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MICROSTRUCTURE AND MECHANICAL PROPERTIES OF Fe-Ni-Co-BASE SUPERALLOY AFTER LONGTERM AGING AT 650℃

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Acta Metallurgica Sinica(English Letters) 1991年第3期4卷 194-198页

作者： WANG Shuhe GUO Jianting LAI Wanhui GE Yunlong tan Minghui li hui Institute of Metal Research,Academia Sinica,Shenyang,China

The microstructure and mechanical properties of a Ni-Fe-Co base superalloy with low thermal expansion coefficient after aging at 650℃ for 200,500,1000 and 2000 h have been *** was found that they are stable at 650℃.... 详细信息

关键词： superalloy microstructure mechanical property long-term aging

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi hui Ren Woon Genevieve Saw li Zeng Eng King tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

EFFECT OF ALLOYING ELEMENT ON MECHANICAL PROPERTIES OF Fe_3 AL AND FeAI ALLOYS

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Acta Metallurgica Sinica(English Letters) 1990年第4期3卷 249-255页

作者： GUO Jianting SUN Chao tan Minghui li hui LAI Wanhui Institute of Metal Research,Academia Sinica,Shenyang,China Professor,Institute of Metal Research,Academia Sinica,Shenyang 110015,China

The effect of alloying element such as Mo,Si or B and its stoichoimetric composition on the tensile properties at room and elevated temperatures,and also on the microstructure of Fe_3Al and FeAl alloys has been *** Fe aluminides were found to be obviously strengthened by all of three elements,but seriously embrittled by Mo and *** improvemen over the plasicity of FeAl may be made by adding B,and the fracture surface is variedfrom intergranular to transgranular cleavage *** room temperature plasticity of the Fe-rich Fe_3Al or Al-rich FeAl is much better than that of the stoichoimetric *** anoma- lous temperature dependence on the yield strength of Fe_3Al in range of 400 to 500℃ or of FeAl in range of 400 to 500℃ was *** has been carried out by the aspect of microstructure.

关键词： intermetallic compound Fe_3Al FeAl mechanical properties alloying element microstructure

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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具有不同诱导槽结构的薄壁圆管抗撞性优化

振动与冲击 2014年第8期33卷 16-21页

作者：谭丽辉谭洪武毛志强崔晓梅徐涛吉林大学机械科学与工程学院长春130022 吉林化工学院机电工程学院吉林吉林132022 中油吉林石化公司有机合成厂吉林吉林132022 中油吉林石化公司炼油厂吉林吉林132022

在金属薄壁圆管(原模型)的基础上,分别引入不同形式的圆弧形诱导槽结构并以其为研究对象,建立以诱导槽半径、槽端距、槽间距为优化参数,以比吸能和最大峰值碰撞力为评价指标的多目标优化模型。分析研究了诱导凹槽、凸槽及凸凹交替的诱... 详细信息

在金属薄壁圆管(原模型)的基础上,分别引入不同形式的圆弧形诱导槽结构并以其为研究对象,建立以诱导槽半径、槽端距、槽间距为优化参数,以比吸能和最大峰值碰撞力为评价指标的多目标优化模型。分析研究了诱导凹槽、凸槽及凸凹交替的诱导槽结构对薄壁构件吸能、最大峰值碰撞力的影响。采用有限元软件LS-DYNA得到不同几何参数模型的碰撞响应,结合径向基函数法构造近似函数,并采用理想点法进行优化设计,得出使结构最优时的不同形式的诱导槽半径、槽端距及槽间距,从而得到了不同形式的理想诱导槽优化结构。

关键词：薄壁构件比吸能最大峰值碰撞力抗撞性诱导槽

EFFECTS OF Cr AND Nb ON MICROSTRUCTURES AND MECHANICAL PROPERTIES OF Fe_3Al ALLOYS

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Acta Metallurgica Sinica(English Letters) 1993年第3期6卷 157-160页

作者： SUN Chao GUO Jianting tan Minghui li hui WANG Shuhe Institute of Metal Research,Academia Sinica,Shenyang,China professor,Institute of Metal Research,Academia Sinica,Shenyang 110015,China

The effects of Cr and Nb on tensile properties at room and elevated temperatures and also on the microstructure have been *** improvement in ductiliy plasicity and the cleavage strength of Fe_3AI may result from adding Cr;the improvement is more pronounced at over 400℃.The formation of Fe_2Nb containing A1 precipitates in the Fe_3AI+Nb alloy provide significant strengthening *** of Cr and Nb in Fe_3AI can cause a signifi- cant improvement in the yield strength at 550℃.

