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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li tan guo-yao ZHANG Qiang ZHANG Qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

A deformation criterion of pressurized non-circular cross-section cabin and its effects on cruise performance of BWB civil aircraft

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Chinese Journal of Aeronautics 2024年第6期37卷 78-88页

作者： Siyi guo Zhenli CHEN Xuanyu yao School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Aero Engine Academy of China Beijing 101304China

Blended-Wing-Body(BWB)aircraft is promoted as one of the most possible layouts to achieve more sustainable civil *** to the non-circular cross-section of the center-body,a bulge deformation forms over the upper surface of the body under the coupled loads of the internal pressurization of the cabin and the aerodynamic bending moments of the wing,which reduces the lift-to-drag ratio of BWB *** a limited deformation,the relationship between the aerodynamic performance and the structural weight needs to be *** this work,the effects of stiffness constraints on the center-body deformation,structural weight of the airframe and aerodynamic performance were investigated by using an analytical model of the Pultruded Rod Stitched Efficient Unitized Structure(PRSEUS)for the airframe and the computational fluid dynamics method,*** results show that as the stiffness constraint increases,the spacings between the rod stringers and the frame stiffeners decrease,and the structural weight increases inversely.A 5.2% reduction of the lift-to-drag ratio is encountered at cruise for a medium deformation design of 42.8 mm/m.A higher aerodynamic penalty is suffered when the stiffness constraint is further *** final deformation criterion is different when the weight vector of the aerodynamic performance and structural weight is different.

关键词： Blended-Wing-Body(BWB) Deformation PultrudedRod Stitched Effi-cient Unitized Structure(PRSEUS) Cabin structure Stiffness constraint

Quantum Curve and Bilinear Fermionic Form for the Orbifold Gromov–Witten Theory of P[r]

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Acta Mathematica Sinica,English Series 2024年第1期40卷 43-80页

作者： Chong yao CHEN Shuai guo Mathematics Department Duke UniversityBox 90320DurhamNC 27708-0320USA School of Mathematical Sciences Peking UniversityBeijing 100871P.R.China

We construct the quantum curve for the Baker-Akhiezer function of the orbifold Gromov-Witten theory of the weighted projective line P[r].Furthermore,we deduce the explicit bilinear Fermionic formula for the(stationary... 详细信息

关键词： Quantum curve Free Fermions Gromov-Witten invariants Orbifold P^(1)

Exploring the potential of olivine-containing copper-nickel slag for carbon dioxide mineralization in cementitious materials

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 562-573页

作者： Qianqian Wang Zequn yao Lijie guo Xiaodong Shen College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing 211816China BGRIMM Technology Group Beijing 100160China

Water-quenched copper-nickel metallurgical slag enriched with olivine minerals exhibits promising potential for the production of CO_(2)-mineralized cementitious *** this work,copper-nickel slag-based cementitious material(CNCM)was synthesized by using different chemical activation methods to enhance its hydration reactivity and CO_(2) mineralization *** water curing ages and carbonation conditions were explored related to their carbonation and mechanical properties ***,thermogravimetry differential scanning calorimetry and X-ray diffraction methods were applied to evaluate the CO_(2) adsorption amount and carbonation products of *** development of carbonated CNCM blocks was examined by backscattered electron imaging(BSE)with energy-dispersive X-ray *** showed that among the studied samples,the CNCM sample that was subjected to water curing for 3 d exhibited the highest CO_(2) sequestration amount of 8.51wt%at 80℃and 72 h while presenting the compressive strength of 39.07 *** result indicated that 1 t of this CNCM can sequester 85.1 kg of CO_(2) and exhibit high compressive *** the addition of citric acid did not improve strength development,it was beneficial to increase the CO_(2) diffusion and adsorption amount under the same carbonation conditions from BSE *** work provides guidance for synthesizing CO_(2)-mineralized cementitious materials using large amounts of metallurgical slags containing olivine minerals.

