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Journal of Materials Science & Technology 2019年第7期35卷 1508-1514页

作者： Gabor Ribarik Bertalan Joni tamas ungar Department of Materials Physics Edtvos University BudapestPO Box 32H-15J8Hungary School of Materials The University of ManchesterM139PLUK

Line profile analysis of X-ray and neutron diffraction patterns is a powerful tool for determining the microstructure of crystalline materials. The Convolutional-Multiple-Whole-Profile (CMWP) procedure is based on physical profile functions for dislocations, domain size, stacking faults and twin boundaries. Order dependence, strain anisotropy, hkl dependent broadening of planar defects and peak shape are used to separate the effect of different lattice defect types. The Marquardt-Levenberg (ML) numerical optimiza-tion procedure has been used successfully to determine crystal defect types and densities. However, in more complex cases like hexagonal materials or multiple phases the ML procedure alone reveals uncer-tainties. In a new approach the ML and a Monte-Carlo statistical method are combined in an alternative manner. The new CMWP procedure eliminates uncertainties and provides globally optimized parameters.

关键词： X-ray line profile analysis Neutron line profile analysis CMWP Global optimum Dislocation densities Grain size Planar defects Monte-Carlo method

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Short RNAs in Tomato

Journal of Integrative Plant Biology 2010年第4期52卷 388-392页

作者： tamas Dalmay School of Biological Sciences University of East Anglia

Short RNAs are 20-24 nucleotide long non-coding RNA molecules generated by one of the Dicer-like enzymes. They recognize specific RNA or DNA sequences and guide the RNA silencing complex to their targets leading to post-transcriptional or transcriptional gene silencing of the target. Most of our knowledge about short RNAs comes from studying the model species Arabidopsis. Recently, however, several reports emerged about short RNAs in tomato, which is a model plant for fleshy fruit development and ripening. Tomato short RNAs have been sequenced and a database was established. Novel non-conserved microRNAs were found that showed differential expression between fruit and other tissues, even during fruit development, suggesting that they may play a role in fruit formation. Several target genes were predicted and validated for both conserved and non-conserved miRNAs and some of these targets are key players in fruit ripening, such as Colourless non-ripening. The present study reviews the current state of tomato short RNAs research and suggests future directions.

关键词： Short RNAs in Tomato DCL RNA siRNAs

Coupling the 4M crop model with national geo-databases for assessing the effects of climate change on agro-ecological characteristics of Hungary

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International Journal of Digital Earth 2014年第5期7卷 391-410页

作者： Nandor Fodor Laszlo Pasztor tamas Nemeth Institute for Soil Science and Agricultural Chemistry Centre for Agricultural ResearchHungarian Academy of SciencesBudapestHungary Hungarian Academy of Sciences BudapestHungary

The 4M crop model was used to investigate the prospective effects of climate change on the agro-ecological characteristics of *** model was coupled with a detailed meteorological database and spatial soil information systems covering the whole territory of ***-specific model parameters were determined by inverse *** meteorological data were produced from the present meteorological data by combining a climate change scenario and a stochastic weather *** the available and the generated data,the present and the prospective agro-ecological characteristics of Hungary were *** to the simulation results,average yields will decrease considerably(-30%)due to climate *** rate of nitrate leaching will prospectively decrease as *** fluctuations of both the yields and the annual nitrate leaching rates will most likely increase approaching the end of the twenty-first *** the basis of the simulation results,the role of autumn crops is likely to become more significant in *** achieved results can be generalized for more extended regions based on the concept of spatial(geographical)analogy.

关键词： agro-ecological features crop modeling climate change effects spatial soil information systems

Omics Approaches to Identify PotentialBiomarkers of Inflammatory Diseases in the FocalAdhesion Complex

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Genomics, Proteomics & Bioinformatics 2017年第2期15卷 101-109页

作者： Johanne Brooks Alastair Watson tamas Korcsmaros Gut Health and Food Safety Institute Strategic Programme Institute of Food Research Norwich Research Park Norwich NR4 7UA United Kingdom Norwich Medical School University of East Anglia Norwich Research Park Norwich NR4 7T J United Kingdom Gastroenterology Department Norfolk and Norwich University Hospital Norwich NR4 7UY United Kingdom Earlham Institute Norwich Research Park Norwich NR4 7UZ United Kingdom

Inflammatory diseases such as inflammatory bowel disease(IBD) require recurrent invasive tests, including blood tests, radiology, and endoscopic evaluation both to diagnose and assess disease activity, and to determine optimal therapeutic strategies. Simple ‘bedside’ biomarkers could be used in all phases of patient management to avoid unnecessary investigation and guide further management. The focal adhesion complex(FAC) has been implicated in the pathogenesis of multiple inflammatory diseases, including IBD, rheumatoid arthritis, and multiple sclerosis. Utilizing omics technologies has proven to be an efficient approach to identify biomarkers from within the FAC in the field of cancer medicine. Predictive biomarkers are paving the way for the success of precision medicine for cancer patients, but inflammatory diseases have lagged behind in this respect. This review explores the current status of biomarker prediction for inflammatory diseases from within the FAC using omics technologies and highlights the benefits of future potential biomarker identification approaches.

