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Exploring the role of natural bioactive molecules in genitourinary cancers:how far has research progressed?

Natural Products and Bioprospecting 2023年第1期13卷 302-320页

作者： Fahadul Islam Nikhil Nath Mehrukh Zehravi Jishan Khan Sumiya Ben-Ta Jashim Manoj Shrawan Charde Rita Dadarao Chakole K.Praveen Kumar AKishore Babu Firzan Nainu Sharuk LKhan Safia Obaidur Rab talha Bin Emran Polrat Wilairatana Department of Pharmacy Faculty of Allied Health SciencesDaffodil International UniversityDhaka 1207Bangladesh Department of Pharmacy International Islamic University ChittagongKumiraChittagong 4318Bangladesh Department of Clinical Pharmacy College of Dentistry&PharmacyBuraydah Private CollegesBuraydah 51418Kingdom of Saudi Arabia Government College of Pharmacy VidyanagarKaradSatara 415124MaharashtraIndia Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesGovt.of NCT of DelhiDelhi Pharmaceutical Sciences and Research University(DPSRU)Mehrauli-Badarpur RoadPushpViharSector 3New Delhi 110017India Ratnadeep College of Pharmacy RatnapurJamkhedAhmednagar 413206MaharashtraIndia Department of Pharmacy Faculty of PharmacyHasanuddin UniversityMakassar 90245Indonesia Department of Pharmaceutical Chemistry N.B.S.Institute of PharmacyAusa 413520MaharashtraIndia Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia Department of Pathology and Laboratory Medicine Warren Alpert Medical School&Legorreta Cancer CenterBrown UniversityProvidenceRI 02912USA Department of Clinical Tropical Medicine Faculty of Tropical MedicineMahidol UniversityBangkok 10400Thailand

The primary approaches to treat cancerous diseases include drug treatment,surgical procedures,biotherapy,and radiation *** has been the primary treatment for cancer for a long time,but its main drawback is that it kills cancerous cells along with healthy ones,leading to deadly adverse health ***,genitourinary cancer has become a concern in recent years as it is more common in middle-aged ***,researchers are trying to find possible therapeutic options from natural small molecules due to the many drawbacks associated with chemotherapy and other radiation-based *** of research was conducted regarding genitourinary cancer to determine the promising role of natural small ***,this review focused on natural small molecules along with their potential therapeutic targets in the case of genitourinary cancers such as prostate cancer,renal cancer,bladder cancer,testicular cancer,and so ***,this review states some ongoing or completed clinical evidence in this regard.

关键词： Genitourinary cancers Apoptosis Urinary tract Chemotherapy Polyphenols

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巴哈利亚绿洲土壤水分与物理性质间的关系

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世界沙漠研究 1989年第3期 35-39页

作者： talha.,M 康国定

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Epidemiology of Okra Yellow Vein Mosaic Virus (OYVMV) and Its Management through Tracer, Mycotal and Imidacloprid

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American Journal of Plant Sciences 2012年第12期3卷 1741-1745页

作者： Muhammad Irfan Ali Muhammad Aslam Khan Abdul Rashid Muhammad Ehetisham-ul-haq Muhammad talha Javed Muhammad Sajid Department of Plant Pathology University of Agriculture Faisalabad Pakistan

Field trials were conducted to evaluate the epidemiological factors of okra yellow vein mosaic virus (OYVMV). Four varieties of okra were subjected to screening and evaluation of the chemicals. The variety Saloni F1 was highly resistant while Subz Pari was moderately resistant. Diksha was the tolerant variety while Lush Green was moderately susceptible. The chemical Imidacloprid was most effective to control whitefly population and okra yellow vein mosaic virus (OYVMV). Correlation of environmental factors (maximum and minimum temperature, relative humidity and rainfall) with percent plant infection of okra yellow vein mosaic virus (OYVMV) was also determined. There was a significant correlation between environment and disease severity.

关键词： Epidemiology Imidacloprid Okra (Abelmoschus esculentus L. Moench) Okra Yellow Vein Mosaic Virus (OYVMV) and Whitefly

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Evaluating the Intercropping of Millet with Cowpea for Forage Yield and Quality

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American Journal of Plant Sciences 2018年第9期9卷 1781-1793页

作者： Naveed Islam Muhammad Shahid Ibni Zamir Shan Mohi Ud Din Umer Farooq Haseeb Arshad Aqib Bilal Muhammad talha Sajjad Department of Agronomy University of Agriculture Faisalabad Pakistan Department of Botany University of Agriculture Faisalabad Pakistan

A field study was scheduled to estimate the impact of intercropping of pearl millet with cowpea on forage yield and quality at Agronomy Research Farm, University of Agriculture, Faisalabad. It was done in kharif season 2016. Randomized complete block design was used to conduct this experiment. It has three replications. The size of net plot is 3.6 m × 6 m. It comprised of five treatments (T1 = one row of millet alternating with one row of cowpea (1M:1C), T2 = two rows of millet alternating with one row of cowpea (2M:1C), T3 = one row of millet alternating with two rows of cowpea (1M:2C), T4 = sole millet, T5 = sole cowpea). We found that intercropping significantly effected the yield and quality of forage. Intercropping system had significant effects on nutritive value of forage crop. Within various treatments of intercropping, it is evident that treatment T2 (two rows of millet alternating with one row of cowpea) gives maximum total dry matter yield (9.68 t ha-1). It was then tracked by treatment T1 (one row of millet alternating with one row of cowpea) and treatment T3 (one row of millet alternating with two rows of cowpea) producing dry matter yield (9.07 t ha-1 and 8.33 t ha-1, respectively). Based on high grain and suitable environmental condition, intercrop productivity compared to sole crop could be selected for improving the productivity of millet/cowpea mixture in the Punjab.

