检索结果-南通市图书馆

Silymarin-laden PVP-PEG polymeric composite for enhanced aqueous solubility and dissolution rate: Preparation and in vitro characterization

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2019年第1期9卷 34-39页

作者： Abid Mehmood Yousaf Usman Rashid Malik Yasser Shahzad Tariq Mahmood talib hussain Department of Pharmacy COMSATS University IslamabadLahore Campus Faculty of Pharmacy University of Central Punjab

The aim of this work was to develop, optimize and characterize a silymarin-laden polyvinylpyrrolidone(PVP)-polyethylene glycol(PEG) polymeric composite to resolve low aqueous solubility and dissolution rate problem of the drug. A number of silymarin-laden polymeric formulations were fabricated with different quantities of PVP K-30 and PEG 6000 by the solvent-evaporation method. The effect of PVP K-30 and PEG 6000 on the aqueous solubility and dissolution rate was investigated. The optimized formulation and its constituents were characterized using powder X-ray diffraction(PXRD), differential scanning calorimetry(DSC), scanning electron microscopy(SEM) and Fourier transform infrared spectroscopy(FTIR) techniques. Both the PEG 6000 and PVP K-30 positively affected the aqueous solubility and dissolution rate of the drug. In particular, a formulation consisting of silymarin, PVP K-30 and PEG 6000(0.25/1.5/1.5, w/w/w) furnished the highest solubility(24.3972.95 mg/mL) and an excellent dissolution profile( $100% in 40 min). The solubility enhancement with this formulation was $ 1150-fold as compared to plain silymarin powder. Moreover, all the constituents existed in the amorphous state in this silymarin-laden PVP-PEG polymeric composite. Accordingly, this formulation might be a promising tool to administer silymarin with an enhanced effect via the oral route.

关键词： Silymarin Hydrophilic polymers Inclusion Solid dispersion Aqueous solubility Dissolution rate

Improving the Efficiency of Water Splitting and Oxygen Reduction Via Single-Atom Anchoring on Graphyne Support

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第5期7卷 272-282页

作者： Shamraiz hussain talib Beenish Bashir Muhammad Ajmal Khan Babar Ali Sharmarke Mohamed Ahsanulhaq Qurashi Jun Li Advanced Materials Chemistry Center(AMCC) Khalifa University of Science and TechnologyAbu Dhabi P.O.Box 127788UAE Department of Chemistry Khalifa University of Science and TechnologyAbu Dhabi P.O.Box 127788UAE Department of Chemistry and Biochemistry George Mason University4400 University DriveFairfaxVirginia 22030USA Interdisciplinary Research Center for Refining and Advanced Chemicals King Fahd University of Petroleum&MineralsDhahran 31261Saudi Arabia Department of Chemistry and Engineering Research Center of Advanced Rare-Earth Materials of Ministry of Education Tsinghua UniversityBeijing 100084China Department of Chemistry and Guangdong Provincial Key Laboratory of Catalytic Chemistry Southern University of Science and TechnologyShenzhen 518055China

