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Toll-like receptor 4 as a possible therapeutic target for delayed brain injuries after aneurysmal subarachnoid hemorrhage

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Neural Regeneration Research 2017年第2期12卷 193-196页

作者： takeshi Okada Hidenori Suzuki Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan

Neuroinflammation is a well-recognized consequence of subarachnoid hemorrhage（SAH）, and Toll-like receptor（TLR） 4 may be an important therapeutic target for post-SAH neuroinflammation. Of the TLR family members, TLR4 is expressed in various cell types in the central nervous system, and is unique in that it can signal through both the myeloid differentiation primary-response protein 88-dependent and the toll receptor associated activator of interferon-dependent cascades to coordinate the maximal inflammatory response. TLR4 can be activated by many endogenous ligands having damage-associated molecular patterns including heme and fibrinogen at the rupture of an intracranial aneurysm, and the resultant inflammatory reaction and thereby tissue damages may furthermore activate TLR4. It is widely accepted that the excreted products of TLR4 signaling alter neuronal functions. Previous studies have focused on the pathway through nuclear factor（NF）-κΒ signaling among TLR4 signaling pathways as to the development of early brain injury（EBI） such as neuronal apoptosis and blood-brain barrier disruption, and cerebral vasospasm. However, many findings suggest that both pathways via NF-κΒ and mitogen-activated protein kinases may be involved in EBI and cerebral vasospasm development. To overcome EBI and cerebral vasospasm is important to improve outcomes after SAH, because both EBI and vasopasm are responsible for delayed brain injuries or delayed cerebral ischemia, the most important preventable cause of poor outcomes after SAH. Increasing evidence has shown that TLR4 signaling plays an important role in SAH-induced brain injuries. Better understanding of the roles of TLR4 signaling in SAH will facilitate development of new treatments.

关键词： cerebral aneurysm cerebral vasospasm early brain injury delayed brain injury delayed cerebral ischemia inflammation subarachnoid hemorrhage Toll-like receptor 4

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Effect of serum concentration on adhesion of monocytic THP-1 cells onto cultured EC monolayer and EC-SMC co-culture

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 623-629页

作者： Li-jie FAN takeshi KARINO Laboratorv of Biofluid Dvnamics Research Institute for Electronic Science Hokkaido University Sapporo 060-0812 Japan Department of Stomatology School of Medicine Zhejiang University Hangzhou 310006 China

Background:The adhesion of monocytes to the endothelium following accumulation of low-density lipoprotein (LDL) in subendothelial spaces is an important step in the development of intimal hyperplasia in arterially implanted vein grafts and atherosclerosis in both animals and humans. However, it is not well known how serum factors affect the adhesion of monocytes. Methods: We have studied the effect of fetal calf serum (FCS), which we considered a source of LDL, on the adhesion of monocytes to endothelial cells (ECs) by using human monocytic THP-1 cells and both a monolayer of cultured bovine aortic endothelial cells (EC monoculture) and a co-culture with bovine aortic smooth muscle cells (EC-SMC co-culture). Results: It was found that the addition of FCS to the medium greatly affected the adhesion of THP-1 cells, and the higher the concentration of FCS in the medium, the greater the adhesion of THP-1 cells to endothelial cells. Adhesion of THP-1 cells to an EC-SMC co-culture was approximately twofold greater than that to an EC monoculture, and after adhering to endothelial cells, many THP-1 cells trans-migrated into the layer of smooth muscle cells. Conclusion: The results suggest that the elevation of the LDL (cholesterol) level in blood provides a favorable condition for the development of intimal hyperplasia and atherosclerosis by promoting the adhesion of monocytes to the endothelium and their subsequent migration into subendothelial spaces.

