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SARS-CoV-2 Seroprevalence in People Referred to Private Medical Laboratories in Different Districts of Tehran, Iran from May 2020 to April 2021

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Virologica Sinica 2021年第5期36卷 1236-1240页

作者： Zahra Heydarifard Sevrin Zadheidar Jila Yavarian Shirin Kalantari Ahmad Nejati talat mokhtari-azad Nazanin Zahra Shafiei-Jandaghi Virology Department School of Public HealthTehran University of Medical SciencesTehran ***Iran

Dear Editor,The first cases of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)in Iran were identified in Qom on February 19,2020,which soon spread throughout the country(Yavarian et al.2020).As of May 12,2021,2,691,352 confirmed cases of COVID-19(the disease caused by SARS-Co V-2)and 75,568 associated deaths have been reported in the country by Iran Ministry of Health.

关键词： acute respiratory

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窟野河流域土壤侵蚀时空特征及趋势预测

水土保持学报 2024年

作者：何源陈俞池 talat Ahmed Ehab 王健赵广举姜泰西北农林科技大学水土保持研究所南京水利科学研究院韩城市水土保持工作站

[目的]窟野河流域是黄河中游粗沙区的主要侵蚀策源地。阐明窟野河流域土壤侵蚀时空变化特征,预测流域土壤侵蚀发展趋势,为流域未来水土流失综合治理提供决策支持。[方法]基于窟野河流域2010—2020年多源数据,刻画流域土壤侵蚀空间分布,... 详细信息

[目的]窟野河流域是黄河中游粗沙区的主要侵蚀策源地。阐明窟野河流域土壤侵蚀时空变化特征,预测流域土壤侵蚀发展趋势,为流域未来水土流失综合治理提供决策支持。[方法]基于窟野河流域2010—2020年多源数据,刻画流域土壤侵蚀空间分布,结合土壤侵蚀强度动态度、信息熵、综合指数和转移矩阵等定量指标,分析土壤侵蚀强度变化特征;构建CA-Markov模型,预测流域2025年土壤侵蚀状况。[结果]（1）研究区土壤侵蚀以微度、轻度侵蚀为主,面积占比超过70%,较强度侵蚀主要分布于流域中下游和支流悖牛川区域。2010—2020年间,平均土壤侵蚀量由1 955.56 t/（km2·a）降至892.98 t/（km2·a）,微度侵蚀面积大幅增加,其他侵蚀等级面积相应减少,大部分区域土壤侵蚀强度不变或下降,仅有不到3%的区域侵蚀强度加剧。（2）窟野河流域土壤剧烈、极强度、强度侵蚀的动态度变化较大,土壤侵蚀强度信息熵由1.29稳定下降至0.81,土壤侵蚀强度综合指数由178.96降低至76.61且前5年下降幅度更高,流域土壤侵蚀强度朝减弱方向转化,主要发生在邻近两侵蚀强度等级之间。（3）CA-Markov模拟显示,预计到2025年,流域土壤侵蚀状况将进一步改善,微度侵蚀占比超75%。[结论] 2010—2020年间,研究区土壤侵蚀状况持续好转,后5年水土流失治理效率更高,2025年流域土壤侵蚀状况将进一步改善。

关键词：土壤侵蚀 CA-Markov模型动态分析窟野河

Impact of adalimumab on disease burden in moderate-to-severe ulcerative colitis patients: The one-year, real-world UCanADA study

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World Journal of Gastroenterology 2022年第34期28卷 5058-5075页

作者： talat Bessissow Geoffrey C Nguyen Osman Tarabain Laurent Peyrin-Biroulet Nathalie Foucault Kevin McHugh Joannie Ruel Department of Medicine McGill University Health CenterMontreal H3G 1A4QuebecCanada Mount Sinai Hospital Inflammatory Bowel Disease Centre Toronto M5T 3L9OntarioCanada Dr.O.Tarabain Clinic Windsor N8W 1E6OntarioCanada Department of Gastroenterology University of LorraineCHRUNancyNancy F-54000France AbbVie Corporation Saint-Laurent H4S 1Z1QuebecCanada Department of Medicine Sherbrooke University Hospital CenterSherbrooke J1H 5N4QuebecCanada

