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The Application of Deep Brain Stimulation for Parkinson’s Disease on the Motor Pathway:A Bibliometric Analysis across 10 Years

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Current Medical Science 2023年第6期43卷 1247-1257页

作者： Yong-tang song Yan-bo LIU Hong-bing XIANG Anne Manyande Zhi-gang HE Medical Association of Hubei Province Wuhan430060China Department of Anesthesiology Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain HealthWuhan Clinical Research Center for Geriatric AnesthesiaTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China School of Human and Social Sciences University of West LondonLondon0044UK Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background and Objective Since its initial report by James Parkinson in 1817,Parkinson’s disease(PD)has remained a central subject of research and clinical *** disease is estimated to affect approximately 1%of adults aged 60 and *** brain stimulation,emerging as an alternative therapy for end-stage cases,has offered a lifeline to numerous *** review aimed to analyze publications pertaining to the impact of deep brain stimulation on the motor pathway in patients with PD over the last *** Data were obtained from the Web of Science Core Collection through the library of Huazhong University of Science and Technology(China).The search strategy encompassed the following keywords:“deep brain stimulation”,“Parkinson’s disease”,“motor pathway”,and“human”,from January 1,2012,to December 1,***,this review visualized the findings using the Citespace *** The results indicated that the United States,the United Kingdom,Germany,and China were the primary contributors to this research *** College London,Capital Medical University,and Maastricht University were the top 3 research institutions in the research *** Foltynie ranked first with 6 publications,and the journals of Brain and Brain Stimulation published the greatest number of relevant *** prevailing research focal points in this domain,as determined by keywords“burst analysis”,“encompassed neuronal activity”,“nucleus”,“hyper direct pathway”,*** This study has provided a new perspective through bibliometric analysis of the deep brain stimulation therapy for treating patients with PD,which can shed light on future research to advance our comprehension of this particular field of study.

关键词： deep brain stimulation Parkinson’s disease motor pathway bibliometric analysis

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Effect of Air Distribution on the Transport Characteristics of Solid Particles in the Thermal Storage and Release System of Circulating Fluidized Bed

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Journal of Thermal Science 2024年第4期33卷 1554-1563页

作者： JI Zengcai song Guoliang tang Zihua SUN Liwei State Key Laboratory of Coal Conversion Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Dalian National Laboratory for Clean Energy Dalian116023China

Solid particle heat storage technology offers a potential solution to the challenges posed by the significant growth of renewable energy sources,particularly in terms of grid security and ***,it has the capability to optimize the energy utilization efficiency of the power *** order to investigate the transport regulation characteristics of solid particles in the thermal storage and release system of a circulating fluidized bed(CFB),a test rig with a capacity of 0.1 MW(th)was *** rig was utilized to systematically study the transport regulation characteristics of solid particles under the double U-type valve feed structure and U-type valve discharge *** experimental findings indicate that the system's design enables efficient and rapid storage and release of solid particles in the *** air distribution mode,specifically the double U-type valve feed structure and the U-type valve discharge structure,significantly influence the feed and discharge characteristics of the ash storage *** was observed that the impact of loose air on these characteristics is more substantial than that of the return air,irrespective of the feed structure or the return *** adjusting the feed and discharge rate,it is recommended to adopt a scheme that involves coarse adjustment through loose air and fine adjustment through return air.

关键词： solid particle thermal storage air distribution mode transport regulation

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Damage Characteristics Analysis and Fractal Study of Shale With Prefabricated Fractures under Thermal-mechanical Coupling

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 570-586页

作者：张辉邬忠虎 song Huailei WANG Wentao tang Motian CUI Hengtao College of Civil Engineering Guizhou UniversityGuiyang 550025China

To study the damage and failure of shale with different fracture inclination angles under uniaxial compression loading,in this work,RFPA2D-Thermal,a two-dimensional real failure process analysis software,was used for numerical *** simulation results show that quartz in shale mainly affects the tensile and compressive strength of shale by increasing rock *** coupling of temperature and pressure will cause lateral and volume destruction of shale,which enables the shale body to be more easily *** inclination is the key factor affecting shale damage *** failure mode of shale with low-and high-angle fractures is mainly shear failure,and the compressive strength does not vary with crack *** damage mode of obliquely intersecting fractured shale is slip damage along the fracture face,the compressive strength decreases and then increases with the fracture inclination,and a minimum value *** acoustic emission simulation results of the damage process effectively reflect the accumulated internal damage and macroscopic crack appearance until fracture instability when the prefabricated fractured shale is subjected to uniaxial compressive *** crack inclinations of 0°and 120℃ corresponds to the most complex"N"shape damage *** crack inclinations of 30°and 60°,and the damage mode is an inverted"λ"shape.

