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Clonal immunoglobulin heavy chain and T-cell receptor γ gene rearrangements in primary gastric lymphoma

World Journal of Gastroenterology 2013年第34期19卷 5727-5731页

作者： Guo-Dong Shan Feng-Ling Hu Ming Yang Hong-tan Chen wen-Guo Chen Yun-Gui Wang Li-Hua Chen You-Ming Li Guo-Qiang Xu Department of Gastroenterology the First Affiliate HospitalSchool of MedicineZhejiang University

AIM:To study the diagnostic value of immunoglobulin heavy chain(IgH)and T-cell receptorγ (TCR-γ)gene monoclonal rearrangements in primary gastric lymphoma(PGL).METHODS:A total of 48 patients with suspected PGL at our hospital were prospectively enrolled in this study from January 2009 to December *** patients were divided into three groups(a PGL group,a gastric linitis plastica group,and a benign gastric ulcer group)based on the pathological results(gastric mucosal specimens obtained by endoscopy or surgery)and *** ultrasonography(EUS)and EUSguided biopsy were performed in all the *** tissue specimens were used for histopathological examination and for IgH and TCR-γ gene rearrangement polymerase chain reaction ***:EUS and EUS-guided biopsy were successfully performed in all 48 *** the PGL group(n=21),monoclonal IgH gene rearrangements were detected in 14(66.7%)patients.A positive result for each set of primers was found in 12(57.1%),8(38.1%),and 4(19.0%)cases using FR1/JH,FR2/JH,and FR3/JH primers,***,12(75%)patients with mucosal-associated lymphoid tissue lymphoma(n=16)and 2(40%)patients with diffuse large B-cell lymphoma(n=5)were positive for monoclonal IgH gene *** patients in the gastric linitis plastica group(n=17)and only one(10%)patient in the benign gastric ulcer group(n=10)were positive for a monoclonal IgH gene *** TCRgene monoclonal rearrangements were *** sensitivity of monoclonal IgH gene rearrangements was 66.7%for a PGL diagnosis,and the specificity was96.4%.In the PGL group,8(100%)patients with stage IIE PGL(n=8)and 6(46.1%)patients with stage IE PGL(n=13)were positive for monoclonal IgH gene ***:IgH gene rearrangements may be associated with PGL staging and may be useful for the diagnosis of PGL and for differentiating between PGL and gastric linitis plastica.

关键词： Immunoglobulin heavy chain T-cell receptor γ Gene rearrangement Primary gastric lymphoma Endoscopic biopsy specimen

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Parallel-batch scheduling with deterioration and rejection on a single machine

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Applied Mathematics(A Journal of Chinese Universities) 2020年第2期35卷 141-156页

作者： LI Da-wei LU Xi-wen School of Science East China University of Science and TechnologyShanghai 200237China.

The single machine parallel-batch scheduling with deteriorating jobs and rejection is considered in this paper.A job is either rejected,in which a rejection penalty should be paid,or accepted and processed on the *** job’s processing time is an increasing linear function of its starting *** machine can process any number of jobs simultaneously as a *** processing time of a batch is equal to the largest processing time of the jobs in the *** objectives are to minimize the makespan and the total weighted completion time,respectively,under the condition that the total rejection penalty cannot exceed a given upper bound *** show that both problems are NP-complete and present dynamic programming algorithms and fully polynomial time approximation schemes(FPTASs)for the considered problems.

关键词： parallel-batch scheduling rejection deterioration FPTAS NP-complete

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“Smurf”-ing tumors on the chromatin through RNF20

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Protein & Cell 2012年第2期3卷 81-83页

作者： wen-Wei Tsai Peptide Biology Laboratories Salk Institute for Biological StudiesLa JollaCA 92037USA

In the modern mythology of Dutch comic world,Smurfs are little blue creatures who say“smurf”for anything they *** the parlance of molecular biology,there live two Smurfs so named because they are Smad ubiquitination regulator factor 1 and *** like those blue devils on the television,the molecular Smurfs are also versatile;capable of controlling bone development,actin cytoskeleton dynamics,cellular senescence,and planar cell polarity in addition to their prototypic function in transforming growth factorβ(TGF-β)***,the realm of Smurf influence has expanded even further to epigenetic modifications of histones governing the chromatin landscape.A recent study from Ying E.