BACKGROUND A gap remains in documenting the impact of anti-tumor necrosis factor therapy on disease burden in ulcerative colitis(UC)patients treated in a real-world *** use of patient-reported outcomes(PROs)has been discussed as a primary endpoint in the context of the FDA PRO Guidance,for labelling ***,the efficacy and safety of adalimumab have been demonstrated in pivotal trials;however,data are needed to understand how clinical results translate into improvements in key aspects of the daily lives of UC patients,such as symptoms,health-related quality of life(HRQoL),and *** To assess real-world effectiveness of adalimumab on PRO measures in patients with moderate-to-severe *** UCanADA was a single arm,prospective,1-year multicenter Canadian post-marketing observational study in which multiple PRO questionnaires were completed—with psychologic distress/depression symptoms as the primary endpoint—by patients with moderate-to-severe *** were performed during patients’routine care visit schedule,which was at the initiation of adalimumab(baseline),after induction(approximately 8 wk),and 52 wk after *** optional assessments between weeks 8 and 52 were collected at least once but no more than two times during this *** safety events and per-protocol adverse events were *** From 23 Canadian centres,100 patients were enrolled and 48 completed the *** with the Patient Health Questionnaire–9 items at week 52,61.5%(40/65)[95%confidence interval(CI):49.7%-73.4%]of the patients improved in psychologic distress/depression symptoms,which was slightly higher in completers[65.9%(29/44);95%CI:51.9%-79.9%].At week 52,clinical response and clinical remission were achieved respectively by 65.7%(44/73)and 47.8%(32/73)of the *** odds of improving depressive symptoms for those achieving a clinical remission at week 52 was 7.94 higher compared with those not achieving a clinic

关键词： Disease burden Patient-reported outcome Depressive symptoms Ulcerative colitis Adalimumab Real-world data

Optical recursional binormal optical visco Landau-Lifshitz electromagnetic optical density

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Communications in Theoretical Physics 2023年第5期75卷 17-37页

作者： talat Körpinar Zeliha Körpinar Muş Alparslan University Department of Mathematics49250MuşTurkey Muş Alparslan University Department of Administration49250MuşTurkey

In this manuscript,we study a new version of the optical recursional binormal microbeam model for a flexible binormal microscale beam in terms of a binormal normalized ***,we give new explanations for the optical recursional visco Landau-Lifshitz binormal electromagnetic binormal microscale ***,we obtain an optical application for the normalized visco Landau-Lifshitz electromagnetic binormal optimistic density with an optical binormal resonator.

关键词： optical recursion optical visco Landau-Lifshitz microscale flexible elastic microscale electromagnetic optimistic density visco microbeam model

Salvadora persica extract attenuates cyclophosphamide-induced hepatorenal damage by modulating oxidative stress, inflammation and apoptosis in rats

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Journal of Integrative Medicine 2022年第4期20卷 348-354页