关键词： shale temperature and pressure numerical simulation fracture dip angle fractal dimension

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Targeting calcium signaling in Alzheimer’s disease: challenges and promising therapeutic avenues

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Neural Regeneration Research 2024年第3期19卷 501-502页

作者： LinLin song YongPei tang Betty Yuen Kwan Law Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administration RegionChina

The critical role of calcium dyshomeostasis in the pathogenesis of Alzheimer’s disease(AD):AD is a progressive neurodegenerative disease characterized by cognitive decline,memory impairment,and behavioral *** an estimated 50 million people being affected worldwide,the incidence of AD is constantly increasing *** hallmark of AD is the accumulation of amyloid-beta protein(Aβ)in the form of amyloid plaques and hyperphosphorylated tau protein in the form of neurofibrillary ***,increasing evidence suggests that calcium ion(Ca2+)dysregulation also plays a crucial role in the pathogenesis of AD(Calvo-Rodriguez and Bacskai,2021).As a key second messenger,Ca2+regulates a wide range of cellular processes,including the release of neurotransmitters,gene expression,and cell ***^(2+)also regulates the activity of Calcium/calmodulin-dependent protein kinase II,which is critical for synaptic plasticity,learning,and memory(Kaushik et al.,2022).Alternation in the Ca^(2+)signal is an early event in the pathogenesis of AD,which can lead to synaptic dysfunction,neuronal loss,and cognitive impairment.

关键词： Alzheimer homeostasis globally

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Mechanism and experimental study on the fruit detachment of Chinese wolfberry through reciprocating vibration

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 47-58页

作者： song Mei Jinpeng Wang Zhiyu song Dunbing tang Cheng Shen College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Nanjing Research Institute for Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014China Nanjing Forestry University Nanjing 210037China

In order to realize the efficient and high-quality mechanical picking for Chinese wolfberry,firstly,the forced reciprocating vibration picking principle of the Chinese wolfberry branch was studied,and the mechanical model of vibration picking was established based on the simplified cantilever model,and the response analysis and solution of all positions for the branch were carried *** the same time,the critical mechanical model of fruit detachment under the condition of fruit hanging on branches was established,and the theoretical values of inertia force for each component of the branch were ***,through actual measurement and finite element modeling,the natural frequency and forced vibration response simulation for each component of the branch of Chinese wolfberry terminal branch model were both studied,and the relationship between single-point periodic excitation force and high-quality fruit shedding parameters was ***,according to the conclusion of the picking model,a test bench with many groups of adjustable parameters was ***,the last branch of fruit-hanging Chinese wolf berry for Ningqi No.1 was taken as the experimental object,a four-level orthogonal experiment was designed with three factors:frequency,amplitude and entrance ***,the net picking rate,damage rate and false picking rate were taken as the evaluating indicators,referring to the comprehensive scores of the three *** was concluded that the primary and secondary relations of factors affecting the picking effect are frequency,amplitude and entrance angle,and the best operation parameters are frequency of 20 Hz,amplitude of 15 mm,and entrance angle of 45°,then,a hand-held vibration picker with setting parameters was trial-produced,and the optimal parameter combination was verified in the Chinese wolfberry planting base of the National Chinese wolfberry Engineering and Technology Research *** results showed that the net picking rate of rip

关键词： Chinese wolfberry branches reciprocating vibration inertial force orthogonal experiment

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m6A修饰与妇科恶性肿瘤相关性的研究进展

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临床误诊误治 2024年第1期37卷 147-152页

作者：张海花雷燕刘宇唐松王露姚冬梅武汉科技大学医学部医学院武汉430070 湖北省妇幼保健院妇科武汉430070 湖北医药学院湖北十堰442000

N6-甲基腺苷(m6A)修饰是一种常见的表观遗传学修饰,动态调控RNA代谢的整个过程。m6A包括甲基转移酶、去甲基酶及m6A结合蛋白。m6A的甲基化修饰通过调节RNA的衰变、运输、剪切、翻译来调节细胞的增殖和分化,m6A与妇科恶性肿瘤的发生发展... 详细信息

N6-甲基腺苷(m6A)修饰是一种常见的表观遗传学修饰,动态调控RNA代谢的整个过程。m6A包括甲基转移酶、去甲基酶及m6A结合蛋白。m6A的甲基化修饰通过调节RNA的衰变、运输、剪切、翻译来调节细胞的增殖和分化,m6A与妇科恶性肿瘤的发生发展有关。笔者就近年来m6A甲基化修饰在宫颈癌、子宫内膜癌和卵巢癌中的相关研究进展进行回顾,分析m6A通过作用于RNA的修饰调节妇科恶性肿瘤发生发展的机制,为妇科恶性肿瘤的治疗、改善预后提供新的方向。

关键词： m6A甲基化生殖器肿瘤,女(雌)性妇科肿瘤宫颈肿瘤卵巢肿瘤子宫内膜肿瘤综述

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Stress-induced phase transformation and phase boundary sliding in Ti: An atomically resolved in-situ analysis

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Journal of Materials Science & Technology 2023年第21期152卷 30-36页

作者： Zongde Kou Xuteng Li Rong Huang Lixia Yang Yanqing Yang Tao Feng Si Lan Gerhard Wilde Qingquan Lai song tang Herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Institute of Materials Physics University of MuensterWilhelm-Klemm Street 10Muenster 48149Germany Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing 210009China

In-situ tensile experiments on pure Ti were performed in a transmission electron microscope at room *** dynamic process of stress-induced hexagonal closed-packed(hcp)to face-centered cu-bic(fcc)structural transformation ahead of a crack tip was captured at the atomic ***,a sliding behavior of the ensuing(0001)hcp/(1¯11)_(fcc) phase boundary was observed to further accommodate the plastic deformation until crack *** sliding was accomplished via the successive conserva-tive glide of extended dislocations along the(0001)hcp/(1¯11)_(fcc) phase boundary.A molecular dynamics simulation was carried out to corroborate the experiments and the results confirm the new dislocation-mediated sliding mechanism.