关键词：平滑肌细胞血管疾病单核细胞脂蛋白

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On the effects of spatial resolution on effective distance measurement in digital landscapes

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Ecological Processes 2021年第1期10卷 659-677页

作者： Rachel Mundeli Murekatete takeshi Shirabe KTH Royal Institute of Technology School of Architecture and the Built EnvironmentTeknikringen 10A11428 StockholmSweden University of Rwanda College of Science and TechnologyCentre for Geographic Information Systems and Remote SensingKN 67 Street NyarugengeKigaliRwanda

Background:Connectivity is an important landscape attribute in ecological studies and conservation practices and is often expressed in terms of effective *** the cost of movement of an organism over a landscape is effectively represented by a raster surface,effective distances can be equated with the cost-weighted distance of least-cost *** is generally recognized that this measure is sensitive to the grid’s cell size,but little is known if it is always sensitive in the same way and to the same degree and if not,what makes it more(or less)*** conducted computational experiments with both synthetic and real landscape data,in which we generated and analyzed large samples of effective distances measured on cost surfaces of varying cell sizes derived from those *** particular focus was on the statistical behavior of the ratio—referred to as‘accuracy indicator’—of the effective distance measured on a lower-resolution cost surface to that measured on a higher-resolution cost ***:In the experiment with synthetic cost surfaces,the sample values of the accuracy indicator were generally clustered around 1,but slightly greater with the absence of linear sequences(or barriers)of high-cost or inadmissible cells and smaller with the presence of such *** latter tendency was more dominant,and both tendencies became more pronounced as the difference between the spatial resolutions of the associated cost surfaces *** two real satellite images(of different resolutions with fairly large discrepancies)were used as the basis of cost estimation,the variation of the accuracy indicator was found to be substantially large in the vicinity(1500 m)of the source but decreases quickly with an increase in distance from ***:Effective distances measured on lower-resolution cost surfaces are generally highly correlated with—and useful predictors of—effective distances measured on higher-resolution cost *** relationship t

关键词： Landscape connectivity Effective distance Raster-based least-cost path model Accuracy Spatial resolution

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Long-term submergence of non-methanogenic oxic upland field soils helps to develop the methanogenic archaeal community as revealed by pot and field experiments

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Pedosphere 2020年第1期30卷 62-72页

作者： takeshi WATANABE Susumu ASAKAWA Koichi HAYANO Graduate School of Bioagricultural Sciences Nagoya UniversityNagoya 464-8601(Japan) Kyushu National Agricultural Experiment Station NishigoshiKumamoto 861-1192(Japan)

The community structure of methanogenic archaea is relatively stable,i.e.,it is sustained at a high abundance with minimal changes in composition,in paddy field soils irrespective of submergence and *** contrast,the abundance in non-methanogenic oxic soils is much lower than that in paddy field *** study aimed to describe methanogenic archaeal community development following the long-term submergence of non-methanogenic oxic upland field soils in pot and field *** the pot experiment,a soil sample obtained from an upland field was incubated under submerged conditions for 275 *** samples periodically collected were subjected to culture-dependent most probable number(MPN)enumeration,polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE)analysis of archaeal 16 S r RNA gene,and quantitative PCR analysis of the methyl-coenzyme M reductase alpha subunit gene(mcr A)of methanogenic *** abundance of methanogenic archaea increased from 102 to 103 cells g-1 dry soil and 104 to 107 copies of mcr A gene g-1 dry soil after *** no methanogenic archaeon was detected prior to incubation by the DGGE analysis,members from Methanocellales,Methanosarcinaceae,and Methanosaetaceae proliferated in the soils,and the community structure was relatively stable once *** the field experiment,the number of viable methanogenic archaea in a rice paddy field converted from meadow(reclaimed paddy field)was monitored by MPN enumeration over five annual cycles of field *** was also determined simultaneously in a paddy field where the plow layer soil from a farmer’s paddy field was dressed onto the meadow(dressed paddy field)and an upland crop field converted from the meadow(reclaimed upland field).The number of viable methanogenic archaea in the reclaimed paddy field was below the detection limit before the first cultivation of rice and in the reclaimed upland ***,the number gradually increased

关键词： denaturing gradient gel electrophoresis mcrA gene methanogenic archaea microbial community structure microbial habit most probable number method paddy field soil qPCR

