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无机材料学报 2020年第2期35卷 250-256页

作者： LI Xia SHENASHEN Mohamed A MEKAWY Moataz taniguchi akiyoshi EI-SAFTY Sherif A Research Center for Functional Materials National Institute for Materials ScienceIbaraki 305-0047Japan Cellular Functional Nanomaterials Group Research Center for Functional MaterialsNational Institute for Materials ScienceIbaraki 305-0044Japan Engineering and Advanced Manufacturing University of SunderlandSunderlandUnited Kingdom

Alum has an excellent safety record and is the only licensed inorganic adjuvant for human vaccines.However,the exploration of alum nanosheets as chemotherapy drug delivery system,especially the clarification about the relationship between structures and drug loading properties,is totally insufficient.Herein,aluminum hydroxides(AlOOH)nanosheets with tunable specific surface area and pore size were synthesized by adjusting the synthesis time in the presence of triblock copolymers.The obtained materials exhibited the highest surface area about 470 m2/g.The structure-dependent chemotherapy drug loading capability for AlOOH nanosheets was observed:the higher specific surface area and pore size are,the higher amount of chemotherapy drug is loaded.AlOOH nanosheets loaded with doxorubicin showed a pH-dependent sustained release behavior with quick release in low pH about 5 and slow release in pH around 7.4.Doxorubicin-loaded AlOOH nanosheets exhibited much higher cancer cellular uptake efficiency than that in free form by flow cytometry.Moreover,doxorubicin-loaded AlOOH nanosheets with high specific surface area showed an increased cellular uptake efficiency and enhanced ratios of apoptosis and necrosis,compared with those showing low specific surface area.Therefore,AlOOH nanosheets are promising materials as chemotherapy drug delivery system.

关键词： aluminum hydroxide nanosheet cancer chemotherapy storage drug delivery

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Peritoneal mesothelioma

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 114-125页

作者： Yutaka Yonemura Haruaki Ishibashi akiyoshi Mizumoto Takuji Fujita Yang Liu Satoshi Wakama Syouzou Sako Nobuyuki Takao Toshiyuki Kitai Kanji Katayama Yasuyuki Kamada Keizou taniguchi Daisuke Fujimoto Asian School of Peritoneal Surface Malignancy Treatment Kyoto CityKyoto 600-8189 Japan Department of Regional Cancer Therapy Peritoneal Dissemination CenterKishiwada Tokushukai HospitalKishiwada CityOosaka 596-8522 Japan Department of Regional Cancer Therapy Peritoneal Dissemination CenterKusatsu General HospitalKusatsu CityShiga 525-8585 Japan Department of Surgery Mizonokuchi HospitalTeikyo UniversitySchool of MedicineKawasakiKanagawa 213-8507Japan

This review provides an overview of articles about peritoneal mesothelioma(PM)to analyze the effect of treatment modalities on response rates,post-treatment side effects,morbidity and mortality,and survival.Median survival in months following systemic chemotherapy(SC)ranged from 8.7 to 26.8 months.However,no patient was reported to have survived for more than five years with SC alone.In contrast,comprehensive treatment that included cytoreductive surgery(CRS)+perioperative chemotherapy(POC)showed a significantly longer median survival time than SC alone.Additionally,CRS+POC demonstrated 10-year survival rates of 12%-35%.Accordingly,CRS+POC is an innovative treatment that provides long-term survival in selected patients with PM.Selection criteria are performance status(ECOG PS≤1),the absence of extraperitoneal metastasis,PCI less than cutoff levels(from<10 to<28),MIB-1 index(<10),and histologic type(epithelioid type).Postoperative morbidity and mortality rates after CRS+POC were significantly higher than with more conventional operations.Accordingly,CRS and POC should be done at the specialized peritoneal surface malignancy centers.

关键词： Peritoneal mesothelioma mesothelioma intraperitoneal chemotherapy HIPEC peritonectomy

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