关键词： Intercropping Forage Quality Yield Crop Productivity

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伊维菌素在犬乳腺肿瘤治疗中的研究进展

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现代畜牧兽医 2024年第10期 93-96页

作者：冯会利 talha Umar 王海棚程征河南农业职业学院河南郑州451450 华中农业大学动物科学技术学院动物医学院湖北武汉430070

犬乳腺肿瘤是一种犬常见的恶性肿瘤,其发病率逐年上升,严重影响了犬的健康和生活质量。传统的治疗方法包括手术切除、化疗和放疗等,但上述方法存在一定的副作用和局限性。近年来,伊维菌素作为一种新型的抗肿瘤药物,逐渐引起了研究者的... 详细信息

犬乳腺肿瘤是一种犬常见的恶性肿瘤,其发病率逐年上升,严重影响了犬的健康和生活质量。传统的治疗方法包括手术切除、化疗和放疗等,但上述方法存在一定的副作用和局限性。近年来,伊维菌素作为一种新型的抗肿瘤药物,逐渐引起了研究者的关注。文章简述了伊维菌素抗肿瘤的作用机制,探讨伊维菌素在犬乳腺肿瘤治疗中的应用与研究进展,以期为临床实践提供参考。

关键词：伊维菌素犬乳腺肿瘤信号通路

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从大西洋沿岸到沙漠中心一座座盐道重镇的繁荣与衰落

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环球人文地理 2021年第7期 26-35页

作者：水星梁庭俊 Achraf talha Ivan Lin admin flicker unsplash

从公元6世纪到21世纪,历经千年的漫长岁月,食盐之路给人们留下了什么?这个答案,或许就隐藏在那一座座"盐道重镇"中。如今,当人们穿梭于这些古城,领略着美妙的异域风光时,那些传奇与往事便一一浮现在眼前……沙漠中的商道贸易,刺激了文... 详细信息

从公元6世纪到21世纪,历经千年的漫长岁月,食盐之路给人们留下了什么?这个答案,或许就隐藏在那一座座"盐道重镇"中。如今,当人们穿梭于这些古城,领略着美妙的异域风光时,那些传奇与往事便一一浮现在眼前……沙漠中的商道贸易,刺激了文明的交互,也推动沿途的城镇走向繁荣。从北非的地中海沿岸、大西洋沿岸,到撒哈拉沙漠的深处,分布着数个大大小小的商业重镇,它们曾经是盐商中途补给、休息的地点,也各自成为当地文化与经济的中心。

关键词：廷巴克图尼日尔河食盐贸易马拉喀什丹吉尔清真寺大西洋

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犬乳腺肿瘤的诊断与治疗综述

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河南农业 2023年第30期 63-64页

作者：冯会利贺丽欣 talha Umar 银岭河南农业职业学院华中农业大学动物科技学院、动物医学院

犬乳腺肿瘤是母犬常见的肿瘤之一,其发生机制复杂,受多种因素的影响。介绍了犬乳腺肿瘤诊断与治疗方面的基本知识和最新研究进展,包括犬乳腺肿瘤的发生机制和影响因素、临床表现和诊断方法、治疗方法和预后评估等内容。以期为犬乳腺肿... 详细信息

犬乳腺肿瘤是母犬常见的肿瘤之一,其发生机制复杂,受多种因素的影响。介绍了犬乳腺肿瘤诊断与治疗方面的基本知识和最新研究进展,包括犬乳腺肿瘤的发生机制和影响因素、临床表现和诊断方法、治疗方法和预后评估等内容。以期为犬乳腺肿瘤临床诊疗提供参考。

关键词：犬乳腺肿瘤发生机制诊断与治疗预后评估

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The Possibilities of Chronic Renal Failure Patients Contracting Occult Hepatitis B Virus Infection, Sudan

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Advances in Microbiology 2022年第3期12卷 91-102页

作者： Elhadi Abdalla Ahmed Abdelrahman Eldaw Mohammed Bakri Yousif Mohamed Nour Albadawi Abdelbagi talha Zienab Hamid Mubarak Ahmed Elshafia Mubarak Ahmed Elshafia Mohamed Elamin Salih Department of Medical Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Medical Parasitology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Clinical Laboratory Sciences College of Applied Medical Sciences Al Jouf University Sakakah KSA Department of Haematology and Immunohaematology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Surgery Faculty of Medicine-AlQunfudtha Umm Al-Qura University Mecca KSA

