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Molecular Detection of Pathogens Involved in Sexually Transmitted Infections in Brazzaville, Congo

Open Journal of Medical Microbiology 2024年第3期14卷 190-205页

作者： Jeanine Mireille Sita Maboundou Bitsi Nina Esther Ngoyi Ontsira Edith Sophie Kombo Bayonne tanguy mieret Geril Sekangue Obili Herlen Tsoumou Lina Foungou Kessengue Samantha Potokoue Mpia Chloé Dupont Guilhem Conquet Gickel Mpika Bitsene Bienvenu Roland Ibara Ossibi Axel Aloumba Etienne Nguimbi Sylvain Godreuil Faculty of Sciences and Technology Marien NGOUABI University Brazzaville Republic of the Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Republic of the Congo Bacteriology-Virology Laboratory University Hospital Center Brazzaville Republic of the Congo Department of Infectious Diseases Referral Hospital Center of Talanga Brazzaville Republic of the Congo Parasitology-Mycology Laboratory University Hospital Center Brazzaville Republic of the Congo Department of Gynecology-Obstetrics University Hospital Center Brazzaville Republic of the Congo UMR IRD224-CNRS5290-UM MIVEGEC Infectious Diseases and Vectors: Ecology Genetics Evolution and Control CREES (Reshearch Center in Ecology and Evolution Health) Montpellier France Bacteriology Laboratory Arnaud de Villeneuve University Hospital CHU of Montpellier Montpellier France Department of Infectious Diseases University Hospital Center Brazzaville Republic of the Congo

The objective of this multicentric study was to assess the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma génitalium and Trichomonas vaginalis infections in Brazzaville, in the Republic of Congo, using molecular methods. From January to December 2021, the sexually transmitted disease risk participants were recruited from six centers: The Association of Young HIV-Positive People of Congo, The Congolese Association for Family Welfare, The Association for Support to Vulnerable Groups, Talangaï hospital, Brazzaville university hospital (outpatient service) and the private clinic COGEMO (outpatient service). The real-time multiplex PCR was carried out to detect these pathogens. Each patient had at least one specimen (urine, urethral, anal and/or vaginal samples). The patients were considered infected when one of their samples was positive. 287 participants made of 227 women and 60 men were tested. The general prevalence of these infections was: Chlamydia trachomatis 2.79%, Neisseria gonorrhoeae 3.14%, Mycoplasma génitalium 3.45% and Trichomonas vaginalis 2.97. The prevalence rates according to sex were: C. trachomatis, M. génitalium, N. gonorrhea and T. vaginalis were 1.32%, 2.05%, 1.32% and 3.42% in women and 8.33%, 7.02%, 10% and 1.75% in men, respectively. Most infected patients were asymptomatic. Prevalence rates were higher in bisexual individuals, with the exception of T. vaginalis which showed higher prevalence in heterosexual patients. The bisexual and homosexual individuals represent a major public health problem in sexually active young adults, particularly among men having sex with men. These sexually transmitted infections are mainly asymptomatic, their diagnosis and management remain difficult in developing countries.

关键词： Prevalence Chlamydia trachomatis Neisseria gonorrhoeae Mycoplasma génitalium Trichomonas vaginalis

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Evaluation of HIV Viral Load Activity at the Bacteriology-Virology Laboratory in the University Hospital Center of Brazzaville

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Open Journal of Medical Microbiology 2019年第4期9卷 178-185页

作者： Esther Nina Ontsira Ngoyi tanguy mieret Roland Bienvenu Ossibi Ibara Axel Aloumba Géril Obili Sekangue Armel Claude Itoua Irène Laure Opfou Christian Diamant Mossoro-Kpinde Hervé Léon Iloki Bertrand Dupont Christine Rouzioux Bacteriology-Virology Laboratory of the Teaching Hospital Center (CHU) Brazzaville Congo Health Sciences Faculty of MarienNgouabi University Brazzaville Congo National Laboratory of Clinical Biology and Public Health Ministry of Public Health Central African Republic and University of Bangui Faculty of Health sciences Central African Republic Bangui Central African Republic Infectious Diseases Department of the Teaching Hospital Center (CHU) Brazzaville Congo Gynecology and Obstetrical Department of the Teaching Hospital Center (CHU) Brazzaville Congo Infectious Diseases and Tropical Department Neckerteaching Hospital Center Paris France Virology Laboratory of the Necker Teaching Hospital Center Paris Descartes University Paris France

