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Relaxation Oscillation of Thermal Convection in Rotating Cylindrical Annulus

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Chinese Physics Letters 2010年第3期27卷 220-223页

作者：陶建军谭文长 SKLTCS and CAPT Department of Mechanics and Aerospace Engineering College of Engineering Peking University Beijing 100871

Chaotic thermal convection in a rapidly rotating cylindrical annulus is investigated numerically and the relaxation oscillation state is obtained under the no-slip boundary condition. The dominant frequency of the oscillation is inherited directly from a vacillating mode, whose nonlinear interaction with another high-frequency vacillating mode leads to the chaotic state at high Rayleigh numbers through an RTN-type route. Furthermore, the effects of Coriolis parameter and Rayleigh number on the quasi-periodic burst of kinetic energy are discussed as well.

关键词： Fluid dynamics Statistical physics and nonlinear systems

Weekly taxane-anthracycline combination regimen versus tri-weekly anthracycline-based regimen for the treatment of locally advanced breast cancer:a randomized controlled trial

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Chinese Journal of Cancer 2017年第6期36卷 274-281页

作者： Qiu-wen tan Ting Luo Hong Zheng Ting-Lun Tian Ping He Jie Chen He-Lin Zeng Qing Lv Department of Breast Surgery West China HospitalSichuan University Department of Medical Oncology West China HospitalSichuan University

Background:Extensive studies have confirmed the efficacy of taxanes in combination with anthracycline-based chemotherapy on breast ***,few studies have assessed the efficacy of weekly taxane-anthracycline regimens on locally advanced breast *** study was to compare the efficacy and safety of a weekly taxaneanthracycline regimen with those of tri-weekly anthracycline-based regimen in patients with locally advanced breast ***:Patients with locally advanced breast cancer were randomized to receive 4-6 cycles of neoadjuvant chemotherapy with tri-weekly 5-fluorouracil-epirubicin-cyclophosphamide(FEC) regimen or weekly paclitaxel-epirubicin(PE) *** primary endpoint was the pathologic complete response(pCR) *** endpoints included the clinical tumor response,breast-conserving surgery rate,and adverse ***:Between March 2010 and September 2013,293 patients were randomized to the FEC(n=151) and PE(n=142) *** overall clinical response rate was significantly higher in the PE arm than in the FEC arm(76.06%vs.59.95%,P=0.001).Consistently,the post-chemotherapy pathologic T and N stages were significantly lower in the PE arm than in the FEC arm(P<0.001).However,the pCR rate was similar in the two arms(10.61%vs.12.31%,P=0.665).Overall,36(27.27%) patients in the FEC arm and 6(35.28%) in the PE arm were qualified for breast-conserving *** adverse events were comparable in both arms,with more severe neutropenia in the PE arm than in the FEC arm(11.97%vs.5.96%,P=0.031).Conclusions:In patients with locally advanced breast cancer,weekly PE was not superior to FEC in terms of ***,weekly PE has a higher response rate and superior down-staging *** this account,the PE regimen may be considered an alternative option for locally advanced breast ***-term follow-up data are needed to confirm the efficacy of this regimen on locally advanced breast *** registration Chinese clinical trial registry,Ch

关键词：随机对照试验治疗方案乳腺癌紫杉烷晚期环类药物蒽

Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation

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Protein & Cell 2021年第2期12卷 128-144页

作者： Chengcheng Wang Taiping Zhang Quan Liao Menghua Dai Junchao Guo Xinyu Yang wen tan Dongxin Lin Chen Wu Yupei Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Etiology and Carcinogenesis National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China CAMS Oxford Institute(COI) Chinese Academy of Medical SciencesBeijing 100730China

Pancreatic ductal adenocarcinoma(PDAC)has poor prognosis due to limited therapeutic *** study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic *** have identified HNF4G gene whose silencing most effectively repressed PDAC cell ***4G overexpression is induced by the deficiency of transcriptional factor and tumor suppressor *** HNF4G are correlated with SMAD4 deficiency in PDAC tumor samples and associated with metastasis and poor survival time in xenograft animal model and in patients with PDAC(log-rank P=0.036;HR=1.60,95%CI=1.03–2.47).We have found that Metformin suppresses HNF4G activity via AMPK-mediated phosphorylation-coupled ubiquitination degradation and inhibits in vitro invasion and in vivo metastasis of PDAC cells with SMAD4 ***,Metformin treatment significantly improve clinical outcomes and survival in patients with SMAD4-deficient PDAC(log-rank P=0.022;HR=0.31,95%CI=0.14–0.68)but not in patients with SMAD4-normal *** analysis shows that HNF4G may act in PDAC through the cell-cell junction *** results indicate that SMAD4 deficiency-induced overexpression of HNF4G plays a critical oncogenic role in PDAC progression and metastasis but may form a druggable target for Metformin treatment.

