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World Journal of Gastroenterology 2017年第29期23卷 5412-5421页

作者： tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp Institute of Internal Medicine Department of Gastroenterology University of Debrecen Faculty of Medicine Department of Laboratory Medicine University of Debrecen Faculty of Medicine Debrecen Inova Diagnostics Inc.San Diego 1^st Department of Pediatrics Semmelweis University 1^st Department of Medicine University of Pecs Gastroenterology Department of Medicine Borsod-Abauj Zemplen County Hospital 1^st Department of Medicine Semmelweis University

To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis (PSC) patients. METHODSSera of 67 PSC patients [median age (range): 32 (5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin (AAA IgA/IgG) and gliadin (AGA IgA/IgG)] and for serum level of intestinal fatty acid-binding protein (I-FABP) by ELISA. Markers of lipopolysaccharide (LPS) exposure [LPS binding protein (LBP)] and various anti-microbial antibodies [anti-OMP Plus IgA and endotoxin core IgA antibody (EndoCAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99 (14-106) mo]. One hundred and fifty-three healthy subjects (HCONT) and 172 ulcerative colitis (UC) patients were the controls. RESULTSA total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA IgA, AAA IgG, AGA IgA and AGA IgG, respectively. Frequencies of AAA IgA and AAA IgG (P AAA IgA posvsneg: 365 vs 166 pg/mL, P = 0.011), but not with serum LBP level. CONCLUSIONPresence of IgA type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various micr

关键词： Primary sclerosing cholangitis Gut barrier dysfunction Intestinal fatty acid-binding protein Anti-F-actin antibody Anti-gliadin antibody

NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients

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World Journal of Gastroenterology 2010年第41期16卷 5233-5240页

作者： Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos Department of Molecular Diagnostics Hun-garian National Blood Transfusion Service H-1113 BudapestHungary 1st Depart-ment of Medicine Semmelweis University H-1083 BudapestHungary IBD Clinicaland Research Centre ISCARE IVF and 1st Medical FacultyCharles University 170 04 Prague Czech Republic 1st Department of Medicine Csolnoky F.County Hospital H8200 Veszprem Hungary 1st Department of Medicine University ofSzeged H6720 Szeged Hungary Department of Biochemistry andLaboratory Diagnostics 1st Medical Faculty Charles Univer-sity 170 04 Prague Czech Republic 2nd Department of Medicine University of Debrecen H4032 Debrecen Hungary 2nd Department of Medicine Semmelweis University H1085 Budapest Hungary

AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations.

关键词： Crohn’s disease Ulcerative colitis NKX2-3 Immunity-related GTPase family M ECM1 Genotype Phenotype Pharmacogenetics

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基于形态特征的芒果树L系统建模及其可视化

系统仿真学报 2008年第S1期20卷 344-347,351页

作者：吴瑞姣陈崇成马亨冰唐丽玉 Janscó tamas 福州大学福建省空间信息工程研究中心空间数据挖掘与信息共享教育部重点实验室福建福州350002 福建省经济信息中心福建福州350003 西匈牙利大学地球信息科学学院

树木是虚拟森林景观的重要要素,也是自然景观可视化中较难建模与表达的要素之一。传统的树木建模方法无法用简单规律描述形态复杂的树木,且生成的树木往往也忽略生物学意义。因此限制了其实用性。针对这些问题提出了一种能较为全面反映... 详细信息

树木是虚拟森林景观的重要要素,也是自然景观可视化中较难建模与表达的要素之一。传统的树木建模方法无法用简单规律描述形态复杂的树木,且生成的树木往往也忽略生物学意义。因此限制了其实用性。针对这些问题提出了一种能较为全面反映生物学形态结构特征的L系统树木建模方法,并以热带水果种类之一的芒果树为模型对该方法进行了初步的设计与实现,结果表明这种方法能生成植物学形态特征的、具有不同树龄的三维逼真芒果树。

关键词： L系统树木建模形态特征三维可视化

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简单的赞礼

建筑实践 2014年第5期 27-29+26页

作者：常号 Szentirmai tamas

流芳传世的建筑作品中,不少都是教堂建筑,世人用憧憬、尊敬的眼神望向为神明构建的房屋,也望向设计的精华。除去那些体型恢弘、结构复杂的地标性建筑,最接近我们身边的祷告处可能就是那些朴素简单的教会,体量不大却功能齐全。来自SAGRA ... 详细信息

流芳传世的建筑作品中,不少都是教堂建筑,世人用憧憬、尊敬的眼神望向为神明构建的房屋,也望向设计的精华。除去那些体型恢弘、结构复杂的地标性建筑,最接近我们身边的祷告处可能就是那些朴素简单的教会,体量不大却功能齐全。来自SAGRA Architects的建筑师们在匈牙利索尔诺克为当地的基督教会修建了一座教堂。这个建筑复合体主要包含了三部分:一座教堂、一座带有牧师工作室的教会场所和一座钟塔。至现在,教会场所和钟塔已经建设完毕,教堂部分因为一些财政问题还待修建。