Introduction: Chronic kidney disease (CKD) is a major cause of death in sub-Saharan Africa. The effects of the CKD on the host and the continuous therapeutic measures increase the hypothesis of blood-borne diseases transmission. Objective: This study aimed to find the frequency of occult hepatitis B virus (OBI) in patients of chronic renal failure (CRF) and to study the possibilities of infection acquisition. Methods: During 2017 and 2019, two hundred CRF patients under regular haemodialysis and attending Gezira Hospital for Renal Diseases and Surgery were recruited. Plasma specimens were collected and used for detection of hepatitis B surface antigens (HbsAg), total hepatitis B core antibodies (anti-HBc) and hepatitis B virus DNA isolation. Nested PCR reaction was followed to identify HBV. Socio-clinical data for each participant was obtained. Results: Male patients represented 64% (128/200), most frequent age group was from 41 to 60 years with percentage of 56.5% (113/200), 86% (172/200) of CRF patients were received blood while 42% (84/200) get HBV vaccination. Hepatitis B core antibodies were found in 54% (108/200) of studied cases, and 22% (42/188) of tested DNA were positively amplified for target gene. Detection of Hepatitis B core antibodies was significantly associated with marital status while absence of vaccination significantly associated with the detection of both hepatitis B core antibodies and HBV DNA. Conclusion: This study found high frequency of OBI in CRF patients, to reduce the transmission of the disease, possible hypotheses should be studied, including blood transfusion, haemodialysis process and HBV vaccination status.

关键词： Chronic Renal Failure OBI Nested PCR Sudan

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Quantitative proteomic analysis of the sugarcane defense responses incited by Acidovorax avenae subsp. avenae causing red stripe

Quantitative proteomic analysis of the sugarcane defense res...

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第十九届中国作物学会学术年会

作者：周敬如 Hui-Dong Sun Ahmad Ali talha Javed Philippe C.Rott Hua-Ying Fu 高三基 National Engineering Research Center for Sugarcane Fujian Agriculture and Forestry University CIRAD UMR BGPI BGPI Univ Montpellier CIRAD INRA L'institut Agro

The causal agent of red stripe, Acidovorax avenae subsp. avenae(Aaa), can incite significant economic losses during sugarcane production. Proteomics is a useful tool for the comprehensive identification of defense response proteins in plants. In this study, we used analysis of iTRAQ-based proteomics to identify proteins that were produced in sugarcane in defense to Aaa in two Saccharum spp. cultivars: one was resistant(ROC22) and the other one(MT11-610) was susceptible to red stripe. Defense response was evaluated at 0 h(mock-inoculation) and 24 h post-inoculation with the bacterial pathogen, and 10,502 high-confidence proteins and 2,889 differentially expressed proteins(DEPs) were identified. These DEPs included 1,027 proteins(671 upregulated, 354 downregulated) in ROC22 and 1,130 proteins(566 upregulated, 564 downregulated) in MT11-610. Gene ontology analysis revealed that most DEPs were clustered in the metabolic, single-organism metabolic, and oxidation-reduction processes, and in catalytic activity. In a KEGG analysis, these proteins belonged to common pathway such as metabolic pathways, secondary metabolite biosynthesis, and biosynthesis of phenylpropanoids. Thirty-six DEPs were identified, especially epoxide hydrolase 1, dynamin-related protein 1 C-like, cytochrome oxidase subunit I, FK506-binding protein, acetoacetyl CoA thiolase isoform 2, anthocyanidin 3-o-glucosyltransferase, ubiquitin carboxyl-terminal hydrolase 4, protein disulfide isomerase-like protein, and jumonji-like transcription factor family protein. These proteins were characterized by enhanced expression with ≥ 1.5-fold increases in resistant ROC22 versus susceptible MT11-610, and are therefore biomarker candidates in the sugarcane response against Aaa. These data could be very useful in molecular breeding for sugarcane resistance to red stripe.

关键词： Acidovorax avenae subsp.avenae differentially expressed proteins iTRAQ proteomics Saccharum spp

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股骨粗隆间骨折的加速康复外科治疗:如何影响住院时间和并发症?

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中华医学杂志 2020年第37期100卷 2888-2888页

作者：李长润(编译) Gomez M Marc C talha A 北京积水潭医院创伤骨科不详

股骨粗隆间骨折治疗的医疗和经济学影响日趋明显。本研究着眼于在不影响治疗质量的情况下加速康复外科(ERAS)理念下治疗股骨粗隆间骨折对住院时间的影响。通过对2014至2016年法国Angers教学医院AO分型A1或A2型股骨近端骨折行髓内钉手术... 详细信息

股骨粗隆间骨折治疗的医疗和经济学影响日趋明显。本研究着眼于在不影响治疗质量的情况下加速康复外科(ERAS)理念下治疗股骨粗隆间骨折对住院时间的影响。通过对2014至2016年法国Angers教学医院AO分型A1或A2型股骨近端骨折行髓内钉手术以及接受急性期后康复(PAR)治疗的病例进行前瞻性、观察性、单中心队列研究,比较ERAS治疗组与对照组的区别。

关键词：股骨粗隆间骨折加速康复外科股骨近端骨折治疗质量 AO分型教学医院治疗组观察性

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