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Microstructure and mechanical properties of ZrO_2(Y_2O_3)-Al_2O_3 nanocomposites prepared by spark plasma sintering

Particuology 2012年第3期10卷 345-351页

作者： Shufeng Li Hiroshi Izui Michiharu Okano Weihua Zhang taku watanabe College of Science and Technology Nihon University7-24-1NarashinodaiFunabashiChiba 274-8501Japan College of Science and Technology Nihon University1-8-14KandasurugadaiChiyoda.Tokyo 101-8308Japan College of Materials Science and Technology Xi'an University of Technology5 SouthJinhua RoadXi'anShaanxi 710048China

Zirconia （yttria）-alumina ceramic nanocomposites were fabricated from different powders by spark plasma sintering （SPS）. One powder was a commercially available nanocomposite powder TZP-3Y2OA, consisting of 3 mol% yttria-stabilized zirconia （3-YSZ） reinforced with 20wt% alumina, and the other, used as a comparison, was a conventional mechanically mixed powder 3YSZ-2OA, a blend made of 3 mol% yttria-stabilized zirconia powder ZrO2 （3Y） and 20 wt% ,x-alumina powder. The effect of the sintering temperature on the densification, the sintering behavior, the mechanical properties and the microstructure of the composites was investigated. The results showed that the density increased with increasing sintering temperature, and thus, the mechanical properties were strengthened because of the increased densification. The nanocomposite powder TZP-3Y20A was easily sintered, and good mechanical properties were achieved as compared with the powder from the conventional mechanically mixed method, the maximum flexural strength and fracture toughness of which were 967 MPa and 5.27 MPa m 1/2, respectively.

关键词： Zirconia-aluminaNanocompositeSpark plasma sintering (SPS)Mechanical propertiesMicrohardnessFracture toughnessDensification

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Hemodynamic effects of ambrisentan-tadalafil combination therapy on progressive portopulmonary hypertension

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World Journal of Hepatology 2014年第11期6卷 825-829页

作者： Yu Yamashita Ichizo Tsujino Takahiro Sato Asuka Yamada taku watanabe Hiroshi Ohira Masaharu Nishimura First Department of Medicine Hokkaido University Hospital

Intravenous epoprostenol is recommended for World Health Organization functional class(WHO-FC) Ⅳ patients with pulmonary arterial hypertension(PAH) in the latest guidelines. However, in portopulmonary hypertension(PoP H) patients, advanced liver dysfunction and/or thrombocytopenia often makes the use of intravenous epoprostenol challenging. Here we report the cases of two WHO-FC Ⅳ PoP H patients who were successfully treated with a combination of two oral vasodilators used to treat PAH: ambrisentan and tadalafil. Oral vasodilator therapy using a combination of ambrisentan and tadalafil may be a safe and effective therapeutic option for WHO-FC Ⅳ PoP H patients and should be considered for selected patients with severe and rapidly progressing PoP H.

关键词： Portopulmonary hypertension Ambrisentan Tadalafil Thrombocytopenia

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Performance Evaluation of Electromagnetic Shield Constructed from Open-Cell Metal Foam Based on Sphere Functions

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Computer Modeling in Engineering & Sciences 2022年第7期132卷 43-53页

作者： Yuya Hanaoka taku Itoh Kohei Tateyama Susumu Nakata Keiko watanabe Graduate School of Industrial Technology Nihon UniversityNarashinoChiba 275-8575Japan College of Industrial Technology Nihon UniversityNarashinoChiba 275-8575Japan College of Science and Engineering Ritsumeican UniversityKusatsuShiga 525-8577Japan College of Information Science and Engineering Ritsumeican UniversityKusatsuShiga 525-8577Japan

This study evaluates the performance of a model of open-cell metal foams generated by sphere *** this end,an electromagnetic shield constructed from the model was inserted between two horn antennas in an electromagnetic wave propagation *** foam-hole diameter in the electromagnetic shield model was varied as d=2.5 and 5.0 mm,and the frequency of the electromagnetic waves was varied from 3 to 13 *** the numerical experiments of shield effectiveness,the shields with foam holes of both diameters attenuated the electromagnetic waves across the studied frequency *** shield effectiveness was enhanced at low frequencies and in the shield with smaller hole diameter.

关键词： Electromagnetic propagation electromagnetic shielding materials metal foams numerical simulation

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Regulation of RNase E during the UV stress response in the cyanobacterium Synechocystis *** 6803

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mLife 2023年第1期2卷 43-57页

作者： Satoru watanabe Damir Stazic Jens Georg Shota Ohtake Yutaka Sakamaki Megumi Numakura Munehiko Asayama taku Chibazakura Annegret Wilde Claudia Steglich Wolfgang R.Hess Faculty of Biology Genetics and Experimental BioinformaticsUniversity of FreiburgFreiburgGermany Department of Bioscience Tokyo University of AgricultureSetagayakuTokyoJapan School of Agriculture Molecular GeneticsIbaraki UniversityIbarakiJapan Faculty of Biology Molecular GeneticsUniversity of FreiburgFreiburgGermany Nexxiot Prime Tower(Hardstrasse 201)ZurichSwitzerland.

