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Preoperative concurrent chemoradiotherapy with S-1 for oral squamous cell carcinoma

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中国口腔颌面外科杂志 2008年第B5期6卷 170-170页

作者： Masashi Nagata Hideki Nakayama Aya Nakahara takuya Tanaka Masanori Shinohara Department of Oral and Maxillofacial Surgery KumamotoUniversity Kumamato 860-8556 Japan

Purpose: We previously performed intra-arterial chemoradio- therapy (IAC) with cisplatin followed by radical surgery for oral squamous cell carcinoma, and found that it did not improve the survival rate. S-1 composed of 5-FU prodrug and two enzyme inhibitors is an orally administered effective anticancer agent and widely used in Japan. We determine the usefulness the preoperative concurrent chemoradiotherapy with S-1, compared with IAC, which uses cisplatin. Methods: Sixty-six patients in IAC group and 72 patients in S-1 group were included. S-I was administered orally at 80-120 mg/day for 14 consecutive days. All patients received 30 Gy irradiation to the primary tumor and cervical lymph node areas. The toxicity of chemoradiotherapy was evaluated according to National Cancer Institute Common Terminology Criteria for Adverse Event (version 3.0). Surgery was performed approximately 3 weeks after preoperative treatment. Tumor responses were evaluated by World Health Organization criteria. Histological responses were graded according to the criteria of Shimosato et al. Results: The overall clinical response rate for the primary tumors was 92.5% in S-1 group. Severe (Grade 3 or 4) mucositis, leucopenia, anemia, and thrombocytopenia were observed in eleven (15.2%), one (1.3%), one (1.3%), one (1.3%) respectively in S-1 group. The overall histological response (GradesⅡb,Ⅲ,Ⅳ) rate for the primary tumors was 86.1% in S-1 group, 87.9% in IAC group, that for the metastatic lymph nodes was 67.1% in S-1 group,

关键词：口腔鳞状细胞癌治疗方法临床分析

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影响小学科学学力因素的中日比较研究

外国中小学教育 2010年第5期 33-38,29页

作者：孟令红角屋重树清水钦也松浦拓也北京教育学院教师教育数理学院日本广岛大学大学院教育学研究科

本研究以中国为主体、日本为客体对影响小学科学学力的七个因素(设定为①家长的支持;②班级环境;③学习科学的积极性;④朋友环境;⑤校外学习时间;⑥家长对科学的关心;⑦家长对科学教育的期望),通过利用构造方程式模型(Structural Equati... 详细信息

本研究以中国为主体、日本为客体对影响小学科学学力的七个因素(设定为①家长的支持;②班级环境;③学习科学的积极性;④朋友环境;⑤校外学习时间;⑥家长对科学的关心;⑦家长对科学教育的期望),通过利用构造方程式模型(Structural Equation Modeling),明确各因素对学力影响的关系构造的中日比较研究。目的是通过比较研究更加深入地理解中国小学科学教育的特点,同时,为我国小学科学教育改革提供具有可操作性的经验。

关键词：小学科学影响学力因素中日比较

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高强度管线钢DWTT性能研究

焊管 2010年第10期33卷 74-79页

作者：杨扬李为卫中国石油集团石油管工程技术研究院西安710065

DWTT(落锤撕裂试验)是一种主要用于评价脆性断裂止裂性能的试验方法。实验室在不同条件下轧制了X100管线钢,并按JIS(日本工业标准)和API SPEC 5L/ISO3183标准加工了拉伸试样和DWTT试样,在-20℃条件下进行DWTT并测量DWTT能量和剪切面积... 详细信息

DWTT(落锤撕裂试验)是一种主要用于评价脆性断裂止裂性能的试验方法。实验室在不同条件下轧制了X100管线钢,并按JIS(日本工业标准)和API SPEC 5L/ISO3183标准加工了拉伸试样和DWTT试样,在-20℃条件下进行DWTT并测量DWTT能量和剪切面积。研究了始冷温度对DWTT性能、脆性断口形貌、显微组织及织构的影响。结果表明:X100管线钢DWTT典型的脆性断裂是分离和倾斜断裂,当管线钢形成铁素体和贝氏体双相显微组织时,即产生断口分离;当形成单相贝氏体显微组织时产生倾斜断裂。抑制倾斜断裂和明显的断口分离对提高管线钢的DWTT性能十分重要。

关键词：高强度管线钢 DWTT 分离倾斜断裂织构铁素体贝氏体

Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

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World Journal of Gastrointestinal Pathophysiology 2011年第6期2卷 93-99页

作者： Tsutomu Nishida Shusaku Tsutsui Motohiko Kato takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan

Treatment strategies,whether as follow-up or"total incisional biopsy"for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic *** on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive ***,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during *** advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade *** studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness.

