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Sex differences in the risk of retinopathy of prematurity:a systematic review,frequentist and Bayesian meta‑analysis,and meta‑regression

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World Journal of Pediatrics 2024年第4期20卷 340-352页

作者： tamara m.hundscheid Silvia Gulden mohamad F.Almutairi František Bartoš Giacomo Cavallaro Eduardo Villamor Division of Neonatology Department of PediatricsMosaKids Children’s HospitalMaastricht University Medical Center(MUMC+)School for Oncology and Reproduction(GROW)Maastricht UniversityP.Debyelaan 25.P.O.Box 58006202 AZ MaastrichtThe Netherlands Neonatal Intensive Care Unit Sant’Anna HospitalComoItaly Department of Psychology University of Amsterdam1001 NK AmsterdamThe Netherlands Neonatal Intensive Care Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly

Background Retinopathy of prematurity(ROP)is generally considered to be more frequent in males than in ***,it is not known whether sex differences in ROP affect all degrees of the condition,are global and have changed as neonatology has *** aimed to conduct a systematic review and meta-analysis of studies addressing sex differences in the risk of developing *** Pubmed/mEDLINE and Embase databases were *** frequentist,random-effects risk ratio(RR)and 95%confidence interval(CI)were *** model averaged(BmA)meta-analysis was used to calculate the Bayes factors(BFs).The BF10 is the ratio of the probability of the data under the alternative hypothesis(H1)over the probability of the data under the null hypothesis(H0).Results We included 205 studies(867,252 infants).Frequentist meta-analysis showed a positive association between male sex and severe ROP(113 studies,RR=1.14,95%CI=1.07–1.22)but no association with any ROP(144 studies,RR=1.00,95%CI=0.96–1.03).BmA showed extreme evidence in favor of H1 for severe ROP(BF10=71,174)and strong evidence in favor of H0 for any ROP(BF10=0.05).The association between male sex and severe ROP remained stable over time and was present only in cohorts from countries with a high or high-middle sociodemographic *** Our study confirms the presence of a male disadvantage in severe ROP but not in less severe forms of the *** are variations in the sex differences in ROP,depending on geographical location and sociodemographic level of the countries.

关键词： Oxidative stress Retinopathy of prematurity Sex characteristics

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New insights into the regulation of cholesterol eft from the sperm membrane

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Asian Journal of Andrology 2015年第4期17卷 561-567页

作者： tamara Leahy Bart m Gadella Faculty of Veterinary Science University of Sydney 2006 Sydney Australia Department of Farm Animal Health and of Biochemistry and Cell Biology Faculty ofVeterinary Medicine Utrecht University Yalelaan 2 3584 CM Utrecht The Netherlands.

Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly controlled at multiple levels. It has been clearly shown that cholesterol redistribution and depletion from the sperm membrane is a key part of the spermatozoon＇s preparation for fertilization. Some factors that regulate these events are described （e.g., bicarbonate, calcium） but the mechanisms underlying cholesterol export are poorly understood. How does a hydrophobic cholesterol molecule inserted in the sperm plasma membrane enter the energetically unfavorable aqueous surroundings？ This review will provide an overview of knowledge in this area and highlight our gaps in understanding. The overall aim is to better understand cholesterol redistribution in the sperm plasma membrane, its relation to the possible activation of a cholesterol transporter and the role of cholesterol acceptors. Armed with such knowledlze, sl）erm handlin~ techniques can be adapted to better prepare spermatozoa for in vitro and in vivo fertilization.

关键词： ATP binding cassette transporters albumin high-density lipoprotein lipid rafts membrane fluidity membranemicrodomains membrane packing oxysterols reverse cholesterol transport sterol transporters

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Stop flow lithography synthesis of non-spherical metal oxide particles

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Particuology 2014年第3期12卷 91-97页

作者： David Baah Tobias Donnell Julaunica Tigner tamara Floyd-Smith materials Science & Engineering Department Tuskegee UniversityTuskegeeAL 36088USA Chemical Engineering Department Tuskegee UniversityTuskegeeAL 36088USA

Non-spherical micron and hand-sized particles and their composites have become essential in select application areas of optics, wear resistance, personnel protection, chemical mechanical polishing, and biomedicine. In this paper, the synthesis of composite and ceramic non-spherical particles using stop flow lithography is reported. Precursor suspensions of poly（ethylene glycol） diacrylate, 2-hydroxy- 2-methylpropiophenone and SiO2 or Al2O3 are prepared. The precursor suspension flows through a microfluidic device mounted on an upright microscope and is polymerized in an automated process. A photomask patterned with transparent geometric features, which define the cross-sectional shapes of the particles, masks the UV light to synthesize micron sized particles. Particles with axial dimensions ranging from 35 to 167μm were synthesized. Control of device channel depth and objective lens magnification enables the manipulation of the particle size. Composite particles in triangular, square, pentagonal, hexagonal, and circular cross sections were synthesized. Subsequently, the transformation of the composite particles into the corresponding metal oxide particles was achieved through polymer burn-offand sintering.

