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Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium:Integration of herbal medicine,enzyme engineering,and nanotechnology

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Journal of Pharmaceutical Analysis 2023年第3期13卷 239-254页

作者： Yi Lu Qiulan Luo Xiaobin Jia James P.tam Huan Yang Yuping Shen Xin Li School of Pharmacy Jiangsu UniversityZhenjiangJiangsu212013China College of Fashion&Design Jiaxing Nanhu UniversityJiaxingZhejiang314001China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing211198China School of Biological Sciences Nanyang Technological University637551SingaporeSingapore DWI-Leibniz-Institute for Interactive Materials e.V. 52056AachenGermany Institute for Technical and Macromolecular Chemistry RWTH Aachen University52074AachenGermany

Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii Folium(EF)and possess excellent therapeutic effects on various ***,in 2022,icaritin soft capsules were approved to reach the market for the treatment of hepatocellular carcinoma(HCC)by National Medical Products Administration(NMPA)of ***,recent studies demonstrate that icaritin can serve as immune-modulating agent to exert anti-tumor ***,both production efficiency and clinical applications of epimedium flavonoids have been restrained because of their low content,poor bioavailability,and unfavorable in vivo delivery ***,various strategies,including enzyme engineering and nanotechnology,have been developed to increase productivity and activity,improve delivery efficiency,and enhance therapeutic effects of epimedium *** this review,the structure-activity relationship of epimedium flavonoids is ***,enzymatic engineering strategies for increasing the productivity of highly active baohuoside I and icaritin are *** nanomedicines for overcoming in vivo delivery barriers and improving therapeutic effects of various diseases are ***,the challenges and an outlook on clinical translation of epimedium flavonoids are proposed.

关键词： Flavonoids Enzymatic hydrolysis Nanomedicine Therapeutic effects Clinical translation Epimedii Folium

Lie Algebras Associated with Group U(n)

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Communications in Theoretical Physics 2007年第8期48卷 215-226页

作者： Honwah tam Department of Computer Science Hong Kong Baptist UniversityHong KongChina

Starting from the subgroups of the group U（n）,the corresponding Lie algebras of the Lie algebra A;arepresented,from which two well-known simple equivalent matrix Lie algebras are *** follows that a few expandingLie algebras are obtained by enlarging *** of them can be devoted to producing double integrable couplingsof the soliton hierarchies of nonlinear evolution *** can be used to generate integrable oouplings involvingmore potential *** above Lie algebras are classified into two *** one type can generate the integrablecouplings,whose Hamiltonian structure could be obtained by use of the quadratic-form *** addition,onecondition on searching for integrable couplings is improved such that more useful Lie algebras are enlightened to *** two explicit examples are shown to illustrate the applications of the Lie ***,with the help of closedcycling operation relations,another way of producing higher-dimensional Lie algebras is given.

关键词： Lie algebra group integrable couplings

Optimization Agricultural Supply Chain:A Case Study of Fertilizer Supplier Selection

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Computers, Materials & Continua 2022年第8期72卷 4057-4068页

作者： Nguyen Van Thanh Nguyen Thi Kim Lan Syed tam Husain Nguyen Hoang Hai Nguyen Viet Tinh Faculty of Commerce Van Lang UniversityHo Chi Minh CityVietnam International Education Institute Van Lang UniversityHo Chi Minh CityVietnam

The 21st century is associated with the IndustrialRevolution 4.0 and the organic agriculture trend,making the utilization of high-quality fertilizers,abundant nutritional content,economical,and no affect to environment *** to the new concept,clean agricultural production and organic agricultural products are not allowed to excessively use synthetic chemicals such as chemical fertilizers,and plant protection drugs,but priority is to use manure,organic fertilizers,and natural mineral *** must meet the balanced nutritional requirements of crops,maintain,and improve the fertility of the ground,protect the surrounding ecosystem,and leave harmful effects in agricultural products,products with high quality,safe for users and high economic efficiency for *** achieve the above goal,the selection of a fertilizer supplier is an important decision,supporting the supply chain’s sustainable development,fertilizer supplier selection is a multicriteria decision making model,the decision maker must assess all qualitative and quantitative *** this paper,the author proposed an integer decision making model including Fuzzy Analytic Hierarchy Process(FAHP)and Complex Proportional Assessment of Alternatives(COPRAS)for fertilizer supplier *** weightings of the criteria are calculated by using FAHP,COPRAS is then applied for ranking some potential fertilizer *** efficiency of the proposed models is proved by a case study conducted in a farm located in the south of *** research is the first fertilizer supplier evaluation and se-lection model in Vietnam by interviewing experts and reviewing the ***-search result is to provide a case study on evaluating supplier in agricultural supply chain utilizing the model proposed by the combination of FAHP and COPRAS models.

