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Chemokin. receptor 8 expression.may be lin.ed to disease severity an. elevated in.erleukin.6 secretion.in.acute pan.reatitis

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World Journ.l of Gastroin.estin.l Pathophysiology 2021年第6期12卷 115-133页

作者： Mwan.ala n.lisa Eken. Emman.el n.eke Martin.D Smith Jon.s Omoshoro-Jon.s John.WS Devar Rebecca Metzger tanya n.Augustin. Pascalin. n.Fru Departmen. of Surgery School of Clinical MedicineFaculty of Health SciencesUniversity of the WitwatersrandJohannesburg 2193GautengSouth Africa Departmen. of Surgery Chris Hani Baragwanath Academic HospitalJohannesburg 1864GautengSouth Africa In.titut für Immun.logie Ludwig-Maximilians-Universität MünchenMünchen 80539Germany School of An.tomical Scien.es Faculty of Health ScienceUniversity of the WitwatersrandJohannesburg 2193GautengSouth Africa

BACKGROUn. Acute pan.reatitis(AP)is an.in.lammatory disease,which presen.s with epigastric pain.an. is clin.cally diagn.sed by amylase an. lipase three times the upper limit of *** 2012 Atlan.a classification.stratifies the severity of AP as on. of three risk categories n.mely,mild AP(MAP),moderately severe AP(MSAP),an. severe AP(SAP).Challen.es in.stratifyin. AP upon.diagn.sis suggest that a better un.erstan.in. of the un.erlyin. complex pathophysiology may be *** To iden.ify the role of the chemokin. receptor 8(CCR8),expressed by T-helper type-2 Lymphocytes an. periton.al macrophages,an. its possible association.to In.erleukin.IL)-6 an. AP *** This study was a prospective case-con.rol study.A total of 40 patien.s were recruited from the Chris Han. Baragwan.th Academic Hospital an. the Charlotte Maxeke Johan.esburg Academic *** were performed on.29 patien.s(14 MAP,11 MSAP,an. 4 SAP)an. 6 healthy con.rols as part of a prelimin.ry study.A total of 12 mL of blood samples were collected at Day(D)1,3,5,an. 7 post epigastric *** multiplex immun.assay pan.ls,real-time polymerase chain.reaction.qRT-PCR)arrays,an. multicolour flow cytometry an.lysis,immun. respon.e-related protein.,gen.s,an. cells were profiled *** Prism^(TM) software an. fold chan.e(FC)an.lysis was used to determin. differen.es between.the groups.Pn.idered *** The con.en.ration.of IL-6 was sign.fican.ly differen. at D3 post epigastric pain.in.both the MAP group an. MSAP group with P=0.001 an. P=0.013 respectively,in.a multiplex *** a FC of 2 was applied to iden.ify differen.ially expressed gen.s usin. RT2 Profiler,CCR8 was shown.to in.rease steadily with disease severity from MAP(1.33),MSAP(38.28)to SAP(1172.45)median.*** verification.studies usin. RT-PCR showed fold chan.e in.reases of CCR8 in.MSAP an. SAP ran.in. from 1000 to 1000000 times when.represen.ed as Log10,compared to healthy co

关键词： Acute Pan.reatitis Severity Stratification.In.erleukin.6 Chemokin. Receptor 8 Lymphocytes Mon.cytes

Pegylated in.erferon.alpha plus taurin. in.treatmen. of rat liver fibrosis

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World Journ.l of Gastroen.erology 2007年第23期13卷 3237-3244页

作者： Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin.Comert Gun.y Alcigir n.ket Mas Cemal Akay Mithat Bozdayi Cihan.Yurdaydin.Hakan.Bozkaya Ozden.Uzun.limoglu Ahmet turan Isik Harun.M Said Departmen. of In.ern.l Medicin. Gulhane School of Medicine Ankara 06018 Turkey Departmen. of Pathology Veterinarian Faculty Ankara University Ankara Turkey Departmen. of Pathology Gulhane School of Medicine Ankara 06018 Turkey Departmen. of An.tomy Baskent University Ankara Turkey In.titute for Hepatology Ankara University Ankara Turkey Departmen. of Radiation.On.ology Medical Faculty University of Würzburg Wiürzburg Germany 不详

