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Lymphatic plastic bronchitis and primary chylothorax: A study based on computed tomography lymphangiography

World Journal of Clinical Cases 2024年第14期12卷 2350-2358页

作者： Xing-Peng Li yan Zhang Xiao-Li Sun Kun Hao Meng-ke Liu Qi Hao Ren-Gui Wang Department of Radiology Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of Radiology Qilu HospitalShandong UniversityJinan 250063Shandong ProvinceChina Department of Lymph Surgery Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of Radiology People's Hospital of Peking UniversityThe Second School of Clinical Medicine of Peking UniversityBeijing 100034China

BACKGROUND This study presents an evaluation of the computed tomography lymphangio-graphy(CTL)features of lymphatic plastic bronchitis(PB)and primary chylotho-rax to improve the diagnostic accuracy for these two *** To improve the diagnosis of lymphatic PB or primary chylothorax,a retrospective analysis of the clinical features and CTL characteristics of 71 patients diagnosed with lymphatic PB or primary chylothorax was *** The clinical and CTL data of 71 patients(20 with lymphatic PB,41 with primary chylothorax,and 10 with lymphatic PB with primary chylothorax)were collected *** was performed in all *** clinical manifestations,CTL findings,and conventional chest CT findings of the three groups of patients were *** chi-square test or Fisher's exact test was used to compare the differences among the three groups.A difference was considered to be statistically significant when Pkening in 12(60.0%),11(26.8%)and 3(30.0%)patients;bronchovascular bundle thickening in 14(70.0%),6(14.6%)and 4(40.0%)patients;localized mediastinal changes in 14(70.0%),14(34.1%),and 7(70.0%)patients;diffuse mediastinal changes in 6(30.0%),5(12.2%),and 3(30.0%)patients;cystic lesions in the axilla in 2(10.0%),6(14.6%),and 2(20.0%)patients;and cystic lesions in the chest wall in 0(0%),2(4.9%),and 2(4.9%)*** CTL is

关键词： Lymphatic Plastic bronchitis Primary chylothorax Direct lymphangiography Computed tomography lymphangiography

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SHR-A1811(antibody-drug conjugate)in advanced HER2-mutant non-small cell lung cancer:a multicenter,open-label,phase 1/2 study

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3483-3492页

作者： Ziming Li Zhengbo Song Wei Hong Nong yang Yongsheng Wang Hong Jian Zibin Liang Sheng Hu Min Peng yan Yu yan Wang Zicong Jiao Kaijing Zhao ke Song You Li Wei Shi Shun Lu Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiaotong University School of MedicineShanghai 200030China Phase I Clinical Trial Ward Zhejiang Cancer HospitalHangzhou 310000China Department of Thoracic Oncology Zhejiang Cancer HospitalHangzhou 310000China Department of Lung&Gastrointestinal Oncology Hunan Cancer HospitalChangsha 410031China Thoracic Oncology Ward/Cancer Center West China Hospital of Sichuan UniversityChengdu 610041China Department of Thoracic Oncology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 51900China Department of Medical Oncology Hubei Cancer HospitalWuhan 43000China Department of Oncology Renmin Hospital of Wuhan UniversityWuhan 430200China Department of Thoracic Medicine Harbin Medical University Cancer HospitalHarbin 150081China Department of Medical Oncology Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Geneplus-Beijing CoLtd.Beijing 102206China Jiangsu Hengrui Pharmaceuticals Co.Ltd.Shanghai 200120China

A dose-escalation and expansion,phase 1/2 study(***,NCT04818333)was conducted to assess the novel antibodydrug conjugate SHR-A1811 in pretreated HER2-altered advanced non-small cell lung cancer(NSCLC).Here,we report results from the phase 1 *** who had previously failed or were intolerant to platinum-based chemotherapy were enrolled and received SHR-A1811 intravenously at doses of 3.2 to 8.0 mg/kg every 3 *** escalation followed a Bayesian logistic regression model that included overdose control,with subsequent selection of tolerable levels for dose ***,63 patients were enrolled,including 43 receiving a recommended dose for expansion of 4.8 mg/*** patients had HER2-mutant ***-limiting toxicity occurred in one patient in the 8.0 mg/kg dose ***≥3 treatment-related adverse events occurred in 29(46.0%)*** patient in the 6.4 mg/kg cohort died due to interstitial lung *** of April 11,2023,the 4.8 mg/kg cohort showed an objective response rate of 41.9%(95%Cl 27.0-57.9),and a disease control rate of 95.3%(95%Cl 84.2-99.4).The median duration of response was 13.7 months,with 13 of 18 responses *** median progression-free survival was 8.4 months(95%CI 7.1-15.0).SHR-A1811 demonstrated favourable safety and clinically meaningful efficacy in pretreated advanced HER2-mutantNSCLC.