关键词： copper-nickel slag fayalite CO_(2)sequestration cementitious material admixtures carbonation conditions

Harnessing sub-comb dynamics in a graphene-sensitized microresonator for gas detection

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Frontiers of Optoelectronics 2024年第2期17卷 11-21页

作者： Yupei Liang Mingyu Liu Fan tang Yanhong guo Hao Zhang Shihan Liu Yanping Yang Guangming Zhao Teng tan Baicheng yao Key Laboratory of Optical Fiber Sensing and Communications(Ministry of Education) University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Engineering Center of Integrated Optoelectronic&Radio Meta-Chips University of Electronic Science and TechnologyChengdu 611731China

Since their inception, frequency combs generated in microresonators, known as microcombs, have sparked significant scientific interests. Among the various applications leveraging microcombs, soliton microcombs are often preferred due to their inherent mode-locking capability. However, this choice introduces additional system complexity because an initialization process is required. Meanwhile, despite the theoretical understanding of the dynamics of other comb states, their practical potential, particularly in applications like sensing where simplicity is valued, remains largely untapped. Here, we demonstrate controllable generation of sub-combs that bypasses the need for accessing bistable regime. And in a graphene-sensitized microresonator, the sub-comb heterodynes produce stable, accurate microwave signals for high-precision gas detection. By exploring the formation dynamics of sub-combs, we achieved 2 MHz harmonic comb-to-comb beat notes with a signal-to-noise ratio (SNR) greater than 50 dB and phase noise as low as – 82 dBc/Hz at 1 MHz offset. The graphene sensitization on the intracavity probes results in exceptional frequency responsiveness to the adsorption of gas molecules on the graphene of microcavity surface, enabling detect limits down to the parts per billion (ppb) level. This synergy between graphene and sub-comb formation dynamics in a microcavity structure showcases the feasibility of utilizing microcombs in an incoherent state prior to soliton locking. It may mark a significant step toward the development of easy-to-operate, systemically simple, compact, and high-performance photonic sensors.

关键词： Microresonator Optical frequency comb Graphene Gas sensing

Traditional Chinese medicine for the treatment of immune-related nephropathy:A review

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Acta Pharmaceutica Sinica B 2024年第1期14卷 38-66页

作者： Pu Jiang Changliang yao De-an guo School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Immune-related nephropathy(IRN)refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal *** pathogenesis of IRN is not fully understood;therefore,treatment is *** Chinese medicines(TCMs)have potent clinical effects in the treatment of the IRN conditions immunoglobulin A nephropathy,lupus nephropathy,and diabetic *** underlying mechanisms mainly include its inhibition of inflammation;improvements to renal interstitial fibrosis,oxidative stress,autophagy,apoptosis;and regulation of *** this review,we summarize the clinical symptoms of the three IRN subtypes and the use of TCM prescriptions,herbs,and bioactive compounds in treating IRN,as well as the potential mechanisms,intending to provide a reference for the future study of TCM as IRN treatments.

关键词： IgA nephropathy Diabetic nephropathy Lupus nephritis Traditional Chinese medicine Immunity Pathogenesis Mechanism Pathophysiology

Comparative analysis of frictional behavior and mechanism of molybdenum ditelluride with different structures

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Friction 2024年第1期12卷 110-119页

作者： Lina ZHANG Xinfeng tan Jianguo JIAO Dan guo Jianbin LUO State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