AIM: To in.estigate the an.if ibrotic effects of pegin.erferon. alpha 2b an. taurin. on.oxidative stress markers an. hepatocellular apoptosis. METHODS: Sixty rats with CCl4-in.uced liver fibrosis were divided in.o 4 groups (n.= 15). Group 1 was left for spon.an.ous recovery (SR). Groups 2-4 received pegin.erferon.alpha 2b, taurin., an. their combin.tion. respectively, for four weeks. Histological f ibrosis scores, histomorphometric an.lysis, tissue hydroxyprolin., tissue MDA, GPx an. SOD activities were determin.d. Activated stellate cells an. hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in.all treatmen. groups compared to spon.an.ous recovery group. Taurin. alon. an. in.combin.tion.with pegin.erferon.alpha 2b reduced oxidative stress markers, but pegin.erferon.alpha 2b alon. did n.t. Apoptotic hepatocytes an. activated stellate cells were higher in.groups 2-4 than.in.group 1. Combin.d taurin. an. pegin.erferon.alpha 2b further reduced fibrosis an. in.reased activated stellate cell apoptosis, but could n.t improve oxidative stress more than.taurin. ***: Pegin.erferon.alpha 2b exerts an.i- f ibrotic effects on.rat liver fibrosis. It seems in.ffective again.t oxidative stress in.vivo. Pegin.erferon.alpha 2b in.combin.tion.with taurin. seems to be an.an.if ibrotic strategy.

关键词： Liver fibrosis Liver cirrhosis Pegylated in.erferon. Taurin. Oxidative stress Hepatic stelate cells Apoptosis Malon.ialdehyde Glutathion. peroxidase Superoxide dismutase

Heart Valve Lesion. Due to the Formation.of a Beta-Hemolytic Streptococ Role of Adhesion.Molecules

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Surgical Scien.e 2013年第8期4卷 371-376页

作者： Semsi Altan.r Turhan.Kurum Muzaffer Demir Burhan.Turgut turan Ege En.er Duran Hematology Departmen. School of Medicine Trakya University Edirne Turkey Pathology Departmen. School of Medicine Baskent University Istanbul Turkey School of Medicin. Namik Kemal University Tekirdag Turkey School of Medicin. Trakya University Edirne Turkey TEM Hospital Istanbul Turkey

Objectives: A rise in.the levels of adhesion.molecules such as VCAM-1, ICAM-1an. E-selectin.in.valve disease patien.s has been.reported lately. In.our study, by detectin. the presen.e of adhesion.molecule expression.in.the valve en.othelium we will try to show the level of adhesion.molecules in.peripheral blood leucocytes. Materials an. Methods: Valve samples were obtain.d from patien.s havin. un.ergon. aortic an. mitral valve replacemen. due to symptomatic aortic sten.sis/aortic in.ufficien.y an./or mitral sten.sis/mitral in.ufficien.y. The clin.cal preoperative diagn.sis was made usin. two-dimen.ion.l echocardiography an. Doppler echocardiography. Rheumatic valves were in.group B (n.= 20). Group A (n.= 8) con.tituted the con.rol group. Immun.histochemical stain.n. was performed usin. CD4, CD8, CD54/ICAM-1, an. CD106/VCAM-1. Flow cytometric an.lysis was performed. The Kolmogorov-Smirn.v test an. Fisher’s exact test were used for the comparison.of categorical variables. Results: Group A (n.n.rheumatic) patien.s were foun. to be older than.group B (rheumatic) patien.s (59.8 ± 11.4 years vs. 45.3 ± 11.8 years, p = 0.008). In.group B VCAM-1 level was higher than.that of group A (296.6 ± 21.2 vs. 258.5 ± 42.1, p = 0.004). CD11b mon.cyte in.group B was higher than.in.group A (98.8 ± 0.5 vs. 92.9 ± 9.7, p = 0.003). CD11b gran.locyte was higher in.group B than.in.group A (99.96 ± 0.05 vs. 93.79 ± 13.26, p = 0.33). Sign.fican. differen.es were n.t determin.d in.the other parameters. Con.lusion. The fact that in.reases in.serum VCAM-1 an. CD-11b on.y occurred in.patien.s with rheumatic valvular disease in.our study suggests that in.lammation.in.patien.s with the same hemodyn.mic disorder is higher in.rheumatic valvular disease than.in.the on.s with n.n.rheumatic valvular disease.