关键词： pancreatic cancer HNF4G SMAD4 deficiency SMAD4-deficient PDAC Metformin

Engineering single-molecule fluorescence withasymmetric nano-antennas

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Light(Science & Applications) 2021年第5期10卷 858-866页

作者： wenqi Zhao Xiaochaoran Tian Zhening Fang Shiyi Xiao Meng Qiu Qiong He Wei Feng Fuyou Li Yuanbo Zhang Lei Zhou Yan-wen tan State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Shanghai Institute for Advanced Communication and Data Science Shanghai UniversityShanghai 200444China Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai UniversityShanghai 200444China Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200433China Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Multiscale Research Institute of Complex Systems Fudan UniversityShanghai 200433China

As a powerful tool for studying molecular dynamics in bioscience,single-molecule fluorescence detection providesdynamical information buried in ensemble *** in the near-infrared(NIR)is particularly usefulbecause it offers higher signal-to-noise ratio and increased penetration depth in tissue compared with *** low quantum yield of most NIR fluorophores,however,makes the detection of single-moleculefluorescence ***,we use asymmetric plasmonic nano-antenna to enhance the fluorescence intensity ofAlEE1000,a typical NIR dye,by a factor up to *** asymmetric nano-antenna achieve such an enhancement mainlyby increasing the quantum yield(to~80%)rather than the local field,which degrades the molecules'*** coupled-mode-theory analysis reveals that the enhancements stem from resonance-matching between antennaand molecule and,more importantly,from optimizing the coupling between the near-and far-ield modes withdesigner asymmetric *** work provides a universal scheme for engineering single-molecule fluorescence inthe near-infrared regime.

关键词： stability. asymmetric quantum

Surveillance of childhood blood lead levels in 11 cities of China

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World Journal of Pediatrics 2014年第1期10卷 29-37页

作者： Tao Li Yao-Hua Dai Xiao-Hua Xie Zang-wen tan Shuai-Ming Zhang Zong-Han Zhu Department of Integrated Early Childhood Development Capital Institute of Pediatrics BeijingChina Chinese Pediatrician Association BeijingChina

Background:Exposure to lead can be deleterious to children’s *** for blood lead levels(BLLs)is reported every year in the USA and some other ***,such reports are lacking in China which has the world’s largest population of *** this study,we provided the latest nationally representative data on BLLs among Chinese children living in cities,described the change in BLLs since 2004,and explored the risk factors for elevated BLLs(EBLLs)among ***:We studied 12693 children aged 0–6 years in 2004 and 11255 children aged 0–6 years in *** evaluated the average BLLs and the prevalence of EBLLs,and a multivariate logistic regression model was used to estimate predictors of ***:The geometric mean BLLs of children aged 0–6 years dropped by 16%(from 46.38±2.10μg/L in 2004 to 38.95±1.83μg/L in 2010),while the prevalence of EBLLs dropped by 87%(from 9.78%in 2004 to 1.32%in 2010).In a multivariate analysis,the following factors were associated with EBLLs:(1)children being cared for at home or at a boarding nursery(compared to children being cared for in a day nursery),(2)children having fathers with a lower education level,and(3)children often eating popcorn and chewing fingernails or sucking fingers were associated with ***:The results of this study demonstrated a substantial decline in BLLs from 2004 to 2010 among Chinese children 0–6 years living in ***,these levels were higher than levels in countries,such as the USA,Canada,Japan and *** data demonstrate that Chinese children’s lead exposure remains a public health problem that requires additional effort and resources.

关键词： child gasoline lead surveillance

Epidemiological features of chronic hepatitis C infection caused by remunerated blood donors:A nearly 27-year period survey

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World Journal of Gastroenterology 2018年第11期24卷 1250-1258页

作者： You-wen tan Yan Tao Long-Gen Liu Yun Ye Xin-Bei Zhou Li Chen Cong He Department of Hepatology The Third Hospital of Zhenjiang Affiliated Jiangsu University Department of Hepatology The Third People’s Hospital of Changzhou