关键词： Gastric intraepithelial neoplasia Adenoma Dysplasia Endoscopic submucosal dissection Endoscopic mucosal resection Endoscopic resection Adenocarcinoma

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磷对镍铁基合金蠕变性能的影响

水钢科技 2015年第3期 60-66页

作者： Koichi TAKASAWA Hibiki CHINEN takuya OHKAWA Eiji MAEDA Takashi HATANO 刘立德高长益张东升叶雅妮赵光凤日本室兰制钢所研究室首钢水钢技术中心贵州六盘水553028

本文研究了在333MPa应力下在973K温度下磷含量为8-450ppm的镍基超合金的蠕变性能。在蠕变测试前。通过热处理，在含磷合金中产生了很多富集Nb、P的析出物。P含量为130ppm的舍金具有最大的晶界析出物覆盖率p=0．56。断裂寿命和最小蠕变... 详细信息

本文研究了在333MPa应力下在973K温度下磷含量为8-450ppm的镍基超合金的蠕变性能。在蠕变测试前。通过热处理，在含磷合金中产生了很多富集Nb、P的析出物。P含量为130ppm的舍金具有最大的晶界析出物覆盖率p=0．56。断裂寿命和最小蠕变速率与P值相关。P含量为130ppm的合金与P含量为8ppm、p=0的合金相比，破裂寿命延长30倍，最小蠕变速率下降两个数量级。晶界析出物明显推迟了蠕变加速段的起点，因此延长了断裂寿命。这些结果表明．P值的优化是改善合金蠕变性能的关键。

关键词：镍铁基合金磷断裂寿命最小蠕变速率晶界析出物晶界覆盖率晶界析出强化

A Case of Simultaneous Triple Primary Cancers of the Hypopharynx, Esophagus, and Stomach Which Were Dissected by Endoscopic Laryngo-Pharyngeal Surgery Combined with Endoscopic Submucosal Dissection

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Open Journal of Gastroenterology 2018年第3期8卷 94-102页

作者： Kenro Kawada Taro Sugimoto Ryuhei Okada Kazuya Yamaguchi Yuudai Kawamura Masafumi Okuda Yuuichiro Kume Andres Mora Tairo Ryotokuji takuya Okada Akihiro Hoshino Yutaka Tokairin Yasuaki Nakajima Yusuke Kiyokawa Fuminori Nomura Yoshuke Ariizumi Shohei Tomii Takashi Ito Takahiro Asakage Yusuke Kinugasa Tatsuyuki Kawano Department of Gastrointestinal Surgery Tokyo Medical and Dental University Tokyo Japan Department of Head and Neck Surgery Tokyo Medical and Dental University Tokyo Japan Department of Human Pathology Tokyo Medical and Dental University Tokyo Japan

A 65-year-old man was admitted to our hospital following 6 months of dysphagia. At first, conventional endoscopy showed a reddish and depressed lesion in the stomach and an elevated lesion in the posterior wall of the hypopharynx. An endoscopic biopsy showed adenocarcinoma in the stomach, and squamous cell carcinoma in the hypopharynx. On the further examination, trans-nasal endoscopy with narrow band imaging (NBI) was performed. During the trumpet maneuver, a huge protruded lesion was observed and it reached to the orifice of the esophagus. Other superficial lesion located at left pyriform sinus was detected by NBI system as brownish area with brown dots. Furthermore, superficial esophageal cancer in the cervical esophagus was detected. Finally, 4 carcinomas in upper gastrointestinal tract were detected. Among them, the hypopharyngeal cancer was the most advanced (T3N0). The patient hoped to preserve his voice and swallowing function, endoscopic laryngo-pharyngeal surgery (ELPS) was performed for the hypopharyngeal cancer. Endoscopic mucosal resection (EMR) was performed for the esophageal cancer, and Endoscopic submucosal dissection (ESD) was performed for the gastric cancer. Under collaboration between a head and neck surgeon and an endoscopist, the tumor was resected en-bloc. The histopathological findings of hypopharyngeal cancer were squamous cell carcinoma, subeipthelial invasion, 29 × 28 × 4.2 mm. The others were diagnosed as mucosal cancers. The patient is currently alive with no recurrence at 28 months after the surgery;there is no stricture at the cervical esophagus. Endoscopic laryngopharyngeal surgery for the tumor of pharyngo-esophageal junction can provide a less invasive treatment.