关键词： microfluidics Stop flow lithography Electron microscopy

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Ad libitum water consumption prevents exercise-associated hyponatremia and protects against dehydration in soldiers performing a 40-km route-march

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military medical Research 2019年第3期6卷 201-207页

作者： Heinrich WNolte Kim Nolte tamara Hew-Butler movement Physiology Research Laboratory School of PhysiologyFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Division Biokinetics and Sport Science Department of PhysiologyUniversity of PretoriaPretoriaSouth Africa Division of Kinesiology Wayne State UniversityDetroitMIUSA.

Background: It remains unclear if ad libitum water drinking, as a hydration strategy, prevents exercise-associated hyponatremia(EAH) during prolonged exercise. The aim of this study was to determine the incidence of EAH within the broader context of fluid regulation among soldiers performing a 40-km route-march ingesting water ad ***: Twenty-eight healthy male soldiers participated in this observational trial. Pre-and post-exercise body mass, blood and urine samples were collected. Blood samples were assessed for serum sodium([Na+]), glucose, creatinine, urea nitrogen(BUN), plasma osmolality, creatine kinase(CK), and plasma arginine vasopressin(AVP) concentrations. Plasma volume(PV) was calculated using hematocrit and hemoglobin. Urine samples were analyzed for osmolality and (Na+)Water intake was assessed by weighing bottles before, during and after the march. The mean relative humidity was 55.7%(21.9–94.3%) and the mean dry bulb temperature was 27.1°C(19.5°C-37.0°C) during the ***: Twenty-five soldiers(72±10 kg)(mean±SD) completed the march in 09:11±00:43(hr:min). Participants consumed 736±259 ml/h of water and lost 2.8±0.9 kg(4.0%±1.4%, Pmass. Significant(pre-march vs. post-march;Pm [Na+](141 mmol/L vs. 136 mmol/L), plasma osmolality(303 m Osmol/kg H2O vs. 298 m Osmol/kg H2O), and serum creatinine(111 μmol/L vs. 101 μmol/L) and urine [Na+](168 mmol/L vs. 142 mmol/L), as well as significant increases in plasma AVP(2 pg/ml vs. 11 pg/ml), plasma CK(1423 U/L vs. 3894 U/L) and urine osmolality(1035 m Osmol/kg H2O vs. 1097 m Osmol/kg H2O) were found. The soldier(72 kg) with the lowest postexercise sodium level completed the march in 08:38. He drank 800 ml/h, lost 2% body mass, and demonstrated(prepost) increases in plasma osmolality(294–314 m Osmol/kg H2O), BUN(20–30 mg/dl), AVP(2–16 pg/ml) and PV(41%). His urine osmolality decreased from 1114 m Osmol/kg H2O to 1110 m Osmol/kg H2O. No participants finished

关键词： Serum sodium concentration Exercise-associated hyponatremia Arginine vasopressin Fluid balance Electrolyte balance military

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Does playing a sports active video game improve object control skills of children with autism spectrum disorder?

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Journal of Sport and Health Science 2017年第1期6卷 17-24,127页

作者： Jacqueline Edwards Sarah Jeffrey tamara may Nicole J.Rinehart Lisa m.Barnett School of Health and Social Development Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Department of Paediatrics Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneParkvilleVIC 3052Australia School of Psychology Faculty of HealthDeakin UniversityGeelongVIC 3125Australia murdoch Childrens Research Institute ParkvilleVIC 3052Australia

Background: Active video games(AVGs) encourage whole body movements to interact or control the gaming system, allowing the opportunity for skill development. Children with autism spectrum disorder(ASD) show decreased fundamental movement skills in comparison with their typically developing(TD) peers and might benefit from this approach. This pilot study investigates whether playing sports AVGs can increase the actual and perceived object control(OC) skills of 11 children with ASD aged 6–10 years in comparison to 19 TD children of a similar *** was a secondary ***: Actual(Test of Gross motor Development) and perceived OC skills(Pictorial Scale of Perceived movement Skill Competence for Young Children) were assessed before and after the intervention(6 × 45 min).Results: Actual skill scores were not improved in either group. The ASD group improved in perceived skill. All children completed the required dose and parents reported the intervention was ***: The use of AVGs as a play-based intervention may not provide enough opportunity for children to perform the correct movement patterns to influence skill. However, play of such games may influence perceptions of skill ability in children with ASD, which could improve motivation to participate in physical activities.

