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Ultra-processed food targets bone quality via endochondral ossification

Bone Research 2021年第2期9卷 200-212页

作者： Janna Zaretsky Shelley Griess-Fishheimer Adi Carmi Tamara Travinsky Shmul Lior Ofer tali sinai Svetlana Penn Ron Shahar Efrat Monsonego-Ornan School of Nutrition Science Institute of BiochemistryFood Science and NutritionThe Hebrew UniversityRehovot 76100Israel Koret School of Veterinary Medicine The Robert H.Smith Faculty of AgricultureFoodand EnvironmentThe Hebrew UniversityRehovot 76100Israel

Ultra-processed foods have known negative implications for health;however,their effect on skeletal development has never been ***,we show that young rats fed ultra-processed food rich in fat and sugar suffer from growth retardation due to lesions in their tibial growth *** bone mineral density decreases significantly,and the structural parameters of the bone deteriorate,presenting a sieve-like appearance in the cortices and poor trabecular parameters in long bones and *** results in inferior mechanical performance of the entire bone with a high fracture *** sequence analysis of the growth plates demonstrated an imbalance in extracellular matrix formation and degradation and impairment of proliferation,differentiation and mineralization *** findings highlight,for the first time,the severe impact of consuming ultra-processed foods on the growing *** pathology extends far beyond that explained by the known metabolic effects,highlighting bone as a new target for studies of modern diets.

关键词： consuming sugar skeleton

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Peripheral maternal leukocytes are activated in response to cytokines secreted by uterine tissues of pregnant women

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Cellular & Molecular Immunology 2017年第7期14卷 635-638页

作者： tali Farine Stephen Lye Oksana Shynlova Lunenfeld-Tanenbaum Research Institute Mount Sinai HospitalTorontoOntario M5G 1X5Canada Department of Physiology University of TorontoTorontoOntario M5S 1A1Canada Department of Obstetrics&Gynecology University of TorontoOntarioM5S 1A1Canada

The infiltration of leukocytes into uterine tissue is an essential step in *** phenomenon,described as physiologic sterile inflammation,has been demonstrated over the past decade through the observation of multiple leukocyte subpopulations(monocytes,granulocytes and lymphocytes)migrating into various reproductive tissues such as the cervix.

关键词： uterine inflammation cytokines

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