Endoribonucleases govern the maturation and degradation of RNA and are indispensable in the posttranscriptional regulation of gene expression.A key endoribonuclease in Gram-negative bacteria is RNase *** ensure an appropriate supply of RNase E,some bacteria,such as Escherichia coli,feedback-regulate RNase E expression via the rne 5′-untranslated region(5′UTR)in ***,the mechanisms involved in the control of RNase E in other bacteria largely remain *** rely on solar light as an energy source for photosynthesis,despite the inherent ultraviolet(UV)*** this study,we first investigated globally the changes in gene expression in the cyanobacterium Synechocystis *** ^(6)803 after a brief exposure to *** the 407 responding genes 2 h after UV exposure was a prominent upregulation of rne mRNA ***,the enzymatic activity of RNase E rapidly increased as well,although the protein stability *** unique response was underpinned by the increased accumulation of full-length rne mRNA caused by the stabilization of its 5′UTR and suppression of premature transcriptional termination,but not by an increased transcription *** of RNA 3′ends and in vitro cleavage assays revealed that RNase E cleaves within a stretch of six consecutive uridine residues within the rne 5′UTR,indicating *** observations suggest that RNase E in cyanobacteria contributes to reshaping the transcriptome during the UV stress response and that its required activity level is secured at the RNA level despite the enhanced turnover of the protein.

关键词： cyanobacteria protein turnover ribonuclease stress response

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糖尿病和肥胖症动物模型肌肉及脂肪组织的葡萄糖摄取:利用18F-FDG评价胰岛素和β3受体激动剂的作用

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中华核医学与分子影像杂志 2018年第1期38卷 73-73页

作者：唐军 Seigo Ishino taku Sugita Yusuke Kondo Mika Okai Kazue Tsuchimori Masanori watanabe Ikuo Mori Masaki Hosoya Takashi Horiguchi Hidenori Kamiguchi 上海交通大学医学院附属苏州九龙医院核医学科 Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited

目的糖尿病和肥胖症的主要原因是胰岛素功能不足导致肌肉和脂肪组织内的糖摄取、糖代谢异常。因此,许多药物的研发都是基于促进肌肉和脂肪组织对葡萄糖的摄取。现已可通过测定血液相关参数来评价上述组织糖代谢的增加,但这仅仅反映了用... 详细信息

目的糖尿病和肥胖症的主要原因是胰岛素功能不足导致肌肉和脂肪组织内的糖摄取、糖代谢异常。因此,许多药物的研发都是基于促进肌肉和脂肪组织对葡萄糖的摄取。现已可通过测定血液相关参数来评价上述组织糖代谢的增加,但这仅仅反映了用药后的全身反应。课题组进行了数项研究来调查药理实验中疾病动物模型的不同肌肉和脂肪组织葡萄糖摄取测定的实用性。方法对肥胖大鼠模型(2型糖尿病模型)、饮食诱导的肥胖鼠模型(肥胖模型)和相应的对照组模型分别注射18F-脱氧葡萄糖(FDG),各模型肌肉和脂肪组织(白色和棕色脂肪)的基础葡萄糖摄取通过生物分布法进行比较。另外,可促进肌肉和脂肪组织葡萄糖摄取的胰岛素和β3受体激动剂(CL316,243)亦用于各模型来评价两者的作用。18F-FDG在各组织的摄取通过测量各组织放射性的方法进行,而18F-FDG的分布采用放射自显影的方法来分析。结果2型糖尿病模型与对照组(瘦大鼠)相比,所有组织的测量结果均显示其基础葡萄糖摄取水平降低。肥胖模型的白色脂肪组织也有相同表现,但肥胖模型棕色脂肪组织的基础葡萄糖摄取水平增加。胰岛素可促进2型糖尿病模型和瘦大鼠模型的葡萄糖摄取,尽管前者的葡萄糖摄取增加有所抑制。同样的现象也存在于对照组,但使用胰岛素后肥胖模型的肌肉和棕色脂肪组织没有观察到葡萄糖摄取的明显增加。2型糖尿病模型与瘦大鼠使用β3受体激动剂后可观察到与使用胰岛素后一样的反应,但前者脂肪组织的葡萄糖摄取增加受抑。结论通过18F-FDG监测组织葡萄糖摄取水平能够观察到疾病动物模型和相应对照模型间葡萄糖摄取的差别,同时可识别各组织对胰岛素和β3受体激动剂的反应。总之,18F-FDG生物分布法可在疾病动物模型上用于抗糖尿病和抗肥胖药物的评价研究。

关键词： 18F-FDG 肥胖大鼠模型饮食诱导的肥胖鼠模型胰岛素 β3受体激动剂

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