关键词： Autism spectrum disorder Child Exergaming Fundamental movement skills Physical self-perception Xbox

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Biomass responses to intraspecific competition differ between wild species and CO_(2)

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Journal of Plant Ecology 2008年第1期1卷 25-32页

作者： Xianzhong Wang Angela R.Ngigi Daniel L.Smith tamara m.mcPeek Department of Biology Indiana University–Purdue University Indianapolis723 WestMichigan StreetIndianapolisIN 46202USA Department of Biological Sciences Butler University4600 Sunset AvenueIndianapolisIN 46208USA

Aims How growth of wild and crop species responds to global environmental perturbations has both ecological and agricultural significance in a changing *** primary aim of this synthesis was to quantitatively assess the interactive effects of intraspecific competition and elevated CO_(2) on biomass production in herbaceous *** Using meta-analytical techniques,we synthesized data from publications before 2006 that reported biomass responses to elevated CO_(2) in 321 herbaceous species grown in isolation or in competition with con-specific *** findings Intraspecific competition differentially modified biomass responses to elevated CO_(2) in wild and crop *** example,competition reduced CO_(2) stimulation of total biomass(WT)from 27 to 23%in wild species,but by a much greater magnitude,i.e.,from 43 to 32%in *** had no effect on responses of either above-(WAG)or below-ground(WBG)biomass to elevated CO_(2) in wild species,but significantly diminished CO_(2) enhancement of WAG,although not of WBG,in *** variations were found among functional groups in the modification of growth responses to elevated CO_(2) by intraspecific competition,which exerted greater depression on CO_(2) enhancement in C3 than in C4 species and in non-legumes than in *** CO_(2) affected leaf and stem growth of individually grown C3 graminoids and forbs similarly,but increased leaf growth only in C4 graminoids and stem growth only in C4 *** from this synthesis demonstrated that intraspecific competition differentially affected growth responses to elevated CO_(2) in wild and crop *** wildcrop species differences will have important implications for understanding primary production by herbaceous species in both natural and agricultural ecosystems in the future when atmospheric CO_(2) is significantly higher than the current level.

关键词： biomass production CO_(2)enrichment functional groups meta-analysis

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minimum invasive associating liver partition and portal vein ligation for staged hepatectomy

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Laparoscopic, Endoscopic and Robotic Surgery 2020年第1期3卷 1-5页

作者： michal Kawka tamara m.H.Gall Long R.Jiao Hepato-pancreato-biliary Surgical Unit Department of Surgery&CancerImperial CollegeHammersmith Hospital CampusLondonW120HSUnited Kingdom

Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has gained interest,as the potential alternative to portal vein embolisation for inducing future liver remnant hypertrophy in patients at risk of post-hepatectomy liver failure but is associated with high morbidity and *** a result,several variant ALPPS have been reported to reduce ALPPS related morbidity and *** is able to induce more extensive hypertrophy in a shorter time-period than portal vein ***-invasive surgery,which has known benefits with regards to morbidity and mortality,has also been applied to ALPPS,with promising results regarding safety and feasibility and patient *** suggests that both laparoscopic and robot-assisted ALPPS present technically feasible and safe options for ***-invasive ALPPS offers a clear benefit to patients,including reduction of fibrous adhesions,shorter length of hospital stay,and lower ***,the technical difficulty of the procedure still limits its wide application,even to experienced hepato-pancreato-biliary centres.

关键词： ALPPS Robotic hepatectomy Laparoscopic hepatectomy Staged liver resection

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U–Pb LA-ICP-mS geochronology of polygenetic zircons from Beshta and Kamenistaya intrusions(the Greater Caucasus)

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Acta Geochimica 2022年第6期41卷 1019-1029页

作者： David Shengelia Leonid Shumlyanskyy Giorgi Chichinadze tamara Tsutsunava Giorgi Beridze Irakli Javakhishvili Al.Janelidze Institute of Geology of Iv.Javakhishvili Tbilisi State University TbilisiGeorgia School of Earth and Planetary Sciences Curtin UniversityPerthAustralia m.P.Semenenko Institute of Geochemistry Mineralogy and Ore FormationKyivUkraine