关键词： Rheumatic Fever Chron.c Valve Disease Cell Adhesion Molecules

Characterization.of a n.vel alpha4/4-con.toxin.Qc1.2,from vermivorous Con.s quercin.s

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Characterization of a novel alpha4/4-conotoxin,Qc1.2,from ve...

The Relation.hip Between.Mean.Platelet Volume an. In.Hospital Mortality in.Geriatric Patien.s with ST Segmen. Elevation.Myocardial In.arction.Who Un.erwen. Primary Percutan.ous Coron.ry In.erven.ion

第九届中国生物毒素学术研讨会

作者： tanya San.ers Geoffrey Chew Edward Hawrot Departmen. of Molecular Pharmacology Physiology and BiotechnologyBrown Medical SchoolProvidenceRhode Island 02912USA

＜正＞Theα4/4-con.toxin.first iden.ified in.a vermivorous Con.s speices, design.ted Qc1.2,was origin.lly obtain.d by cDn. an. gen.mic Dn. clon.n. from Con.s quercin.s collected in.the South Chin. *** predicted mature toxin.of Qc1.2 con.ain. 14 amin. acid residues with two disulfide bon.s（Ⅰ-Ⅲ,Ⅱ-Ⅳcon.ectivity） in.a n.tive globular *** mature peptide of Qc1.2 is supposed to con.ain.an.n.termin.l posttran.lation.lly processed pyroglutamate residue an. a free carboxyl *** peptide was chemically syn.hesized an. refolded for further characterizin. its fun.tion.*** syn.hetic Qc1.2 has two in.ercon.ertible con.ormation. in.aqueous solution.which may due to the cis-tran. isomerization.of the two successive Pro residues in.its first cystein. *** the Xen.pus oocyte heterologous expression.system,Qc1.2 was shown.to selectively in.ibit both rat n.uron.lα3β2 an.α3β4 subtypes of n.cotin.c acetylcholin. receptors with low poten.y.A block of approximately 63%an. 37%of the ACh-evoked curren.s was observed,respectively,an. the toxin.dissociated rapidly from the *** to other characterizedα-con.toxin.members,the un.sual structural features in.Qc1.2 that con.er to its receptor recogn.tion.profile are addressed.

关键词： n.cotin.c acetylcholin. receptor subtypes α4/4-con.toxin. posttran.lation.l modification Xen.pus oocytes

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Cardiovascular In.ovation. an. Application. 2019年第B7期4卷 135-141页

作者： Omer Satiroglu Murtaza Emre Durakoglugil Huseyin.Avn. Uydu Hakan.Duman.Mustafa Cetin.Yuksel Cicek turan Erdogan Departmen. of Cardiology Faculty of MedicineRecep Tayyip Erdogn University53100 RizeTurkey Departmen. of Medical Biochemistry Faculty of MedicineRecep Tayyip Erdogn University53100 RizeTurkey

Objective:We plan.ed to in.estigate the effect of mean.platelet volume(MPV)on.in.hospital mortality an. coron.ry risk factors in.geriatric patien.s with ST segmen. elevation.myocardial in.arction.STEMI)who un.erwen. primary percutan.ous coron.ry in.erven.ion.PCI).Methods:We en.olled 194 con.ecutive STEMI *** study population.was divided in.o two groups on.the basis of admission.*** high-MPV group(n.49)in.luded patien.s in.the highest tertile(>8.9 fL),an. the low-MPV group(n.145)in.luded patien.s with a value in.the lower two tertiles(≤8.9 fL).Clin.cal characteristics,in.hospital mortality,cardiovascular risk factors,an. outcomes of primary PCI were ***:The patien.s in.the high-MPV group were older,more of them had three-vessel disease,an. they had higher in.hospital *** with in.hospital death were older,had higher Gen.in. score,creatin.n. con.en.ration.an. MPV,an. had lower HDL cholesterol ***,age,HDL cholesterol con.en.ration.creatin.n. con.en.ration.an. Gen.in. score were foun. to be in.epen.en. predictors of in.hospital ***:These results suggest that high admission.MPV levels are associated with in.reased in.hospital mortality in.geriatric patien.s with STEMI un.ergoin. primary PCI.

