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Phytochemical analysis of Tinospora cordifolia and Withania somnifera and their therapeutic activities with special reference to COVID-19

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World Journal of Experimental Medicine 2024年第3期14卷 39-47页

作者： Prateek Rai tanya Garain Deepshikha Gupta Chemistry Amity Institute of Applied SciencesAmity UniversityNoida 201301Uttar PradeshIndia

Various important medicines make use of secondary metabolites that are produced by *** plants,such as Withania somnifera and Tinospora cordifolia,are rich sources of chemically active compounds and are reported to have numerous therapeutic *** therapeutic use of medicinal plants is widely mentioned in Ayurveda and has folkloric importance in different parts of the *** aim of this review is to summarize the phytochemical profiles,folkloric importance,and primary pharmacological activity of *** and *** with emphasis on their action against the novel coronavirus.

关键词： Phytochemical analysis Tinospora cordifolia Withania somnifera COVID-19 Immunomodulators Giloy Ashwagandha

Numerical study of convective heat transfer in static arrangements of particles with arbitrary shapes:A monolithic hybrid lattice Boltzmann-finite difference-phase field solver

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Particuology 2024年第2期85卷 186-197页

作者： Reza Namdar Mohammadhassan Khodsiani Hesameddin Safari tanya Neeraj Seyed Ali Hosseini Frank Beyrau Benoit Fond Dominique Thevenin Fathollah Varnik Interdisciplinary Centre for Advanced Materials Simulation(ICAMS) Ruhr-University BochumBochum44801Germany Laboratory of Technical Thermodynamics University of Magdeburg"Otto von Guericke"Magdeburg39106Germany Laboratory of Fluid Dynamics and Technical Flows University of Magdeburg"Otto von Guericke"MagdeburgD-39106Germany Department of Mechanical and Process Engineering ETH ZurichZurich8092Switzerland ONERA The French Aerospace Lab Department of AerodynamicsAeroelasticity and Acoustics(DAAA)Paris-Saclay UniversityMeudon92190France

A compressible lattice Boltzmann-finite difference method is extended by the phase-field approach into a monolithic scheme to study fluid flow and heat transfer through regular arrangements of solid bodies of circular,elliptical and irregular *** advantage of using the phase-field method is demon-strated both in its simplicity of accounting for flow and thermal boundary conditions at solid surfaces with irregular shapes and in the capability of generating such complex-shaped *** an array of discs,numerical results for the overall solid-to-gas heat transfer rate are validated via experiments on flow through arrays of hot *** thus validated compressible LB-FD-PF hybrid scheme is used to study the dependence of heat transfer on flow and thermal boundary conditions(Reynolds number,temperature difference between the hot solid bodies and the inlet gas),porosity as well as on the shape of solid *** are rationalized in terms of the residence time of the gas close to the solid body and downstream variations of gas velocity and *** for further applications of the proposed methodology are also discussed.

关键词： Lattice Boltzmann method Finite difference scheme Convective heat transfer Diffuse interface Thermal compressible flow

Steric Control over Interligand Dihedrals and Splay Leads to the Formation of Fe^(II)_(6)L_(6)and Fe^(II)_(8)L_(8)Antiprisms

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CCS Chemistry 2024年第10期6卷 2411-2419页

作者： Yuchong Yang Yuyin Du tanya K.Ronson Jonathan R.Nitschke Yusuf Hamied Department of Chemistry University of CambridgeCambridge CB21EW

Macrocycles have found uses in guest capture,sensing,and porous materials,motivating the development of new methods for their *** we report the construction of two types of barrelshaped macrocyclic assemblies,with trigonal antiprismatic Fe^(II)_(6)L_(6)and square antiprismatic Fe^(II)_(8)L_(8)architectures,from FeII and boron-containing tritopic *** factors,the steric hindrance of ligands and the preferred coordination angles at different vertices,were observed to regulate the dihedral angles between adjacent ligands,leading to the formation of the structures *** effects of ligand steric hindrance led to the formation of a Fe^(II)_(6)L_(6)trigonal antiprism,which efficiently encapsulated persistent environmental pollutant perfluorosulfonate *** contrast with the iminopyridine chelating groups of the Fe^(II)_(6)L_(6)structure,the incorporation of azopyridine moieties coordinated with the FeII centers not only increased the vertex opening angle,resulting in the construction of a Fe^(II)_(8)L_(8)square antiprism,but also enabled the redox-driven reversible disassembly of this *** design strategies that have enabled the construction of these antiprismatic macrocycles may provide insight into the design principles governing the formation of more complex functional assemblies.