Introduction: The bacteriology-virology laboratory of the teaching university hospital of Brazzaville, was equipped with a real-time PCR device like Miniopticon (Biorad? , France). The aim of this work was to do an evaluation of the HIV viral load activity, with a view to proposing some recommendations. Material and methods: Retrospective study, January 2013 to March 2015, in patients on first line ARV three-therapy, pre-inclusion therapy checkup in HIV positive patients, but again screening after sexual abuse in women or accident of exposure (AES). A blood sample on EDTA tube was made and RNA extraction with Qiagen kit. Ultrasensitive HIV-RNA quantification was performed using the Generic HIV real-time PCR assay (Biocentric?, Bandol, France). Results: 126 patients were included. The mean age was 37.63 years +/- 10.43 years, sex ratio F/H = 2.3. The HIV viral load was detectable in 94 cases (74.6%). Concerning patients with detectable viral load (copies/ml): 403 to 996 in 35 cases (37.23%), 1411 to 1812 in 41 cases (43.62%) and >1814 in 5 cases (5.32%) (therapeutic failure). Conclusion: This work reports success in the setting up of the molecular biology unit. Procedures that implement information and education actions on the risks associated with AES must be disclosed.

关键词： Viral Load HIV Miniopticon CHU Brazzaville

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cagAand vacAHelicobacter pyloriPathogenicity Factors in Brazzaville, Congo

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Open Journal of Medical Microbiology 2019年第4期9卷 186-200页

作者： E. N. Ontsira Ngoyi C. Guilloteau L. Benejat A. Mongo Onkouo A. Buissonnière E. Sifre A. Aloumba tanguy mieret F. Bossali F. Yala A. A. Abena J. Vadivelu K. L. Goh J. R. Ibara B. I. AtipoIbara A. Menard P. Lehours F. Megraud Equipe 2 Helicobacter pylori infection inflammation and cancer Inserm U1053 Bordeaux university Bordeaux France Health Sciences Faculty Marien Ngouabi University Brazzaville Congo French National Reference Center for Helicobacters and Campylobacters Bordeaux France University of Malaya Kuala Lumpur Malaysia Bacteriology laboratory Pellegrin University Hospital Bordeaux France

Introduction: CagA and VacA are the most important and well-studied virulence factors found in Helicobacter pylori. The aim of this work was to identify genes corresponding to H. pylori pathogenicity factors in Brazzaville, Congo. Material & Methods: A cross-sectional study was carried out from October 2013 to December 2016. Biopsy specimens were obtained from patients scheduled for upper gastrointestinal endoscopy in Brazzaville, Congo and were sent to the French National Reference Center for Campylobacters and Helicobacters in Bordeaux, France. H. pylori detection was conducted by real-time PCR using a fuorescence resonance energy transfer-melting curve analysis protocol. The identification of the genes encoding pathogenicity factors was carried out by conventional PCR using the appropriate primers for determination of CagA phosphorylation motifs 1, 2, 3;and vacAs, I and m regions: vacAi1, vacAi2, vacAs1a, vacAs1b. Results: A high prevalence of H. pylori infection was reported (108/143;75.5%). In 92.2% (n = 71/77), the presence of P1, P2 and P3 CagA phosphorylation motifs was noted. Concerning vacA, vacAs1m1 was observed in 82% of the strains (n = 59/72). vacAi1 was present in all strains (n = 76). With regard to the distribution according to the vacAs1 subtype, the majority of the strains (59/71;83%) were vacAs1b positive, as compared to vacAs1c (17/34, 33%). The vacAs1a gene was absent in all of these patients. Conclusion: The presence of genes associated with severe gastric diseases indicates the importance of H. pylori eradication in the prevention of these diseases in Congo.

关键词： Pathogenicity Factors CagA VacA

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Traumatic Diaphragmatic Hernia in Children: A Case Report

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Surgical Science 2024年第3期15卷 111-117页

作者： Lucienne Irène Patricia Ondima Rhodia Hélène Bosseba Missengue Nuptia Erica Akobande Cardinale Princilia Okiemy Niendet Jean-Claude mieret Caryne Mboutol-Mandavo Department of Pediatric Surgery Marien Ngouabi University Brazzaville Congo Department of Paediatric Surgery Hospital and University Centre (HUC) Brazzaville Congo

