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RLINl,encoding a putative coproporphyrinogen Ⅲ oxidase,is involved in lesion initiation in rice

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Journal of Genetics and Genomics 2011年第1期38卷 29-37页

作者： Changhui Sun Linchuan Liu jiuyou tang Aihong Lin Fantao Zhang Jun Fang Genfa Zhang Chengcai Chu Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education College of Life Science Beijing Normal University Beijing 100875 China The State Key Laboratory of Plant Genomics and National Plant Gene Research Center (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Datun Road Chaoyang District Beijing 100101 China Graduate School of the Chinese Academy of Sciences Yuquan Road Beijing 100039 China Rice Research Institute Sichuan Agricultural University Chengdu 611130 China

Lesion mimic is necrotic lesions on plant leaf or stem in the absence of pathogenic infection, and its exact biological mechanism is varied. By a large-scale screening of our T-DNA mutant population, we identified a mutant rice lesion initiation 1 （rlin1）, which was controlled by a single nuclear recessive gene. Map-based cloning revealed that RLIN1 encoded a putative coproporphyrinogen Ⅲ oxidase in tetrapyrrole biosynthesis pathway. Sequencing results showed that a G to T substitution occurred in the second exon of RLIN1 and led to a missense mutation from Asp to Tyr. Ectopic expression of RLIN1 could rescue rlin1 lesion mimic phenotype. Histochemical analysis demonstrated that lesion formation in rlin1 was light-dependent accompanied by reactive oxygen species accumulated. These results suggest that tetrapyrrole participates in lesion formation in rice.

关键词： Rice Map-based cloning Lesion mimic Coproporphyrinogen Ⅲ oxidase Tetrapyrrole

An activated form of NB-ARC protein RLS1 functions with cysteine-rich receptor-like protein RMC to trigger cell death in rice

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Plant Communications 2023年第2期4卷 151-166页

作者： Yiqin Wang Zhenfeng Teng Hua Li Wei Wang Fan Xu Kai Sun Jinfang Chu Yangwen Qian Gary JLoake Chengcai Chu jiuyou tang State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biologythe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Genetics and Developmental Biology and National Center for Plant Gene Research(Beijing) Chinese Academy of SciencesBeijing 100101China Biogle Genome Editing Center Changzhou 213125China Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93BFUK Guangdong Laboratory for Lingnan Modern Agriculture State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesCollege of AgricultureSouth China Agricultural UniversityGuangzhou 510642China

A key event that follows pathogen recognition by a resistance(R)protein containing an NB-ARC(nucleotide-binding adaptor shared by Apaf-1,R proteins,and Ced-4)domain is hypersensitive response(HR)-type cell death accompanied by accumulation of reactive oxygen species and nitric ***,the integral mechanisms that underlie this process remain relatively ***,we show that a gain-offunction mutation in the NB-ARC protein RLS1(Rapid Leaf Senescence 1)triggers high-light-dependent HR-like cell death in *** RLS1-mediated defense response is largely independent of salicylic acid accumulation,NPR1(Nonexpressor of Pathogenesis-Related Gene 1)activity,and RAR1(Required for Mla12 Resistance 1)function.A screen for suppressors of RLS1 activation identified RMC(Root Meander Curling)as essential for the RLS1-activated defense *** encodes a cysteine-rich receptor-like secreted protein(CRRSP)and functions as an RLS1-binding ***,their co-expression resulted in a change in the pattern of subcellular localization and was sufficient to trigger cell death accompanied by a decrease in the activity of the antioxidant enzyme ***,our findings reveal an NBARC-CRRSP signaling module that modulates oxidative state,the cell death process,and associated immunity responses in rice.

关键词： hypersensitive response NB-ARC protein cysteine-rich receptor-like secreted protein disease resistance antioxidant enzymes

Significant Improvement of Cotton Verticillium Wilt Resistance by Manipulating the Expression of Gastrodia Anlffungal Proteins

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Molecular Plant 2016年第10期9卷 1436-1439页

作者： Yiqin Wang Chengzhen Liang Shenjie Wu Xueyan Zhang jiuyou tang Guijiang Jian Gaili Jiao Fuguang Li Chengcai Chu State Key Laboratory of Plant Genomics and National Center for Plant GeneResearch (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Biotechnology Research Institute Chinese Academy of Agricultural Sciences Beijing 100081 China Institute of Economic Crops Shanxi Academy of Agricultural Sciences Yuncheng Shanxi Province 044000 China Institute of Cotton Research Chinese Academy of Agricultural Sciences Anyang Henan Province 455000 China Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100193 China

Dear Editor Verticillium wilt caused by Verticillium dahliae Kleb. is the most destructive disease in cotton-growing areas around the world. The infection significantly reduces cotton yield and fiber quality due to leaf chlorosis, necrosis or wilting, leaf or boll abscission, and even plant death. The losses may reach up to 80% of lint cotton yield （Wei et al., 2015）.

