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Potent antioxidant peptides derived from honey major protein enhance tolerance of eukaryotic cells toward oxidative stress

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Food Production, Processing and Nutrition 2021年第1期3卷 115-124页

作者： Hisham R.Ibrahim Fukiko Nanbu takeshi Miyata Department of Biochemistry and Biotechnology Faculty of AgricultureKagoshima UniversityKagoshima 890-0065Japan

Honey is known for its medicinal benefits and receiving renewed attention as natural *** on health benefits of honey attributed its antioxidant activity to phenolic compounds,but the contribution of proteins and peptides to the antioxidant activity of honey is *** aim of this study was to explore the contribution of proteins and peptides to the antioxidant activity of honey,which remained obscure for *** honey proteins(THP)were isolated by dialysis method and hydrolyzed through simulated gastrointestinal *** hydrolysates were fractionated using size-exclusion *** antioxidant activity was determined by using superoxide radical-scavenging,DPPH reduction and intracellular ROS *** was shown to exhibit superoxide-scavenging activity but its pepsin-hydrolysate(HP-p)showed superior scavenging *** HP-p produced five peptide fractions(P1~P5)when fractionated on Sephacryl S-100 size-exclusion *** five fractions showed superoxide-scavenging activities and DPPH reducing activities,whereas the slow-eluting peptide fractions(P3 and P4)were the most ***-TOF/MS analysis identified a pentapeptide(TSNTF)as the dominant peptide in the active fractions P3 and *** colonic epithelial cells treated with P3 and P4 peptides exhibited lower intracellular ROS,when oxidative stress was induced by H2O2 or diethyl maleate(DEM),indicating strong tolerance to oxidative *** viabilities of human cells or yeast cells were largely decreases under oxidative stress,but treated cells with P3 and P4 showed higher viability compared with the untreated *** results are the first to describe a novel antioxidant peptide from honey that confer ex vivo anti-oxidative function within a complicated milieu of eukaryotic cells and pave the way for its potential as nutraceutical or therapeutic peptide for risk-reduction of oxidative-stress and related diseases.

关键词： Honey Proteins Biopeptides Antioxidant Intracellular oxidative stress

Direct correlation of radiolarian Kilinora spiralis Zone with the Late Jurassic ammonite faunal succession in the Kurisaka Formation, Kurosegawa Terrane, SW Japan

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Science China Earth Sciences 2009年第12期52卷 1910-1923页

作者： ISHIDA Keisuke TSUJINO Yasuyuki KOZAI takeshi SATO Tadashi HIRSCH Francis Laboratory of Geology Institute of SAS Faculty of Science University of Tokushima Tokushima 770-8502 Japan Tokushima Prefectural Museum Bunka-no-Mori Park Tokushima 770-8070 Japan Laboratory of Geosciences Naruto University of Education Naruto 772-8502 Japan Fukada Geological Institute Hon-Komagome 2-13-12 Bunkyo-Ku Tokyo 113-0021 Japan

The last appearance datum of the radiolarian Kilinora spiralis is recorded above the first appearance datum of the ammonite Ataxioceras (A.) kurisakense in the Todoro Section of the Kurisaka Formation, Southern Kurosegawa Terrane, Shikoku, SW Japan. The constraint by ammonite age prolongs the range of the Kilinora spiralis Zone, a remarkable Jurassic radiolarian zone in Japan-NW Pacific region, into the lower Kimmeridgian. The direct correlation of the Kilinora spiralis zone with the Late Jurassic ammonite faunal succession in the Kurisaka Formation will provide a clue to the still pending chronological difference between European and North American radiolarian zones.

关键词： Late Jurassic LAD of Kilinora spiralis radiolarian zonation FAD of Ataxioceras (A.) kurisakense Kurisaka Formation Kurosegawa Terrane SW Japan

Distinctive Precursory Air–Sea Signals between Regular and Super El Ni os

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Advances in Atmospheric Sciences 2016年第8期33卷 996-1004页

作者： Lin CHEN Tim LI Swadhin K.BEHERA takeshi DOI Key Laboratory of Meteorological Disaster Joint International Research Laboratory of Climate and Environmental Changeand Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and Technology International Pacific Research Center School of Ocean and Earth Science and Technology University of Hawaii Application Laboratory Japan Agency for Marine-Earth Science and Technology

Statistically different precursory air–sea signals between a super and a regular El Ni no group are investigated, using observed SST and rainfall data, and oceanic and atmospheric reanalysis data. The El Ni no events during 1958–2008 are first separated into two groups： a super El Ni no group（S-group） and a regular El Ni no group（R-group）. Composite analysis shows that a significantly larger SST anomaly（SSTA） tendency appears in S-group than in R-group during the onset phase[April–May（0）], when the positive SSTA is very small. A mixed-layer heat budget analysis indicates that the tendency difference arises primarily from the difference in zonal advective feedback and the associated zonal current anomaly（u）.This is attributed to the difference in the thermocline depth anomaly（D） over the off-equatorial western Pacific prior to the onset phase, as revealed by three ocean assimilation products. Such a difference in D is caused by the difference in the wind stress curl anomaly in situ, which is mainly regulated by the anomalous SST and precipitation over the Maritime Continent and equatorial Pacific.