Introduction: Traumatic diaphragmatic hernia is a rare condition in children complicating closed or penetrating trauma to the abdomen and thorax. We report the case of an 11-year-old girl with a traumatic diaphragmatic hernia. Case Presentation: An 11-year-old girl was seen in the paediatric surgery department for a thoracolumbar spine deformity and intermittent chest pain. These symptoms occurred after a domestic accident involving a fall from a low wall onto the thoracolumbar spine 5 months previously. The diagnosis was suggested by the presence of a left hemithoracic hydroaera and confirmed by a thoraco-abdominal CT scan. Surgical exploration revealed a linear rupture of the entire left hemi-diaphragm with herniation of the stomach, small intestine, cecum, transverse colon and omentum. We performed a double-layer suture of the diaphragmatic rupture with a non-absorbable suture without edge rejuvenation after the reduction of the hernia. The outcome was favourable with normal postoperative radiographs at one year follow-up. Conclusion: Traumatic diaphragmatic hernia, although uncommon and difficult to diagnose, is a condition that is relatively easy to manage surgically, even if it is discovered late. In all cases of trauma to the thoracolumbar spine, regular follow-up and repeat X-rays are necessary if pain persists.

关键词： Hernia Diaphragm Trauma Child Case Report

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Large Conventional Osteosarcoma of the Proximal Humerus in a 13-Year-Old Child: Case Report

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Open Journal of Pediatrics 2024年第2期14卷 297-304页

作者： Lucienne Irène Patricia Ondima Rhodia Hélène Bosseba Missengue Cardinale Princilia Okiemy Niendet Nuptia Erica Akobande Jean Claude mieret Caryne Mboutol-Mandavo Redy Atipo Galloye Judith Nsondé Malanda Jennifer Mave Sirimé Ngandzo Fabien Mouamba Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Paediatric Surgery Department Brazzaville University Hospital Centre Brazzaville Congo Department of General Surgery Brazzaville University Hospital Centre Brazzaville Congo Carcinology Department Brazzaville University Hospital Centre Brazzaville Congo Anatomo-Pathology Laboratory Brazzaville University Hospital Centre Brazzaville Congo

Introduction: Osteosarcoma is the most common primary malignant bone tumor in children. It is highly aggressive and has a poor prognosis. A late presentation modifies and makes difficult the management affecting the survival of children. We report the case of a large conventional osteosarcoma in a 13-year-old girl. Case Presentation: Adolescent girl admitted for painful swelling of the left shoulder with absolute functional impotence of the thoracic limb and severe anemia. The painful swelling was thought to have been caused by a minor trauma that had occurred six months previously. The patient’s general condition was poor, and she presented with a large, shiny, painful mass over the shoulder and upper 2/3 of the left arm, measuring 28 cm long by 28 cm wide and 57 cm in circumference, and a large fistulous axillary adenopathy. CT scan showed a tumour lesion of the left humerus with liver and lung metastases, raising suspicion of osteogenic osteosarcoma. The tumor was classified according to TNM staging: T2N1M1(a + b). Management was modified when uncontrolled bleeding developed. It consisted of an extended amputation of the left thoracic limb. Pathological analysis showed a high-grade conventional osteosarcoma. Quality improvement was obtained for thirty days, followed by the onset of dyspnea. The evolution was towards death at forty days post-operatively. Conclusion: Osteosarcoma is a highly aggressive cancer. Delayed treatment leads to a fatal outcome. Early diagnosis is one of the challenges to be met in order to improve survival.

关键词： Osteosarcoma Child Conventional Case Report

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Traumatic Diaphragmatic Hernia in Children: A Case Report

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Surgical Science（外科学） 2024年第3期 111页

作者： Lucienne Irène Patricia Ondima Rhodia Hélène Bosseba Missengue Nuptia Erica Akobande Cardinale Princilia Okiemy Niendet Jean-Claude mieret Caryne Mboutol-Mandavo1

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Rectal Prolapse of the Child at the Center University Hospital of Brazzaville

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Open Journal of Pediatrics 2017年第4期7卷 359-362页

作者： mieret Jean Claude Moyen Engoba Koumbourou Judicael Antsiemi Yves Mboutol Mandavo Carine Yaokreh Jean Baptiste Moyen Georges Department of Pediatric Surgery Center University Hospital of BrazzavilleBrazzavilleCongo Pediatric Intensive Care Unit Center University Hospital of BrazzavilleBrazzavilleCongo Department of Pediatric Surgery Yopougon University HospitalAbidjanCote d’Ivoire

Summary: The aim of this work was to determine the frequency of rectal prolapse and to describe the therapeutic aspects. Material and Methods: A descriptive study with a retrospective collection was carried out between January 2013 and May 2016 in 29 months in the pediatric surgery department at the Center University Hospital of Brazzaville. Children between the ages of 1 and 15 years of age, treated for rectal prolapse and whose records were exploitable were included. The variables studied were: age, gender, parental socio-economic status, consultation time, preference factors, pre-admission treatment, treatment initiated and progression. Results: In 29 months, 22 cases of rectal prolapse were collected, i.e. a hospital frequency of 0.96%. The mean age was 4.5 years extremes (1 and 11 years). The average time of consultation was 5 days extremes (1 and 21 days). Diarrhea 5 cases (23%), constipation diarrhea 3 cases (14%), constipation 10 cases (45%), bronchopneumopathy 4 cases (18%). The treatment was surgical according to the Thiersch technique in all cases. The evolution was favorable. Conclusion: Rectal prolapse, a benign pathology, is relatively uncommon. Constipation remains the main factor favoring the need to take care of upstream. Treatment by the Thiersch method remains the first choice in children.

