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Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis

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World Journal of Gastroenterology 2021年第2期27卷 162-175页

作者： Kei Motooka Koichi Morishita Nami Ito Shinichiro Shinzaki taku tashiro Satoshi Nojima Kayoko Shimizu Mutsuhiro Date Natsumi Sakata Momoko Yamada Shinji Takamatsu Yoshihiro Kamada Hideki Iijima Tsunekazu Mizushima Eiichi Morii Tetsuo Takehara Eiji Miyoshi Department of Molecular Biochemistry and Clinical Investigation Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan Department of Gastroenterology and Hepatology Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan Department of Pathology Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan FUJIFILM Wako Pure Chemical Corporation Amagasaki 661-0963HyogoJapan Department of Gastroenterological Surgery Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan

BACKGROUND Inflammatory bowel disease(IBD)is a chronic,relapsing inflammation of the digestive *** fecal and serum biomarkers have been extremely important and supportive for monitoring of IBD,their low sensitivity and high variability characteristics limit clinical ***,the establishment of better biomarkers is *** is one of the most important glycosylation modifications of *** haptoglobin(Fuc-Hpt)is used as a biomarker for several cancers and inflammation-related *** recently established a novel glycan monoclonal antibody(mAb),designated 10-7G,which recognizes *** developed an enzyme-linked immunosorbent assay(ELISA)to measure serum levels of Fuc-Hpt(10-7G values).AIM To investigate the usefulness of the serum 10-7G values as a potential biomarker for monitoring disease activity in *** This was a case control *** tissues of IBD patients(n=10)were examined immunohistochemically using the 10-7G *** determined 10-7G values using serum from patients with ulcerative colitis(UC,n=110),Crohn’s disease(n=45),acute enteritis(AE,n=11),and healthy volunteers(HVs)who exhibited normal(n=20)or high(n=79)C-reactive protein(CRP)levels at medical *** investigated the correlation between the 10-7G value and various clinical parameters of IBD patients by correlation *** operating characteristic(ROC)curve analysis was performed to evaluate the usefulness of the 10-7G values as a biomarker for clinical and endoscopic remission of UC compared to conventional serum *** In the immunohistochemical analysis,positive 10-7G mAb staining was observed in lymphocytes infiltrating into inflammatory sites of the mucosal layer and lymphoid *** 10-7G values were significantly higher in patients with IBD(P<0.001)and AE(P<0.05)compared with *** addition,10-7G values were correlated with clinical examination parameters related to inflammation in patients with

关键词： Inflammatory bowel disease Biomarkers Glycosylation Fucosylated haptoglobin Prohaptoglobin Endoscopic remission

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