of these methods but also underscores the need for continued exploration in this ***,to provide a comprehensive overview,this paper offers several novel developments that aim to illuminate potential directions for future research.

关键词： Topology optimization sequential approximate optimization convex linearization method ofmoving asymptotes sequential quadratic programming

Discovery and Asymmetric Total Synthesis of Phlegmine A as a Selective Inhibitor of ASIC1a

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CCS Chemistry 2024年第10期6卷 2529-2536页

作者： Zai-Feng Yuan fei Liu Yu-fei Ou Wen-yan Li Li-yan Peng Xiao-Nian Li Qin-Shi Zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201 School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137 University of Chinese Academy of Sciences Beijing 10049

Phlegmine A(1),a novel type of Lycopodium alkaloid with a unique skeleton,was isolated from the rare and endangered herbal medicinal plant,Phlegmariurus *** methods and X-ray diffraction analysis were employed to unambiguously elucidate the structure of phlegmine A(1).Furthermore,we realized the asymmetric total synthesis of the natural product phlegmine A(1)in 18 linear steps from commercial ingredients,achieving a 1.3%overall *** intramolecular carbene cyclization,dimethyldioxirane(DMDO)enamine oxidation,and Stevens rearrangement were exploited to establish the sterically congested vicinal quaternary centers,and an epimerization/aldol condensation/deacetylation reaction was utilized for the rapid assembly of enone at the final *** our semisynthesis attempts,a novel transformation was developed to constructα-aminoketone from enamine ***,the synthetic sample obtained from this work enabled the successful verification of phlegmine A(1)as a new type of highly selective acidsensing ion channel 1a(ASIC1a)inhibitor,which also exerted an in vivo analgesic effect,rendering it a promising lead compound.

关键词： Lycopodium alkaloids phlegmine A total synthesis ASIC1a inhibitor analgesic

High-throughput fluorescent screening of thioredoxin reductase inhibitors to inhibit Mycobacterium tuberculosis

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Chinese Chemical Letters 2024年第3期35卷 358-362页

作者： fei yan Xin Zhao Ruibo Li Xiuyan Han Qiulong yan Lei Feng Xiulan Xin Jingnan Cui Xiaochi Ma Second Affiliated Hospital Dalian Medical UniversityDalian 116044China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China College of Bioengineering Beijing PolytechnicBeijing 100029China

Tuberculosis(TB)is a chronic infectious disease,which is caused by the pathogen Mycobacterium tuberculosis(Mtb)and reemerged as a global health risk with a significant proportion of multi-drug resistant and extensively drug resistant TB *** is very urgent to find some novel high-confidence drug targets in Mtb for discovering the effective anti-TB *** reductase(TrxR)has been identified to be a highly viable target for anti-TB drugs for its important role in protecting the pathogen from thiol-specific oxidizing stress,regulating intracellular dithiol/disulfide homeostasis and DNA replication and *** the present work,a near-infrared(NIR)fluorescent probe DDAT was developed for the detection of TrxR activity and used to high-throughput screen the TrxR inhibitors from natural *** screened TrxR inhibitors from Sappan Lignum and microbial metabolites that were further used to inhibit Mycobacterium *** the results indicate that DDAT is a practical fluorescent molecular tool for the discovery of potential anti-TB drugs.

关键词： Thioredoxin reductase NIR fluorescent probe Fluorescence imaging High-throughput screening inhibitors Inhibit Mycobacterium tuberculosis

Engineering molecular regulation for SiO_(x) with long-term stable cycle and high Coulombic efficiency as lithium-ion battery anodes

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Rare Metals 2024年第2期43卷 588-598页

作者： fei Wang Han Gao Zhao-Yu Niu Yao-Peng Zheng Ming-yan Chuai Jia-Nan Xu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China

In the current situation where the practical application of silicon anode materials encounters great challenges,silicon oxide(SiO_(x),0≤x≤2)has attracted the attention of researchers due to its relatively small volume expansion,stable cycling performance,and low cost,which is possible to realize commercial applications earlier than silicon ***,it remains a challenge to prepare SiO_(x)materials with long-term stable cycling performance and high Coulombic efficiency using low-cost *** this work,SiO_(x)anode material with high Coulombic efficiency and good long-term cycling stability was prepared at a low cost by hydrolysis of siloxane and in situ polymerization of phenolic *** hydrolysis of siloxane was further regulated by different silane coupling agents to regulate the size and microstructure of prepared SiO_(x)materials,which displayed the substantially improved electrochemical *** excellent electrochemical performance of SiO_(x)prepared by regulated hydrolysis of siloxane with silane coupling agents is attributed to the effect of silane coupling agent on size and microstructure of SiO_(x),revealing that the strategy of modulating the hydrolysis of siloxane by silane coupling agent is a potential method to prepare high-performance SiO_(x)materials.