关键词： In situ HRTEM Hcp-to-fcc transformation Pure Ti Phase boundary sliding Molecular dynamics simulation

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Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

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Zoological Research 2024年第4期45卷 747-766页

作者： Hong-Yi Zheng Tian-Zhang song Yong-tang Zheng State Key Laboratory of Genetic Evolution&Animal Models KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole ***,developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** review summarizes current progress related to COVID-19 animal models,including non-human primates(NHPs),mice,and hamsters,with a focus on their roles in exploring the mechanisms of immunopathology,immune protection,and long-term effects of SARS-CoV-2 infection,as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 *** among these animal models and their specific applications are also highlighted,as no single model can fully encapsulate all aspects of *** effectively address the challenges posed by COVID-19,it is essential to select appropriate animal models that can accurately replicate both fatal and non-fatal infections with varying courses and *** animal model libraries and associated research tools is key to resolving the global COVID-19 pandemic,serving as a robust resource for future emerging infectious diseases.

关键词： SARS-CoV-2 COVID-19 Animal models Infection immunology Immunotherapy

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生物样品中聚苯乙烯纳米塑料指示物的热裂解-气相色谱质谱检测方法研究

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环境卫生学杂志 2024年第6期14卷 501-507页

作者：谢颖李明姣杨波张少平董小艳王琼唐宋徐州医科大学公共卫生学院徐州221004 中国疾病预防控制中心环境与人群健康重点实验室/中国疾病预防控制中心环境与健康相关产品安全所北京100021 北京市顺义区疾病预防控制中心

目的采用热裂解-气相色谱质谱法(Py-GC/MS)建立一种从生物组织样品中定量测定纳米级聚苯乙烯(PS)塑料的方法。方法通过比较和优化不同消解液、蛋白沉淀剂以及仪器检测参数体系,确定生物样品中PS塑料的最优前处理和检测方法。通过开展实... 详细信息

目的采用热裂解-气相色谱质谱法(Py-GC/MS)建立一种从生物组织样品中定量测定纳米级聚苯乙烯(PS)塑料的方法。方法通过比较和优化不同消解液、蛋白沉淀剂以及仪器检测参数体系,确定生物样品中PS塑料的最优前处理和检测方法。通过开展实验研究确定方法特性指标(包括检出限、定量限、精密度和准确度),并基于方法开展了实际样品测定。结果本研究建立了大鼠肝和肺组织样本经10%氢氧化钾溶液消解和无水乙醇蛋白沉淀后上Py-GC/MS检测的方法,PS在0.05~2.00μg范围内线性关系良好,相关系数为0.999,检出限和定量限分别为0.012和0.036μg/g,且当添加水平为低浓度(2μg/g)、中浓度(10μg/g)、高浓度(30μg/g)PS时,其加标回收率分别为68.0%~85.0%、80.0%~105%和62.0%~93.1%,精密度(RSD)范围在7.8%~15.2%。结论本研究建立的方法满足方法学要求,且为其他生物样本及其他类型微塑料的检测提供了参考,为进一步开展纳米塑料的人群内暴露水平研究和健康风险评估奠定了技术基础。

关键词：热裂解-气相色谱质谱法生物组织纳米塑料

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A rare case of purulent pericarditis secondary to subdiaphragmatic abscess

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World Journal of Emergency Medicine 2023年第3期14卷 244-246页

作者： song Yang Chao Cui Wen-peng Yin Yu-dong Fu Guang-li tang Xiao-jun Yang Guo-feng Qu Zhi-jun Jia Lin-na Cao Ke-song tang Bao-jian Zhang Xia-lei Du Department of Emergency Medicine Beijing Huairou HospitalBeijing 101499China Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

Subdiaphragmatic abscess is the accumulation of pus in the space between the diaphragm and the transverse colon and its mesentery.[1]Subdiaphragmatic abscess is clinically characterized by fever and local *** clinical manifestations are often vague and diverse,and its symptoms and signs together constitute thoracoabdominal syndrome,leading to delayed diagnosis and a high incidence rate and mortality.[2]Subdiaphragmatic abscess is often secondary to acute peritonitis or remote infection with hematogenous *** bacteriological characteristics of these abscesses include aerobic and facultative bacteria,such as Escherichia coli,group D Enterococcus and Staphylococcus aureus,as well as less common anaerobic organisms,such as Bacteroides.

关键词： abscess diagnosis mortality

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