关键词： Dutch expanded versatile

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Design of Fault Detection Observer Based on Hyper Basis Function

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Tsinghua Science and Technology 2015年第2期20卷 200-204页

作者： Xin wen Xingwang Zhang Yaping Zhu Faculty of Aerospace Engineering Shenyang Aerospace University College Astronautics Nanjing University of Aeronautics and Astronautics College Astronautics Nanjing University of Aeronautics and Astronautics

In this paper, we propose the Hyper Basis Function （HBF） neural network on the basis of Radial Basis Function （RBF） neural network. Compared with RBF, HBF neural networks have a more generalized ability with different activation functions. A decision tree algorithm is used to determine the network center. Subsequently, we design an adaptive observer based on HBF neural networks and propose a fault detection and diagnosis method based on the observer for the nonlinear modeling ability of the neural network. Finally, we apply this method to nonlinear systems. The sensitivity and stability of the observer for the failure of the nonlinear systems are proved by simulation, which is beneficial for real-time online fault detection and diagnosis.

关键词： observer fault detection hyper basis function neural networks

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Quantum Chromodynamics Sum Rules for the 1^(-/+) Vector Odd-Glueball

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Chinese Physics Letters 1996年第5期13卷 340-342页

作者： LU wen-tao LIU Jue-ping Department of Physics Wuhan UniversityWuhan 430072

The transverse part of the two-point function of the 1^(-/+) vector gluonic current is calculated by including the perturbative contributions and the non-perturbative ones resulted from condensates of dimensions up to *** a usual"resonance plus continuum " model of the spectral function,the quantum chromodynamics sum rules for the 1^(-/+) vector odd-glueball are derived,and the 1^(-/+) mass of that glueball is determined to be 1.87 GeV.

关键词： dimensions function transverse

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Dynamic response characteristics of a circular lined tunnel under anisotropy frost heave of overlying soil at the tunnel portal section in cold regions

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Journal of Mountain Science 2023年第5期20卷 1424-1440页

作者： ZHANG Shuo-cheng CHEN wen-hua School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China

The rapid development of traffic engineering in cold regions and its consequent problems need to be *** this paper,the dynamic response characteristics of the tunnel portal section in cold regions with harmonic load acting on the lining were studied in the frequency *** lining is in close contact with the frozen soil,and there is relative movement between the frozen and unfrozen soil due to the phase *** analytical solution of the vibration of tunnel portal section caused by the harmonic load acting on the lining was derived under the consideration of the anisotropy frost heave of overlying *** on the continuity conditions and boundary conditions,the undetermined coefficients were obtained,and the analytical solutions for different medium displacements and stresses of the cold-region tunnel system were *** vertical pressure coefficient was equivalently simplified as a variable that could be used to replace the thickness of the overlying soil above the *** analysis of the parameter model shows that the change of the medium parameters(lining,frozen,and unfrozen soil)affects the circumferential stresses,the radial displacements and their peak frequencies of the *** example,the increase of density ratio of tunnel lining to frozen soil decreases the radial stresses of the frozen and unfrozen soil;the increase of volumetric frost heaving strain of the frozen soil increases the radial displacements of the frozen surface and decreases the stability of the frozen surface;the increasing of thickness of the frozen soil significantly reduces the radial displacement of unfrozen soil at dimensionless radius η=4.5 compared with that of frozen soil at η=1.5.

关键词： Frost heave Tunnel portal section Relative movement Dynamic response characteristics Cold region

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A Thermodynamic Perspective on Polymer Glass Formation

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Chinese Journal of Polymer Science 2023年第9期41卷 1329-1341,I0004页

作者： wen-Sheng Xu Zhao-Yan Sun State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China

The dynamics of polymeric and other glass-forming liquids dramatically slows down upon cooling toward the glass transition temperature without any obvious significant change in their static structure.A quantitative understanding of this extraordinary dynamic slowdown remains one of the most significant challenges in condensed matter ***,extensive efforts have been devoted to explaining the dynamics of glass-forming liquids in terms of thermodynamic properties,leading to a number of semi-empirical models emphasizing distinct thermodynamic ***,a thermodynamic perspective is provided on the glass formation of polymeric and other *** begin with an overview of the thermodynamic models of glass formation,including the intuitively appealing“free volume”models,enthalpy models originally emphasized by Goldstein and later by others,and the highly influential configurational entropy-based *** review of these models is followed by a discussion of the advances that attempt to bring together some of the seemingly disparate thermodynamic viewpoints on glass formation by revealing a close interrelation between thermodynamic *** conclude this review with remarks on several key topics in this field,along with our viewpoint for future work.