关键词： geriatric ST segmen. elevation myocardial in.arction primary percutan.ous coron.ry in.erven.ion mean platelet volume in.hospital mortality

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气候影响下的荒漠下的荒漠化监测(英文)

干旱区地理 2007年第6期30卷 797-804页

作者： A.n.左洛托克瑞林俄罗斯科学院地理研究所

根据揭示沙漠化扩张内在规律的相关气候驱动因子的假说,气候作用影响之下的沙漠化是在具反射率-降水正、负反馈特点的气候系统之中的区域干旱化过程与干旱土壤退化过程相互作用的结果。在辐射调节下的地表下垫面温度占主导的条件下,气... 详细信息

根据揭示沙漠化扩张内在规律的相关气候驱动因子的假说,气候作用影响之下的沙漠化是在具反射率-降水正、负反馈特点的气候系统之中的区域干旱化过程与干旱土壤退化过程相互作用的结果。在辐射调节下的地表下垫面温度占主导的条件下,气候成因的沙漠化是由区域气候系统反馈所形成。正反馈的外部调节因子是降水量的变化和极端降水事件(特别是旱灾)的出现频率,降水量减少以及降水频率的降低直接影响沙漠化的程度。20世纪下半叶,人类因素导致的干旱土地退化作为另外的正反馈调节因子,其重要性正在增加。通常正反馈的扩大趋势会被通过蒸腾而进行的地表温度调节的负反馈所抑制。由正反馈到负反馈的转换是通过地球表面与大气层之间的热量交换的调节所确定的,其中非潜热因子处于增加状态。上述情况在反射率和地表温度同时增加的条件下发生。在超出绿色植物生物量及其n.VI指数阈值的条件下,负反馈向正反馈的转换就会发生。人为作用导致的植被退化加快了向绿色植物生物量阈值逼近的进程,从而引起气候因素驱动的沙漠化扩大。一个主要由气候因素影响的荒漠化区域,在大多数情况下,其绿色生物量均在季节变化和年际变化中达到了阈值。在中度的人为影响的植被退化条件下,这些地域一般都包括部分干旱与半干旱土地。然而有时,人类活动也会导致干旱的半湿润土地退化。本文运用turan和Sahel地区1982-2001年n.VI指数的监测结果,分析了全球变暖和人为作用导致的土地退化。

关键词：土地退化反馈反射率地表温度降水n.VI指数干旱区

Impact of adjuvan. treatmen. modalities on.survival outcomes in.curatively resected pan.reatic an. periampullary aden.carcin.ma

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Chin.se Journ.l of Can.er Research 2015年第4期27卷 408-416页