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Effect of impact deformation on shape recovery behavior in Fe-Mn-Si shape memory alloy under shape memory training process with cyclic thermo-mechanical loading

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Science China(Technological Sciences) 2021年第7期64卷 1389-1400页

作者： SUN Qian CAO Bo IWAMOTO takeshi SUO Tao Graduate School of Engineering Hiroshima UniversityHigashi-Hiroshima739-8527Japan Cluster of Excellence livMatS@FIT-Freiburg Center for Interactive Materials and Bioinspired Technologies University of FreiburgFreiburgD-79110Germany Academy of Science and Technology Hiroshima UniversityHigashi-Hiroshima739-8527Japan School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China

In the past studies, it has been discovered that the shape memory effect(SME) in the Fe-Mn-Si shape memory alloy(Fe-SMA)can gradually be enhanced by a pre-process called as shape memory training process under cyclic thermo-mechanical *** the other hand, it has been shown that the SME of Fe-SMA can also be affected by changing the strain rate. Therefore, it is possible to improve the SME by combining the strain rate sensitivity and shape memory training process. However, the improvement of SME caused by the training process under impact condition is still unclear. For the training process under impact condition, it is difficult to interrupt the test at the desired strain level due to many reflections of stress waves, which reload the specimen from the free ends. In this paper, to obtain reliable experimental results of SME after the training process under impact condition, the stress waves after first loading are eliminated by the double momentum-trap structure introduced into the impact tensile testing apparatus based on the split Hopkinson pressure bar method. In order to achieve an optimum design of the structure used in experiments, the finite element simulation of the structure is performed. Then, tensile tests in the training process of Fe-28Mn-6Si-5Cr alloy at different strain rates including the impact level are conducted and temperature change of the specimen is measured during training and heating process. As a result, the improvement of SME in the alloy after the training process under quasi-static and impact loading is compared with that under quasi-static loading through verification processes.

关键词： Fe-Mn-Si shape memory alloy training cyclic thermo-mechanical process split Hopkinson pressure bar momentumtrap impact deformation

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PRECISE SYNTHESIS OF OLEFIN BLOCK COPOLYMERS USING A SYNDIOSPECIFIC LIVING POLYMERIZATION SYSTEM

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Chinese Journal of Polymer Science 2013年第4期31卷 541-549页

作者：蔡正国 Hai-hui Su takeshi Shiono State Key Lab for Modification of Chemical Fibers and Polymer Materials College of Material Science and EngineeringDonghua University Graduate School of Engineering Hiroshima University

This feature article summarizes the synthesis of novel olefin block copolymers using fast syndiospecific living homo- and copolymerization of propylene, higher 1-alkene, and norbornene with ansa-fluorenylamidodimethyltitanium- based catalyst according to the authors＇ recent results. The catalytic synthesis of monodisperse polyolefin and olefin block copolymer was also described using this living system.

关键词： Single-site catalyst Propylene Norbomene Living polymerization Block copolymer.

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Effect of visual attention guidance by camera work in visualization using dome display

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 42-54页

作者： Tetsuro Ogi takeshi Yokota Graduate School of System Design and Management Keio University Japan

Dome display is expected to be used as effective visualization environment for modeling and simulation due to the features of frameless and high immersive ***,since the users in the dome display can see the projected image in arbitrary direction freely,it is difficult to share information among the *** this research,in order to solve such a problem,the effect of visual attention guidance in the dome environment due to the effect of camera work was *** a visualization system,DomePlayer that can express the effect of camera work based on the camera work description language was *** the result of evaluation experiments using this system,the constraint condition of the camera work in the dome environment was derived and the effect of visual attention guidance by the camera work was evaluated.