关键词： self-assembly metal-organic cages host-guest chemistry redox-responsive materials dihedral control

Nonsteroidal anti-inflammatory drugs before endoscopic ultrasound guided tissue acquisition to reduce the incidence of post procedural pancreatitis

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World Journal of Gastroenterology 2024年第8期30卷 811-816页

作者： Mike de Jong Foke van Delft Christine Roozen Erwin-Jan van Geenen tanya Bisseling Peter Siersema Marco Bruno Department of Gastroenterology and Hepatology Radboud University Medical CenterNijmegen 6525 GANetherlands Department of Gastroenterology and Hepatology Erasmus University Medical CenterRotterdam 3015 GDNetherlands

Endoscopic ultrasound(EUS)with fine needle aspiration or fine needle biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and auto-immune pancreatitis or to analyze cyst *** most common reported adverse event of fine needle aspiration and/or fine needle biopsy is acute pancreatitis,which is likely induced by the same pathophysiological mechanisms as after en-doscopic retrograde cholangiopancreatography(ERCP).According to the current European Society of Gastrointestinal Endoscopy guideline,nonsteroidal anti-inflammatory drugs are administered prior to ERCP as a scientifically proven treatment to reduce post-ERCP pancreatitis incidence rate.A single suppository of diclofenac or indomethacin prior to EUS guided tissue acquisition(TA)is harm-less in healthy *** it is associated with low costs and,most important,may prevent a dreadsome complication,we strongly recommend the adminis-tration of 100 mg diclofenac rectally prior to *** will explain this recom-mendation in more detail in this review as well as the risk and pathophysiology of post-EUS TA pancreatitis.

关键词： Pancreatitis Endoscopic ultrasound Tissue acquisition Nonsteroidal antiinflammatory drugs Pancreatic cancer

Effect of Dietary Components on the Shear Bond Strength of Orthodontics Brackets after Thermal Aging

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Open Journal of Stomatology 2024年第6期14卷 309-315页

作者： Philip Punzalan tanya Al Talib Anthony Fusco Neamat Hassan Abubakr School of Dental Medicine University of Nevada Las Vegas Nevada USA

Introduction: The stability of orthodontic brackets throughout orthodontic treatment plays a critical role in the treatment’s effectiveness. The present in vitro study was designed to assess the impact of various dietary components on the performance of orthodontic brackets. Methods: Metal orthodontic brackets were bonded to 66 extracted anterior teeth divided into groups based on the solution type: Milk, Gatorade, Cold Coffee, and a control group using water. Each group consisted of 20 teeth except for the control group, which included six teeth. The bracketed teeth were submerged in their respective solutions for 15 minutes three times daily at different intervals to mimic an in vivo environment and were stored in artificial saliva at room temperature (23?C). The specimens underwent artificial aging through 10,000 cycles of thermocycling (representing one clinical year) between 5?C and 55?C. Shade measurements were taken using a VITA Easy Shade device, capturing the classic shade and L*, a*, and b* values. Delta E values were calculated immediately post-bonding and after 7 days, 1 month, 1, and 2 clinical years. The shear bond strength of each bracket was measured using an ultra-tester machine. Results: After two clinical years, significant differences in ΔE color values were observed across all groups, with the most substantial change noted in teeth immersed in cold coffee. Brackets submerged in milk demonstrated lower shear bond strength than other solutions, whereas the control group exhibited the highest shear bond strength (P = 0.01). Conclusion: The study indicates that dietary components significantly influence tooth color stability and the shear bond strength of orthodontic brackets, underscoring the importance of considering these factors in orthodontic treatment planning.

关键词： Shear Bond Orthodontic Brackets Color Stability Thermal Aging

From source to emplacement:The origin of leucogranites from the Sikkim-Darjeeling Himalayas,India

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Geoscience Frontiers 2024年第1期15卷 384-401页

作者： tanya Srivastava Nigel Harris Catherine Mottram Kumar Batuk Joshi Nishchal Wanjari Department of Geology Sikkim UniversityGangtokIndia School of Environment Earth&Ecosystem SciencesOpen UniversityMiltonKeynesUK School of the Environment Geography and GeosciencesUniversity of PortsmouthUK National Centre for Earth Science Studies ThiruvananthapuramKeralaIndia

Himalayan leucogranites are important for understanding the tectonic evolution of collision zones in general and the causes of crustal melting in the Himalayan orogen in *** paper aims to understand the melt source and emplacement age of the leucogranites from Sikkim in order to decipher the deep geodynamic processes of the eastern *** U-Pb analysis of the Higher Himalayan Sequence(HHS)metamorphic core reveals a prolonged period of crustal melting between>33 Ma and ca.14 *** and trace element abundances are presented for 27 leucogranites from North Sikkim that are classified into two-mica and tourmaline leucogranite *** are peraluminous in composition,characterized by high SiO2(70.91-74.9 wt.%),Al2O3(13.69-15.82 wt.%),and low MgO(0.13-0.74 wt.%).Elemental abundances suggest that Sikkim Himalayan leucogranites are derived from crustal *** two-mica leucogranites are derived from a metagreywacke source,whereas the tourmaline leucogranites are sourced from metapelitic sources,with inherited zircons indicating an HHS origin for both types.U-Pb zircon geochronology of the two mica leucogranites indicates ages of ca.19-15 Ma,consistent with crustal melting recorded in HHS gneisses from *** from both the two-mica and tourmaline leucogranites yield a crystallization age of ca.15-14 Ma,coeval with movement on the Main Central Thrust and South Tibetan Detachment System which further provides constraints on the timing and mechanism of petrogenesis of leucogranites in the Sikkim Himalayas.

