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Synthesis and Structure of bc-Dichloro-af-dihydroxo-de-bis(N-3-pyridinylmethanesulfonamide)platinum(Ⅳ) Diydrate

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Chinese Journal of Structural Chemistry 2012年第10期31卷 1476-1482页

作者： Nicolay I. DODOFF Boris L. SHIVACHEV Rositsa P. NIKOLOVA Maria LALIA-KANTOURI Vesna MILETI tamara I. PAJPANOVA Acad. R. Tsanev Institute of Molecular Biology Bulgarian Academy of Sciences Acad. G. Bonchev Str. Block 21 1113 Sofia Bulgaria Institute of Mineralogy and Crystallography Bulgarian Academy of Sciences Acad. G. Bonchev Str. Block 107 1113 Sofia Bulgaria Department of Chemistry Faculty of Sciences Aristotle University of Thessaloniki P.O. Box 135 54124 Thessaloniki Greece Institute of Chemistry Faculty of Science University of Kragujevac 34000 Kragujevac Serbia

The Pt（IV） complex cis,cis,trans-[Pt（PMSA）2Cl2（OH）2]·2H2O（1）, where PMSA = N-3-pyridinylmethanesulfonamide, has been synthesized and characterized by elemental analysis, molar electric conductivity and IR spectrum. X-ray crystallography revealed that the title compound crystallizes in the monoclinic C2/c space group with unit cell dimensions a = 16.5424（7）, b = 8.6973（3）, c = 16.6079（6） A, β = 117.185（5）° and Z = 4. Pt（IV） has an octahedral coordination geometry and the PMSA ligands are coordinated via the pyridine N atom. They are in a transoid orientation between each other and are inclined in the same direction with respect to the Pt-C1-Cli-N-Ni plane at an angle of 64.6（1）° （symmetry operation：（i） 1- x, y, 3/2-z）. The structure is stabilized by a system of hydrogen bonds involving the complex and water molecules.

关键词： Pt(IV) complex sulfonamide pyridine crystal structure cytostatic

Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease

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Bone Research 2021年第3期9卷 385-395页

作者： Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David Division of Nephrology and Hypertension Department of Medicineand Center for Translational Metabolism and HealthInstitute for Public Health and MedicineNorthwestern University Feinberg School of MedicineChicagoILUSA Nephrology Division Program in Membrane BiologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Division of Nephrology Department of Medicineand Duke Clinical Research InstituteDuke University School of MedicineDurhamNCUSA

Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD *** investigated bone FGF23 regulation by circulating *** 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum ***2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone *** results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in ***2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD.

关键词： FGF23 kidney inflammation

Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight

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Journal of Genetics and Genomics 2016年第7期43卷 421-430页

作者： Bin Qiu Richard L.Bell Yong Cao Lingling Zhang Robert B.Stewart tamara Graves Lawrence Lumeng Weidong Yong Tiebing Liang Institute of Laboratory Animal Science Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China Department of Psychiatry Indiana University School of Medicine Indianapolis IN 46202 USA Department of Gastroenterology Indiana University School of Medicine Indianapolis IN 46202 USA Department of Psychology Purdue School of Science Indiana University-Purdue University of Indianapolis Indianapolis IN 46202 USA Experimental Medicine Center The First Affiliated Hospital of Sichuan Medical University Luzhou 646000 China

Neuropeptide Y（NPY） is widely expressed in the central nervous system and influences many physiological *** is located within the rat quantitative trait locus（QTL） for alcohol preference on chromosome ***-nonpreferring（NP） rats consume very little alcohol,but have significantly higher NPY expression in the brain than alcohol-preferring（P） *** capitalized on this phenotypic difference by creating an Npy knockout（KO） rat using the inbred NP background to evaluate NPY effects on alcohol *** finger nuclease（ZNF） technology was applied,resulting in a 26-bp deletion in the Npy ***-PCR,Western blotting and immunohistochemistry confirmed the absence of Npy mRNA and protein in KO *** consumption was increased in Npy＋/- but not Npy-/- rats,while Npy-/- rats displayed significantly lower body weight when compared to Npy^（＋/＋） *** whole brain tissue,expression levels of Npy-related and other alcohol-associated genes,Npy1 r,Npy2r,Npy5 r,Agrp,Mc3 r,Mc4r,Crh and CrMr,were significantly greater in Npy-/- rats,whereas Pome and Crhr2 expressions were highest in Npy＋/- *** findings suggest that the NPY-system works in close coordination with the melanocortin（MC） and corticotropin-releasing hormone（CRH） systems to modulate alcohol intake and body weight.

关键词： Knockout rat Alcohol drinking behavior NPY and receptors CRH and receptors Melanocortin and receptors BDNF

The role of mitochondria in inflammatory syndromes

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BIOCELL 2016年第1期40卷 47-50页

作者： VIRGINIA VANASCO TIMOTEO MARCHINI NATALIA MAGNANI tamara VICO MARIANA GARCES LOURDES CACERES ALEJANDRO GUAGLIANONE PABLO EVELSON SILVIA ALVAREZ Institute of Biochemistry and Molecular Medicine(IBIMOL UBA-CONICET)School of Pharmacy and BiochemistryUniversity of Buenos AiresJunín 956C1113AAD Buenos AiresArgentina.