关键词： SHR HER2 doses

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AB-DTPA提取法在重金属污染土壤修复模拟试验中的应用可行性

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岩矿测试 2010年第2期29卷 131-135页

作者：陈燕芳刘晓端谭科艳国家地质实验测试中心北京100037

将碳酸氢铵-二乙三胺五乙酸(AB-DTPA)提取重金属生物有效态的方法应用于重金属污染土壤修复的模拟试验中,该土壤的污染元素主要是铜、锌和镉,试验所用修复材料是钠化膨润土。研究表明,AB-DTPA提取法具有很好的稳定性,而且能准确指示铜... 详细信息

将碳酸氢铵-二乙三胺五乙酸(AB-DTPA)提取重金属生物有效态的方法应用于重金属污染土壤修复的模拟试验中,该土壤的污染元素主要是铜、锌和镉,试验所用修复材料是钠化膨润土。研究表明,AB-DTPA提取法具有很好的稳定性,而且能准确指示铜、锌、镉元素在土壤中的有效态含量,同时AB-DTPA对土壤中铜、锌、镉元素的提取率也适用于模拟试验中修复效果的平行对比。AB-DTPA提取法在重金属污染土壤修复模拟试验中的应用是可行的。

关键词：碳酸氢铵-二乙三胺五乙酸生物有效态提取铜锌镉钠化膨润土土壤修复

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Selective his bundle pacing eliminates crochetage sign:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5276-5282页

作者： yan-Guang Mu ke-Sen Liu Department of Arrhythmia Weifang People's HospitalWeifang 261000Shandong ProvinceChina

BACKGROUND Crochetage sign is a specific electrocardiographic manifestation of ostium secundum atrial septal defects(ASDs),which is associated with the severity of the left-to-right ***,we reported a case of selective his bundle pacing(SHBP)that eliminated crochetage sign in a patient with ostium secundum *** SUMMARY A 77-year-old man was admitted with a 2-year history of chest tightness and shortness of *** echocardiography revealed an ostium secundum ***-lead electrocardiogram revealed atrial fibrillation with a prolonged relative risk interval,incomplete right bundle branch block,and crochetage *** patient was diagnosed with an ostium secundum ASD,atrial fibrillation with a second-degree atrioventricular block,and heart *** patient was treated with selective his bundle pacemaker *** the procedure,crochetage sign disappeared during his bundle pacing on the *** S-HBP eliminated crochetage sign on *** sign may be a manifestation of a conduction system disorder.

关键词： Crochetage sign Atrial septal defect Pacemaker Selective his bundle pacing Case report

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冬季热带西太平洋MJO活动强弱年的环境场特征

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热带气象学报 2015年第1期31卷 1-10页

作者：陈雄李崇银谭言科郭文华解放军理工大学气象海洋学院江苏南京211101 中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室北京100029

利用1948—2011年NCEP等再分析资料,采用合成分析等方法对比分析了冬季(冬半年)热带西太平洋MJO(Madden-Julian Oscillation)活动强、弱年的环境场特征。结果表明,冬季热带西太平洋MJO的活动具有显著的年际和年代际变化。MJO活动强年,... 详细信息

利用1948—2011年NCEP等再分析资料,采用合成分析等方法对比分析了冬季(冬半年)热带西太平洋MJO(Madden-Julian Oscillation)活动强、弱年的环境场特征。结果表明,冬季热带西太平洋MJO的活动具有显著的年际和年代际变化。MJO活动强年,对流层低层在菲律宾以东洋面上空有异常气旋式环流,赤道东太平洋上空为较强的东风距平,赤道印度洋到赤道西太平洋上空是异常西风,西太平洋地区有较强辐合,从而导致热带西太平洋地区积云对流活动显著加强;而MJO活动弱年的环流特征相反。热带MJO以东传为主,有少量西传波动。在MJO活动强年,无论东传还是西传其时空谱值都显著大于MJO活动弱年,其中心频率较MJO活动弱年偏高。MJO活动的异常和海温及东亚冬季风紧密相连,在MJO活动强年,海平面气压和500 h Pa位势高度异常场表现为中高纬度的正异常和低纬地区的负异常,东亚冬季风活动偏强,中国大陆中部气温普遍偏低,同时,黄河以南长江以北地区降水偏多,而长江以南地区降水偏少;台湾附近海域受强东亚冬季风影响,海表温度偏低,东太平洋上海温距平呈现La Nia型的异常分布,而在MJO活动弱年上述特征基本相反。

