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涂料技术与文摘 2005年第5期26卷 32-33页

作者： taku takeshi Nippon Chemical Industrial Co.Ltd.

该涂料含无机基料（如硅酸烷基酯）、防腐颜料和水合钨矿3CaO·Al2O3·Ca（NO2）2·nH2O（n≤20）。例如，将由Na2O、Al2O3、熟石灰和Ca（NO2）2制得的亚硝酸型水合钙矿与硅酸乙酯和业磷酸锌混合，

关键词：无机涂料亚硝酸水合钙矿防腐性制备方法

Successful endoscopic closure of a colonic perforation one day after endoscopic mucosal resection of a lesion in the transverse colon

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World Journal of Clinical Cases 2016年第8期4卷 238-242页

作者： Kazuya Inoki taku Sakamoto Masau Sekiguchi Masayoshi Yamada takeshi Nakajima Takahisa Matsuda Yutaka Saito Endoscopy Division National Cancer Center HospitalTokyo Cancer Screening Division Research Center for Cancer Prevention and Screening National Cancer Center HospitalTokyo

A 73-year-old man underwent endoscopic mucosal resection(EMR) of a 20-mm flat elevated lesion on the transverse colon. The morning after the procedure, he started to have severe right upper quadrant pain after his first meal. A computed tomography scan revealed free air and a stomach filled with food. He was diagnosed to have delayed post-EMR intestinal perforation. He underwent emergent colonoscopy and clipping of the perforated site. He was discharged 8 d after the endoscopic closure without the need for surgical intervention. The meal was not the cause of the colon transversum perforation.

关键词： Colonoscopy Colorectal tumors Endoscopic surgical procedure Emergencies Intestinal perforation

Condyloma acuminatum of the anal canal,treated with endoscopic submucosal dissection

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World Journal of Gastroenterology 2016年第8期22卷 2636-2641页

作者： Akiko Sasaki takeshi Nakajima Hideto Egashira Kotaro Takeda Shinnosuke Tokoro Chikamasa Ichita Sakue Masuda Haruki Uojima Kazuya Koizumi takeshi Kinbara taku Sakamoto Yutaka Saito Makoto Kako Gastroenterology Medicine Center Shonan Kamakura General Hospital 1370-1 Okamoto Kamakura Endoscopy Division National Cancer Center Hospital5-1-1 Tsukiji Chuoku Diagnostic Pathology Shonan Kamakura General Hospital 1370-1 Okamoto Kamakura

Condyloma acuminatum(CA) is a common sexually transmitted disease caused by human papilloma virus infection. Not all individuals develop persistent, progressive disease, but careful follow up is required with moderate-to-severe dysplasia to prevent progression to malignancy. Standard therapies include surgical treatments(trans-anal resection and transanal endoscopic microsurgery) and immunotherapeutic and topical methods(topical imiquimod); however, local recurrence remains a considerable problem. Here, we report a case with superficial CA of the anal canal, treated with endoscopic submucosal dissection(ESD). A 28-year-old man presented with a chief complaint of hematochezia. Digital exam did not detect a tumor. Screening colonoscopy revealed 10-mm long, whitish condyles extending from the anal canal to the lower rectum. The lesion covered almost the whole circumference, and only a small amount of normal mucosa remained. Magnifying endoscopy with narrow band imaging showed brownish hairpin-shaped, coiled capillaries. Although histopathological diagnosis by biopsy revealed CA, accurate histological differentiation between CA, papilloma, and squamous cell carcinoma can be difficult with a small specimen. Therefore, weperformed diagnostic ESD, which provides a complete specimen for precise histopathological evaluation. The pathological diagnosis was CA, with moderate dysplasia(anal intraepithelial neoplasia 2). There was no recurrence at 16 mo after the initial ESD. Compared to surgical treatment, endoscopic diagnosis and resection could be performed simultaneously and the tumor margin observed clearly with a magnifying chromocolonoscopy, resulting in less recurrence. These findings suggest that endoscopic resection may be an alternative method for CA that prevents recurrence.

关键词： Condylomata acuminate Recurrence Endoscopy Dissection Carcinoma in situ

Spectral vegetation indices as the indicator of canopy photosynthetic productivity in a deciduous broadleaf forest

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Journal of Plant Ecology 2013年第5期6卷 393-407页

作者： Hiroyuki Muraoka Hibiki M.Noda Shin Nagai takeshi Motohka taku M.Saitoh Kenlo N.Nasahara Nobuko Saigusa Institute for Basin Ecosystem Studies Gifu University1-1 YanagidoGifu501-1193 Japan Faculty of Life and Environment Sciences University of TsukubaTsukuba305-8572 Japan Research Institute for Global Change Japan Agency for Marine-Earth Science and Technology(JAMSTEC)Yokohama236-0001 Japan Earth Observation Research Center Japan Aerospace Exploration AgencyTsukuba305-8505 Japan Center for Global Environmental Research National Institute for Environmental StudiesTsukuba205-8506 Japan

Aims Understanding of the ecophysiological dynamics of forest canopy photosynthesis and its spatial and temporal scaling is crucial for revealing ecological response to climate *** observations and analyses of plant ecophysiology and optical remote sensing would enable us to achieve these *** order to examine the utility of spectral vegetation indices(VIs)for assessing ecosystem-level photosynthesis,we investigated the relationships between canopy-scale photosynthetic productivity and canopy spectral reflectance over seasons for 5 years in a cool,temperate deciduous broadleaf forest at‘Takayama’super site in central *** Daily photosynthetic capacity was assessed by in situ canopy leaf area index(LAI),(LAI×Vcmax[single-leaf photosynthetic capacity]),and the daily maximum rate of gross primary production(GPPmax)was estimated by an ecosystem carbon cycle *** examined five VIs:normalized difference vegetation index(NDVI),enhanced vegetation index(EVI),green–red vegetation index(GRVI),chlorophyll index(CI)and canopy chlorophyll index(CCI),which were obtained by the in situ measurements of canopy spectral *** Findings Our in situ observation of leaf and canopy characteristics,which were analyzed by an ecosystem carbon cycling model,revealed that their phenological changes are responsible for seasonal and interannual variations in canopy *** correlations were found between the five VIs and canopy photosynthetic capacity over the seasons and years;four of the VIs showed hysteresis-type relationships and only CCI showed rather linear *** the VIs examined,we applied EVI–GPPmax relationship to EVI data obtained by Moderate Resolution Imaging Spectroradiometer to estimate the temporal and spatial variation in GPPmax over central *** findings would improve the accuracy of satellite-based estimate of forest photosynthetic productivity in fine spatial and temporal resolutions,which are

关键词： canopy photosynthesis deciduous broadleaf forest phenology remote sensing vegetation index

Endoscopic submucosal dissection for colorectal neoplasms:A review

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World Journal of Gastroenterology 2014年第43期20卷 16153-16158页

作者： taku Sakamoto Genki Mori Masayoshi Yamada Yuzuru Kinjo Eriko So Seiichiro Abe Yosuke Otake takeshi Nakajima Takahisa Matsuda Yutaka Saito Endoscopy Division National Cancer Center Hospital

The introduction of colorectal endoscopic submucosal dissection(ESD)has expanded the application of endoscopic treatment,which can be used for lesions with a low metastatic potential regardless of their *** has the advantage of achieving en bloc resection with a lower local recurrence rate compared with that of piecemeal endoscopic mucosal ***,in the past,surgery was indicated in patients with large lesions spreading to almost the entire circumference of the rectum,regardless of the depth of invasion,as endoscopic resection of these lesions was technically ***,a prime benefit of ESD is significant improvement in the quality of life for patients who have large rectal *** the other hand,ESD is not as widely applied in the treatment of colorectal neoplasms as it is in gastric cancers owing to the associated technical difficulty,longer procedural duration,and increased risk of *** diversify the available endoscopic treatment strategies for superficial colorectal neoplasms,endoscopists performing ESD need torecognize its indications,the technical issues involved in its application,and the associated *** review outlines the methods and type of devices used for colorectal ESD,and the training required by endoscopists to perform this procedure.

关键词： Colorectum Endoscopic submucosal dissection Short-term outcomes Training indication for endoscopic treatment

Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate

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Bone Research 2023年第2期11卷 340-353页

作者： takeshi Oichi Joe Kodama Kimberly Wilson Hongying Tian Yuka Imamura Kawasawa Yu Usami Yasushi Oshima taku Saito Sakae Tanaka Masahiro Iwamoto Satoru Otsuru Motomi Enomoto-Iwamoto Department of Orthopedics School of MedicineUniversity of MarylandBaltimoreMD21201USA Sensory&Motor System Medicine Faculty of MedicineThe University of TokyoBunkyo-kuTokyo1138655Japan Department of Orthopedics Teikyo University School of MedicineTokyo1738608Japan Department of Biochemistry and Molecular Biology Pennsylvania State University College of MedicineHersheyPA17033USA Department of Oral Pathology Osaka University Graduate School of DentistrySuitaOsaka5650871Japan

Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate,where chondrocytes accumulate and synthesize the matrix scaffold that is replaced by *** chondroprogenitors in the resting zone maintain the continuous turnover of chondrocytes in the growth *** is a leading cause of growth retardation in children;however,after recovery from nutrient deprivation,bone growth is accelerated beyond the normal rate,a phenomenon termed catch-up *** nutritional status is a known regulator of long bone growth,it is largely unknown whether and how chondroprogenitor cells respond to deviations in nutrient ***,using fate-mapping analysis in Axin2CreERT2 mice,we showed that dietary restriction increased the number of Axin2+chondroprogenitors in the resting zone and simultaneously inhibited their *** nutrient deficiency was resolved,the accumulated chondroprogenitor cells immediately restarted differentiation and formed chondrocyte columns,contributing to accelerated ***,we showed that nutrient deprivation reduced the level of phosphorylated Akt in the resting zone and that exogenous IGF-1 restored the phosphorylated Akt level and stimulated differentiation of the pooled chondroprogenitors,decreasing their *** study of Axin2CreERT2 revealed that nutrient availability regulates the balance between accumulation and differentiation of chondroprogenitors in the growth plate and further demonstrated that IGF-1 partially mediates this regulation by promoting the committed differentiation of chondroprogenitor cells.

关键词： progenitor plate maintain

Endoscopic submucosal dissection for large laterally spreading tumors involving the ileocecal valve and terminal ileum

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World Journal of Gastroenterology 2012年第3期18卷 291-294页

作者： Gustavo Kishimoto Yutaka Saito Hajime Takisawa Haruhisa Suzuki taku Sakamoto takeshi Nakajima Takahisa Matsuda National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji Chuo-ku Tokyo 104-0045 Japan

Endoscopic submucosal dissection is a challenging technique that enables en-bloc resection for large colorectal tumors, as laterally spreading tumors, particularly difficult, if the ileocecal valve and terminal ileum is involved. Herein, we report on one of 4 cases. The procedures, using a bipolar needle knife (B-Knife) to reduce the perforation risk and carbon dioxide instead of conventional air insufflation for patient comfort, achieved curative resections without any complications.

关键词： Ileocecal valve Colorectal neoplasms Lat- erally spreading tumor Endoscopic mucosal resection Endoscopic submucosal dissection Bipolar current needle knife B-Knife IT-Knife

Assessment of the validity of the clinical pathway for colon endoscopic submucosal dissection

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World Journal of Gastroenterology 2012年第28期18卷 3721-3726页

作者： Takaya Aoki takeshi Nakajima Yutaka Saito Takahisa Matsuda taku Sakamoto Takao Itoi Yassir Khiyar Fuminori Moriyasu Endoscopy Division National Cancer Center Hospital Tokyo 104-0045 Japan Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo 160-0023 Japan

AIM: To determine the effective hospitalization period as the clinical pathway to prepare patients for endoscopic submucosal dissection (ESD). METHODS: This is a retrospective observational study which included 189 patients consecutively treated by ESD at the National Cancer Center Hospital from May 2007 to March 2009. Patients were divided into 2 groups; patients in group A were discharged in 5 d and patients in group B included those who stayed longer than 5 d. The following data were collected for both groups: mean hospitalization period, tumor site, median tumor size, post-ESD rectal bleeding requiring urgent endoscopy, perforation during or after ESD, abdominal pain, fever above 38 ℃, and blood test results positive for inflammatory markers before and after ESD. Each parameter was compared after data collection. RESULTS: A total of 83% (156/189) of all patients could be discharged from the hospital on day 3 postESD. Complications were observed in 12.1% (23/189) of patients. Perforation occurred in 3.7% (7/189) of patients. All the perforations occurred during the ESD procedure and they were managed with endoscopic clipping. The incidence of post-operative bleeding was 2.6% (5/189); all the cases involved rectal bleeding. We divided the subjects into 2 groups: tumor diameter ≥ 4 cm and < 4 cm; there was no significant difference between the 2 groups (P = 0.93, χ 2 test with Yates correction). The incidence of abdominal pain was 3.7% (7/189). All the cases occurred on the day of the procedure or the next day. The median white blood cell count was 6800 ± 2280 (cells/μL; ± SD) for group A, and 7700 ± 2775 (cells/μL; ± SD) for group B, showing a statistically significant difference (P = 0.023, t-test). The mean C-reactive protein values the day after ESD were 0.4 ± 1.3 mg/dL and 0.5 ± 1.3 mg/dL for groups A and B, respectively, with no significant difference between the 2 groups (P = 0.54, t -test). CONCLUSION: One-day admission is sufficient in the absence of compl