Single-atom catalysts(SACs)have received significant interest for optimizing metal atom utilization and superior catalytic performance in hydrogen evolution reaction(HER),oxygen evolution reaction(OER),and oxygen reduction reaction(ORR).In this study,we investigate a range of single-transition metal(STM_(1)=Sc_(1),Ti_(1),V_(1),Cr_(1),Mn_(1),Fe_(1),Co_(1),Ni_(1),Cu_(1),Zr_(1),Nb_(1),Mo_(1),Ru_(1),Rh_(1),Pd_(1),Ag_(1),W_(1),Re_(1),Os_(1),Ir_(1),Pt_(1),and Au_(1))atoms supported on graphyne(GY)surface for HER/OER and ORR using first-principle *** initio molecular dynamics(AIMD)simulations and phonon dispersion spectra reveal the dynamic and thermal stabilities of the GY *** exceptional stability of all supported STM_(1)atoms within the H1 cavity of the GY surface exists in an isolated form,facilitating the uniform distribution and proper arrangement of single atoms on *** particular,Sc_(1),Co_(1),Fe_(1),and Au_(1)/GY demonstrate promising catalytic efficiency in the HER due to idealisticΔG_(H^(*))values via the Volmer-Heyrovsky ***,Sc_(1)and Au_(1)/GY exhibit superior HER catalytic activity compared to other studied ***_(1)/GY catalyst exhibits higher selectivity and activity for the OER,with an overpotential(0.46 V)comparable to MoC_(2),IrO_(2),and RuO_(2).Also,Rh_(1)and Co_(1)/GY SACs exhibited promising electrocatalysts for the ORR,with an overpotential of 0.36 and0.46 V,***,Co_(1)/GY is a versatile electrocatalyst for metal-air batteries and *** study further incorporates computational analysis of the kinetic potential energy barriers of Co_(1)and Rh_(1)in the OER and ORR.A strong correlation is found between the estimated kinetic activation barriers for the thermodynamic outcomes and all proton-coupled electron transfer *** establish a relation for the Gibbs free energy of intermediates to understand the mechanism of SACs supported on STM,/GY and introduce a key *** stu

关键词： Oxygen Reduction Reaction Graphyne Support Hydrogen Evolution Reaction Oxygen Evolution Reaction Single-Atom Catalyst Water Splitting

Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl_4-induced hepatocellular carcinoma in Wistar rats

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 623-629页

作者： talib hussain Hefazat H Siddiqui Sheeba Fareed M Vijayakumar Chandana V Rao Department of Pharmacology and Toxicology Faculty of PharmacyIntegral Universitykursi roadLucknow-226026Uttar PradeshIndia Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute(CSIR)Rana Pratap MargP.B.No.436Lucknow 226 001Uttar PradeshIndia

Objective:To investigation the chemopreventive potential of Fumaria indica（***） extract（FIE） on N-nitrosodiethylamine and CCl4-induced hepatocarcinogenesis in Wislar ***:The experimental animals were divided into six groups（n=6）.Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine（NDEA） in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl4（3 mL/kg/week） for 6 weeks,as the promoter of carcinogenic *** administration of the carcinogen,200 and 400 mg/kg of FIE were administered orally once a day throughout the *** the end of 20 weeks,the body weight,liver weight and relative liver weight were *** percentage of nodule incidence and liver cancer markers such as aspartate transaminase（AST）,alanine transaminase（ALT）,alkaline phosphatase（ALP）,γ-glutamyl transferase（γ-GT）,total bilirubin level（TBL）,α-feto protein（AFP） and carcinoembryonic antigen were estimated along with histopathological investigation in experimental groups of rats. Results:Obtained results demonstrated that the cotreatment with FIE significantly prevented the decrease of the body weight and also increased in relative liver weight caused by NDEA. The treatment with FIE significantly reduced the nodule incidence and nodule multiplicity in the rats after NDEA *** levels of liver cancer markers such as AST,ALT,ALP,γ-glutamyl transferase,TBL,AFP and carcinoembryonic antigen were substantially increased by NDEA ***,FIE treatment significantly reduced the liver injury and restored the entire liver cancer *** observations of liver tissues too correlated with the biochemical ***:These finding powerfully supports that *** exert chemopreventive effect by suppressing the tumor burden and restoring the activities of hepatic cancer marker enzymes on NDEA and CCl4-induced hepatocarcinogenesis in Wis

关键词： Fumaria indica Hepatocellular carcinoma N-nitrosodiethylamine Alkaline phosphatase α-feto protein

CO oxidation on MXene(Mo_(2)CS_(2)) supported single-atom catalyst: A termolecular Eley-Rideal mechanism