Several authors have addressed the importance of mitochondrial function in inflammatory syn-dromes,as it may play a role in the genesis of tissue *** and exposition to environmental particles are examples of inflammatory *** occurs with an exacerbated inflammatory response that damages tissue mitochondria and impairs bioenergetic *** of the current hypotheses for the molecular mech-anisms underlying the complex condition of sepsis is that enhanced NO production and oxidative stress lead to mitochondrial dysfunction,bioenergetic derangement and organ *** mechanism of particulate mat-terhealth effects are believed to involve inflammation and oxidative *** in particles that elicit inflammation have been poorly investigated,although recent research points out to the contribution of composi-tional elements and particle *** metabolism and mitochondrial function appear to be important areas of study in inflammatory conditions for clarifying molecular mechanisms involved.

关键词： mitochondrial function bioenergetics heart endotoxemia ambient air particles

Assessment of palmar subcutaneous tissue vascularization in patients with Dupuytren's contracture

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World Journal of Orthopedics 2018年第9期9卷 130-137页

作者： Nathalia Shchudlo Tatyana Varsegova Tatyana Stupina tamara Dolganova Michael Shchudlo Nathalia Shihaleva Vadim Kostin Clinics and Experimental Laboratory for Reconstructive Microsurgery and Hand Surgery Russian Ilizarov Scientific Center "Restorative Traumatology and Orthopaedics" Laboratory of Morphology of Federal State Budget Institution Russian Ilizarov Scientific Center "Restorative Traumatology and Orthopaedics"

AIM To investigate the structural and functional characte-ristics of palmar hypodermal tissue vascularization in Dupuytren's contracture patients of different *** Eighty-seven Dupuytren's contracture patients underwent partial fasciectomy. Twenty-two of them were less than 55 years old(Y-group, n = 22); the others were 55 and older(O-group, n = 65). In surgically excised representative tissue samples, a histomorphometric analysis of the perforating arteries of the palmar aponeurosis and stereologic analysis of hypodermis vascularity were performed. The method of laser flowmetry estimated the microcirculation of the skin of the *** Frequency of cases with rapid development of contracture(less than 5 years) was 13.6% in the Y-group and 40% in the O-group, P < 0.05. The external and luminal diameters of perforating arteries in palmar fascia were decreased more severely in Y. The thickness of intima increased three times compared with healthy control, and the intima/media relation also increased, especially in O. Increased numerical and volumetric micro-vessel densities in hypodermis, percentage of large vessels(more than 12 μm in diameter), and percentage of vessels with signs of periadventitial inflammatory infiltration were noted in Y. The percentage of vessels with adventitial fibrosis was greater in O than in Y. Base capillary flow in Y was increased compared to healthy control subjects and to O, and peak capillary flow was increased in comparison with *** Compared to the O-group, Y-group patients exhibited more severe constrictive remodeling of palmar fascia perforating arteries supplying hypodermis but more expressed compensatory changes of its capillarization.

关键词： Dupuytren’s contracture Laser Doppler flowmetry Hypodermis Histo-morphometry Palmar fascia

Knowledge and practice of care-givers who have under-five diarrhoeal children:a quantitative cross-sectional study in Mataniko settlements in Honiara, Solomon Islands, 2016

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Global Health Journal 2017年第2期1卷 12-22页

作者： Ambrose Gali Keshwa N.Krishna Sabiha Khan John Lowry tamara Mangum Masoud Mohammadnezhad Research Unit Department of Health PromotionMinistry of HealthP.O.Box 349HoniaraSolomon Islands Department of Environmental and Epidemiology Fiji National UniversityPrincess RoadTamavuaSuvaFiji Islands School of People Environment and PlanningMassey UniversityPalmerston NorthNew Zealand Department of Public Health Fiji National UniversityPrincess RoadTamavuaSuvaFiji Islands

Introduction:Diarrhoea remains the second most serious health problem among children below five years old in Solomon Islands and is one of the leading causes of infant mortality,which caused about one in every ten children dying before the age of five ***,around 6 million children (＜5 years) suffer from diarrhoea each *** of lack of previous studies,this study aims to assess the predictors of knowledge and practice of caregivers towards diarrhoea among under-five children in Mataniko informal settlements in Honiara,Solomon Islands,***:This quantitative study was conducted at three randomly selected settlements in Honiara,Solomon Islands from June to July *** study was conducted among both male and female caregivers who had children under five years of age,were aged 18 and over,live in Solomon Islands and were willing to participate in the study.A validated structured questionnaire was used to collect the data based on a 2-week recall of diarrhoea *** avoid double-counting,each surveyed household was geo-referenced using global positioning system (GPS).The collected data were entered and analysed using SPSS (version 23.0) and descriptive and analytical statistics.P＜0.05 was considered as statistically *** study was approved by relevant ethical ***:A total of 205 caregivers with at least one child under-five years participated in the *** mean ages of caregivers and the under-five children were (30.7+8.2) years and (2.6+1.5) years,*** 205 caregivers,94 of them had reported that their children (＜5 years) had suffered with at least one episode of diarrhoea within the last 2 weeks prior to the *** gave a prevalence rate of 45.9％.The caregiver's knowledge about the causes (99.0％) and prevention (98.0％) of under-five diarrhoea was extremely ***,less than half had regularly practiced essential hygiene *** factors which appeared to be significantly associat

