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Synthesis of brookite-typed titania from titanium chloride solution

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中国科学:技术科学 2010年第4期 459-459页

作者： satoshi OKANO Saeki YAMAMURO Toshiro tanaka Ehime University

The brookite-phase TiO2 was prepared by a hydrothermal synthesis of titanium chloride *** thermolysis time and the pH value of the solution were controlled during the synthesis.X-ray diffraction experiments showed that TiO2 powders partially containing the brookite-phase were successfully obtained.A great amount of OH -in the reaction solution was found to be important to obtain the brookite phase because the intermediate complex leading to the brookite phase consumes more OH-than other phases like the rutile.

关键词： brookite phase titanium chloride solution hydrothermal synthesis

Oral tolerance is inducible during active dextran sulfate sodium-induced colitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 242-253页

作者： satoshi Ino Chikara Kohda Kosuke Takeshima Hiroki Ishikawa Tomoko Norose Toshiko Yamochi Masafumi Takimoto Hiroshi Takahashi Kazuo tanaka Department of Microbiology and Immunology School of Medicine Showa University Department of Pathology and Laboratory Medicine School of Medicine Showa University Division of Gastroenterology Department of Internal Medicine Showa University

AIM:To investigate whether oral tolerance is inducible during the active phase of dextran sulfate sodium(DSS)-induced ***:Colitis was induced in 6-to 8-wk-old female BALB/c mice by the administration of 2%*** induce oral tolerance,mice that received water with DSS[DSS(+)]and mice that received autoclaved water[DSS(-)]were intragastrically(i.g.)administered ovalbumin(OVA)as a tolerogen before systemic challenge with *** this,serum levels of OVA-specific Ig E antibodies were *** mice with activecolitis,CD4+CD25+Foxp3+cell and B10 cell frequencies were evaluated using flow *** m RNA expression profiles were evaluated by reverse transcription real-time polymerase chain ***:Regardless of the presence of DSS colitis,OVA-specific immunoglobulin E concentrations were significantly reduced in mice that were *** OVA compared to mice that were *** PBS[DSS(+):4.4(4.2-9.5)ng/m L vs 83.9(66.1-123.2)ng/m L,P<0.01;DSS(-):27.7(0.1-54.5)ng/m L vs116.5(80.6-213.6)ng/m L,P<0.01].These results demonstrated that oral tolerance was induced in both the presence and absence of *** the spleen and mesenteric lymph nodes(MLN),the frequencies of CD4+CD25+Foxp3+cells and B10 cells,both of which are associated with oral tolerance,did not significantly *** the spleen,interferon-γm RNA expression significantly decreased in mice with colitis[DSS(+):0.42(0.31-0.53)vs DSS(-):1.00(0.84-1.39),P<0.01].The expression levels of other cytokines did not significantly ***:Oral tolerance is inducible during active DSS *** stability of regulatory cell populations in the spleen and MLN in colitis might correlate with these results.

关键词： Cytokine Dextran sulfate sodium colitis Oral tolerance Regulatory T cell Regulatory B cell

Solid-pseudopapillary pancreatic tumor,mimicking submucosal tumor of the stomach:A case report

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World Journal of Gastrointestinal Surgery 2011年第12期3卷 201-203页

作者： satoshi Furuhashi Hiroshi Takamori Shinnya Abe Osamu Nakahara Hiroshi tanaka Kei Horino Toru Beppu Ken-ichi Iyama Hideo Baba Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto University Department of Surgical Pathology Kumamoto University Hospital

Solid-pseudopapillary tumors of the pancreas(SPTs) are comparatively rare and have low malignancy,with a predilection for young *** is difficult when a SPT develops in a boundary region with other ***,we report a 42-year old woman with a SPT of the pancreas mimicking a submucosal tumor of the stomach on *** was admitted to our hospital complaining of abdominal *** suspected a submucosal tumor of the stomach from the f indings of endoscopy,endoscopic ultrasonography and abdominal computed ***,angiography showed that some of the tumor vessels arose from the *** f indings revealed the tumor originated from the ***,distal pancreatectomy was *** pathological diagnosis was SPT of the pancreas.

关键词： Solid pseudopapillary tumor Submucosal tumor Gastrointestinal stromal tumors Endoscopic ultrasonography Fine needle aspiration Cluster of differentiation Somatostatin receptor

采用联合全腹腔干切除的胰体尾切除术治疗局部晚期胰体癌:远期结果

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医学信息（手术学分册） 2008年第5期21卷 400-400页

作者： Hirano satoshi Kondo satoshi Hara Takashi Ambo Yoshiyasu tanaka Eiichi Shichinohe Toshiaki Suzuki On Hazama Kazuaki

目的:联合全腹腔干切除的胰体尾切除术(distal pancreatectomy with en bloe celiac axis resection,DP-CAR)是治疗局部晚期胰体癌的一种新型扩大术,本文旨在分析其远期结果。背景:胰体癌往往波及肝总动脉和/或腹腔干,因此被视为是一种... 详细信息

目的:联合全腹腔干切除的胰体尾切除术(distal pancreatectomy with en bloe celiac axis resection,DP-CAR)是治疗局部晚期胰体癌的一种新型扩大术,本文旨在分析其远期结果。背景:胰体癌往往波及肝总动脉和/或腹腔干,因此被视为是一种无法切除的疾病。我们曾在10例患者及3个早期病例十中报告了DP-CAR的可行性和安全性,但其远期结果仍不得而知。方法:1998年5月至2005年9月期间共有23例患者实施了DP-CAR。由于早期自肠系膜上动脉经由胰十二指肠动脉弓形成了动脉侧支循环通路,[第一段]