关键词： Fertilizer industry optimization model fuzzy theory agricultural supply chain

Myo-inositol versus metformin effects on clinical features, endocrine and metabolic profiles in infertile women with polycystic ovary syndrome: A randomized controlled trial

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Asian pacific Journal of Reproduction 2023年第6期12卷 256-265页

作者： Nguyen Sa Viet Le Minh tam Le Thanh Ngoc Cao Center for OBGYN Hue Central Hospital16 Le Loi StreetHueVietnam Center for Reproductive Endocrinology and Infertility Hue University of Medicine and PharmacyHue University06 Ngo Quyen StreetHueVietnam

Objective:To compare the effectiveness of inositol and metformin on the clinical characteristics,and endocrine and metabolic profiles of infertile polycystic ovarian syndrome(PCOS)women from ***:From June 2018 to August 2022,a randomized trial was undertaken at the Hue Center for Endocrinology and Reproduction on infertile women aged 18 to 40 years with polycystic ovarian *** clinical,endocrine,and metabolic features of these individuals were assessed before and after 3 months of treatment with 2 g of inositol or 1700 mg of metformin per *** pregnancy rates,adverse effects,and tolerance of inositol were ***:The study included 171 infertile PCOS women who were eligible to participate and took part in the baseline assessment,of whom 132 women participated in data analysis after 3 *** metformin treatment,42.1%of women with oligomenorrhea experienced regular *** significantly lowered body mass index(BMI),waist circumference and testosterone levels,but had no effect on other clinical characteristics,endocrine profiles,or metabolic profiles.29.2%Of women reported experiencing side effects.21%Of them attained pregnancy,which resulted in 17.1%of live *** the inositol group,the rate of regular cycle increased by 18.2%and the total testosterone concentration significantly *** overweight/obese women with PCOS,inositol significantly decreased weight,BMI,waist and hip circumferences(P<0.05).100%Of women tolerated inositol and continued treatment.18.9%Of them became pregnant,leading to 17%of live ***:Metformin and inositol can improve weight and waist circumference in overweight/obese infertile women with *** is associated with a higher rate of regular menstruation,whereas inositol is associated with a lower rate of adverse *** spontaneous conception,clinical pregnancy,and live birth rates between two groups are comparable.

关键词： Polycystic ovarian syndrome Inositol Metformin Endocrine Metabolic Menstrual cycle Pregnancy

Robust,Breathable and Flexible Smart Textiles as Multifunctional Sensor and Heater for Personal Health Management

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Advanced Fiber Materials 2023年第1期5卷 282-295页

作者： Dewen Xu Zhaofeng Ouyang Yanjuan Dong Hou‑Yong Yu Shuang Zheng Shenghong Li Kam Chiu tam Key Laboratory of Intelligent Textile and Flexible Interconnection of Zhejiang Province Zhejiang Sci-Tech UniversityXiasha Higher Education Park Avenue 2 No.928Hangzhou 310018China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemical Engineering Waterloo Institute for NanotechnologyUniversity of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada

Smart textiles with high sensitivity and rapid response for various external stimuli have gained tremendous attentions in human healthcare monitoring,personal heat management,and wearable ***,the current smart textiles only acquire desired signal passively,regularly lacking subsequent on-demand therapy ***,a robust,breathable,and flexible smart textiles as multi-function sensor and wearable heater for human health monitoring and gentle thermotherapy in real time is *** composite fiber as strain sensor(CFY@PU)was fabricated via warping carbon fiber yarns(CFY)onto polyurethane fibers(PU),which endowed composite fiber with high conductivity,excellent sensitivity(GF=76.2),and fantastic dynamic durability(7500 cycles)in strain *** addition,CFY@PU can detect various degrees of human movements such as elbow bending,swallowing and pulse,which can provide effective information for disease *** surprisingly,weaving CFY@PU into a fabric can assemble highly sensitive pressure sensor for remote communication and information *** CFY onto Kevlar would obtain temperature-sensitive composite fiber(CFY@Kevlar)as temperature sensor and wearable heater for on-demand thermotherapy,which provided unique opportunities in designing smart textiles with ultrahigh sensitivity,rapid response,and great dynamic durability.

关键词： Smart textiles Carbon fiber yarns Multifunctional sensor Personal heat management Wearable electronics

Association between the Phenotypes and Genotypes of Antimicrobial Resistance in Haemophilus parasuis Isolates from Swine in Quang Binh and Thua Thien Hue Provinces, Vietnam

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Engineering 2020年第1期6卷 40-48页

作者： Chao Nguyen Van Lijun Zhang tam Vu Thi Thanh hung Pham Hoang Son Tuan Tran Ngoc Qi Huang Rui Zhou State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China Faculty of Animal Science and Veterinary Medicine University of Agricultural and ForestryHue UniversityHue 53000Vietnam Mientrung Institute for Scientific Research Vietnam Academy of Science and TechnologyHue 53000Vietnam Guangdong Provincial Key Laboratory of Marine Biology Shantou UniversityShantou 515063China Cooperative Innovation Center of Sustainable Pig Production Wuhan 430070China International Research Center for Animal Diseases The Ministry of Science and TechnologyWuhan 430070China

Haemophilus parasuis (H. parasuis) is one of the bacterial pathogens of great concern as it causes huge economic losses to the swine industry worldwide. One of the reasons why the control of H. parasuis has failed is the increase in antimicrobial resistance (AMR). The country of Vietnam has the second-largest pig production in Asia. However, there is still a lack of data about the AMR prevalence of H. parasuis in *** purpose of this study is to investigate the prevalence of AMR and analyze the association between AMR and AMR genes (ARGs). The H. parasuis strains used in this research were isolated from swine in the Quang Binh and Thua Thien Hue Provinces, Central Vietnam, as reported in our previous study. All of the strains were tested for AMR against 25 antibacterial agents using the broth microdilution method and for the presence of ARGs using the polymerase chain reaction (PCR) method. The tested strains were shown to have a high frequency of resistance to trimethoprim/sulfamethoxazole (94.6%), followed by resistance to colistin, chloramphenicol, gentamicin, penicillin, lincomycin, and amoxicillin. The most prevalent ARGs in these strains were blaTEM-1 (94.6%), int (76.8%), gyrA (58.9%), and rmtD (50.0%). Cefuroxime, chloramphenicol, and tobramycin resistances were strongly correlated with the presence of the ARGs blaROB-1 (odds ratio (OR) = 26.3, 95% confidence interval (CI) 2.7–255.7, p = 0.002), catl (OR = 25.1, 95% CI 2.4–258.9, p = 0.004), and strB (OR = 23.5, 95% CI 2.6–212.6, p = 0.001), *** study reveals for the first time the current situation of H. parasuis AMR in Central Vietnam, which is helpful for the clinical control of this disease, as well as for the development of policies and clinical practice guidelines to reduce AMR in swine production in Central Vietnam.