作者： talat Albukhari Bassem Refaat El-Sayed Bakr Sameh Baz Bodour Rajab Hossam Gadalla Mohamed El-Boshy Department of Immunology and Hematology Faculty of MedicineUmm Al-Qura UniversityMakkah 21955Saudi Arabia Department of Laboratory Medicine Faculty of Applied Medical SciencesUmm Al-Qura UniversityMakkah 7607Saudi Arabia Clinical Nutrition Department Faculty of Applied Medical Sciences Umm Al-Qura UniversityMakkah 7607Soudi Arabia Clinical Pathology Department Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective: Salvadora persica(SP) is used as a food additive and is a common ingredient in folk *** study investigates the antioxidant, anti-inflammatory, and beneficial effects of SP against cyclophosphamide(CYP) toxicity in ***: In a 10-day study, 32 male rats were equally allocated into 4 groups(8 rats/group) as follows:the normal control(NC group), normal rats that only received oral aqueous extract of SP(100 mg/[kg·d];SP group), animals treated with intraperitoneal CYP injections(30 mg/[kg·d];CYP group), and the CYP + SP group that concurrently received CYP with SP aqueous extract. Serum samples were collected to measure the liver and renal biochemical profiles, as well as antioxidant and oxidative stress markers and the concentrations of interleukin-1β(IL-1β), IL-6, IL-10, tumor necrosis factor-a(TNF-a), nuclear factor-κB(NF-κB) and adenosine 5’-monophosphate-activated protein kinase(AMPK). Hepatic and renal tissues were also harvested for histopathology and to measure apoptosis using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling technique, alongside tissue levels of oxidative stress ***: Liver enzymes, total bilirubin, creatinine and urea, as well as serum IL-1β, IL-6, TNF-a and NF-κB increased significantly, whilst total protein, albumin, calcium, IL-10 and AMPK declined in serum of the CYP group relative to the NC group. The hepatorenal concentrations of glutathione, glutathione peroxidase and catalase declined markedly in the CYP group, whereas malondialdehyde, protein adducts, and apoptosis index increased compared with the NC group. By contrast, the hepatorenal biochemistry and apoptosis index of the SP group were comparable to the NC group. Interestingly, the CYP + SP group had significant improvements in the liver and renal biochemical parameters, enhanced anti-oxidative and anti-inflammatory effects, and marked declines in hepatic and renal apoptosis relative to the CYP group. Moreover, all mon

关键词： Cyclophosphamide Salvadora persica Cytokine NF-κB AMP-activated protein kinases Antioxidants Anti-inflammatory agents

Disease monitoring strategies in inflammatory bowel diseases: What do we mean by “tight control”?

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World Journal of Gastroenterology 2019年第41期25卷 6172-6189页

作者： Lorant Gonczi talat Bessissow Peter Laszlo Lakatos First Department of Medicine Semmelweis UniversityBudapest H-1083Hungary Division of Gastroenterology McGill University Health CentreMontreal H3G 1A4QuebecCanada

In recent years,there has been a critical change in treatment paradigms in inflammatory bowel diseases(IBD)triggered by the arrival of new effective treatments aiming to prevent disease progression,bowel damage and *** insufficiency of symptomatic disease control and the well-known discordance between symptoms and objective measures of disease activity lead to the need of reviewing conventional treatment algorithms and developing new concepts of optimal therapeutic *** treat-to-target strategies,defined by the selecting therapeutic targets in inflammatory bowel disease consensus recommendation,move away from only symptomatic disease control and support targeting composite therapeutic endpoints(clinical and endoscopical remission)and timely *** data suggest that early therapy using a treat-to-target approach and an algorithmic therapy escalation using regular disease monitoring by clinical and biochemical markers(fecal calprotectin and C-reactive protein)leads to improved *** review aims to present the emerging strategies and supporting evidence in the current therapeutic paradigm of IBD including the concepts of“early intervention”,“treat-to-target”and“tight control”*** also discuss the real-word experience and applicability of these new strategies and give an overview on the future perspectives and areas in need of further research and potential improvement regarding treatment targets and(“tight”)disease monitoring strategies.

关键词： Crohn’s disease Ulcerative colitis Treat-to-target Tight control Monitorting Biomarker

Management of inflammatory bowel disease with Clostridium difficile infection

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World Journal of Gastroenterology 2017年第27期23卷 4986-5003页

作者： Julie D’Aoust Robert Battat talat Bessissow Division of Internal Medicine Jewish General Hospital Division of Gastroenterology Jewish General Hospital Division of Gastroenterology Mc Gill University Health Centre

AIM To address the management of Clostridium difficile(C. difficile) infection(CDI) in the setting of suspected inflammatory bowel disease(IBD)-*** A systematic search of the Ovid MEDLINE and EMBASE databases by independent reviewers identified 70 articles including a total of 932141 IBD patients or IBDrelated hospitalizations. RESULTS In those with IBD,CDI is associated with increased morbidity,including subsequent escalation in IBD medical therapy,urgent colectomy and increased hospitalization,as well as excess mortality. Vancomycincontaining regimens are effective first-line therapies for CDI in IBD inpatients. No prospective data exists with regards to the safety or efficacy of initiating or maintaining corticosteroid,immunomodulator,or biologic therapy to treat IBD in the setting of CDI. Corticosteroid use is a risk factor for the development of CDI,while immunomodulators and biologics are not. CONCLUSION Strong recommendations regarding when to initiate IBD specific therapy in those with CDI are precluded by a lack of evidence. However,based on expert opinion and observational data,initiation or resumption of immunosuppressive therapy after 48-72 h of targeted antibiotic treatment for CDI may be considered.