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第2期34卷 519-528页

作者： Shamraiz hussain talib Zhansheng Lu Beenish Bashir Sajjad hussain Khalil Ahmad Salahuddin Khan Sajjad Haider Zongxian Yang Kersti Hermansson Jun Li School of Physics Henan Normal UniversityXinxiang 453007China Department of Chemistry and Key Laboratory of Organic Optoelectronics&Molecular Engineering of Ministry of Education Tsinghua UniversityBeijing 100084China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Chemistry Minhaj UniversityLahore 54000Pakistan Department of Chemistry Mirpur University of Science and Technology(MUST)MirpurAJK 10250Pakistan College of Engineering King Saud UniversityPO Box 800Riyadh 11421Saudi Arabia Chemical Engineering Department College of EngineeringKing Saud UniversityPO Box 800Riyadh 11421Saudi Arabia Department of Chemistry-Ångström Uppsala UniversityBox 538Uppsala 75121Sweden Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Finding transition metal catalysts for effective catalytic conversion of CO to CO_(2)has attracted much *** as a new 2D layered material of early transition metal carbides,nitrides,and carbo-nitrides is a robust support for achoring metal *** this study,the electronic structure,geometries,thermodynamic stability,and catalytic activity of MXene (Mo_(2)CS_(2)) supported single noble metal atoms (NM=Ru,Rh,Pd,Ir,Pt and Au) have been systematically examined using first-principles calculations and ab initio molecular dynamic (AIMD) ***,AIMD simulations and phonon spectra demonstrate the dynamic and thermal stabilities of Mo_(2)CS_(2)*** likely reaction pathways,LangmuirHinshelwood (LH),Eley-Rideal (ER),and Termolecular Eley–Rideal (TER) for CO oxidation on the Ru1-and Ir_(1)@Mo_(2)CS_(2)SACs,have been studied in *** is found that CO oxidation mainly proceeds via the TER mechanism under mild reaction *** corresponding rate-determining steps are the dissociation of the intermediate (OCO-Ru_(1)-OCO) and formation of OCO-Ir_(1)-OCO *** downshift d-band center of Ru1-and Ir_(1)@Mo_(2)CS_(2)help to enhance activity and improve catalytst ***,a microkinetic study predicts a maximum CO oxidation rate of 4.01×10^(2)s^(-1)and 4.15×10^(3)s^(-1)(298.15K) following the TER pathway for the Ru_(1)-and Ir_(1)@Mo_(2)CS_(2)catalysts,*** work provides guideline for fabricating and designing highly efficient SACs with superb catalyts using MXene materials.

关键词： CO oxidation Quantum chemical study 2D MXene monolayer M1@Mo_(2)CS_(2) Termolecular Eley–Rideal Single-atom catalysis

Intercalation assisted liquid phase production of disulfide zirconium nanosheets for efficient electrocatalytic dinitrogen reduction to ammonia

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2023年第4期8卷 1174-1184页

作者： Yangshuo Li Huiyong Wang Bing Chang Yingying Guo Zhiyong Li Shamraiz hussain talib Zhansheng Lu Jianji Wang Henan Key Laboratory of Green Chemistry Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007China School of Environment Henan Key Laboratory for Environmental Pollution ControlKey Laboratory for Yellow River and Huai River Water Environment and Pollution ControlMinistry of EducationHenan Normal UniversityXinxiangHenan453007China School of Physics Henan Normal UniversityXinxiangHenan453007China

Disulfide zirconium(ZrS_(2)) is a two-dimensional(2D) transition metal disulfide and has given rise to extensive attention because of its distinctive electronic structure and ***,mass production of high quality of ZrS_(2)nanosheets to realize their practical application remains a ***,we have successfully exfoliated the bulk ZrS_(2)powder with the thickness of micron into single and few-layer nanosheets through liquid-phase exfoliation in N-methylpyrrolidone(NMP) assisted via aliphatic amines as *** is found that the exfoliation yield is as high as 27.3%,which is the record value for the exfoliation of ZrS_(2)nanosheets from bulk ZrS_(2)powder,and 77.1% of ZrS_(2)nanosheets are 2-3 *** molecular geometric size and aliphatic amine basicity have important impact on the ***,the ZrS_(2)nanosheets have been used as catalyst in the electrocatalytic dinitrogen reduction with the NH3yield of 57.75 μg h^(-1)mg_(cat.)^(-1),which is twice that by ZrS_(2)nanofibers reported in literature and three times that by the bulk ZrS_(2)***,the liquid phase exfoliation strategy reported here has great potential in mass production of ZrS_(2)nanosheets for high activity electrocatalysis.