Two-dimensional(2D)transition metal dichalcogenides(TMDCs)have layered structures with excellent tribological *** the energy difference between hexagonal-molybdenum ditelluride(2H-MoTe_(2))and distorted octahedral-molybdenum ditelluride(1T′-MoTe_(2))is very small among the transition metal dichalcogenides(TMDCs),MoTe_(2) becomes one of the most promising candidates for phase *** our experiment,we found that the friction force and friction coefficient(COF)of 2H-MoTe_(2) were an order of magnitude smaller than those of 1T′-MoTe_(2) by the atomic force microscope(AFM)*** friction difference between 1T′-MoTe_(2) and 2H-MoTe_(2) was further verified in molecular dynamics(MD)*** density functional theory(DFT)calculations suggest that the friction contrast is related to the difference in sliding energy barrier of the potential energy surface(PES)for a tip sliding across the *** PES obtained from the DFT calculation indicates that the maximum energy barrier and the minimum energy path(MEP)energy barrier of 2H-MoTe_(2) are both smaller than those of 1T′-MoTe_(2),which means that less energy needs to be dissipated during the sliding *** difference in energy barrier of the PES could be ascribed to its larger interlayer spacing and weaker Mo–Te interatomic interactions within the layers of 2H-MoTe_(2) than those of 1T′-MoTe_(2).The obvious friction difference between 1T′-MoTe_(2) and 2H-MoTe_(2) not only provides a new non-destructive means to detect the phase transition by the AFM,but also provides a possibility to tune friction by controlling the phase transition,which has the potential to be applied in extreme environments such as space lubrication.

关键词： friction two-dimensional(2D)materials distorted octahedral-molybdenum ditelluride(1T′-MoTe_(2)) hexagonal-molybdenum ditelluride(2H-MoTe_(2)) phase transition

Three-dimensional morphological and fluorescent imaging of zebrafish with a continuous-rotational light-sheet microscope

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 59-66页

作者： Dongmin Zhang Guang Yang yao tan Chong Chen Jie Zhang Hui Li School of Biomedical Engineering(Suzhou)Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230041 P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese A cademy of Sciences Suzhou Jiangsu 215163P.R.China

Light-sheet fluorescence microscopy(LSFM)has been widely used to image the three-dimensional(3D)structures and functions of various millimeter-size bio-specimen such as ***,the sample adsorption and scattering cause shading of the light-sheet illumination,preventing the even 3D image of thick ***,we report a continuous-rotational light-sheet microscope(CR-LSM)that enables simultaneous 3D bright-field and fluorescence *** a high-accuracy rotational stage,CR-LSM records the outline projections and the fluorescent images of the sample at multiple rotation ***,3D morphology and fluorescent structure were reconstructed with a developed *** CR-LSM,zebrafish’s whole-fish contour and blood vessel structures were obtained simultaneously.

关键词： Light-sheet microscope zebrafish blood vessels morphology

Emergence of machine language: towards symbolic intelligence with neural networks

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National Science Review 2024年第4期11卷 27-30页

作者： Yuqi Wang Xu-yao Zhang Cheng-Lin Liu Tieniu tan Zhaoxiang Zhang State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of Sciences

Representation learning is a core issue in artificial intelligence (AI). Currently,there exists a disparity in the choice of representation between humans and machines. Humans rely on discrete language for communicati...

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Combining reinforcement learning with mathematical programming:An approach for optimal design of heat exchanger networks

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Chinese Journal of Chemical Engineering 2024年第5期69卷 63-71页

作者： Hui tan Xiaodong Hong Zuwei Liao Jingyuan Sun yao Yang Jingdai Wang Yongrong Yang State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China

Heat integration is important for energy-saving in the process *** is linked to the persistently challenging task of optimal design of heat exchanger networks(HEN).Due to the inherent highly nonconvex nonlinear and combinatorial nature of the HEN problem,it is not easy to find solutions of high quality for large-scale *** reinforcement learning(RL)method,which learns strategies through ongoing exploration and exploitation,reveals advantages in such ***,due to the complexity of the HEN design problem,the RL method for HEN should be dedicated and designed.A hybrid strategy combining RL with mathematical programming is proposed to take better advantage of both *** insightful state representation of the HEN structure as well as a customized reward function is introduced.A Q-learning algorithm is applied to update the HEN structure using theε-greedy *** results are obtained from three literature cases of different scales.

关键词： Heat exchanger network Reinforcement learning Mathematical programming Process design