关键词：生物学的治疗 Clostridium 顽固煽动性的肠疾病 Ulcerative 大肠炎 Crohns 疾病 Corticosteroids

Wound dehiscence with continuous versus interrupted mass closure of transverse incisions in children with absorbable suture:a randomized controlled trial

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World Journal of Pediatric Surgery 2019年第2期2卷 9-14页

作者： Safwan Khan Muhammad Saleem Nabila talat Department of Pediatric Surgery Armed Forces Hospital Southern RegionKhamis MushaytSaudi Arabia Department of Pediatric Surgery The Children's Hospital and The Institute of Child HealthLahorePakistan

Introduction Numerous meta-analyses done on adults suggest superiority of continuous mass closure technique,but any such study does not exist for the pediatric age *** results in adults cannot be applied to pediatrics because of numerous physiologic and anatomic *** This is a single-blinded,randomized controlled trial,1:1 parallel groups,that compares the frequency of dehiscence between the interrupted and continuous mass closure techniques for transverse incisions in pediatric *** age range was from birth to 12 *** sampled 350 patients undergoing emergency or elective exploratory laparotomies in our pediatric surgery *** randomization was used and only the patients remained blinded during the *** group was closed with interrupted mass closure(group A)and the other group with continuous mass closure technique(group B).We had to drop 50 patients for not meeting the inclusion *** The wound dehiscence rate for group A was 1.34%(4 patients)and for group B was 3.0%(9 patients).Significance was calculated usingχ^(2)(p<0.156).The global wound dehiscence rate was 4.34%(13 patients).The maximum number of patients dehisced on the fifth postoperative day,while the range was 4-11 *** only statistically significant confounding factor was wound classification(p<0.002).Discussion Statistically there is no significant difference between interrupted and continuous mass closures techniques in terms of wound *** dirty wounds are at a maximum risk of developing wound dehiscence irrespective of the technique *** need to strictly adhere to the basic principles of closure especially when dealing with dirty *** registration number TCTR20150318001.

关键词： wound closure interrupted

Quality of care in inflammatory bowel diseases: What is the best way to better outcomes?

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World Journal of Gastroenterology 2018年第22期24卷 2363-2372页

作者： Matthew Strohl Lorant Gonczi Zsuzsanna Kurt talat Bessissow Peter L Lakatos Division of Gastroenterology McGill University Health Center First Department of Medicine Semmelweis University

Inflammatory bowel disease(IBD) is a lifelong, progres-sive disease that has disabling impacts on patient's lives. Given the complex nature of the diagnosis of IBD and its management there is consequently a large economic burden seen across all health care systems. Quality in-dicators(QI) have been created to assess the different fa?ades of disease management including structure, process and outcome components. Their development serves to provide a means to target and measure quality of care(Qo C). Multiple different QI sets have been published in IBD, but all serve the same purpose of trying to achieve a standard of care that can be attained on a national and international level, since there is still a major variation in clinical practice. There have been many recent innovative developments that aim to improve Qo C in IBD including telemedicine, home biomarker assessment and rapid access clinics. These are some of the novel advancements that have been shown to have great potential at improving Qo C, while offloading some of the burden that IBD can have vis-a-vis emergency room visits and hospital admissions. The aim of the current review is to summarize and discuss available QI sets and recent developments in IBD care including telemedicine, and to give insight into how the utilization of these tools could benefit the Qo C of IBD patients. Additionally, a treating-to-target structure as well as evidence surrounding aggressive management directed at tighter disease control will be presented.

关键词： Inflammatory bowel disease Telemedicine Quality indicators Quality of care Treat-to-target