关键词： Visual attention guidance dome display 360◦image camera work VR sickness

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Dynamic Lower-Limb Alignment Focusing on Gait Stability

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Open Journal of Therapy and Rehabilitation 2022年第4期10卷 179-188页

作者： Kan Imai takeshi Onishi Koshiro Sawada Department of Orthopaedics Kyoto Prefectural Rehabilitation Hospital for Mentally and Physically Disabled Kyoto Japan Department of Orthopaedics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Department of Consultation and Assessment Section Kyoto Prefectural General Family Support Center Kyoto Japan Department of Rehabilitation Medicine Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Department of Multidisciplinary Promote for Physical Activity University Hospital Kyoto Prefectural University of Medicine Kyoto Japan

Introduction: Prosthetic limbs must be developed with proper alignment to facilitate safe and efficient gait patterns. This study aimed to identify factors impacting clinically proper gait patterns by objectively evaluating them in persons with lower-limb amputations who use prosthetic limbs. Materials and Methods: This non-experimental descriptive study assessed 58 persons with amputation who used prosthetic limbs. The mechanical axis angle (MAA) of the lower limb during the heel contact, midstance, and toe-off phases and the angle between the tube and floor during the midstance phase were measured using coronal plane gait images. We also investigated whether the MAA and tube angle during the midstance phase have a multimodal distribution. In case of multimodal distributions, we tested for significant between-group differences in patient characteristics. Results: The MAA and tube angle in the coronal plane during the midstance phase had a bimodal distribution (mean 0°). There was a significant difference in the duration of prosthetic limb use between the MAA < 0° and ≥0° groups during the midstance phase. Deviations in the lower limb MAA between the heel contact and midstance phases were 3.3° ± 2.2° and 3.1° ± 2.3° for persons with lower limb amputations in the MAA Conclusions: In this study, prosthetic alignment during the midstance phase had a bimodal distribution. In both groups, deviations in the lower limb MAA were aligned to be approximately 3°.

关键词： Prosthetic Limbs Alignment Gait Below-the-Knee Amputation

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Middle Jurassic spinicaudatan Shizhuestheria from the Sichuan Basin and its ontogenetic implication

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Science China Earth Sciences 2009年第12期52卷 1962-1968页

作者： HIRANO Hiromichi KOZAI takeshi SAKAI Takashi Department of Earth Sciences School of Education Waseda University Tokyo 169-8050 Japan Laboratory Geosciences Faculty of Science Naruto University of Education Tokushima 772-8502 Japan Department of Earth and Planetary Sciences Kyushu University Fukuoka 810-8560 Japan

The diagnosis of the Middle Jurassic spinicaudatan genus Shizhuestheria is revised following the re-examination under a scanning electron microscope of a type specimen from Yanxi of Shizhu, and the newly collected specimens from Xintiangou of Chengjiang Town, Beibei, Chongqing. Small-sized reticulations occur not only in the middle-sized reticulations on growth bands on the dorsal side of the carapace, but also on growth bands on the ventral side of the carapace, which have been overlooked in the original description. The shift from wide dorsal growth bands to narrow ventral ones might indicate an onset of sexual maturity, and the transition in biological priorities from rapid juvenile growth to reproductive activities.

关键词： spinicaudatan Middle Jurassic ontogeny biostratigraphy Sichuan Basin

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A Case of Multiple Idiopathic Root Resorption

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Open Journal of Stomatology 2023年第4期13卷 156-165页

作者： Ryosuke Konishi Arisa Mori takeshi Yoshida Department of Oral and Maxillofacial Surgery Graduate School of Medicine Kyoto University Kyoto Japan

Tooth root resorption is multifactorial, and its etiology and pathogenesis are poorly understood. Tooth root resorption is often incidentally revealed on radiographic examination. Here, we report a case of root resorption in multiple teeth of unknown etiology. Radiographic examination revealed root resorption in the cervical region of the left lateral incisor, canine, first and second premolars, and first and second molars of the mandible. Panoramic radiographs revealed no mandibular lesions that could cause tooth resorption. The patient did not wish to undergo any treatment and is currently under observation. Tooth root resorption with unknown etiology is rare, and further case collection is needed to determine the cause and treatment.

关键词： Multiple Teeth Cement Enamel Junction External Cervical Resorption

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