关键词： Hydrolysis Silane coupling agent Long cycle SiO_(x) anode Lithium-ion battery(LIB)

Effect of comprehensive nursing on the quality of life and swallowing function in individuals diagnosed with ischemic stroke

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World Journal of Clinical Cases 2024年第8期12卷 1406-1415页

作者： Heng-Fen Hu Yu-fei Sang yan-Qing Xiao Medical School Hunan Vocational and Technical College of Environmental BiologyHengyang 421005Hunan ProvinceChina Medical Team The Unit 95246 Of Chinese People’s Liberation ArmyNanning 530007Guangxi Zhuang Autonomous RegionChin Department of Gynecology and Obstetrics Hengyang Maternal and Child Health HospitalHengyang 421001Hunan ProvinceChina

BACKGROUND Ischemic stroke(IS)is a widely recognized disease characterized by high preva-lence,mortality,morbidity,disability,and recurrence *** ranks prominently in terms of mortality,constituting 60%-80%of stroke *** To explore the impact of comprehensive nursing care on the quality of life and swallowing function in individuals diagnosed with *** This study comprised 172 patients with IS admitted to our hospital between February 2018 to March *** participants were divided into two groups,namely the control group(n=80)receiving routine care and the research group(n=92)receiving comprehensive *** assessment scales,including the standard swallowing function assessment scale(SSA),National Institutes of Health Stroke scale(NIHSS),European stroke scale(ESS),self-rating anxiety scale(SAS),self-rating depression scale(SDS),Barthel index(BI),and the motor func-tion assessment scale(MAS),were employed to evaluate the improvement in swallowing function,neurological deficits,clinical outcomes,anxiety,depression,daily living activities,and motor function before and after ***,the study compared the occurrence of adverse reactions during the nursing period,life quality before and after the intervention,rehabilitation compliance,and nursing satisfaction between the two *** After the nursing intervention,the research group exhibited significantly improved SSA and NIHSS scores compared to the control group(P<0.05).Moreover,both groups demonstrated significant reductions in SAS and SDS scores(P<0.05),with the research group showing more obvious advantages(P<0.05).Compared to the control group,the research group displayed significantly better ESS,BI,and MAS scores(P<0.05),coupled with a lower incidence of adverse reactions(P<0.05).Additionally,the research group demonstrated markedly higher levels of life quality,rehabilitation compliance,and nursing satisfaction compared to the control group(P<0.05).CONCLUSION Comprehensive nu

关键词： Comprehensive nursing Stroke Swallowing function Quality of life Patient satisfaction

Systematic investigation of Radix Salviae for treating diabetic peripheral neuropathy disease based on network Pharmacology

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World Journal of Diabetes 2024年第5期15卷 945-957页

作者： tao Kang Xiao Qin yan Chen Qian yang Department of Neurology Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Diabetic peripheral neuropathy(DPN)is a debilitating complication of diabetes mellitus with limited available treatment *** Salviae,a traditional Chinese herb,has shown promise in treating DPN,but its therapeutic mech-anisms have not been systematically *** Radix Salviae(Danshen in pinin),a traditional Chinese medicine(TCM),is widely used to treat DPN in ***,the mechanism through which Radix Salviae treats DPN remains ***,we aimed to explore the mechanism of action of Radix Salviae against DPN using network *** The active ingredients and target genes of Radix Salviae were screened using the TCM pharmacology database and analysis *** genes associated with DPN were obtained from the Gene Cards and OMIM databases,a drug-com-position-target-disease network was constructed,and a protein–protein inter-action network was subsequently constructed to screen the main *** Ontology(GO)functional annotation and pathway enrichment analysis were performed via the Kyoto Encyclopedia of Genes and Genomes(KEGG)using *** A total of 56 effective components,108 targets and 4581 DPN-related target genes of Radix Salviae were *** with Radix Salviae for DPN mainly involved 81 target *** top 30 major targets were selected for enrichment analysis of GO and KEGG *** These results suggested that Radix Salviae could treat DPN by regulating the AGE-RAGE signaling pathway and the PI3K-Akt signaling ***,Danshen may affect DPN by regulating inflammation and apoptosis.