The Beshta-Kamenistaya intrusions are located in the main Range structural zone of the Greater *** are composed of tonalitic gneisses that genetically resemble granites of the tholeiitic series of the ophiolitic *** Beshta-Kamenistaya orthogneisses and associated rocks of the nappes differ markedly from those of the main Range *** of them were overthrust to the main Range zone during the Bretonian *** age of their protolith and the metamorphism are still not *** the zircon U-Pb LA-ICP-mS dating two age populations of zircons have been distinguished in the rocks of the Beshta-Kamenistaya *** age of the main population of zircons from orthogneisses is 426-300 *** age groups can be distinguished in this *** main group yielded a Concordia age of386.9±1.4 *** are also smaller peaks at 409-405,375-373,and 351 *** oldest ages(426-395 ma)were detected in the core parts of the complex *** assume that the crystallization of the parental for orthogneisses rocks(tonalities)took place at 410-395 ma,whereas the Concordia age of 386.9±1.4 ma and a peak at 375-373 ma correspond to the metamorphic *** whole metamorphic cycle,including progressive and regressive stages,occurred between 395 and 370 ***,dated in the Beshta-Kamenistaya intrusion at350 ma and younger,correspond to the Late Variscan *** dated 3102-2769 ma represent xenocrysts captured by the melts during their formation from the ancient rocks in the crystalline basement.

关键词： The Greater Caucasus magmatism metamorphism Orthogneisses U–Pb zircon dating

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Ready to migrate?Reading cellular signs of migration in an epithelial to mesenchymal transition model

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BIOCELL 2022年第11期46卷 2353-2356页

作者： tamara FERNÁNDEZ-CALERO IGNACIO LÓPEZ mARCOS DAVYT CORA CHALAR RICARDO EHRLICH mÓNICA mARÍN Biochemistry-molecular Biology Faculty of ScienceUniversidad de la RepúblicaMontevideo11400Uruguay Bioinformatics Unit Institut Pasteur de MontevideoMontevideo11400Uruguay Departamento de Ciencias Exactas y Naturales Universidad Católica del UruguayMontevideo11600Uruguay Institut Pasteur de montevideo Montevideo11400Uruguay

The epithelial to mesenchymal transition(EmT)is a cellular program that drives de-differentiation of cells in both physiological and pathological *** of the characteristics of cells describing an EmT is the(re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the *** molecular mechanisms that control the EmT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EmT includes adjustments of the translation machinery and metabolic pathways to cope with a high demand of extracellular components.

关键词： EmT migration Translation machinery metabolism

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A framework for considering ecological interactions for common non-timber forest product species:a case study of mountain date palm(Phoenix loureiroi Kunth)leaf harvest in South India

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Ecological Processes 2013年第1期2卷 212-220页

作者： Lisa mandle tamara Ticktin Snehlata Nath Siddappa Setty Anita Varg Botany Department University of Hawai'i at MānoaMānoaHawai'iUSA Ecology Evolution and Conservation Biology ProgramUniversity of Hawai'i at MānoaMānoaHawai'iUSA Keystone Foundation KotagiriTamil NaduIndia Ashoka Trust for Research in Ecology and the Environment BangaloreKarnatakaIndia Natural Capital Project Woods Institute for the EnvironmentStanford UniversityStanfordCAUSA.

Introduction:many economically important non-timber forest products(NTFPs)come from widespread and common plant *** of these species often is assumed to be sustainable due to their ***,because of the ecological roles of common species,harvest may affect and be affected by ecological interactions at broader scales,which are rarely considered when evaluating the sustainability of *** use a case study of the mountain date palm(Phoenix loureiroi Kunth),harvested in South India to produce brooms,to present a conceptual framework illustrating how intensive harvest of a common species interacts with other anthropogenic management practices,plant-animal interactions and surrounding environmental ***:We apply this framework to understanding the impacts of mountain date palm harvest in the southern Western Ghats regions of the Indian states of Tamil Nadu and *** integrate data on the extent and levels of commercial harvest,local management practices,the ecological context in which harvest occurs,and research on harvest *** use this information to document the intensity and extent of mountain date palm harvest in the study area,identify the ecological implications of harvest,and demonstrate how a framework that considers harvest in the context of ecological communities and ecosystems is important for assessing the impacts of harvest of common NTFP ***:We show that mountain date palm leaves are heavily harvested from natural areas in the southern Western Ghats but that harvest levels have declined in recent *** date palm management and harvest occur within a network of ecological interactions,linking human activities to population-,community-,and ecosystem-level *** demonstrate that understanding the effects of return interval of anthropogenic fire,herbivory by wild animals and livestock,as well as the light environment in which harvest occurs are critical to assessing the sustainab

关键词： Non-timber forest product(NTFP) Western Ghats Savanna woodland Resource management Plant-animal interactions Fire Herbivory

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