关键词：天气气候统计特征 MJO 东亚冬季风 ENSO

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热带印度洋春季海表温度异常与南海夏季风强度变化的关系

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气候与环境研究 2006年第4期11卷 514-524页

作者：李东辉朱益民谭言科张瑰中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室解放军理工大学气象学院南京211101 解放军理工大学理学院南京211101

利用50年的Reynolds月平均海表温度资料和NCEP／NCAR全球大气再分析资料，分析了热带印度洋春季海温异常对南海夏季风强度变化的影响。结果表明：1）热带印度洋春季海表温度距平（SSTA）的模态主要是全区一致型（USBM）和热带南印度洋... 详细信息

利用50年的Reynolds月平均海表温度资料和NCEP／NCAR全球大气再分析资料，分析了热带印度洋春季海温异常对南海夏季风强度变化的影响。结果表明：1）热带印度洋春季海表温度距平（SSTA）的模态主要是全区一致型（USBM）和热带南印度洋偶极型（SIODM），USBM模态既有年际时间尺度的变化特征，又有年际以上时间尺度的变化特征，既包含有对冬季ENSO信号响应的变化特征，又有独立于ENSO的变化特征；SIODM模态主要表现为独立于ENSO的年际时间尺度变化。2）USBM模态与南海夏季风强度变化呈显著负相关关系，且二者都是对冬季ENSO信号的响应，USBM模态的年际变化不能独立于ENSO信号影响南海夏季风的强度变化。3）经（1～8年）带通滤波及去除ENSO信号的热带印度洋春季SSTA的SIODM型分布是影响南海夏季风强度变化的主要模态，表现为热带东南印度洋为负（正）、其他海区为正（负）时，南海夏季风强度增强（减弱），大气环流对热带东南印度洋SSTA热力作用的响应是造成这一关系的直接原因，SIODM型的SSTA分布与南海夏季风年际异常关系在热带印度洋长期变化趋势的暖位相期显著，在长期变化趋势的冷位相期不显著。

关键词：热带印度洋春季海表温度南海夏季风

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Universal silicon ring resonator for error-free transmission links

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Photonics Research 2024年第4期12卷 701-711页

作者： JUNBO ZHU WEIWEI ZHANG ke LI BHARAT PANT MARTIN EBERT XINGZHAO yan MEHDI BANAKAR DEHN T.TRAN CALLUM G.LITTLEJOHNS FUWAN GAN GRAHAM REED DAVID J.THOMSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK National key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d B optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

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WRF3.0参数化敏感性及集合预报试验

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解放军理工大学学报（自然科学版） 2010年第1期11卷 89-96页

作者：李刚王铁谭言科冯文田白涛解放军理工大学气象学院解放军66393部队解放军94162部队

为了研究WRF模式中的参数化方案对暴雨数值模拟的影响及物理过程集合预报在WRF降水集合预报中的适用性,利用中尺度WRF3.0数值模式,将模式中的物理过程参数化方案进行组合,构造了20个集合预报成员,对2003年7月8、9日发生在江淮地区的一... 详细信息

为了研究WRF模式中的参数化方案对暴雨数值模拟的影响及物理过程集合预报在WRF降水集合预报中的适用性,利用中尺度WRF3.0数值模式,将模式中的物理过程参数化方案进行组合,构造了20个集合预报成员,对2003年7月8、9日发生在江淮地区的一次降水过程进行了集合预报试验。得到:集合成员之间存在一定的不确定性,不确定性随降水量级增大而增大,最终维持在一个较高的水平;通过定量比较发现,对于0.1 mm量级降水和25 mm以上量级降水,积云对流参数化方案对降水的影响要大于行星边界层方案对降水的影响;而对于10 mm量级降水,行星边界层方案对降水的影响要大于积云参数化方案对降水的影响。对20个预报成员进行了集合平均及降水概率预报试验,结果表明,集合平均的结果要比各个成员的稳定、可靠;概率预报能够提供一些有利于降水预报的信息。