关键词： Focal adhesion complex Biomarkers Inflammation Omics Systems biology

Spatial cage solitons——taming light bullets

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Photonics Research 2022年第1期10卷 148-154页

作者： CHAO MEI IHAR BABUSHKIN tamas NAGY GüNTER STEINMEYER Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy 12489 BerlinGermany School of Computer and Communication Engineering University of Science and Technology Beijing(USTB)Beijing 100083China Institute of Quantum Optics Leibniz University Hannover30167 HannoverGermany Institut für Physik Humboldt Universitat zu Berlin12489 BerlinGermany

Multimode nonlinear optics is used to overcome a long-standing limitation of fiber optics,tightly phase locking several spatial modes and enabling the coherent transport of a wave packet through a multimode fiber.A similar problem is encountered in the temporal compression of multimillijoule pulses to few-cycle duration in hollow gas-filled *** the fiber length to up to 6 m,hollow fibers have recently reached 1 TW of peak *** the remarkable utility of the hollow fiber compressor and its widespread application,however,no analytical model exists to enable insight into the scaling behavior of maximum compressibility and peak *** we extend a recently introduced formalism for describing mode locking to the analog scenario of locking spatial fiber modes *** formalism unveils the coexistence of two soliton branches for anomalous modal dispersion and indicates the formation of stable spatiotemporal light bullets that would be unstable in free space,similar to the temporal cage solitons in mode-locking *** model enables deeper understanding of the physical processes behind the formation of such light bullets and predicts the existence of multimode solitons in a much wider range of fiber types than previously considered possible.

关键词： locking solitons optics

Changing human-environment interactions in medium mountains:the Apuseni Mts(Romania)as a case study

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Journal of Mountain Science 2016年第9期13卷 1675-1687页

作者： TELBISZ tamas IMECS Zoltan MARl Laszlo BOTTLIK Zsolt Department of Physical Geography Eotvos University1117BudapestPazrnany Peter setany 1/CBudapestHungary Department of Geography in Hungarian Babes-Bolyai University400006Cluj-NapocaStr.Clinicilor 5-7Romania Department of Regional Science Eotoos University1117BudapestPazmany Peter setany 1/CBudapestHungary

The study of human-environment relationships in mountain areas is important for both theoretical and practical reasons, as many mountain areas suffer similar problems, such as depopulation, unemployment and natural hazards. Medium mountains constitute a special case within mountains, because they are more populated but less attractive as tourist destinations than high mountains. In this context, the Apuseni Mts （Romania） are considered as a ease study. In this paper, we apply GIS-based, quantitative methods to characterize the strength and dynamics of human-environment interactions, taking into consideration some environmental factors （elevation, relative height, slope, river distance, lithology, land cover, natural attractions） as well as historical population and recent tourism data. We found that population density has strong （r2〉0.8） relationships with all relief factors （elevation, relative height, slope, river distance）, and that best-fit functions are nonlinear. We outlined the varying demographic scenarios by elevation zones and interpreted the historically switching sign of population change versus elevation relationship. We demonstrated that lithology also has an impact on the spatial distribution of population, although it is not independent from the relief effect. The land cover of the mainly cultural landscape is very strongly correlated with relief parameters （especially slope）, which suggests good adaptation. We pointed out the dominance of karst objects in the natural tourism potential of the Apuseni Mts and also explored further components of real tourism （spas, heritage, towns）. Finally, we concluded that the environmental settings investigated do in fact constrain the spatial framework of society, but soeio-economic changes in history can be explained from the side of society, which conforms to the theory of cultural possibilism.

关键词： Human-environment relations ApuseniMountains Geographical information system (GIS) Possibilism Tourism Karst

On Modifications of Continuous and Discrete Maximum Principles for Reaction-Diffusion Problems

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Advances in Applied Mathematics and Mechanics 2011年第1期3卷 109-120页

作者： Istvan Farago Sergey Korotov tamas Szabo Department of Applied Analysis and Computational Mathematics Eotvos Lorand UniversityH–1117BudapestPazmany P.s.1/c.Hungary BCAM-Basque Center for Applied Mathematics Bizkaia Technology ParkBuilding 500E–48160 DerioBasque CountrySpain

In this work,we present and discuss some modifications,in the form of two-sided estimation(and also for arbitrary source functions instead of usual sign-conditions),of continuous and discrete maximum principles for th... 详细信息

关键词： Reaction-diffusion problem maximum principle discrete maximum principle monotone matrix two-sided a priori estimation code validification