关键词： Disulfide zirconium Liquid-phase exfoliation Aliphatic amines Electrocatalytic dinitrogen reduction Ammonia

Effects of drug-polymer dispersions on solubility and in vitro diffusion of artemisinin across a polydimethylsiloxane membrane

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2012年第14期57卷 1685-1692页

作者： SHAHZAD Yasser SHAH Syed Nisar hussain ANSARI Muhammad Tayyab RIAZ Romana SAFDAR Aasma hussain talib MALIK Madeeha Faculty of Pharmacy Bahauddin Zakariya University Division of Pharmacy and Pharmaceutical Sciences School of Applied SciencesUniversity of Huddersfield Hamdard Institute of Pharmaceutical Sciences Hamdard University

Artemisinin(ART) is a sesquiterpene lactone with an endo-peroxide bridge that is thought to be responsible for its antimalarial *** has low oral bioavailability because of aqueous insolubility,which leads to local toxicity at the site of *** present work focused on increasing its solubility and evaluating its permeation across a model membrane to mimic transdermal delivery that bypasses the hepatic *** this purpose,physical mixtures(PM),solid dispersions(SD) and lyophilized dispersions(LD) with different drug-polymer ratios(1:0.5,1:1,1:2,1:4 and 1:9) were prepared using the hydrophilic polymer polyvinylpyrrolidone(PVP).Drug-polymer dispersions were characterized using X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FTIR).Solubility was measured in three solvents:de-ionized water,phosphate buffered saline(PBS) and *** toluene-water partition coefficient was evaluated and compared with the literature and calculated logP *** vitro diffusion of ART was studied across a polydimethylsiloxane membrane from a saturated solution of drug-polymer *** patterns showed a gradual decrease in crystallinity of ART with increasing polymer concentration,while FTIR confirmed no interactions between ART and *** was increased up to 4-,5-and 8-fold for LD in water,PBS and methanol,*** logP for toluene-water was 2.65 ± 0.3,which is in good agreement with literature and calculated logP *** was enhanced,which is attributed to the decrease in crystallinity and increase in wettability of the *** ART flux was significantly higher than that of pure ART(0.12 ± 0.01) with increasing PVP concentration for SD and LD *** conclusion,drug-polymer dispersions with PVP improve the pharmaceutical properties of ART in the order LD>SD>PM.

关键词：聚合物分散体溶解度测定聚硅氧烷外扩散青蒿素药物傅里叶变换红外光谱水性高分子

Nephroprotective activity of Solanum xanthocarpum fruit extract against gentamicin-induced nephrotoxicity and renal dysfunction in experimental rodents

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 686-691页

作者： talib hussain Ramesh K Gupta K Sweety Bavani Eswaran M Vijayakumar Chandana Venkateswara Rao Pharmacognosy and Ethnopharmacology Division National Botanical Research InstituteLucknowUttar Pradesh226001India Department of Pharmacology and Toxicology Faculty of PharmacyIntegral UniversityLucknowUttar Pradesh226001India