关键词： super El Ni no precursory air–sea signals thermocline depth anomaly ENSO

Does a combined intervention program of repetitive transcranial magnetic stimulation and intensive occupational therapy affect cognitive function in patients with post-stroke upper limb hemiparesis?

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Neural Regeneration Research 2016年第12期11卷 1932-1939页

作者： Takatoshi Hara Masahiro Abo Kiyohito Kakita takeshi Masuda Ryunosuke Yamazaki Department of Rehabilitation Medicine The Jikei University School of Medicine Department of Rehabilitation Medicine Kyoto Ohara Memorial Hospital

Low-frequency repetitive transcranial magnetic stimulation（LF-r TMS） to the contralesional hemisphere and intensive occupational therapy（i OT） have been shown to contribute to a significant improvement in upper limb hemiparesis in patients with chronic stroke. However, the effect of the combined intervention program of LF-r TMS and i OT on cognitive function is unknown. We retrospectively investigated whether the combined treatment influence patient＇s Trail-Making Test part B（TMT-B） performance, which is a group of easy and inexpensive neuropsychological tests that evaluate several cognitive functions. Twenty-five patients received 11 sessions of LF-r TMS to the contralesional hemisphere and 2 sessions of i OT per day over 15 successive days. Patients with right- and left-sided hemiparesis demonstrated significant improvements in upper limb motor function following the combined intervention program. Only patients with right-sided hemiparesis exhibited improved TMT-B performance following the combined intervention program, and there was a significant negative correlation between Fugl-Meyer Assessment scale total score change and TMT-B performance. The results indicate the possibility that LF-r TMS to the contralesional hemisphere combined with i OT improves the upper limb motor function and cognitive function of patients with right-sided hemiparesis. However, further studies are necessary to elucidate the mechanism of improved cognitive function.

关键词： nerve regeneration stroke repetitive transcranial magnetic stimulation Trail-Making Test cognitive function occupational therapy neural regeneration

原位重构限制在三维纳米孔铜内的铋纳米颗粒促电还原CO_(2)

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Science China Materials 2024年第3期67卷 796-803页

作者：赵秋玉王静庄严宫磊张薇宁樊唯镏鲁振张永政藤田武志张平薛其坤 School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China School of Chemistry and Chemical Engineering Shandong UniversityJinan 25010China Institute of Physics Chinese Academy of SciencesBeijing 100190China Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan School of Environmental Science and Engineering Kochi University of TechnologyKami 782-8502Japan

由于单金属Bi在CO_(2)还原反应(CO_(2)RR)中效率较低,通过表面工程复合材料提高电导率和产率是一种有吸引力的方法.在此,我们重构了在三维纳米孔铜结构中的原位生长金属Bi纳米颗粒.得益于三维纳米多孔导电网络和Cu与Bi之间的强相互作用,... 详细信息

由于单金属Bi在CO_(2)还原反应(CO_(2)RR)中效率较低,通过表面工程复合材料提高电导率和产率是一种有吸引力的方法.在此,我们重构了在三维纳米孔铜结构中的原位生长金属Bi纳米颗粒.得益于三维纳米多孔导电网络和Cu与Bi之间的强相互作用,Bi@np-Cu费米能级向上移动,表现出优异的电催化二氧化碳还原性能.Bi@np-Cu在-0.97 V的电位下具有97.7%的甲酸法拉第效率,电流密度为82 mA cm^(-2).重要的是,该催化剂在连续催化反应40 h后仍能实现超过90%的法拉第效率.DFT计算表明,np-Cu有效地调节了Bi的电子态,优化了中间吸附能,从而提高了Bi的本征活性.这项工作为纳米多孔金属在催化中的应用提供了一个新视角.

关键词： 3D nanoporous CO_(2)RR Bi nanoparticle electrocatalysis reconstruction

Advances in high carbon dioxide separation performance of poly(ethylene oxide)-based membranes

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Journal of Energy Chemistry 2020年第7期29卷 30-52,I0002页

作者： Samaneh Bandehali Abdolreza Moghadassi Fahime Parvizian Sayed Mohsen Hosseini takeshi Matsuura Ezatollah Joudaki Department of Chemical Engineering Faculty of EngineeringArak UniversityArak 38156-8-8349Iran Department of Chemical and Biological Engineering University of OttawaOttawaOntario K1N 6N5Canada

Poly(ethylene-oxide)(PEO)-based membranes have attracted much attention recently for CO2 separation because CO2 is highly soluble into PEO and shows high selectivity over other gases such as CH4 and ***,those membranes are not strong enough mechanically and highly crystalline,which hinders their broader applications for separation *** this review discussions are made,as much in detail as possible,on the strategies to improve gas separation performance of PEO-based *** of techniques such as synthesis of graft copolymers that contain PEO,cross-linking of polymers and blending with long chains polymers contributed significantly to improvement of *** of ionic liquids/nanoparticles has also been found ***,surface modification of nanoparticles has been done chemically or physically to enhance their compatibility with polymer *** a result of all such efforts,an excellent performance,i.e.,CO2 permeability up to 200 Barrer,CO2/N2 selectivity up to 200 and CO2/CH4 selectivity up to 70,could be *** method is to introduce functional groups into PEO-based polymers which boosted CO2 permeability up to 200 Barrer with CO2/CH4 selectivity between 40 and *** CO2 permeability of PEO-based membranes increases,without much change in selectivity,when the length of ethylene oxide is increased.