关键词： Diabetic peripheral neuropathy Radix Salviae Network pharmacology Systematic investigation

Application of interpolated double network model for carbon nanotube composites in electrothermal shape memory behaviors

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Acta Mechanica Sinica 2024年第8期40卷 133-153页

作者： Ting Fu Zhao yan Li Zhang Ran tao Yiqi Mao Department of Engineering Mechanics College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China State Key Laboratory of Explosion Science and Technology Institute of Advanced Structure TechnologyBeijing Institute of TechnologyBeijing100081China

Multi-wall carbon nanotube filled shape memory polymer composite(MWCNT/SMC)possessed enhanced modulus,strength,and electric conductivity,as well as excellent electrothermal shape memory properties,showing wide design scenarios and engineering application *** thermoelectrically triggered shape memory process contains complex multi-physical mechanisms,especially when coupled with finite deformation rooted on micro-mechanisms.A multi-physical finite deformation model is necessary to get a deep understanding on the coupled electro-thermomechanical properties of electrothermal shape memory composites(ESMCs),beneficial to its design and wide *** into consideration of micro-physical mechanisms of the MWCNTs interacting with double-chain networks,a finite deformation theoretical model is developed in this work based on two superimposed network chains of physically crosslinked network formed among MWCNTs and the chemically crosslinked *** intact crosslinked chemical network is considered featuring with entropic-hyperelastic properties,superimposed with a physically crosslinked network where percolation theory is based on electric conductivity and electric-heating *** model is calibrated by experiments and used for shape recoveries triggered by heating and electric *** captures the coupled electro-thermomechanical behavior of ESMCs and provides design guidelines for MWCNTs filled shape memory polymers.

关键词： Shape memory polymer composite Viscoplastic constitutive relations Electro-thermomechanics Double network model Multiple shape memory

Superior Mechanical Behavior and Flame Retardancy FRP via a Distribution Controllable 1D/2D Hybrid Nanoclay Synergistic Toughening Strategy

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Engineering 2024年第9期40卷 166-178页

作者： Zixuan Chen Tianyu Yu Zetian yang Zhibiao Wei yan Li Weidong yang tao Yu School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Suochen Information Technology Co. Ltd.Shanghai 200030China Shanghai Key Laboratory of Space Mapping and Remote Sensing for Planetary Exploration Tongji UniversityShanghai 200092China

The incorporation of commercial flame retardants into fiber-reinforced polymer(FRP)composites has been proposed as a potential solution to improve the latter’s poor flame ***,this approach often poses a challenge,as it can adversely affect the mechanical properties of the ***,balancing the need for improved flame resistance with the preservation of mechanical integrity remains a complex issue in FRP *** this critical concern,this study introduces a novel additive system featuring a combination of one-dimensional(1D)hollow tubular structured halloysite nanotubes(HNTs)and two-dimensional(2D)polygonal flake-shaped nano kaolinite(NKN).By employing a 1D/2D hybrid kaolinite nanoclay system,this research aims to simultaneously improve the flame retardancy and mechanical *** innovative approach offers several *** combustion and pyrolysis processes,the 1D/2D hybrid kaolinite nanoclay system proves effective in reducing heat release and volatile ***,the system facilitates the formation of reinforcing skeletons through a crosslinking mechanism during pyrolysis,resulting in the development of a compact char *** char layer acts as a protective barrier,enhancing the material’s resistance to heat and *** terms of mechanical properties,the multilayered polygonal flake-shaped 2D NKN plays a crucial role by impeding the formation of cracks that typically arise from vulnerable areas,such as adhesive phase ***,the 1D HNT bridges these cracks within the matrix,ensuring the structural integrity of the composite *** an optimal scenario,the homogeneously distributed 1D/2D hybrid kaolinite nanoclays exhibit remarkable results,with a 51.0%improvement in mode II fracture toughness(GIIC),indicating increased resistance to crack *** addition,there is a 34.5%reduction in total heat release,signifying improved flame *** study represents a significant step

关键词： 1D/2D nanoclays Hierarchical distribution Flame retardancy Fiber-reinforced polymer Damage mechanism