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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing tang zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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Response of Japanese anchovy(Engraulis japonicus)to the Pacific Decadal Oscillation in the Yellow Sea over the past 400 a

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Acta Oceanologica Sinica 2022年第8期41卷 31-40页

作者： Haoyu Li Qisheng tang yao Sun College of the Environment and Ecology Xiamen UniversityXiamen 361102China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesQingdao 266071China

Quantitative identification of long-term changes in the abundance of Japanese anchovy(Engraulis japonicus)in the Yellow Sea is particularly important for understanding evolutionary processes of the Yellow Sea ***,the driving mechanisms of climate variability on the anchovy are still unclear due to the lack of long-term observational *** this study,we used the fish scale deposition rate in the central Yellow Sea to reconstruct the time series of the anchovy stock over the past 400 *** this basis,we further explored the impacts of the Pacific Decadal Oscillation(PDO)on the *** results show that the anchovy stock is positively correlated with the PDO on a decadal time *** addition,anchovy abundance was relatively high during1620–1860 AD(the Little Ice Age,LIA),though in a state of constant fluctuation;anchovy abundance maintained at a relatively low level after~1860 *** particular,followed by overfishing since the 1980 s,the anchovy stock has declined *** on these findings,we infer that fluctuations of the anchovy stock may be regulated by basin-scale“atmosphere–ocean”***,the role of overfishing should not be ignored.

关键词： Japanese anchovy scale deposition rate population fluctuation Pacific Decadal Oscillation Yellow Sea

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Urinary metabonomics study of Wu-tou-tang and its co-decoction with Pinelliae Rhizoma in adjuvant-induced arthritis rats

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Chinese Chemical Letters 2015年第3期26卷 387-392页

作者： yao Qi Zi-Feng Pi Shu Liu Feng-Rui Song Ying Xu Na Lin zhi-Qiang Liu Changchun Center of Mass Spectrometry Changchun Institute of Applied ChemistryChinese Academy of Sciences Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Wu-tou-tang was applied to treat rheumatoid arthritis,rheumatic arthritis,and joint pain for thousands of *** Radix Cocta is the primary component of Wu-tou-tang,and Aconiti Radix and Pinelliae Rhizoma is one of the famous combination taboos in traditional Chinese medicine.A urinary metabonomics method based on the ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry（UPLC-Q-TOF-MS） had been established to quantify the changes of the endogenous metabolites in the urine of adjuvant-induced arthritis rats treated by Wutou-tang and Wu-tou-tang and Pinelliae Rhizoma（WP） *** was a clear separation between Wu-tou-tang and WP co-decoction treated groups in the PCA model.16 potential biomarkers had been identified which correlated with how Pinelliae Rhizoma influenced the therapeutic effect made by *** showed that it could reduce the therapeutic effects or make some side effects when Pinelliae Rhizoma is added in *** is the first time to use metabonomics to investigate the reason of combination taboo.

关键词： decoction adjuvant Radix endogenous rheumatic urine metabolism taboo urinary quantify

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Enhanced Microwave Absorption Properties of Double-Layer Absorbers Based on Spherical NiO and Co_(0.2)Ni_(0.4)Zn_(0.4)Fe_2O_4 Ferrite Composites

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Acta Metallurgica Sinica(English Letters) 2018年第2期31卷 171-179页

作者： Pei-Jiang Liu Zheng-Jun yao Vincent Ming Hong Ng Jin-tang Zhou zhi-Hong Yang Ling-Bing Kong College of Materials and Technology Nanjing University of Aeronautics and Astronautics Nanjing 211100 China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing 211100 China School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore

Microwave absorption properties of spherical NiO particles and Co0.2Ni0.4Zn0.4Fe2O4（CNZF） ferrites with single-layer and double-layer absorbers were studied in the frequency range of 2–18 GHz. The spherical NiO particles were synthesized by using a hydrothermal process, while the CNZF powders were prepared by using a sol–gel autoignition method. The double-layer absorbers, composed of 30 wt% NiO as matching layer and 30 wt% CNZF as absorption layer,with a total thickness of 3.2 mm, exhibited a maximum reflection loss（RL） of –67.0 d B at 9.2 GHz and an effective absorbing bandwidth below –10 d B to be 3.9 GHz from 7.0 to 10.9 GHz. The excellent microwave absorption performance of the double-layer absorbers should be ascribed to the high impedance matching ratio, the great microwave attenuation capability, and well-coupled layer.

关键词： Hierarchical NiO particle Ferrite Impedance matching Microwave absorption property

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Einstein-Maxwell Field of the Central Mass

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Chinese Physics Letters 2002年第2期19卷 166-168页

作者： Wang Yong-Jiu and tang zhi-Ming Institute of Physics Hu"nan Normal University

We have obtained the exact solution of the Einstein-Maxwell equations outside the central mass with magnetic moment and, at the same time, we have investigated their asymptotic properties

关键词： Magnetic moments

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Microstructure, property and deformation and fracture behavior of 800 MPa complex phase steel with different coiling temperatures

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Journal of Iron and Steel Research International 2021年第3期28卷 346-359页

作者： Jian-zhong Xue Zheng-zhi Zhao Di tang Hui Li Hao-hong Wu Wei-liang Xiong Liang Liang yao Huang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Beijing100083China VALIN LY STEEL Co. Ltd.Loudi417000HunanChina China Electric Power Research Institute Beijing100085China

The microstructure characteristics and properties(especially hole expansion property)of 800 MPa hot-rolled complex phase steel with different coiling temperatures were *** microstructure consisted of polygonal ferrite and precipitates when the steel was coiled at 550℃,and when the steel was coiled between 460–520℃,the microstructure was composed of granular bainite and martensite and austenite(M/A)*** morphology of the crack was analyzed by scanning electron microscopy,and the in situ scanning electron microscope tensile test was used to find out the fracture mechanism and deformation behavior of the steel with different coiling *** the steel was coiled at 550℃,the cracks initiated at the ferrite grain boundary and propagated through the grains or along the grain *** the steel was coiled at 520℃,the cracks first initiated at the junction of ferrite and M/A island and then propagated through the *** steel coiled at 520℃ has quite good mechanical properties and relatively high hole expansion ratio.

关键词： Complex phase steel Coiling temperature Strength In situ tensile test Hole expansion ratio Crack

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A Family of Constacyclic Codes over ■2m+u■2mand Its Application to Quantum Codes

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Chinese Journal of Electronics 2020年第1期29卷 114-121页

作者： tang Yongsheng yao Ting ZHU Shixin KAI Xiaoshan School of Mathematics and Statistics Hefei Normal University School of Mathematics Hefei University of Technology

Let R be the ring ■2m+u■2m,where u2=*** introduce a Gray map from R to ■22m and study(1+u)-constacyclic codes over *** is proved that the image of a(1+u)-constacyclic code length n over R under the Gray map is a distance-invariant binary quasicyclic code of index m and length 2 *** also prove that every code of length 2 mn which is the Gray image of cyclic codes over R of length n is permutation equivalent to a binary quasi-cyclic code of index ***,a family of quantum error-correcting codes obtained from the Calderbank-Shor-Steane(CSS) construction applied to(1+u)-constacyclic codes over R.

关键词： Constacyclic codes Cyclic codes Quasicyclic codes Gray map Quantum codes

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Parallel exploration via negatively correlated search

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Frontiers of Computer Science 2021年第5期15卷 123-135页

作者： Peng YANG Qi YANG Ke tang Xin yao Guangdong Provincial Key Laboratory of Brain-inspired Intelligent Computation Department of Computer Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Effective exploration is key to a successful search *** recently proposed negatively correlated search(NCS)tries to achieve this by coordinated parallel exploration,where a set of search processes are driven to be negatively correlated so that different promising areas of the search space can be visited *** successful applications of NCS,the negatively correlated search behaviors were mostly devised by intuition,while deeper(e.g.,mathematical)understanding is *** this paper,a more principled NCS,namely NCNES,is presented,showing that the parallel exploration is equivalent to a process of seeking probabilistic models that both lead to solutions of high quality and are distant from previous obtained probabilistic *** learning,for which exploration is of particular importance,are considered for empirical *** proposed NCNES is applied to directly train a deep convolution network with 1.7 million connection weights for playing Atari *** results show that the significant advantages of NCNES,especially on games with uncertain and delayed rewards,can be highly owed to the effective parallel exploration ability.

关键词： evolutionary computation reinforcement learning exploration

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Preparation of Mg-Li alloys by electrolysis in molten salt at low temperature

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Chinese Chemical Letters 2007年第3期18卷 329-332页

作者： Mi Lin Zhang Yong De Yan zhi yao Hou Lu An Fan Zeng Chen Ding Xiang tang College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 China

A new technology for preparation of low cost Mg-Li alloys was studied. The alloys were prepared by electrolysis in molten LiCl-KCl （weight ratio is 1：1） electrolyte with Mg rod severing as the consumed cathode. Main factors that affect current efficiency were investigated, and optimal electrolysis parameters were obtained. Mg-Li alloys with low lithium Content （about 25%） were prepared by the unique method of a higher post-thermal treatment temperature after electrolysis at low temperature. The results showed that the electrolysis can be carried out at low temperature, which resulted in reducing preparation cost due to energy saving. The new technology for the oreoaration of Mg-Li alloy by electrolysis in molten salt was laroved to be feasible.

关键词： Mg-Li alloys Molten salt electrolysis Low temperature Current efficiency

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Separation process study of liquid phase catalytic exchange reaction based on the Pt/C/PTFE catalysts

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Chinese Journal of Chemical Engineering 2019年第8期27卷 1837-1845页

作者： Peilong Li Li Guo Renjin Xiong Junhong Luo Ming Wen Yong yao zhi Zhang Jiangfeng Song Yan Shi Tao tang Institute of Materials China Academy of Engineering Physics

The liquid phase catalytic exchange(LPCE) reaction is an effective process for heavy water detritiation and production of deuterium-depleted potable water. In the current study, hydrophobic carbon-supported platinum catalysts(Pt/C/PTFE) with high efficiency as reported previously for LPCE were prepared and comprehensive performance evaluation method is applied to evaluate the separation behaviors of LPCE systematically. Experimental results indicate that the optimum reaction temperature of 60–80℃ and the molar feed ratio G/L of 1.5–2.5 would lead to higher separation efficiencies. As to the packing method, a random packing mode with a packing ratio of hydrophobic catalysts 0.25 is recommended. In addition, thermodynamic analysis corresponds well with experimental results under lower temperature and G/L, while the suppression of kinetic factors should not be neglected when T > 80℃ and G/L > 1.5.

关键词： Liquid phase catalytic exchange(LPCE) Hydrophobic carbon-supported platinum catalysts Separation behaviors Optimal operating condition Water detritiation

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