关键词： Endoscopic Laryngopharyngeal Surgery Hypopharyngeal Cancer Multiple Primary Cancer Trumpet Maneuver Endoscopic Submucosal Dissection

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批判性数学教育与民族数学的交叉点

内蒙古师范大学学报（教育科学版） 2006年第1期19卷 77-81页

作者：马场卓也岩崎秀树日本广岛大学国际协力研究科

在发展中国家和一些有多种文化背景的发达国家里,民族数学已经获得了一定水平的发展动力。另一方面,起源于发达国家的批判性数学教育特别关注民族数学研究的批判性观点。在这种研究中,为了把民族数学和学校数学连接起来,并把它作为教育... 详细信息

在发展中国家和一些有多种文化背景的发达国家里,民族数学已经获得了一定水平的发展动力。另一方面,起源于发达国家的批判性数学教育特别关注民族数学研究的批判性观点。在这种研究中,为了把民族数学和学校数学连接起来,并把它作为教育尝试,批判性数学教育和民族数学之间相辅相成的关系已被详细考虑。因此,为了通过互惠方式加强批判性本质和发展以民族数学为基础的数学教育,一个基础性的框架被建立。

关键词：民族数学批判性数学教育相辅相成的关系批判性反应

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共愉的风景——品鉴春日台中心

建筑技艺 2023年第12期29卷 33-51页

作者：郭屹民金野千惠大野博史马场拓也柳亦春曾群关飞张准东南大学建筑学院 teco建筑设计事务所东京艺术大学东京工业大学 OhnoJAPAN事务所 Aikawa-shunjukai Social welfare Corporation社会福利公司大舍建筑设计事务所同济大学建筑设计研究院(集团)有限公司中国建筑设计院有限公司本土设计研究中心和作结构建筑研究所

作为“AT建筑”首次国外建筑品鉴,我们将目光聚焦日本20世纪80年代前后新一代建筑师的实践与思考。选择金野千惠所做的春日台中心,不仅仅因为它获得了2023年日本建筑学会作品奖,更是因为作品中所展现的建筑师对当代建筑与社会、空间与... 详细信息

作为“AT建筑”首次国外建筑品鉴,我们将目光聚焦日本20世纪80年代前后新一代建筑师的实践与思考。选择金野千惠所做的春日台中心,不仅仅因为它获得了2023年日本建筑学会作品奖,更是因为作品中所展现的建筑师对当代建筑与社会、空间与技术、场所与人、开放性与社会性的深刻洞见和呈现。当站在长长的廊下看广场上玩耍的孩子,当视线穿过两栋之间的走廊望向城市街道和住宅区,当阳光从两层通高的土间通洒下似乎融合又分隔了前部的“榻榻米”公共活动空间与后面半公共的老人照护中心,当在二层推开木窗户感受木结构包裹的氛围下老人欢笑游戏的场景,这种给人的愉悦感就是共愉的风景吧。

关键词：日本建筑学会公共活动空间木结构住宅区建筑与社会品鉴愉悦感国外建筑

Advanced lower gingival cancer successfully treated by modest doses of radiotherapy and adjuvant chemotherapy with S-1

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中国口腔颌面外科杂志 2008年第B5期6卷 171-171页

作者： takuya Tanaka Hideki Nakayama Masashi Nagata Yoshihiro Yoshitake Takehisa Obayashi Masanori Shinohara Department of Oral and Maxillofacial Surgery KumamotoUniversity Kumamoto city 860-8556 Japan

We report the case of a 62-year-old man with advanced lower gingival cancer and nodal metastasis who was successfully treated by modest doses of radiotherapy and adjuvant chemotherapy with S-1。The patient was clinically diagnosed with stage IV (T4NIM0) disease and was initially treated by 30 Gy of radiotherapy given over three weeks as preoperative treatment。Since he refused surgery after preoperative treatment, adjuvant chemotherapy with S-I was elected instead。The treatment regimen consisted of S-I administration for 14 consecutive days, followed by a 7-day rest。Three months after the chemotherapy, the primary oral region showed no sign of cancer, whereas the metastatic lymph node showed enlargement。With his informed consent, he underwent submandibular neck dissection, and after the surgery, he was administered S-1 for 20 months。At present, no sign of cancer has been identified by radiological follow-up examinations。

关键词：牙龈癌治疗方法临床分析化学疗法