关键词： GASTRODIA elata VERTICILLIUM wilt of cotton DISEASE resistance of plants

Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System

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Molecular Plant 2017年第9期10卷 1242-1245页

作者： Lu, Yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei tang, jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen Biogle Genome Editing Ctr Changzhou 213125 Jiangsu Peoples R China Chinese Acad Sci Natl Ctr Plant Gene Res Beijing Inst Genet & Dev Biol State Key Lab Plant Genom Beijing 100101 Peoples R China Chinese Acad Sci Shanghai Ctr Plant Stress Biol Shanghai 201602 Peoples R China Chinese Acad Sci Ctr Excellence Mol Plant Sci Shanghai 201602 Peoples R China Chinese Acad Sci Inst Subtrop Agr Key Lab Agroecol Proc Subtrop Reg Changsha 410125 Hunan Peoples R China

Dear Editor Since the completion of the rice （Oryza sativa） genome- sequencing project, a major goal of rice research has been the functional characterization of all annotated genetic loci in various biological processes. One of the most efficient and widely-used strategies for studying gene function is genetic mutagenesis. Several rice mutant libraries have been generated in the past decade, providing a wealth of resources for plant research （Chang et al., 2012）. CRISPR/Cas9 （clustered regularly interspaced short palindromic repeats-associated nuclease 9） has recently emerged as a powerful tool for rice research and breeding （Cong et al., 2013; Feng et al., 2013; Miao et al., 2013;

关键词： Genome-wide Targeted Mutagenesis Rice Using the CRISPR Cas9 System

Genomic decoding of breeding history to guide breeding-by-design in rice

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National Science Review 2023年第5期10卷 124-137页

作者： Zhuo Chen Qingyun Bu Guifu Liu Maoqing Wang Hongru Wang Huazhao Liu Xiufeng Li Hong Li Jun Fang Yan Liang Zhenfeng Teng Sai Kang Hong Yu Zhukuan Cheng Yongbiao Xue Chengzhi Liang jiuyou tang Jiayang Li Chengcai Chu State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of Sciences Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and AgroecologyChinese Academy of Sciences Key Laboratory of Crop Biotechnology Breeding of the Ministry of Agriculture and Rural Affairs Beidahuang Kenfeng Seed Co.Ltd Institute of Botany Chinese Academy of Sciences Guangdong Laboratory for Lingnan Modern Agriculture and State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of AgricultureSouth China Agricultural University University of Chinese Academy of Sciences State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of Sciences Hainan Yazhou Bay Seed Laboratory

Deciphering the intrinsic molecular logic of empirical crop breeding from a genomic perspective is a decisive prerequisite for breeding-by-design(BbD),but remains not well ***,we decoded the historical features of past rice breeding by phenotyping and haplotyping 546 accessions covering the majority of cultivars bred in the history of Northeast China(NEC).We revealed that three groups founded the genetic diversities in NEC rice with distinct evolution patterns and traced and verified the breeding footprints to known or genome-wide association study(GWAS)-detected quantitative trait loci(QTLs),or introgressions from indica sub-species with chronological changes in allele *** we summarized a rice breeding trend/principle in NEC,and combined with the successful example in breeding and application of Zhongkefa5 to demonstrate the guiding value of our conclusion for BbD in *** study provides a paradigm for decoding the breeding history of a specific crop to guide BbD,which may have implications in different crop breeding.

关键词： rice breeding-by-design breeding history genome-wide association study genomic decoding

Molecular analysis of rice plants harboring a multi-functional T-DNA tagging system

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Journal of Genetics and Genomics 2009年第5期36卷 267-276页

作者： Yimian Ma Luo Liu Chengguang Zhu Changhui Sun Bo Xu Jun Fang jiuyou tang Anding Luo Shouyun Cao Gupo Li Qian Qian Yongbiao Xue Chengcai Chu State Key Laboratory of Plant Genomics and National Plant Gene Research Center (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Graduate University of the Chinese Academy of Sciences Beijing 100039 China State Key Laboratory of Rice Biology China Institute of Rice Research Chinese Academy of Agricultural Sciences Hangzhou 310006 China Laboratory of Molecular and Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China

About 25,000 rice T-DNA insertional mutant lines were generated using the vector pCAS04 which has both promoter-trapping and activation-tagging function. Southern blot analysis revealed that about 40% of these mutants were single copy integration and the average T-DNA insertion number was 2.28. By extensive phenotyping in the field, quite a number of agronomically important mutants were obtained. Histochemical GUS assay with 4,310 primary mutants revealed that the GUS-staining frequency was higher than that of the previous reports in various tissues and especially high in flowers. The T-DNA flanking sequences of some mutants were isolated and the T-DNA insertion sites were mapped to the rice genome. The flanking sequence analysis demonstrated the different integration pattern of the right border and left border into rice genome. Compared with Arabidopsis and poplar, it is much varied in the T-DNA border junctions in rice.

关键词： rice mutant population promoter trap activation tag T-DNA integration

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Industrial Control Anomaly Detection Based on Distributed Linear Deep Learning

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Computers, Materials & Continua 2025年第1期82卷 1129-1150页

作者： Shijie tang Yong Ding Huiyong Wang School of Computer Science and Information Security Guilin University of Electronic TechnologyGuilin541004China School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin541004China Guangxi Engineering Research Center of Industrial Internet Security and Blockchain Guilin University of Electronic TechnologyGuilin541004China Institute of Cyberspace Technology HKCT Institute for Higher EducationHong Kong999077China School of Mathematics&Computing Science Guilin University of Electronic TechnologyGuilin541004China

As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and fast and accurate attack detection techniques are *** key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time *** address this issue,we propose an anomaly detection method based on distributed deep *** method uses a bilateral filtering algorithm for sequential sequences to remove noise in the time series,which can maintain the edge of discrete *** use a distributed linear deep learning model to establish a sequential prediction model and adjust the threshold for anomaly detection based on the prediction error of the validation *** method can not only detect abnormal attacks but also locate the sensors that cause *** conducted experiments on the Secure Water Treatment(SWAT)and Water Distribution(WADI)public *** experimental results show that our method is superior to the baseline method in identifying the types of attacks and detecting efficiency.

关键词： Anomaly detection CPS deep learning MLP(multi-layer perceptron)

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug