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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma takeshi Sudo Hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

Comparison of incidence of acute kidney injury after robot-assisted radical prostatectomy with that after open retropubic and extraperitoneal laparoscopic radical prostatectomies in patients with prostate cancer

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Current Urology 2024年第2期18卷 139-143页

作者： Shunsuke Sato Toshiaki Tanaka takeshi Maehana Kohei Hashimoto Ko Kobayashi Naoya Masumori Department of Urology Sapporo Medical UniversitySapporoJapan

Background:We retrospectively evaluated the postoperative renal function in patients who had undergone radical prostatectomy to compare the incidences of postoperative acute kidney injury(AKI)among the patients who had undergone robot-assisted radical prostatectomy(RARP),retropubic radical prostatectomy(RRP),and extraperitoneal laparoscopic radical prostatectomy(exLRP).Materials and methods:Patients with prostate cancer who had undergone radical prostatectomy at our institution between 2008 and 2014 were ***-assisted radical prostatectomy was performed using an intraperitoneal approach in a 25-degree Trendelenburg position,whereas other procedures were performed with the patient in the supine *** evaluated the serum creatinine levels and estimated glomerular filtration rates immediately after surgery and on postoperative day *** evaluated the incidence of AKI after prostatectomy using the Acute Kidney Injury Network criteria of the Kidney Disease:Improving Global Outcomes ***:A total of 150 consecutive patients were included,with each of the 3 groups(RARP,RRP,and exLRP)comprising 50 *** AKI was observed in 15(30.0%),1(2.0%),and 3(6.0%)patients in the RARP,RRP,and exLRP groups,*** 1 AKI was observed in all the patients except *** incidence of AKI in RARP group was significantly higher than that in the other groups(p<0.001).In the RARP group,the serum creatinine level was significantly elevated immediately after the surgery;however,it returned to baseline on postoperative day *** procedures were the only independent factor associated with AKI ***:This study suggest that compared with RRP and exLRP,RARP is associated with a higher incidence of postoperative AKI,although most patients recover ***-abdominal pneumoperitoneum may contribute to AKI onset.

关键词： Acute kidney injury Renal function Prostatectomy

人血清淀粉样蛋白A家族在肿瘤转移中的作用及机制的初步研究

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中华肿瘤防治杂志 2010年第21期17卷 1701-1704页

作者：周敏欧阳建富田毅丸羲朗南京大学医学院附属鼓楼医院血液科江苏南京210009 东京女子医科大学药理学东京162-8666

目的:探讨人血清淀粉样蛋白A家族成员在肿瘤转移中的作用和机制。方法:表达和纯化人SAA1-GST、SAA2-GST、SAA3-GST和SAA4-GST融合蛋白,采用体外迁移实验,观察和比较人SAA1-GST、SAA2-GST、SAA3-GST、SAA4-GST和GST对lewis肺癌(lewis lung carcinoma LLC)细胞、Ba/mTLR4/mMD2细胞及其对照Ba/κB细胞的迁移作用。通过蛋白质印迹法观察人SAA1-GST、SAA2-GST、SAA3-GST、SAA4-GST和GST作用后LLC细胞的IkB和pIkB蛋白表达。结果:成功表达和纯化人SAA1-GST、SAA2-GST、SAA3-GST和SAA4-GST融合蛋白。与GST对照组相比,人的4种融合蛋白均能显著促进LLC细胞的迁移,P0.05。蛋白质印迹法结果显示,人SAA1-GST、SAA2-GST、SAA3-GST和SAA4-GST较GST作用后LLC细胞pIKB蛋白表达明显增强,P<0.05。结论:人SAA家族成员都能促进肿瘤细胞的迁移,并且可能是通过激活由TLR4(toll like receptor 4)介导的NF-κB信号转导通路发挥该作用。

关键词：血清淀粉样蛋白A 肿瘤转移细胞运动

鼠血清淀粉样蛋白A家族在肿瘤转移中作用的初步研究

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现代肿瘤医学 2010年第11期18卷 2099-2101页

作者：周敏欧阳建富田毅丸義朗南京大学医学院附属鼓楼医院血液科江苏南京210009 东京女子医科大学药理学系

目的:探讨鼠血清淀粉样蛋白A(serum amyloid A,SAA)家族所有成员在肿瘤转移中的作用。方法:采用实时荧光定量PCR的方法,观察荷瘤鼠和正常对照鼠的6种组织(脑,肺,肝,肌肉,肾和脾)中SAA1,2,3,4 mRNA的表达。表达和纯化鼠SAA1,2,3,4-GST4... 详细信息

目的:探讨鼠血清淀粉样蛋白A(serum amyloid A,SAA)家族所有成员在肿瘤转移中的作用。方法:采用实时荧光定量PCR的方法,观察荷瘤鼠和正常对照鼠的6种组织(脑,肺,肝,肌肉,肾和脾)中SAA1,2,3,4 mRNA的表达。表达和纯化鼠SAA1,2,3,4-GST4种融合蛋白,通过肿瘤细胞体外迁移实验观察和比较鼠SAA1,2,3,4-GST对lewis肺癌细胞(LLC)迁移的作用。结果:LLC荷瘤鼠的6种组织中SAA1,2,3,4 mR-NA的表达是正常对照鼠相应组织的0.15-47.29倍,并且他们在肺组织中的表达较其他组织显著增加(P0.05)。结论:SAA1,2,3,4参与了肿瘤转移,对LLC肿瘤细胞的体外迁移有一定直接促进作用。

关键词：血清淀粉样蛋白A 肿瘤转移

Edge enhanced depth perception with binocular meta-lens

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Opto-Electronic Science 2024年第9期3卷 4-13页

作者： Xiaoyuan Liu Jingcheng Zhang Borui Leng Yin Zhou Jialuo Cheng takeshi Yamaguchi Takuo Tanaka Mu Ku Chen Department of Electrical Engineering City University of Hong KongHong Kong SAR 999077China Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongHong Kong SAR 999077China The State Key Laboratory of Terahertz and Millimeter Waves and NanotechnologyCity University of Hong KongHong Kong SAR 999077China Innovative Photon Manipulation Research Team RIKEN Center for Advanced Photonics351-0198Japan Metamaterial Laboratory RIKEN Cluster for Pioneering Research351-0198Japan Institute of Post-LED Photonics Tokushima University770-8506Japan

The increasing popularity of the metaverse has led to a growing interest and market size in spatial computing from both academia and *** portable and accurate imaging and depth sensing systems is crucial for advancing next-generation virtual reality *** work demonstrates an intelligent,lightweight,and compact edge-enhanced depth perception system that utilizes a binocular meta-lens for spatial *** miniaturized system comprises a binocular meta-lens,a 532 nm filter,and a CMOS *** disparity computation,we propose a stereo-matching neural network with a novel *** H-Module incorporates an attention mechanism into the Siamese *** symmetric architecture,with cross-pixel interaction and cross-view interaction,enables a more comprehensive analysis of contextual information in stereo *** on spatial intensity discontinuity,the edge enhancement eliminates illposed regions in the image where ambiguous depth predictions may occur due to a lack of *** the assistance of deep learning,our edge-enhanced system provides prompt responses in less than 0.15 *** edge-enhanced depth perception meta-lens imaging system will significantly contribute to accurate 3D scene modeling,machine vision,autonomous driving,and robotics development.

关键词： metasurfaces meta-lenses deep learning depth perception edge detection

Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata takeshi Sudo Sho Tazuma Naoki Tanimine Takashi Onoe Yosuke Shimizu Atsushi Yamaguchi Kazuya Kuraoka Shinya Takahashi Hirotaka Tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** To determine transmembrane serine protease 4(TMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BTC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between TMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BTC,46(54%)were *** TMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the TMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the TMPRSS4-positive group(median survival time:25.3 months vs not reached,P<0.001;median survival time:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated TMPRSS4 positivity,pT3/T4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).TMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION TMPRSS4 is a potential prognostic biomarker of radical resection for BTC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection Transmembrane serine protease 4