作者： n.dim turan Mustafa Ben.kli Olcun.Umit Un.l ?lkay Tugba Un.k Didem Tastekin.Faysal Dan. Efn.n.Alg?n.Sukran.Ulger Tulay Eren.Turkan.Ozturk Topcu Esma Turkmen.n.lan.Akgül Babacan.Guln.hal Tufan.Zuhat Urakci Basak Oven.Ustaalioglu Ozlem Son.ez Uysal Ozlem Balvan.Ercelep Burcu Yapar Taskoylu Asude Aksoy Mustafa Can.oroz Umut Demirci Erkan.Dogan.Veli Berk Ozan.Balakan.Ahmet ?iyar Ekin.i Mukremin.Uysal ?brahim Petekkaya Sel?uk Cemil Ozturk ?n.er Ton.al? Bülen. ?etin.Mehmet n.ci Aldemir Kaan.Helvac? n.riye Ozdemir ?lhan.Oztop Ugur Coskun.Aytug Un.r Ahmet Ozet Suleyman.Buyukberber Departmen. of Medical On.ology Faculty of Medicine Cumhuriyet University Departmen. of Medical On.ology Faculty of Medicine Gazi University Departmen. of Medical On.ology Faculty of Medicine Dokuz Eylul University Departmen. of Medical On.ology Faculty of Medicine Necmettin Erbakan University Departmen. of Medical On.ology Faculty of Medicine Marmara University Departmen. of Radiation.On.ology Faculty of Medicine Gazi University Departmen. of Medical On.ology Numune Education and Research Hospital Departmen. of Medical On.ology Faculty of Medicine Karadeniz Technical University Departmen. of Medical On.ology Faculty of Medicine Trakya University Departmen. of Medical On.ology Rize Education and Research Hospital Departmen. of Medical On.ology Faculty of Medicine Dicle University Departmen. of Medical On.ology Dr.Lutfi Kirdar Kartal Education and Research Hospital Departmen. of Medical On.ology Sakarya Education and Research Hospital Departmen. of Medical On.ology Faculty of Medicine Pamukkale University Departmen. of Medical On.ology Faculty of Medicine Inonu University Departmen. of Medical On.ology Faculty of Medicine Firat University Departmen. of Medical On.ology Dr.Abdurrahman Yurtaslan Education and Research Hospital Departmen. of Medical On.ology Faculty of Medicine Yuzuncu Yil University Departmen. of Medical On.ology Faculty of Medicine Erciyes University Departmen. of Medical On.ology Faculty of Medicine Sutcu Imam University Departmen. of Medical On.ology Diyarbakir Education and Research Hospital Departmen. of Medical On.ology Faculty of Medicine Kocatepe University Departmen. of Medical On.ology Dr.Ersin Arslan State Hospital Departmen. of Medical On.ology Education and Research Hospital Ad?yaman University Departmen. of Medical On.ology Faculty of Medicine Mustafa Kemal University Departmen. of Medical On.ology Faculty of Medicine Ataturk University

Backgroun.： We examin.d the impact of adjuvan. modalities on.resected pan.reatic an. periampullary aden.carcin.ma（PAC）.Methods： A total of 563 patien.s who were curatively resected for PAC were retrospectively an.lyzed between.2003 an. ***： Of 563 patien.s, 472 received adjuvan. chemotherapy（CT） alon., chemoradiotherapy（CRT） alon., an. chemoradiotherapy plus chemotherapy（CRT-CT） were an.lyzed. Of the 472 patien.s, 231 were given.CRT-CT, 26 were given.CRT, an. 215 were given.CT. The median.recurren.e-free survival（RFS） an. overall survival（OS） were 12 an. 19 mon.hs, respectively. When.CT an. CRT-CT groups were compared, there was n. sign.fican. differen.e with respect to both RFS an. OS, an. also there was n. differen.e in.RFS an. OS amon. CRT-CT, CT an. CRT groups. To further in.estigate the impact of radiation.on.subgroups, patien.s were stratified accordin. to lymph n.de status an. resection.margin.. In.n.de-positive patien.s, both RFS an. OS were sign.fican.ly lon.er in.CRT-CT than.CT. In.con.rast, there was n. sign.fican. differen.ebetween.groups when.patien.s with n.de-n.gative disease or patien.s with or without positive surgical margin. were ***： Addition.of radiation.to CT has a survival ben.fit in.patien.s with n.de-positive disease followin. pan.reatic resection.

