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Long lasting response to second-line everolimus in kidney cancer

World Journal of Clinical Cases 2013年第5期1卷 166-168页

作者： Antonella Virtuoso tania policastro Michela Izzo Piera Federico Carlo Buonerba Pasquale Rescigno Giuseppe Di Lorenzo Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica Università degli Studi Federico Ⅱ80131 NaplesItaly Deparment of Clinical Medicine University Federico Ⅱ of Naples80131 Naples Italy

In the case presented here, everolimus was administered after first line therapy with sunitinib in a patient with metastatic renal cell carcinoma. The safety profile was excellent. The prolonged progression-free survival(PFS) obtained with everolimus in this case is of peculiar interest, as it is a multiple of the median PFS obtained in with everolimus in the regulatory trial. Such finding suggests that a subset of patients with renal cell carcinma may particularly benefit from everolimus.

关键词： Metastatic renal cell carcinoma Everolimus(RAD001) Sunitinib Progression-free survival

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Cabazitaxel in castration resistant prostate cancer with brain metastases: 3 case reports

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World Journal of Clinical Cases 2014年第6期2卷 228-231页

作者： Sabino De Placido Pasquale Rescigno Piera Federico Carlo Buonerba Davide Bosso Livio Puglia Michela Izzo tania policastro Giuseppe Di Lorenzo Genitourinary Cancer Section Medical Oncology Department of Clinical Medicine Federico Ⅱ University

Prostate cancer is the most common non-cutaneous malignancy for men. The skeleton is the most common metastatic site but, following an improvement in survival, metastases in uncommon sites are being found more frequently in clinical practice, especially brain metastases. Despite the new drugs now available for metastatic castration resistant prostate cancer, no clinical evidence exists about their effectiveness on brain metastases. We describe the clinical history of 3 patients treated with cabazitaxel plus whole brain radiotherapy. These case reports demonstrate that cabazitaxel is highly active and well tolerated in brain metastases.

关键词： Cabazitaxel Brain metastases Prostate cancer

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World Journal of Clinical Oncology 2013年第2期4卷 52-57页

作者： Pasquale Rescigno Rossella Di Trolio Carlo Buonerba Gaia De Fata Piera Federico Davide Bosso Antonella Virtuoso Michela Izzo tania policastro Luca Vaccaro Gianfranco Cimmino Francesco Perri Elide Matano Mario Delfino Sabino De Placido Giovannella Palmieri Giuseppe Di Lorenzo Genitourinary Cancer Section and Rare-Cancer Center Medical Oncology DivisionUniversity Federico II80131 NapoliItaly Department of Dermatology University Federico II of Naples80131 NapoliItaly

AIM:To evaluate the outcomes and potential prognostic factors in patients with non-acquired immunodeficiency syndrome(AIDS)-related Kaposi’s sarcoma(KS).METHODS:Patients with histologically proven non-AIDS-related KS treated with systemic chemotherapy were included in this retrospective *** some cases,the human herpes virus 8 status was assessed by *** patients were staged according to the Mediterranean KS staging system.A multivariable model was constructed using a forward stepwise selection procedure.A P value<0.05 was considered statistically significant,and all tests were ***:Thirty-two cases were included in this *** average age at diagnosis was 70 years,with a male/female ratio of approximately 2:***-four percent of the cases had classic *** patients received systemic chemotherapy containing one of the following agents:vinca alkaloid,taxane,and pegylated liposomal *** patients(31.5%)experienced a partial response,and a complete response was achieved in four patients(12.4%)and stable disease in sixteen cases(50%).Two patients(6.2%)were refractory to the systemic *** median progression-free survival(PFS)was 11.7 mo,whereas the median overall survival was 28.5 *** multivariate analysis,the presence of nodular lesions(vs macular lesions only)was significantly related to a lower PFS(hazard ratio:3.09;95%CI:1.18-8.13,P=0.0133).CONCLUSION:Non-AIDS-related KS appears mostly limited to the skin and is well-responsive to systemic *** data show that nodular lesions may be associated with a shorter PFS in patients receiving chemotherapy.

关键词： Kaposi’s sarcoma Human herpes virus 8 Paclitaxel Pegylated liposomal doxorubicin Vinblastine

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