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The Best Choice to Achieve Zero Complications after Pancreatoduodenectomy

Surgical Science 2011年第2期2卷 45-51页

作者： Shinji Osada Hisashi Imai Yoshiyuki Sasaki Itaru Yasufuku Ryuichi Asai Yoshihisa Tokumaru takuji sakuratani Kazuhiro Yoshida 不详

Pancreatoduodenectomy (PD) has been performed commonly, but the occurrence of pancreatic fistula (PF) is a critical trigger of complications, which are potentially life threatening, and is also associated with markedly prolonged hospitalization. Many techniques have been proposed for connecting the pancreatic stump with the gastrointestinal tract, stomach vs. jejunum, etc. Among the risk factors for PF, such as general patient factors or disease-related factors, the most important is the texture of the remnant pancreas. Surgical technique might be one improvable aspect that can reduce the pancreatic leakage rate, therefore;various methods of managing the pancreatic remnant have been studied. Methods of reconstruction between the remnant pancreas and the intestine include end-to-side with/without duct-to-mucosa anastomosis or end-to-end invagination styles, has been argued. Here, we review several trials for safety and methods of treating the pancreatic stump after PD, and demonstrate our experiences.

关键词： Pancreatoduodenectomy Reconstruction Pancreatojejunostomy Pancreatic Fistula Pancreatoenteric Anastomosis

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Cryoablation-Induced Anti-Cancer Immune Reaction—Immune Reaction Induced By Cryoablation

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Journal of Cancer Therapy 2011年第2期2卷 135-139页

作者： Shinji Osada Hisashi Imai Yoshiyuki Sasaki Itaru Yasufuku Ryuichi Asai Yoshihisa Tokumaru takuji sakuratani Kazuhiro Yoshida Surgical Oncology Gifu University School of Medicine Yanagido Gifu City JAPAN.

Among the ablation procedures used against advanced liver cancer, thermal ablation therapy is widely applied, and the safety and efficacy of this technique have been well characterized. In contrast, the principle of cryosurgery is not only to control local recurrence, but also to stimulate the immune system into initiating an anti-tumor response. In recent years, we have developed a treatment method for patients with advanced liver tumors. From these experiences, repeated treatment was demonstrated to induce anti-cancer immune reaction-related factors. In the present review, mechanisms for anti-tumor immune reaction will be argued with introducing a novel strategy of a cryoablation.

关键词： Cryoablation Helper T cell Immune reaction Hepatoma Ablation therapy

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