关键词：集合预报 WRF模式物理参数化方案暴雨

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The effect of fasting plasma glucose on in-hospital mortality after acute myocardial infarction in patients with and without diabetes:findings from a prospective,nationwide,and multicenter registry

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Journal of Geriatric Cardiology 2024年第5期21卷 523-533页

作者： Rui FU Ying-Xuan ZHU Kong-Yong CUI Jin-Gang yanG Hai-yan XU Dong YIN Wei-Hua SONG Hong-Jian WANG Cheng-Gang ZHU Lei FENG Wei WU Kai-HongCHEN yan-yan ZHAO Ye LU ke-Fei DOU Yue-Jin yanG on behalf of the CAMI Registry Investigators Cardiometabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research&Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Coronary Heart Disease Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangzhou Traditional Chinese Medical College First Affiliated HospitalGuangdong ProvinceChina Department of Cardiology Longyan Hospital First HospitalFujian ProvinceChina 不详

OBJECTIVES To evaluate the predictive value of fasting plasma glucose(FPG)for in-hospital mortality in patients with acute myocardial infarction(AMI)with different glucose metabolism *** We selected 5,308 participants with AMI from the prospective,nationwide,multicenter CAMI registry,of which 2,081 were diabetic and 3,227 were *** were divided into high FPG and low FPG groups according to the optim-al cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts,*** primary endpoint was in-hospital *** Overall,94 diabetic patients(4.5%)and 131 nondiabetic patients(4.1%)died during hospitalization,and the optimal FPG thresholds for predicting in-hospital death of the two cohorts were 13.2 mmol/L and 6.4 mmol/L,*** with individuals who had low FPG,those with high FPG were significantly associated with higher in-hospital mortality in diabet-ic cohort(10.1%vs.2.8%;odds ratio[OR]=3.862,95%confidence interval[CI]:2.542-5.869)and nondiabetic cohort(7.4%vs.1.7%;HR=4.542,95%CI:3.041-6.782).After adjusting the potential confounders,this significant association was not ***-more,FPG as a continuous variable was positively associated with in-hospital mortality in single-variable and multivariable models regardless of diabetic *** FPG to the original model showed a significant improvement in C-statistic and net reclassification in diabetic and nondiabetic *** This large-scale registry indicated that there is a strong positive association between FPG and in-hospital mor-tality in AMI patients with and without *** might be useful to stratify patients with AMI.

关键词： patients fasting infarction

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Timp1 Deletion Induces Anxiety-like Behavior in Mice

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Neuroscience Bulletin 2024年第6期40卷 732-742页

作者： Xiaotong Wang Wei Zheng Ziyi Zhu Biyu Xing Weijie yan ke Zhu Lingli Xiao Chaojuan yang Mengping Wei Lei yang Zi-Bing Jin Xueyun Bi Chen Zhang State key Laboratory of Neurology and Oncology Drug Development Nanjing210000China School of Basic Medical Sciences Wenzhou Medical UniversityWenzhou325035China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairAdvanced Innovation Center for Human Brain ProtectionBeijing Laboratory of Oral HealthCapital Medical UniversityBeijing100069China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing100005China Chinese Institute for Brain Research Beijing102206China key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing100191China

The hippocampus is essential for learning and memory,but it also plays an important role in regulating emotional behavior,as hippocampal excitability and plasticity affect anxiety and *** synaptic plasticity may be regulated by tissue inhibitor of matrix metalloproteinase 1(TIMP1),a known protein inhibitor of extracellular matrix(ECM),and the expression of TIMP1 in the hippocampus can be induced by neuronal excitation and various ***,the involvement of Timp1 in fear learning,anxiety,and hippocampal synaptic function remains to be *** study of Timp1 function in vivo revealed that Timp1 knockout mice exhibit anxiety-like behavior but normal fear *** results suggested that Timp1 knockout mice showed hyperactivity in the ventral CA1 region,but the basic synaptic transmission and plasticity were normal in the Schaffer collateral *** together,our results suggest that deletion of Timp1 in vivo leads to the occurrence of anxiety behaviors,but that Timp1 is not crucial for fear learning.

关键词： Timp1 Anxiety Fear Synaptic transmission Synaptic plasticity

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