关键词： diarrhoea knowledge and practice under-five children Solomon Islands

Energy Balance Data from Lactating Dairy Goats Offered Total Mixed Diets

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Open Journal of Animal Sciences 2019年第4期9卷 385-400页

作者： Carlos Fernández tamara Romero Departamento de Ciencia Animal Universitat Politècnica de València Valencia Spain

The objective of the study was to develop a univariate model for analyzing energy balance data from lactating goats at mid lactation and determine maintenance requirements and partial efficiencies of energy utilization. Energy balance data from eight studies involving lactating Murciano-Granadina goats fed total mixed diets, which accounted for a variation in metabolizable energy (MEI) intake, milk energy output (EI), and tissue energy balance, were used. The database included records obtained by indirect calorimetry. Data were adjusted with a mixed model that included the study as a random effect. Then, two multivariate linear models were obtained: metabolizable and net energy models. The metabolizable model was MEI=β0+β2E1+β3Tg+β4T1+ε and the net energy model was E1=β0+β1MEI+β2Tg+β3T1+ε;where β0, β1, β2 and β3 were the parameters, Tg was tissue energy retention and Tl the milk energy derived from body stores. For a better fitted proposed model, net energy for maintenance (NEm) was 283 kJ/kg of Body Weight 0.75 (BW) per day, and the efficiency of utilization of ME for lactation (k1), body weight gain (kg) and body tissue mobilization for milk production (kt) were 62%, 83% and 78%, respectively. Maintenance requirements and partial efficiencies for milk production and tissue energy mobilization were similar to the values proposed by INRA (2018). The increase in the efficiency of utilizing dietary energy for gain, compared with other feeding systems, was partially attributed to the stage of lactation, due to that goats were feeding at mid lactation.

关键词： Energy Efficiency Mixed Diets Mixed Model Lactating Goats

Geographical Patterns of Cultural Values, Entrepreneurship and Economic Development

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Journal of Earth Science and Engineering 2015年第4期5卷 262-269页

作者： Riste Temjanovski tamara Jovanov Marjanova Faculty of Economics GoceDelcev University Stip 2000 Republic of Macedonia

Globalization and information technologies are new realities that have brought profound changes in lifestyles worldwide. This is reshaping the overall pattern of life custom, cultural production, consumption and trade in a world increasingly filled with changes and economic diversity. In an age of globalization, often ask questions and discussions concerning about successes and vitalities of nations. Globalization and technological revolutions race ahead and transform the world, and how to traces the real business to success. There are thousands of good examples where any nations have shown entrepreneurial talents and have succeeded. It is culture that principally explains, in many cases, or geographical pattern where some countries are developing more rapidly and more successfully than others. How to explain economic success of this nation＇s miracles or simple the secret is creative entrepreneurships？ This paper explores the complex interactions between the geographic pattern from one side and cultural, technological and social aspects of entrepreneurship from other side which generates the dynamic processes of the world economy. In this era of transformation, creativity and knowledge entrepreneurship are powerful tools of fostering economic progress and development.

关键词： Geographical pattern culture entrepreneurship economic activity and development.

Blood coagulation factors and platelet response to drug-induced hepatitis and hepatosis in rats

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Animal Models and Experimental Medicine 2023年第1期6卷 66-73页

作者： Daria Korolova Viktoriya Gryshchenko tamara Chernyshenko Oleh Platonov Olha Hornytska Volodymyr Chernyshenko Pavlo Klymenko Yevdokiia Reshetnik Tetyana Platonova Department of Structure and function of proteins Palladin Institute of Biochemistry of NAS of UkraineKyivUkraine National University of Life and Environmental Sciences of Ukraine KyivUkraine SI“D.F.Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine ”KyivUkraine Taras Shevchenko National University of Kyiv KyivUkraine

Background:Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side *** aim of the present work was to compare the changes in the main components of hemostasis under experimental drug-induced hepatosis and hepatitis in ***:We modeled diclofenac-induced hepatitis and tetracycline-induced *** response was gauged by measuring fibrinogen,factor X,protein C(PC),and prothrombin in *** decarboxylated form of prothrombin was de-tected by measuring prothrombin index and ecamulin *** reactivity was studied using ***:Both hepatitis and hepatosis decreased the synthesis of fibrinogen,factor X,and ***,protein carboxylation was not disrupted in hepatosis but was much impaired in *** decreased in both models as a consequence of its consumption possibly during inflammatory *** aggregation rate was lower in hepatosis but higher in ***:Our findings imply the need for a thorough monitoring of the hemostasis system in liver diseases to avoid possible thrombotic *** state indicates the disorder's rate and character.

关键词： hemostasis hepatitis hepatosis platelets prothrombin