Gemcitabine-induced haemolytic uremic syndrome,although infrequent,can it be prevented:A case report and review of literature

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World Journal of Clinical Cases 2018年第12期6卷 531-537页

作者： Esther U Cidon Pilar A Martinez tamas Hickish Department of Medical Oncology Royal Bournemouth and Christchurch Hospital NHS Foundation Trust Department of Oncology Clinical University HospitalValladolid Department of Medical Oncology Royal Bournemouth and Christchurch Hospital NHS Foundation Trust and Bournemouth University

Gemcitabine is an antineoplastic used to treat several malignancies including pancreatic cancer. Its toxicity profile is well known with myelotoxicity, increased vascular permeability and peripheral oedema as most frequent adverse events. However, several cases of acute renal failure have been reported and haemolytic uremic syndrome(HUS) seems to be the underlying process. The cause of HUS remains unknown but its consequences can be lethal. Therefore, a high grade of suspicion is crucial to diagnose it and promptly treat it. This hopefully will reduce its morbidity. HUS is characterized by progressive renal failure associated with microangiopathic haemolytic anaemia and thrombocytopenia. The primary event is damage to endothelial cells and thrombotic microangiopathy(TMA) is the histopathological lesion. TMA affects mainly renal microvasculature. However, some cases evolve with central nervous or cardiovascular systems involvement. We present here a case of gemcitabine-induced HUS, with renal and cardiovascular system affected at the time of diagnosis which to our knowledge this is the first time of such case to be reported.

关键词： Thrombocytopenia Haemolytic uremic syndrome Thrombotic microangiopathy Gemcitabine Microangiopathic haemolytic anaemia

Presepsin teardown- pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis

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World Journal of Gastroenterology 2016年第41期22卷 9172-9185页

作者： Maria Papp tamas Tornai Zsuzsanna Vitalis Istvan Tornai David Tornai tamas Dinya Andrea Sumegi Peter Antal-Szalmas Department of Internal Medicine Division of Gastroenterology University of Debrecen Faculty of Medicine Department of Laboratory Medicine University of Debrecen Faculty of Medicine Debrecen Institute of Surgery University of Debrecen Faculty of Medicine Vascular Biology Thrombosis and Haemostasis Research Group Hungarian Academy of Sciences

AIM To evaluate the diagnostic and prognostic value of presepsin in cirrhosis-associated bacterial infections. METHODS Two hundred and sixteen patients with cirrhosis were enrolled. At admission, the presence of bacterial infections and level of plasma presepsin, serum C-reactive protein(CRP) and procalcitonin(PCT) were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term *** Present 34.7 of patients had bacterial infection. Presepsin levels were significantly higher in patients with infection than without(median, 1002 pg/m L vs 477 pg/m L, P 1206 pg/m L sensitivity, specificity, positive predictive values and negative predictive values were as follows: 87.5%, 74.5%, 61.8% and 92.7%. The accuracy of presepsin, however, decreased in advanced stage of the disease or in the presence of renal failure, most probably because of the significantly elevated presepsin levels in non-infected patients. 28-d mortality rate was higher among patients with > 1277 pg/m L compared to those with ≤ 1277 pg/m L(46.9% vs 11.6%, P < 0.001). In a binary logistic regression analysis, however, only PCT(OR = 1.81, 95%CI: 1.09-3.01, P = 0.022) but neither presepsin nor CRP were independent risk factor for 28-d mortality after adjusting with MELD score and leukocyte *** Presepsin is a valuable new biomarker for defining severe infections in cirrhosis, proving same efficacy as PCT. However, it is not a useful marker of short-term mortality.

关键词： Presepsin Cirrhosis Bacterial infection Organ failure Mortality

Smoking in inflammatory bowel diseases:Good,bad or ugly?

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World Journal of Gastroenterology 2007年第46期13卷 6134-6139页

作者： Peter Laszlo Lakatos tamas Szamosi Laszlo Lakatos Department of Medicine Semmelweis UniversityBudapestHungary Department of Medicine Csolnoky F.County HospitalVeszpremHungary

Smoking is an important environmental factor in inflammatory bowel disease （IBD）, having different effects in ulcerative colitis （UC） and Crohn＇s disease （CD）. A recent meta-analysis partially confirmed previous findings that smoking was found to be protective against ulcerative colitis and, after onset of the disease, might improve its course, decreasing the need for colectomy. However, smoking increases the risk of developing Crohn＇s disease and worsens its course, increasing the need for steroids, immunosuppressants and re-operations. Smoking cessation aggravates ulcerative colitis and improves Crohn＇s disease. Data are however, largely conflictive as well as the potential mechanisms involved in this dual relationship are still unknown. In this review article, the authors review the role of smoking in inflammatory bowel diseases.

关键词： Smoking Crohn's disease Ulcerative colitis Phenotype