Fine 3D control of THz emission in air with dual femtosecond laser pre-pulses at tunnelling ionisation regime

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Light(Advanced Manufacturing) 2024年第3期5卷 62-74页

作者： Hsin-Hui Huang takeshi Nagashima Kota Kumagai Yoshio Hayasaki Saulius Juodkazis Vladimir T.Tikhonchuk Koji Hatanaka Optical Sciences Centre ARC Training Centre in Surface Engineering for Advanced Materials(SEAM)School of ScienceSwinburne University of TechnologyHawthornVictoria 3122Australia Faculty of Science and Engineering Setsunan University17-8 Ikeda-NakamachiNeyagawaOsaka572-8508Japan Center for Optical Research and Education(CORE) Utsunomiya University7-1-2 YotoUtsunomiya 321-8585Japan WRH Program International Research Frontiers Initiative(IRFI)Tokyo Institute of Technology Nagatsuta-choMidori-kuYokohamaKanagawa 226-8503 Japan Laser Research Center Physics FacultyVilnius UniversitySauletekio Ave.1010223 VilniusLithuania Centre Lasers Intenses et Applications Universite de Bordeaux351Cours de la Liberation33405 Talence cedexFrance Extreme Light Infrastructure ERIC ELI Beamlines FacilityZa Radnicic 83525241 Dolni BřežanyCzech Republic Organization for Research Strategy and Development Okayama Univ.1-1-1 Tsushima-nakaKita-kuOkayama 700-8530Japan

Emission of THz radiation from air breakdown at focused ultra-short fs-laser pulses(800 nm/35 fs)was investigated for the 3D spatio-temporal control where two pre-pulses are used before the *** laser pulse induced air breakdown forms a~120μm-long focal volume generate shockwaves which deliver a denser air into the focal region of the main pulse for enhanced generation of THz radiation at 0.1-2.5 THz spectral *** intensity of 162 pre-and main-pulses was at the tunnelling ionisation intensities(1-3)×10 W/cm and corresponded to sub-critical(transparent)plasma formation in *** analysis of THz radiation revealed that orientation of the air density gradients generated by pre-pulses and their time-position locations defined the ellipticity of the generated THz electrical *** rotational component of electric current is the origin of THz radiation.

关键词： THz radiation Femtosecond laser induced breakdown Air breakdown spatio-temporal control

No-touch isolation technique in emergency pancreaticoduodenectomy for neoplastic hemorrhage: Two case reports and review of literature

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1910-1917页

作者： Akihiro Cho Satoshi Katagiri Masao Ota Shunsuke Onizawa Ryota Higuchi Toshiya Sugishita Yukiko Niwa takeshi Ishita Toshihiko Mouri Akita Kato Moe Iwata Division of Gastroenterological Surgery Tokyo Women’s Medical UniversityYachiyo Medical CenterChiba 276-8524Japan

BACKGROUND Emergency pancreaticoduodenectomy(EPD)is a rare event for complex periam-pullary *** intraoperative blood loss is correlated with poor post-operative *** SUMMARY Two patients underwent EPD using a no-touch isolation technique,in which all arteries supplying the pancreatic head region were ligated and divided before manipulation of the pancreatic head and *** operative times were 220 and 239 min,and the blood loss was 70 and 270 g,*** patients were discharged on the 14^(th) and 10^(th) postoperative day,***-two patients underwent EPD for the treatment of neoplastic *** mean operative time was 361.6 min,and the mean blood loss was 747.3 *** comp-lication rate was 37.5%.The in-hospital mortality rate was 9.38%.CONCLUSION The no-touch isolation technique is feasible,safe,and effective for reducing intraoperative blood loss in EPD.

关键词： No-touch isolation technique Pancreaticoduodenectomy Emergency pancre-aticoduodenectomy Neoplastic bleeding Superior mesenteric artery first approach Case report

Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Makoto Saito Zen-Ichi Tanei Masumi Tsuda Toma Suzuki Emi Yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka takeshi Kondo Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BACKGROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： Gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report