关键词：索尔诺克场所建筑钟塔教会

新几内亚及邻近地区的管叶苔属(细鳞苔科)研究(英文)

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新几内亚及邻近地区的管叶苔属(细鳞苔科)研究(英文)

2010全国地衣与苔藓系统学研讨会

作者： tamas Pocs Department of Botany Eszterhasy CollegeH-3301Eger Pf.43Hungary

The members of the genus in this area were relatively lately *** the first two species(*** and ***)were published by Schiffner & Stephani(1900)and by Stephani(1916),Jovet-Ast in her excellent monograph added only one ...

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废墟之上的庆典

建筑实践 2014年第11期 24-31页

作者：李莹 tamas Trk

两千年前,罗马人在匈牙利潘诺尼亚省兴建了一座重要城市,取名绍比纳,这就是今天的佩奇城(Pecs)。位于多瑙河和德拉瓦河之间的佩奇是匈牙利最具吸引力的城市之一,拥有华丽的博物馆和保存完好的土耳其遗迹,以音乐、歌剧和芭蕾而闻名,被称... 详细信息

两千年前,罗马人在匈牙利潘诺尼亚省兴建了一座重要城市,取名绍比纳,这就是今天的佩奇城(Pecs)。位于多瑙河和德拉瓦河之间的佩奇是匈牙利最具吸引力的城市之一,拥有华丽的博物馆和保存完好的土耳其遗迹,以音乐、歌剧和芭蕾而闻名,被称为匈牙利的文化首都。现存文艺复兴时期的萨特马利宫殿遗迹(Szatmay Palace)坐落于佩奇东北部Tettye山谷公园里,是匈牙利最有保护价值的古迹之一,深厚的历史肌理与自然景观在此相遇、交融。Tettye山几乎从城市中心绵延升起,站在最高处,城市的壮丽景象一览无遗。

关键词：重新定义匈牙利宫殿遗址景观元素设计师

Newly developed histological tray for the application of identifying exact lymph node dissections in uro-logical surgical oncology

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Health 2013年第10期5卷 1629-1633页

作者： Istvan Buzogany Laszlo Vaczi Zsolt Domjan Fariborz Bagheri Attila Kiss Alex Dakay tamas Ferenc Molnar Department of Urology and Surgery Peterfy Sandor Hospital KRBKBudapestHungary Department of Urology Dubai HospitalDubaiUAE Petz Aladar Hospital MK Department of Thoracic SurgeryGyorHungary Operational Medicine Department University Medical School PecsPecsHugary

In any urologic cancer surgery, lymph node dissection and its processing play a significant role in staging and management of the patients. Accordingly, precise handling of the dissected lymph nodes is important for histopathological work-up. The authors have developed a lymph node plastic tray shaping the abdomen and pelvis in which the dissected lymph nodes are placed in its determined location. This can be applied for any urologic cancer surgery. The research was designed to test the usage of a new histological tray. The objective was to assess how helpful it was for the surgical team and in the pathological process. The newly developed lymph node tray has been applied in 150 urological cancer surgeries and its efficacy and outcome have been evaluated in all these cases by involved doctors and assistants. This new tray simplifies lymph node removing and identification (staging), making it safer and quicker in any uro-oncological surgery. It facilitates the work of the pathologist and the flow of reliable information along the surgeon—pathologist-oncologist team. With usage of the tray, lymph node dissections are more structured by methodical means compared to any of the present methods.

关键词： Lymph Node Dissection Urogenital Surgical Oncology TNM System Safety and Hazards Histological Tray

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复杂性——未来大科学的图景

世界科学 2002年第10期 6-7页

作者： tamas Vicsek ,江泽淳

任何定义不明确的概念都有被滥用的危险。这句话对于复杂性科学来说再恰当不过了。因为这样一个渗透了从物理学到语言学广泛智能领域的内在跨学科概念,却没有系统的基础理论。时下,许多人常爱把“复杂性科学”这个术语挂在嘴边,为的只... 详细信息

任何定义不明确的概念都有被滥用的危险。这句话对于复杂性科学来说再恰当不过了。因为这样一个渗透了从物理学到语言学广泛智能领域的内在跨学科概念,却没有系统的基础理论。时下,许多人常爱把“复杂性科学”这个术语挂在嘴边,为的只是引人注意或筹集资金。一时间,能与复杂系统沾点边的学会和研究网络便如雨后春笋般冒了出来。

关键词：复杂性科学牛顿球体立体几何

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水泥中掺电镀渣对滤液吸收的影响

国外建材译丛 1993年第2期5卷 3-4页

作者： tamas,FD 程绍华