关键词： Leucogranites Gneiss U-Pb geochronology Zircon Monazite Sikkim-Darjeeling Himalayas

领趋势之先StefanCamenzind和tanyaRuegg访谈录

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室内设计与装修 2024年第11期 95-97页

作者： Stefan Camenzind tanya Ruegg Evolution Design

id+c:Evolution Design作为办公空间设计的佼佼者,您认为哪些设计理念使您的公司与众不同?Stefan Camenzind:我们将人置于工作设计的核心,专注于创造真正满足他们功能和情感需求的空间。通过细致的调研和分析,深入了解用户的工作习惯、... 详细信息

id+c:Evolution Design作为办公空间设计的佼佼者,您认为哪些设计理念使您的公司与众不同?Stefan Camenzind:我们将人置于工作设计的核心,专注于创造真正满足他们功能和情感需求的空间。通过细致的调研和分析,深入了解用户的工作习惯、社交互动以及心理健康的需求,以确保我们的设计能够增强员工的满意度与生产力。

关键词：情感需求办公空间设计社交互动心理健康深入了解满意度

Imaging approach for jaw and maxillofacial bone tumors with updates from the 2022 World Health Organization classification

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World Journal of Radiology 2024年第8期16卷 294-316页

作者： Woongsoon John Choi Peggy Lee Penelope C Thomas tanya J Rath Monique A Mogensen Roberta W Dalley Pattana Wangaryattawanich Division of Neuroradiology Department of RadiologyUniversity of Washington School of MedicineSeattleWA 98195United States Department of Radiology M&S Radiology AssociatesSan AntonioTX 78217United States Division of Oral Radiology University of Washington School of DentistrySeattleWA 98195United States Division of Neuroradiology Department of RadiologyMayo ClinicPhoenixAZ 85054United States

Jaw and maxillofacial bone lesions encompass a wide variety of both neoplastic and non-neoplastic *** lesions can arise from various tissues,including bone,cartilage,and soft tissue,each presenting distinct challenges in diagnosis and *** some pathologies exhibit characteristic imaging features that aid in diagnosis,many others are *** overlap often necessitates a multimodal imaging approach,combining techniques such as radiographs,computed tomography,and magnetic resonance imaging to achieve a diagnosis or narrow the diagnostic *** article provides a comprehensive review of the imaging approach to jaw and maxillofacial bone tumors,including updates on the 2022 World Health Organization classification of these *** relevant anatomy of the jaw and dental structures that is important for accurate imaging interpretation is discussed.

关键词： Mandible Maxilla Maxillofacial Jaw Tumor Neoplasm

Bone-targeted therapies to reduce skeletal morbidity in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 215-220页

作者： tanya B Dorff Neeraj Agarwal USC Keck School of Medicine USC Norris Comprehensive Cancer Center Genitourinary Oncology Los Angeles CA 90033 USA Hunts Man Cancer Institute Universityof Utah 2000 Circle of Hope Salt Lake City UT 84112 USA

Bone metastases are the main driver of morbidity and mortality in advanced prostate cancer. Targeting the bone microenvironment, a key player in the pathogenesis of bone metastasis, has become one of the mainstays of therapy in men with advanced prostate cancer. This review will evaluate the data supporting the use of bone-targeted therapy, including （1） bisphosphonates such as zoledronic acid, which directly target osteoclasts, （2） denosumab, a receptor activator of nuclear factor-kappa B （RANK） ligand inhibitor, which targets a key component of bone stromal interaction, and （3） radium-223, an alpha-emitting calcium mimetic, which hones to the metabolically active areas of osteoblastic metastasis and induces double-strand breaks in the DNA. Denosumab has shown enhanced delay in skeletal-related events compared to zoledronic acid in patients with metastatic castration-resistant prostate cancer （mCRPC）. Data are mixed with regard to pain control as a primary measure of efficacy. New data call into question dosing frequency, with quarterly dosing strategy potentially achieving similar effect compared to monthly dosing for zoledronic acid. In the case of radium-223, there are data for both pain palliation and improved overall survival in mCRPC. Further studies are needed to optimize timing and combination strategies for bone-targeted therapies. Ongoing studies will explore the impact of combining bone-targeted therapy with investigational therapeutic agents such as immunotherapy, for advanced prostate cancer. Future studies should strive to develop biomarkers of response, in order to improve efficacy and cost-effectiveness of these agents.

关键词： bisphosphonate bone metastases prostate cancer radiopharmaceutical receptor activator of nuclear factor-kappa B-ligand