关键词： Glass formation Entropy Free volume Enthalpy

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Structure, biochemical function, and signaling mechanism of plant NLRs

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Molecular Plant 2023年第1期16卷 75-95页

作者： Jizong Wang wen Song Jijie Chai State Key Laboratory of Protein and Plant Gene Research School of Advanced Agricultural SciencesPeking UniversityBeijing 100871China Tsinghua-Peking Joint Center for Life Sciences Center for Plant BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China Institute of Biochemistry University of Cologne50674 CologneGermany Max Planck Institute for Plant Breeding Research 50829 CologneGermany Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences at WeifangWeifangShandong 261000China

To counter pathogen invasion,plants have evolved a large number of immune receptors,including membrane-resident pattern recognition receptors(PRRs)and intracellular nucleotide-binding and leucine-rich repeat receptors(NLRs).Our knowledge about PRR and NLR signaling mechanisms has expanded significantly over the past few *** NLRs form multi-protein complexes called resistosomes in response to pathogen effectors,and the signaling mediated by NLR resistosomes converges on Ca2+-permeable ***2+-permeable channels important for PRR signaling have also been *** findings highlight a crucial role of Ca2+in triggering plant immune *** this review,we first discuss the structural and biochemical mechanisms of non-canonical NLR Ca2+channels and then summarize our knowledge about immune-related Ca2+-permeable channels and their roles in PRR and NLR *** also discuss the potential role of Ca2+in the intricate interaction between PRR and NLR signaling.

关键词： plant immunity PRR NLR resistosome Ca2+-permeable channels Ca2+signaling second messenger

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Effects of Gambogic Acid on Regulation of Steroid Receptor Coactivator-3 in Lung Adenocarcinoma A549 Cells

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Chinese Journal of Cancer Research 2009年第1期21卷 68-73页

作者： Rui Li Yan Chen wen-xiu Shu Fei Zhao Yuan Liu Lu wen Department of Hematology Union Hospital Tongji Medical College Huazhong University Of Science and Technology Wuhan 430022 China

Objective： To investigate the effects of gambogic acid （GA） on the proliferation and apoptosis of Human lung adenocarcinoma A549 cells in vitro, as well as the regulation of steroid receptor coactivator-3 （SRC-3） to explore the relationship between them. Methods： The effect of GA on the growth of A549 cells was studied by MTT assay. Apoptosis was detected through Hoechst 33258 staining. RT-PCR and Western blot technologies were applied to assess the expression of SRC-3, whereas, the localization of SRC-3 was determined by using confocal microscopy method. Results： GA presented striking proliferation inhibition potency on A549 cells in vitro in a time- and dose-dependent manner, with the IC50 value for 24 h was 3.17±0.13 μmol/L. Hoechst 33258 staining showed that GA could induce apoptosis in A549 cells. Over-expression of SRC-3 was found in A549 cells, whereas the mRNA and protein expression levels of SRC-3 were significantly downregulated in A549 cells induced by GA in a dose-dependent manner. The disposition of SRC-3 was situated mainly at the nuclear. Conclusion： GA may exert its strong anti-leukemia effects through the regulation of the expression of SRC-3. It may be a new target for the therapy of lung cancer.

关键词： Gambogic acid Lung cancer Apoptosis SRC-3

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A novel cell search scheme for OFDM cellular systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 10-17页

作者： DING Ming LUO Han-wen WU Yun Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

A novel cell search scheme for OFDM cellular systems is proposed. It is based on one OFDM symbol with several identical slots as preamble, the time domain repetition structure of which can be utilized to accomplish OFDM timing/frequency synchronization. The cell ID is comprised of two parts: a sub-carrier mask index g and a sequence index x. Each sub-carrier mask activates or deactivates some of the sub-carriers, after which a differentially coded sequence is loaded on pairs of the adjacent active sub-carriers. The user equipment (UE) recognizes the mask with index g via power detection of the received frequency domain signal. Then it estimates the index x from differential demodulation followed by detection of the frequency domain se-quence. In order to improve the performance, a method of jointly estimating g and x is devised. Simulation results showed that the proposed scheme is able to support a very large number of cell IDs while maintaining a good performance even in bad multi-cell environment.

关键词： Orthogonal frequency division multiplexing (OFDM) Cell search Cell ID Multi-cell Mask

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