关键词： Clinical pathway Colon Complication Endoscopic submucosal dissection Hospitalization period Rectum

Clinical benefit of radiation therapy and metallic stenting for unresectable hilar cholangiocarcinoma

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World Journal of Gastroenterology 2012年第19期18卷 2364-2370页

作者： Hiroyuki Isayama takeshi Tsujino Yousuke Nakai Takashi Sasaki Keiichi Nakagawa Hideomi Yamashita taku Aoki Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Radiology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Division of Hepato-Biliary-Pancreatic and Transplantation Surgery Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyo 113-8655Japan

AIM： To determine the efficacy of external beam radiotherapy （EBRT）, with or without intraluminal brachytherapy （ILBT）, in patients with non-resected locally advanced hilar cholangiocarcinoma.METHODS： We analyzed 64 patients with locally advanced hilar cholangiocarcinoma, including 25 who underwent resection （17 curative and 8 non-curative）, 28 treated with radiotherapy, and 11 who received best supportive care （BSC）. The radiotherapy group received EBRT （50 Gy, 30 fractions）, with 11 receiving an ad- ditional 24 Gy （4 fractions） ILBT by iridium-192 with remote after loading. ILBT was performed using percu-taneous transhepatic biliary drainage （PTBD） route. Uncovered metallic stents （UMS） were inserted into nonresected patients with obstructive jaundice, with the exception of four patients who received percutaneous transhepatic biliary drainage only. UMS were placed endoscopically or percutaneously, depending on the initial drainage procedure. The primary endpoints were patient death or stent occlusion. Survival time of patients in the radiotherapy group was compared with that of patients in the resection and BSC groups. Stent patency was compared in the radiotherapy and BSC groups.RESULTS： No statistically significant differences in patient characteristics were found among the resection, radiotherapy, and BSC groups. Three patients in the radiotherapy group and one in the BSC group did not receive UMS insertion but received PTBD alone; cholangitis occurred after endoscopic stenting, and patients were treated with PTBD. A total of 16 patients were administered additional systemic chemotherapy （5-fluorouracil-based regimen in 9, S-1 in 6, and gemcitabine in 1）. Overall survival varied significantly among groups, with median survival times of 48.7 mo in the surgery group, 22.1 mo in the radiotherapy group, and 5.7 mo in the BSC group. Patients who underwent curative resection survived significantly longer than those who were not candidates for surgery （P = 0.0076）

关键词： Hilar cholangiocarcinoma Radiotherapy Intra-luminal brachytherapy Biliary metallic stent Ob-structive jaundice

Typical gastroduodenal endoscopic findings in a Crohn's disease patient in remission stage

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World Journal of Gastrointestinal Endoscopy 2012年第3期4卷 96-98页

作者： Masahiro Iizuka taku Harada Hiro-o Yamano takeshi Etou Shiho Sagara Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan Akita Health Care Center Akita Red Cross Hospital

A 39-year-old patient with Crohn's disease (CD) was referred to our hospital for maintenance treatment of *** was diagnosed as having CD of the small and large intestines at 32 years *** underwent partial resection of the ileum at 35 years old because of ileal *** had received enteral nutritional supplement (1200 kcal/d) and metronidazole preparation (500 mg/d),and was in remission Crohn's disease activity index *** performed a routine gastroduodenal endoscopic examination,which revealed the representative endoscopic findings of gastroduodenal lesions in CD,namely,bamboo-joint-like appearance of the gastric body and cardia and a notched sign in the *** findings were clearly observed by using indigo carmine dye *** our patient,typical gastroduodenal findings were observed even in the remission stage,suggesting that these findings would contribute to the early diagnosis of CD not only in the active stage but also during remission.

关键词： Crohn’s disease Gastroduodenal findings Bamboo-joint-like appearance Notched sign