关键词： Membrane gas separation Molecular design Poly(ethylene oxide) CO2/CH4 separation

Liver-targeted hydrodynamic gene therapy: Recent advances in the technique

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World Journal of Gastroenterology 2016年第40期22卷 8862-8868页

作者： takeshi Yokoo Kenya Kamimura Hiroyuki Abe Yuji Kobayashi Tsutomu Kanefuji Kohei Ogawa Ryo Goto Masafumi Oda takeshi Suda Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University Institute for Research Collaboration and Promotion Niigata University

One of the major research focuses in the field of gene therapy is the development of clinically applicable, safe, and effective gene-delivery methods. Since the first case of human gene therapy was performed in 1990, a number of gene-delivery methods have been developed, evaluated for efficacy and safety, and modified for human application. To date, viral-vectormediated deliveries have shown effective therapeutic results. However, the risk of lethal immune response and carcinogenesis have been reported, and it is still controversial to be applied as a standard therapeutic option. On the other hand, delivery methods for nonviral vector systems have been developed, extensively studied, and utilized in in vivo gene-transfer studies. Compared to viral-vector mediated gene transfer, nonviral systems have less risk of biological reactions. However, the lower gene-transfer efficiency was a critical hurdle for applying them to human gene therapy. Among a number of nonviral vector systems, our studies focus on hydrodynamic gene delivery to utilize physical force to deliver naked DNA into the cells in the living animals. This method achieves a high gene-transfer level by DNA solution injections into the tail vein of rodents, especially in the liver. With the development of genome editing methods, in vivo gene-transfer therapy using this method is currently the focus in this research field. This review explains the method principle, efficiency, safety, and procedural modifications to achieve a high level of reproducibility in large-animal models.

关键词： Gene therapy liver Hydrodynamic gene delivery Non-viral image-guided

Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第29期23卷 5379-5385页

作者： Masayuki Miyazaki Masayoshi Yada Kosuke Tanaka takeshi Senjyu takeshi Goya Kenta Motomura Motoyuki Kohjima Masaki Kato Akihide Masumoto Kazuhiro Kotoh Department of Hepatology Iizuka Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical Science Kyushu University Department of Hepatology Harasanshin Hospital

To investigate the factors influenced the efficacy of tolvaptan (TLV) in liver cirrhosis. METHODSWe retrospectively enrolled 61 consecutive patients with refractory hepatic ascites. All of them had been treated with furosemide and spironolactone before admission, and treated with TLV for 7 d in our hospital. The effect of TLV was defined by the rate of body weight loss, and the factors that influenced TLV efficacy were analyzed using multiple regression. RESULTSCoexistent hepatocellular carcinoma (HCC) was the only significant predictive variable that attenuated the efficacy of TLV. In stratified analysis, high doses of furosemide decreased the efficacy of TLV in patients with HCC, and increased efficacy in those without HCC. In the latter, a high Child-Pugh-Turcotte score had a positive influence and a high concentration of lactate dehydrogenase had a negative influence on the effectiveness of TLV. CONCLUSIONDevelopment of ascites may differ between patients with liver failure and those with HCC progression. A sufficient preceding dose of furosemide decreases diuretic effect of TLV.

关键词： Ascites Tolvaptan Furosemide Cirrhosis Hepatocellular carcinoma

Numerical Simulation of Ice Accretion Phenomena on Rotor Blade of Axial Blower

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Journal of Thermal Science 2012年第4期21卷 322-326页

作者： Taiki Matsuura Masaya Suzuki Makoto Yamamoto Shinichiro Shishido takeshi Murooka Hiroshi Miyagawa Graduate School of Mechanical Engineering Tokyo University of Science 1-14-6 Kudankita Chiyoda-ku Department of Mechanical Engineering Tokyo University of Science 1-14-6 Kudankita Chiyoda-ku Research and Engineering Division IHI Corporation 229 Tonogaya Mizuho-cho Nishitama-gun

Ice accretion is the phenomenon that super-cooled water droplets impinge and accrete on a body. It is well known that ice accretion on blades and airfoils leads to performance degradation and severe accidents. For this reason, experimental investigations have been carried out using flight tests or icing tunnels. However, it is too expensive, dangerous, and difficult to set actual icing conditions. Hence, computational fluid dynamics is useful to predict ice accretion. A rotor blade is one of jet engine components where ice accretes. Therefore, the authors focus on the ice accretion on a rotor blade in this study. Three-dimensional icing phenomena on the rotor blade of a commercial axial blower are computed here, and ice accretion on the rotor blade is numerically investigated.

关键词： Icing Computational Fluid Dynamics Euler-Lagrangian Coupling Rotor Blade Axial Blower