AIM To understand the prevalence of hepatitis C virus(HCV) infection in blood donors over a nearly 27-year interval and to explore the factors that affect the outcome of HCV *** A retrospective and cross-sectional study was *** participants,mostly plasma donors,were selected from three administrative villages in the Jiangsu province in Eastern China.A questionnaire was administered among the villagers who had a history of blood donation from the late 1980 s to the early 1990 *** participants underwent physical examination,liver B-ultrasonography,and liver stiffness *** addition,10 m L of blood was collected from each participant to measure simple liver function parameters(albumin,alanine aminotransferase,aspirate aminotransferase),blood factors(platelet),and for hepatitis B surface antigen,anti HCV,and antihuman immunodeficiency virus *** RNA detection,HCV genotyping,and other tests were carried out in anti HCV-positive *** After a median of 27 years(25-31 years) from the last blood donation to the time of survey,a total of 1694 participants were investigated,and the anti HCVpositive individuals were categorized into three groups:blood donors(n = 12,3.3%),plasma donors(n = 534,68.5%),and mixed donors(n = 324,58.8%).A total of 592(68.05%) patients had detectable HCV RNA,and 91.9% had genotype 1 b.A total of 161(27.2%,161/592) patients with chronic HCV were considered to have cirrhosis with a liver stiffness measurement level higher than 12 k *** logistic(binary) regression analysis results showed that platelet and Ig G levels were associated with *** The nearly 27-year interval investigation revealed that chronic hepatitis C infection is a very serious public health problem in Eastern *** donation and subsequent return of blood cells to the donor are the main causes of hepatitis C *** main HCV genotype is 1 *** 28% of cases progressed to ***,especial

关键词： Blood donor Hepatitis C Cross-sectional study Epidemiologic China

A Study of the Strategy of Presupposition in Courtroom Interaction

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校园英语 2017年第9期 176-177页

作者： tan Yao-wen Southwest University of Political Science and Law

Based on presupposition theory,this paper tries to show how presupposition is realized in courtroom interaction and how a favorable effect is made for parties in a *** using the strategy of presupposition,judges,lawyers and public prosecutors can direct the conversation,make a linguistic trap and create a favorable effect for *** is shown that the strategy of presupposition is helpful for judicial professionals to improve their language skills and enhance their efficiency in courtroom interaction.

关键词： courtroom interaction presupposition theory the strategy of presupposition

Polarization-based range-gated imaging in birefringent medium:Effect of size parameter

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Chinese Physics B 2018年第12期27卷 282-290页

作者： Heng Tian Jing-Ping Zhu Shu-wen tan Jing-Jing Tian Yun-Yao Zhang Xun Hou Key Laboratory for Physical Electronics and Devices of the Ministry of Education and Shaanxi Key Laboratory of Information Photonic Technique Xi'an Jiaotong University School of Physics and Electronic Information Engineering Henan Polytechnic University Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education Xi'an Jiaotong University

We have investigated the effect of size parameter of the scatterer on the image quality obtained with polarization-based range-gated imaging in birefringent turbid medium. Both linearly and circularly polarized light were utilized for *** simulated results indicate that the improvement of visibility is more pronounced using circularly polarized light for the birefringent medium composed of smaller-sized scatterers at lower values of optical thickness and the birefringent medium comprising larger-sized scatterers. In contrast, linearly polarized light provides better image quality for the birefringent medium composed of smaller-sized scatterers at larger values of optical thickness. The evolution of the polarization characteristics of backscattered light and target light under the conditions mentioned above was measured to account for these numerical results.

关键词： polarization Monte Carlo simulation birefringence scattering

基于PID参数整定的线性自抗扰控制参数整定

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控制与决策 2021年第7期36卷 1592-1600页

作者：韩文杰谭文华北电力大学控制与计算机工程学院北京102206

线性自抗扰控制(linear active disturbance rejection control,LADRC)是不依赖于被控对象的数学模型,在工业过程中具有极大的应用前景,LADRC参数整定是其在工业过程中能否应用的重要环节.鉴于实际工业控制中大都采用PID控制器,通过对二... 详细信息

线性自抗扰控制(linear active disturbance rejection control,LADRC)是不依赖于被控对象的数学模型,在工业过程中具有极大的应用前景,LADRC参数整定是其在工业过程中能否应用的重要环节.鉴于实际工业控制中大都采用PID控制器,通过对二阶LADRC结构与其状态观测器的传递函数进行分析,得到二阶LADRC与PID控制器具有较强的联系,且LADRC比PID有着更好的控制性能.提出一种通过现有PID参数直接得到LADRC参数初始值的方法,以达到更好的控制性能,并基于一阶惯性加时延模型,得到将现有PID整定方法转化为二阶线性自抗扰控制参数整定方法.最后通过基准系统仿真表明所提出方法的有效性.

关键词：线性自抗扰控制 PID控制参数整定抗干扰性能一阶惯性加时延模型基准系统