关键词： intermetallic compound Fe_3Al alloy mechanical properties Cr Nb

开放边界条件下二维可转向主干道交通流模型的研究

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物理学报 2005年第7期54卷 3044-3050页

作者：黄乒花谭惠丽孔令江刘慕仁广西工学院信息与计算科学系柳州545005 广西师范大学物理与信息工程学院桂林541004

在开放性边界条件下,利用改进的Nagel Schreckenberg交通流模型,引入过路口车辆的可转向机理,建立二维n速主干道元胞自动机交通流模型,研究了转向概率和边界条件对干道交通状况的影响而导致的不同相变特性以及这两个因素对实现改善干道... 详细信息

在开放性边界条件下,利用改进的Nagel Schreckenberg交通流模型,引入过路口车辆的可转向机理,建立二维n速主干道元胞自动机交通流模型,研究了转向概率和边界条件对干道交通状况的影响而导致的不同相变特性以及这两个因素对实现改善干道交通的组织作用.

关键词：交通流模型开放边界条件主干道二维开放性边界条件元胞自动机相变特性交通状况转向概率车辆路口

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两种不同诱导槽结构抗撞性优化设计

长安大学学报（自然科学版） 2016年第1期36卷 120-126页

作者：谭丽辉谭洪武崔晓梅徐涛吉林化工学院机电工程学院吉林吉林132022 吉林大学机械科学与工程学院吉林长春130022 中油吉林石化公司有机合成厂吉林吉林132022

为了提高圆截面金属薄壁构件的抗撞性,在其上引入圆弧形凹、凸2种诱导槽结构并以其为研究对象。建立以诱导槽数量及其半径为优化参数,以比吸能(SEA)和压溃力效率(CFE)为评价指标的多目标优化数学模型。讨论了均布设置的诱导凹槽、凸槽... 详细信息

为了提高圆截面金属薄壁构件的抗撞性,在其上引入圆弧形凹、凸2种诱导槽结构并以其为研究对象。建立以诱导槽数量及其半径为优化参数,以比吸能(SEA)和压溃力效率(CFE)为评价指标的多目标优化数学模型。讨论了均布设置的诱导凹槽、凸槽对结构吸能、最大峰值压溃力及压溃力曲线平稳性的影响。采用全因子试验设计选取设计样本点,通过有限元软件LS-DYNA得到不同样本点的碰撞响应,结合径向基函数法构造优化指标的近似函数,并采用理想点法进行优化设计。研究结果表明:优化后凹、凸2种诱导槽结构与原模型相比,压溃力效率分别提高了53.22%、102.15%,最大峰值压溃力各降低了52.1%、57.49%,压溃力曲线更趋于平稳;由于施加诱导槽造成结构整体质量增加,导致优化后凹、凸2种诱导槽结构的比吸能分别比原模型各减少了4.05%、7.99%,与大幅降低的最大峰值压溃力相比,很好地达到了提高抗撞性的目标。

关键词：汽车工程优化设计比吸能压溃力效率诱导槽薄壁构件

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双向两车道混合车辆交通流的特性

物理学报 2005年第10期54卷 4614-4620页

作者：郑容森谭惠丽孔令江刘慕仁玉林师范学院物理与信息科学系玉林537000 广西师范大学物理与信息工程学院桂林541004

在NaSch模型的基础上,制订了超车规则,建立了双向两车道混合车辆的元胞自动机交通流模型.用计算机模拟了车道密度对称和不对称两种情况下不同参数的混合车辆交通流,得出了相应的速度、流量与密度关系的基本图.经分析发现,双向两车道混... 详细信息

在NaSch模型的基础上,制订了超车规则,建立了双向两车道混合车辆的元胞自动机交通流模型.用计算机模拟了车道密度对称和不对称两种情况下不同参数的混合车辆交通流,得出了相应的速度、流量与密度关系的基本图.经分析发现,双向两车道混合车辆交通状态可分为快车特性区、准慢车特性区和慢车特性区;两车道上车辆密度的不对称性对交通流有重要的影响.

关键词：元胞自动机交通流混合车辆交通流交通流模型混合车辆特性车道双向不对称性计算机模拟