关键词：胰体尾切除术远期结果局部晚期胰体癌腹腔干治疗侧支循环通路肝总动脉

Diagnostic utility of small-caliber and conventional endoscopes for gastric cancer and analysis of endoscopic false-negative gastric cancers

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World Journal of Gastrointestinal Endoscopy 2013年第9期5卷 440-445页

作者： Hiromi Kataoka Kiyoshi Mizuno Noriyuki Hayashi Mamoru tanaka Hirotaka Nishiwaki Masahide Ebi Tsutomu Mizoshita Yoshinori Mori Eiji Kubota satoshi Tanida Takeshi Kamiya Takashi Joh Department of Gastroenterology and Metabolism NagoyaCity University Graduate School of Medical Sciences Division of Endoscopy Nagoya Toei Clinic

AIM: To analyze the diagnostic utility of a small-caliber endoscope(SC-E) and clinicopathological features of false-negative gastric cancers(FN-GCs). METHODS: A total of 21638 esophagogastroduodenoscopy(EGD) gastric cancer(GC) screening examinations were analyzed. Secondary endoscopic examinations(n = 3352) were excluded because most secondary examinations tended to be included in the conventional endoscopy(C-E) group. Detection rates of GCs and FN-GCs were compared between SC-E and C-E groups. FN-GC was defined as GC performed with EGD within the past 3 years without GC detection. Macroscopic types, histopathological characteristics and locations of FN-GCs were compared with firstly foundgastric cancers(FF-GCs) in detail. RESULTS: SC-E cases(n = 6657) and C-E cases(n = 11644), a total of 18301 cases, were analyzed. GCs were detected in 16(0.24%) SC-E cases and 40 C-E(0.34%) cases(P = 0.23) and there were 4 FN-GCs(0.06%) in SC-E and 13(0.11%) in C-E(P = 0.27), with no significant difference. FN-GCs/GCs ratio between SC-E and C-E groups was not significantly different(P = 0.75). The comparison of endoscopic macroscopic types of FN-GCs tended to be a less advanced type(P = 0.02). Histopathologically, 70.6% of FN-GCs were differentiated and 29.4% undifferentiated type. On the other hand, 43.0% of FF-GCs were differentiated and 53.8% undifferentiated type, so FN-GCs tended to be more differentiated type(P = 0.048). CONCLUSION: The diagnostic utility of SC-E for the detection of GCs and FN-GCs was not inferior to that of C-E. Careful observation for superficially depressed type lesions in the upper lesser curvature region is needed to decrease FN-GCs.

关键词： Gastric cancer Small-caliber endoscope False-negative gastric cancer

Genetic and environmental determinants of risk for cholangiocarcinoma in Thailand

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World Journal of Gastrointestinal Pathophysiology 2014年第4期5卷 570-578页

作者： Masanao Miwa satoshi Honjo Gyokukou You Masakazu tanaka Kazuhiko Uchida Petcharin Srivatanakul Thiravud Khuhaprema Watcharin Loilome Anchalee Techasen Chaisiri Wongkham Temduang Limpaiboon Puangrat Yongvanit Sopit Wongkham Nagahama Institute of BioScience and Technology Nagahama Shiga 526-0829 Japan Department of Biochemistry and Molecular Oncology Institute of Basic Medical Sciences University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Department of Pediatrics National Hospital Organization Fukuoka National Hospital Fukuoka 811-1394 Japan Department of Microbiology Faculty of Medicine Kansai Medical University Hirakata City Osaka 573-1010 Japan Cancer Control Unit National Cancer Institute Department of Biochemistry and Liver Fluke and Cholangiocarcinoma Research Center Faculty of Medicine Khon Kaen University Faculty of Associated Medical Sciences Khon Kaen University

Cholangiocarcinoma(CCA) is a difficult cancer to diagnose in the early stage and to treat by curative resec-tion. The incidence of CCA in the northeast of Thailand is the highest in the world. To make progress in detecting a high risk group and in the prevention and detection of CCA, we have been analyzing the risk factors for CCA. Although liver fluke infection is known to be a risk factor, there are patients who are not infected with the liver fluke and not all people infected with the liver fluke will suffer from the disease. Therefore, it is of the utmost importance to analyze the risk factors and the mechanism to prevent the disease and also to detect the disease in its early stage to save patients' lives. Through collaboration among Thai and Japanese researchers, we analyzed the genetic and environmental determinants of risks for CCA. Also, we have been trying to develop methods to detect the disease in a non-invasive way. Without repeating findings reported in various reviews on CCA, we will first discuss the environmental and genetic determinants of the risks for CCA. Second, we will discuss the properties of CCA, including the etiological agents and the mechanism of cholangiocarcinogenesis, and finally, we will discuss future approaches to prevent and cure CCA from the standpoint of evidence-based medicine. We will discuss these points by including the data from our laboratories. We would like to emphasize the importance of the genetic data, especially whole genome approaches, to understand the properties of CCA, to find a high risk population for CCA and to develop effective preventative methods to stop the carcinogenic steps toward CCA in the near future. In addition, it is of the upmost importance to develop a non-invasive, specific and sensitive method to detect CCA in its early stage for the application of modern medical approaches to help patients with CCA.

关键词： Alcohol drinking Cholangiocarcinoma DNA polymorphism Glutathione S transferase 8-oxoguanine glycosylase 1 Liver fluke Opisthorchis viverrini Thailand