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Spatio-temporal changes in rice area at the northern limits of the rice cropping system in China from 1984 to 2013

Journal of Integrative Agriculture 2017年第2期16卷 360-367页

作者： LI Zhi-peng LONG Yu-qiao tang peng-qin TAN Jie-yang LI Zheng-guo WU Wen-bin HU Ya-nan YANG peng Key Laboratory of Agri-informatics Ministry of Agriculture/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences Institute of Agricultural Economics and Regional Planning Hunan Academy of Agricultural Sciences

Rice area has been expanding rapidly during the past 30 years under the influence of global change in northeastern China, which is the northernmost region of rice cultivation in China. However, the spatio-temporal dynamic changes in rice area are still unclear, although they may have important policy implications for environmental protection and adaptation to climate change. In this study, we aimed to identify the dynamic changes of the rice area in Heilongjiang Province of northeastern China by extracting data from multiple Landsat images. The study used ground quadrats selected from Google Earth and the extraction of a confusion matrix to verify the accuracy of extraction. The overall accuracy of the extracted rice area was higher than 95% as a result of using the artificial neural network （ANN） classification method. The results showed that the rice area increased by approximately 2.4×10^6 ha during the past 30 years at an annual rate of 8.0×10^4 ha, and most of the increase occurred after 2000. The central latitude of the rice area shifted northwards from 46 to 47°N during the study period, and moved eastwards from 130 to 133°E. The rice expansion area accounted for 98% of the total change in rice area, and rice loss was notably rare. The rice expansion was primarily from dryland. In addition, rice cultivation in marshland and grassland played a minor role in the rice expansion in this region.

关键词： paddy rice Landsat images artificial neural network Heilongjiang Province

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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过去20年中国耕地生长季起始期的时空变化

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生态学报 2009年第4期29卷 1777-1786页

作者：吴文斌杨鹏唐华俊周清波 Shibasaki Ryosuke 张莉唐鹏钦中国农业科学院农业资源与农业区划研究所北京100081 农业部资源遥感与数字农业重点开放实验室北京100081 日本东京大学空间情报科学研究中心

多时相遥感数据能够较好地描述区域尺度的植被物候和生长季节的变化特征。利用NDVI时序数据,采用非对称性高斯函数拟合方法重建平滑曲线,分别提取了我国20世纪80年代初、90年代初和21世纪初等3个时期为我国耕地第一生长季起始期,计算3... 详细信息

多时相遥感数据能够较好地描述区域尺度的植被物候和生长季节的变化特征。利用NDVI时序数据,采用非对称性高斯函数拟合方法重建平滑曲线,分别提取了我国20世纪80年代初、90年代初和21世纪初等3个时期为我国耕地第一生长季起始期,计算3个时期平均生长起始期,并分析了我国耕地第一生长季起始期的区域空间分异规律;然后,从区域和省份两个尺度分析了20世纪80年代初至90年代初和20世纪90年代初至21世纪初两个阶段我国耕地生长季起始期动态变化趋势和空间格局。结果表明,我国不同区域耕地第一生长季起始期存在十分明显的空间差异,清楚地呈现出一个从南向北逐渐推迟的空间特征;从不同区域看,在20世纪80年代初至90年代初和20世纪90年代初至21世纪初两个时期,我国耕地第一生长季起始期变化都是提前和推迟并存,不同区域变化程度不一;从不同省份看,在过去20年间,我国绝大多数省份耕地第一生长季起始期都表现为总体提前的趋势,但不同省份的起始期变化具有差异性。影响我国耕地生长季起始期变化的因素很多,如何区别气候变化等自然因子和人类活动因子对耕地生长季起始期变化的影响是一个值得深入研究的问题。

关键词： NDVI时序数据耕地生长起始期时空变化

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia peng Wen qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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1980—2010年东北地区种植结构时空变化特征

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中国农业科学 2016年第21期49卷 4107-4119页

作者：刘珍环唐鹏钦范玲玲杨鹏吴文斌中山大学地理科学与规划学院国土资源与环境系中国农业科学院农业资源与农业区划研究所/农业部农业信息技术重点实验室

【目的】探讨过去30年东北地区像元尺度种植结构的时空分布特征和演变规律,为东北地区农业政策的调整提供科学基础。【方法】基于1980—2010年东北三省的玉米、大豆、水稻和小麦种植面积的县级统计数据,利用SPAM-China模型获取10 km像... 详细信息

【目的】探讨过去30年东北地区像元尺度种植结构的时空分布特征和演变规律,为东北地区农业政策的调整提供科学基础。【方法】基于1980—2010年东北三省的玉米、大豆、水稻和小麦种植面积的县级统计数据,利用SPAM-China模型获取10 km像元尺度上种植结构的分布信息,构建以像元内种植面积比例超过30%和占比前三位的种植结构类型的判定方式,利用空间叠加方法分析种植比例及其结构类型的时空变化特征。【结果】运用像元结果初步阐明了东北地区的种植结构变化特征,首先种植规模的优先顺序在2000年左右发生了变化,由玉米>大豆>小麦>水稻变为玉米>大豆>水稻>小麦;其次,30年间共出现14种组合类型,包括6种水稻及其组合类型由1980年的8.30%增至2010年18.64%,主要分布于辽河平原、松嫩平原和三江平原等地;7种玉米及其组合类型占比超过三分之二,累积比例增长3.7%,主要分布在东北的中西部,是该地区的主要种植作物;5种大豆及其组合类型累积比例减少4.2%,空间上发生了显著的置换,由散布在三省的格局迅速北移集中于黑龙江;7种小麦及其组合类型累积比例从26.82%降为3.17%,是变化最为显著的种植结构类型,现有少量集中于黑龙江嫩江附近。再次,3种种植结构类型变化较多,一是由开垦耕地带来的新类型,占所有变化类型比例为20.91%,特别是黑龙江省拓荒带来的大规模水稻种植;二是单一作物型变化为两种或以上作物类型组合,占比为34.90%,组合作物主要为水稻和大豆;三是多种作物组合型变为单一作物型,将种植结构类型集聚,占比为41.36%,主要为玉米种植区的调整。【结论】过去30年种植结构类型变化规律为种植结构类型分布受玉米和大豆主导,其中大豆空间转移至黑龙江,水稻正成为东北地区重要种植类型,而小麦则持续萎缩至局部地区,种植结构类型变化趋势将以玉米、大豆和水稻为主,单一化趋势显著。种植结构调整方向应从减少单一玉米型和增加水稻和大豆组合型入手。

关键词：农作物格局种植结构类型时空变化像元尺度东北地区

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing peng Yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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基于多媒体DSP TM1300的运动估计算法研究及实现

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通信学报 2003年第12期24卷 98-105页

作者：朱秀昌胡栋唐泽鹏秦雷南京邮电学院信息工程系江苏南京210003

提出一种用于H.263视频编码的快速运动估计的算法——NDA,通过PC仿真后将它移植到多媒体DSP TM1300上,并对它进行了改进和优化。实际运行的测试结果表明,NDA的性能要优于TMN3.0给出的运动估计算法,接近FS。文中还给出了衡量实际运动估... 详细信息

提出一种用于H.263视频编码的快速运动估计的算法——NDA,通过PC仿真后将它移植到多媒体DSP TM1300上,并对它进行了改进和优化。实际运行的测试结果表明,NDA的性能要优于TMN3.0给出的运动估计算法,接近FS。文中还给出了衡量实际运动估计算法性能的测试方法。

关键词： H.263 TM1300 运动估计全搜索法 DSP 视频编码 NDA

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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： qin Wang qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju tang Man Luo Xiao-Wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Advance of Rice Recognition and Monitoring by SAR

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Agricultural Science & Technology 2009年第6期10卷 184-188页

作者：唐鹏钦姚艳敏魏娜农业部资源遥感与数字农业重点开放实验室北京100081 中国农业科学院农业资源与农业区划研究所北京100081

Synthetic Aperture Radar（SAR） is a more effective remote sensing data source for rice recognition and monitoring than optical remote sensing in the regions with more wet and cloudy sky due to its all-weather, all-time, high resolution and wide covering characteristics. This paper summarizes SAR types and their feature used for rice study, introduces the backscattering model for rice monitoring, and analyses the main factors influencing backscattering coefficient. The studies of rice recognition and monitoring based on SAR in domestic and abroad are reviewed and the futures in the related areas are prospected.

关键词： Synthetic aperture radar(SAR) Rice Recognition Monitoring

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