关键词： Rectal Prolapse Frequency Children

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Large Conventional Osteosarcoma of the Proximal Humerus in a 13-Year-Old Child:Case Report

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Open Journal of Pediatrics（儿科学期刊） 2024年第2期 297页

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Rare Neonatal Digestive Surgical Emergencies at the Brazzaville University Hospital Center

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Open Journal of Pediatrics 2020年第3期10卷 463-473页

作者： Lucienne Irène Patricia Ondima Caryne Mboutol-Mandavo Moïse Service Yanguedet Didace Massamba Miabaou Jean-Claude mieret Cardinale Princilia Okiemy Niendet Gracia Christelle Ossete Peggy Dahlia Gallou Mawandza Neli Yvette Ngakengni Gaston Ekouya Bowassa Department of Pediatric Surgery University Hospital Center Brazzaville Republic of Congo Department of Visceral Surgery University Hospital Center Brazzaville Republic of Congo Department of Intensive care and Anesthesia University Hospital Center Brazzaville Republic of Congo Department of Neonatology University Hospital Center Brazzaville Republic of Congo

The purpose of our study was to evaluate the morbidity-morality of rare neonatal digestive emergencies in order to improve their management. Observations: 7 newborns ranging in age from 6 hours to 3 weeks were treated for rare digestive pathologies between January 2013 and July 2017 (a period of 3 years and 6 months) in the Department of Pediatric surgery of Brazzaville University Center, Congo. Males were predominant (5 versus 2 females). Pathologies listed were: 1 antenatal volvulus of the small intestine, 1 annular pancreas and 5 gastric perforations. The average time of care in the operating room was 12 hours. The newborns were hospitalized in the pediatric surgery department in 28.6% of cases (n = 2), and 71.4% (n = 5) in the neonatology department. The antenatal volvulus of the intestine and annulus pancreas were integrated into a nosologic entity named neonatal occlusion (NNO). The postoperative outcomes were simple for 4 patients (57.14%) while 3 patients died immediately after surgery (42.86%). Conclusion:

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Isolated Caeco-Vesical Fistula: A Case Report

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Open Journal of Urology 2020年第12期10卷 309-314页

作者： Lucienne Irène Patricia Ondima Melvin Ondongo Atipo Steve Aristide Ondziel Opara Didace Massamba-Miabaou Régis Moyikoua Peggy Dalhia Galou Mawandza Moï se Yanguedet Service Caryne Mboutol-Mandavo Pierre Aymar Oko Jean-Claude mieret Cardinale Princilia Okiemy Niendet Gracia Christelle Ossete Erica Nuptia Akobande Anani Wenceslas Séverin Odzébé Prosper Bouya Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Pediatric Surgery Department University Hospital Center Brazzaville Republic of Congo Urology and Andrology Department University Hospital Center Brazzaville Republic of Congo Visceral Surgery Department University Hospital Center Brazzaville Republic of Congo Medical Imaging Department University Hospital Center Brazzaville Republic of Congo Multipurpose Resuscitation Department University Hospital Center Brazzaville Republic of Congo Pediatric Intensive Care Unit University Hospital Center Brazzaville Republic of Congo

Congenital uro or genito-digestive fistulas are frequently found in the context of caudal pole malformations. Isolated congenital forms without associated anorectal malformation have not been reported until now. We report the first case we know a 9 year old female child received in a pediatric surgery consultation for fecaluria evolving since birth with a permeable anus. She presented a good general condition, a good staturo-ponderal and psychomotor development, a vulva soiled by stool and a permeable anus with a tonic sphincter. A retrograde urethrocystography revealed a caeco-vesical fistula. Surgery consisted of ligation-section of the caeco-vesical septum. A follow-up urethrocystography at three months post-surgery no longer visualized the fistula. Our post-operative follow-up is 4 years. Isolated congenital caeco-vesical fistula is an unknown pathology whose late diagnosis can have serious repercussions.

关键词： Fistula Congenital Isolated Caecum Bladder Child Surgery

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