Objective:To evaluate nephroprotective potential of Solarium xanthocarpum(***) fruit extract(SXE) against gentamicin(GM) induced nephrotoxicity) and renal dysfunction. Methods:Twenty-four Wistar rats were divided into four groups(n=6).Control rats that received normal saline(i.p.) and 0.5%carboxymethyl cellulose(p.o.) per day lor 8 *** was induced in rats by intraperitoneal administration of GM(100 mg/kg/d for 8 d) and were treated with SXE(200 and 400 mg/kg/d(p.o.) for 8 d).Plasma and urine urea and creatinine,kidney weight,urine output,blood urea nitrogen,renal enzymatic and non-enzymatic antioxidants and lipid peroxidation was evaluated along with histopathological investigation in various experimental groupsof ***:It was observed that the GM treatment induced significant elevation(P<0.001) in plasma and urine urea,creatinine,kidney weight,blood urea nitrogen, renal lipid peroxidation along with significant decrement(P<0.001) in urine output,renal enzymatic and non-enzymatic *** 200 and 400 mg/kg treatment to GM treated rats recorded significant decrement(up to P<0.001) in plasma and mine urea and creatinine, renal lipid peroxidation along with significanl increment(up to P<0.001) in renal enzymatic and non-enzvmatic *** obsenatioiis of kidney tissues too correlated with the biochemical ***:These finding powerfully supports that S,xanthocarpum fruit extract acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GM both in the biochemical and histopathological parameters and thus validates its elhnomedicinal use.

关键词： Solanum xanthocarpum Gentamicin Antioxidants Nephrotoxicity Renal dysfunction

Non-noble metal single-atom catalysts with phosphotungstic acid(PTA)support:A theoretical study of ethylene epoxidation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Materials 2020年第6期63卷 1003-1014页

作者： Shamraiz hussain talib Xiaohu Yu Qi Yu Sambath Baskaran Jun Li Department of Chemistry and Key Laboratory of Organic Optoelectronics&Molecular Engineering of Ministry of Education Tsinghua UniversityBeijing 100084China Shaanxi Key Laboratory of Catalysis and School of Chemical&Environment Sciences Shaanxi University of TechnologyHanzhong 723000China School of Materials Science and Engineering and Institute of Graphene at Shaanxi Key Laboratory of Catalysis Shaanxi University of TechnologyHanzhong 723001China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Geometric and electronic structures of phosphotungstic acid(PTA)supported single transition metal atom(Fe,Co,Ni,Ru,Rh,Pd,Os,Ir and Pt)catalysts have been systematically investigated by using the first-principles theoretical *** reaction mechanism for ethylene epoxidation was *** most possible anchoring site for the single transition metal atom is the fourfold hollow site on *** the non-noble metal Fe1-PTA system possesses considerable adsorption energies towards both O2 and C2H4,the strong bonding interaction between Fe1 and PTA cluster was *** is found that the electron transfers from Fe atom to PTA cluster and strong covalent metal-support interactions(CMSI)between the Fe 3 d orbitals and O 2 p orbitals of PTA lay the foundation of high *** proposed catalytic reaction mechanism for ethylene epoxidation on Fe1-PTA single-atom catalyst(SAC)includes three steps:the O2 adsorbs on Fe1-PTA via electron transfer;the first ethylene attacks the adsorbed O2 molecule on Fe1-PTA followed by the formation of C2H4O;finally,the O atom remained on Fe1-PTA reacts with a second ethylene to form the product and accomplish the catalytic *** Fe1-PTA has high selectivity and catalytic activity for ethylene epoxidation via an Eley–Rideal mechanism with low energy barriers.A potentially competitive pathway for the formation of acetaldehyde is not kinetically *** results provide insights for the development of highly efficient heterogeneous SACs for ethylene epoxidation with non-noble metals.

关键词： single-atom catalyst non-noble metal phosphotungstic acid ethylene epoxidation computational modeling

Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 454-460页

作者： talib hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj hussain Md Arif Arshad hussain Md Faiyazuddin Chandana Venkateswara Rao Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute Department of Pharmacology and Toxicology Faculty of Pharmacy Integral University Department of Pharmacology Royal College of Pharmacy and Health Sciences Department of Biotechnology Integral University

Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental ***:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological ***:The results demonstrated that treatment ***(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells ***:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use.

关键词： Solanum xanthocarpum Rifampicin Isoniazid Pyrazinamide Antioxidant Antihepatotoxicity Hepatoprotective effect Antitubercular drug Liver toxicity Liver injury Biochemical parameter Histopathology