关键词： Haemophilus parasuis Antimicrobial resistance Antimicrobial resistance gene Vietnam

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Flexible,anti-damage,and non-contact sensing electronic skin implanted with MWCNT to block public pathogens contact infection

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Nano Research 2022年第3期15卷 2616-2625页

作者： Duan-Chao Wang Hou-Yong Yu Lurong Jiang Dongming Qi Xinxing Zhang Lumin Chen Wentao Lv Weiqiang Xu Kam Chiu tam National Engineering Lab for Textile Fiber Materials&Processing Technology College of Textile Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China College of Information Science and Technology Zhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan University Chengdu 610065China Department of Chemical Engineering Waterloo Institute for NanotechnologyUniversity of Waterloo200 University Avenue WestWaterlooOntario N2L 3G1Canada

If a person comes into contact with pathogens on public facilities,there is a threat of contact(skin/wound)*** urgently,there are also reports about COVID-19 coronavirus contact infection,which once again reminds that contact infection is a very easily overlooked disease exposure ***,we propose an innovative implantation strategy to fabricate a multi-walled carbon nanotube/polyvinyl alcohol(MWCNT/PVA,MCP)interpenetrating interface to achieve flexibility,anti-damage,and non-contact sensing electronic skin(E-skin).Interestingly,the MCP E-skin had a fascinating non-contact sensing function,which can respond to the finger approaching 0−20 mm through the spatial weak *** non-contact sensing can be applied urgently to human–machine interactions in public facilities to block *** scratches of the fruit knife did not damage the MCP E-skin,and can resist chemical corrosion after hydrophobic *** addition,the MCP E-skin was developed to real-time monitor the respiratory and cough for exercise detection and disease ***,the MCP E-skin has great potential for emergency applications in times of infectious disease pandemics.

关键词： prevent contact infection anti-damage sensors non-contact sensing respiratory sensing human–machine interaction

Tinnitus characteristics and associated variables on Tinnitus Handicap Inventory among a hungarian population

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Journal of Otology 2022年第3期17卷 136-139页

作者： Panayiota Mavrogeni Stefani Maihoub László tamás András Molnár Tóth Ilona Health Service Clinical Medical Institute Gorgey Artúr tér 8.H-1212BudapestHungary Department of Otolaryngology and Head and Neck Surgery Semmelweis UniversitySzigony u.36H-1083BudapestHungary

Background:Tinnitus is a sound precepted without an external sound *** background can be categorised into primary and secondary *** secondary cases include pathologies of the external,middle and inner *** can be objective or subjective;the latter can only identified by the *** research results have shown that tinnitus significantly affects the quality of life and daily ***:To analyse the impact of tinnitus on the daily functioning and the possible influence of demographical data and tinnitus duration on ***:630 patients(265 males and 365 females,25e85 years of age)suffering from primary tinnitus were *** the hungarian language,these patients completed the Tinnitus Handicap Inventory(THI)questionnaire and underwent a complete otorhinolaryngological *** SPSS V24 software was used for data processing;correlation tests,the Mann-Whitney U and Kruskal-Wallis nonparametric tests were ***:According to the THI questionnaires outcomes,most patients(62.5%)were presented with a mild *** on statistical analysis,no significant correlation was observed between the total THI points and the age of the patients,along with the duration and localisation of the ***,the total THI scores of male and female patients significantly differed,indicating higher THI values in the female group(p=0.00052*).Conclusions:The tinnitus severity was not affected by the duration,localisation of the symptoms and age but by gender,indicating higher values in the case of females.

关键词： Tinnitus Tinnitus handicap inventory Tinnitus characteristics Daily functioning hungarian population

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Transcanal endoscopic assisted skull base endolymphatic sac tumor resection: A rare disease with advanced technology

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Journal of Otology 2020年第1期15卷 1-5页

作者： Wai Tsz Chang Ka Yue tam hung Yao Kwan Ho Chow Michael Chi Fai Tong Department of Otorhinolaryngology Head and Neck Surgerythe Chinese University of Hong KongHong Kong Department of Pathology Princess Margaret HospitalHong Kong Department of Neurosurgery Princess Margaret HospitalHong Kong

Endolymphatic sac tumors(ELSTs) are rare, papillary adenomatous tumors that arise from the endothelium of the endolymphatic sac. We demonstrate a difficult case of endolymphatic sac tumor and how it is managed via transcanal endoscopic assisted technique, with discussion of feasibility of transcanal approach to lateral skull base tumor.

关键词： Endolymphatic sac Lateral skull base Transcanal endoscopic assisted technique Transcanal combined endoscopic microscopic approach

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