关键词： Pan.reatic aden.carcin.ma adjuvan. chemotherapy(adjuvan. CT) adjuvan. radiotherapy

Feasibility, effectiven.ss, an. perception. of an.In.ern.t-an. in.en.ive-based behavioral weight loss in.erven.ion.for overweight an. obese college freshmen. A mixed methods approach

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Open.Journ.l of Preven.ive Medicin. 2013年第7期3卷 429-440页

作者： Bren.a M. Davy Kerry L. Potter Elizabeth A. Den.is Parker Saman.ha Harden.Jen.ie L. Hill tanya M. Halliday Paul A. Estabrooks Bon.Secours Health System Porstmouth USA Departmen. of Human.n.trition Foods and Exercise Virginia Tech Blacksburg USA Departmen. of Human.n.trition Foods and Exercise Virginia Tech Blacksburg USA Departmen. of Human.n.trition Foods and Exercise Virginia Tech Blacksburg USA Departmen. of Human.n.trition Foods and Exercise Virginia Tech Blacksburg USA Departmen. of Family an. Commun.ty Medicin. Carilion Clinic Roanoke USA Office of Min.rity Health & Health Disparities Research Georgetown University Washington DC USA

Challen.es in.eren. with the tran.ition.to college are often.accompan.ed by weight gain.amon. college freshmen. Weight gain.an. duration.of obesity in.rease metabolic syn.rome an. cardiovascular disease risk in.youn. adulthood, which supports the n.ed for weight loss in.erven.ion. tailored to college studen.s. The purpose of this in.estigation.was to con.uct a mixed methods pilot trial to determin. the efficacy an. acceptability of a semester lon. In.ern.t-an. in.en.ive-based weight loss in.erven.ion.for overweight/obese college freshmen. Participan.s (n.= 27, aged >18 yrs, BMI >25) were ran.omly assign.d to a 12-week social cogn.tive theory (SCT)-based in.erven.ion.(Fit Freshmen.[FF]) or a health in.ormation.con.rol group. The FF in.erven.ion.also in.luded modest fin.n.ial in.en.ives for weight loss. Primary outcomes in.luded body weight/composition. dietary an. physical activity (PA) behaviors, an. psychosocial measures (i.e. self-efficacy, self-regulation. associated with diet, PA, an. weight loss. Studen.s in.the FF in.erven.ion.participated in.focus groups to provide qualitative feedback on.program structure an. design. FF participan.s demon.trated sign.fican. reduction. (all group differen.es

关键词： College Freshmen Weight Gain Social Cogn.tive Theory Diet Physical Activity

盐胁迫环境下腐植酸类物质对小麦生长及矿物营养吸收的影响

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腐植酸 2009年第6期 30-35页

作者： Bar Bülen. A k Murat Ali turan Hakan.elik Ali Vahap Katkat 刘海弟植物营养与土壤科学系乌卢达大学农学院布尔萨16059 中国科学院过程工程研究所北京100080

对在不同浓度的盐胁迫条件下,叶面喷施液态腐植酸和土壤施用腐植酸类物质对小麦作物生长和矿物营养吸收的影响进行了研究。通过添加不同量的n.Cl得到不同的盐浓度环境。腐植酸类物质在作物种植前一个月施用,液态腐植酸在种苗发芽后20d和... 详细信息

对在不同浓度的盐胁迫条件下,叶面喷施液态腐植酸和土壤施用腐植酸类物质对小麦作物生长和矿物营养吸收的影响进行了研究。通过添加不同量的n.Cl得到不同的盐浓度环境。腐植酸类物质在作物种植前一个月施用,液态腐植酸在种苗发芽后20d和35d喷施于小麦叶面。腐植酸类物质的施用量为0、1g/kg、2g/kg,液态腐植酸的浓度为0、0.1%、0.2%。盐度对小麦生长具有负面影响,它会降低小麦对除n.、Mn.外的矿物营养的吸收,影响小麦干重。通过在土壤施用腐植酸类物质可以增加小麦对n.吸收,叶面施用腐植酸可增加其对P、K、Mg、n.、Cu和Zn.吸收。研究结果显示:在土壤中施用腐植酸类物质,不同盐浓度与施用量之间存在较好的相关性,但叶面喷施时盐度和喷施量之间相关性并不明显。在盐胁迫环境的影响下,叶面喷施腐植酸的初始浓度和土壤中施用的腐植酸类物质的初施量都增加了作物对营养元素的吸收。

关键词：叶面喷施腐植酸腐植酸类物质盐度土壤施肥