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Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer

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Asian Journal of Urology 2016年第4期3卷 229-239页

作者： takeshi hirata Seung Chol Park Michelle T.Muldong Christina N.Wu Tomonori Yamaguchi Amy Strasner Omer Raheem Hiromi Kumon Robert L.Sah Nicholas A.Cacalano Catriona H.M.Jamieson Christopher J.Kane Koichi Masuda Anna A.Kulidjian Christina A.M.Jamieson Department of Urology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayamaJapan Department of Urology Wonkwang University School of Medicine and HospitalIksanSouth Korea Moores Cancer Center University of CaliforniaSan DiegoLa JollaCAUSA Department of Urology University of CaliforniaSan DiegoLa JollaCAUSA Department of Surgery University of CaliforniaSan DiegoLa JollaCAUSA Department of Medicine University of CaliforniaSan DiegoLa JollaCAUSA Department of Orthopaedic Surgery School of MedicineUniversity of CaliforniaSan DiegoLa JollaCAUSA Department of Bioengineering University of CaliforniaSan DiegoLa JollaCAUSA Department of Radiation Oncology University of California at Los AngelesLos AngelesCAUSA

Objective:Bone metastasis occurs in up to 90%of men with advanced prostate cancer and leads to fractures,severe pain and *** metastases induce a spectrum of types of bone lesions which can respond differently to therapy even within individual prostate cancer ***,the special environment of the bone makes the disease more complicated and incurable.A model in which bone lesions are reproducibly induced that mirrors the complexity seen in patients would be invaluable for pre-clinical testing of novel *** microstructural changes in the femurs of mice implanted with PCSD1,a new patient-derived xenograft from a surgical prostate cancer bone metastasis specimen,were ***:Quantitative micro-computed tomography(micro-CT)and histological analyses were performed to evaluate the effects of direct injection of PCSD1 cells or media alone(Control)into the right femurs of Rag2/gc/male ***:Bone lesions formed only in femurs of mice injected with PCSD1 *** volume(BV)was significantly decreased at the proximal and distal ends of the femurs(p<0.01)whereas BV(p<0.05)and bone shaft diameter(p<0.01)were significantly increased along the femur ***:PCSD1 cells reproducibly induced bone loss leading to osteolytic lesions at the ends of the femur,and,in contrast,induced aberrant bone formation leading to osteoblastic lesions along the femur ***,the interaction of PCSD1 cells with different bone region-specific microenvironments specified the type of bone *** approach can be used to determine if different bone regions support more therapy resistant tumor growth,thus,requiring novel treatments.

关键词： Bone metastatic prostate cancer Patient-derived xenograft microenvironment Microstructural CT Osteolytic lesions Osteoblastic lesions

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Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men

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World Journal of Gastroenterology 2017年第39期23卷 7150-7159页

作者： Akira Yokoyama Kenro hirata Rieko Nakamura Tai Omori takeshi Mizukami Junko Aida Katsuya Maruyama Tetsuji Yokoyama National Hospital Organization Kurihama Medical and Addiction Center Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Keio University Department of Health Promotion National Institute of Public HealthSaitama Endoscopy Center Kawasaki Municipal Ida Hospital Research Team for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology

AIM To determine whether the presence of columnar-lined esophagus(CLE) is associated with the presence of esophageal varices(EVs) in male Japanese alcoholics. METHODS The subjects were 1614 Japanese alcohol-dependent men(≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis(LC).RESULTS CLE ≥ 5 mm in length was found in 355 subjects(≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e., nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order(P < 0.0001): 23.3% in the group without EVs, 17.4% in the group with small and straight EVs, and 5.7% in the group with advanced EVs. The multivariate ORs(95%CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5 mm was present [0.46(0.23-0.93) and 0.24(0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.

关键词： Alcohol Columnar-lined esophagus Hiatal hernia Liver cirrhosis Portal hypertension Esophageal varices

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Direct Observation of High-Temperature Superconductivity in One-Unit-Cell FeSe Films

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Chinese Physics Letters 2014年第1期31卷 156-160页

作者：张文号孙袆张金松李坊森郭明华赵弇斐张慧敏彭俊平邢颖王慧超 FUJITA takeshi hirata Akihiko 李志丁浩汤辰佳王萌王庆艳何珂季帅华陈曦王俊峰夏正才李亮王亚愚王健王立莉陈明伟薛其坤马旭村 State Key Lab of Low-Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 International Center for Quantum Materials School of Physics Peking University Beijing 100871 Collaborative Innovation Center of Quantum Matter Beijing Institute of Physics Chinese Academy of Sciences Beijing 100190 WPI Advanced Institute for Materials Research Tohoku University Sendai 9808577 Japan Wuhan National High Magnetic Field Center Huazhong University of Science and Technology Vguhan 430071

We prepared one-unit-ceil （1-UC） thick FeSe films on insulating SrTiOa substrates with non-superconducting FeTe protection layers by molecular beam epitaxy for ex situ studies. By direct transport and magnetic measurements, we provide definitive evidence for high temperature superconductivity in the 1-UC FeSe films with an onset Tc above 40 K and an extremely large critical current density fie Jc-1.7× 106 A/cm2 at 2K, which are much higher than Tc-8K and Jc-104 A/cm^2 for bulk FeSe, respectively. Our work may pave the way to enhancing and tailoring superconductivity by interface engineering.

关键词： Selenium compounds

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Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis

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World Journal of Gastroenterology 2015年第44期21卷 12667-12675页

作者： Saifun Nahar Atsushi Iraha Akira Hokama Ayako Uehara Gretchen Parrott Tetsuya Ohira Masatoshi Kaida Tetsu Kinjo takeshi Kinjo Tetsuo hirata Nagisa Kinjo Jiro Fujita Department of Infectious Respiratory and Digestive Medicine University of the Ryukyus Department of Endoscopy University of the Ryukyus

AIM: To evaluate a multiplex PCR assay for the detection of bacterial and viral enteropathogens in stool samples from patients with ulcerative colitis(UC). METHODS: We prospectively analyzed 300 individuals, including immunocompetent patients, immunocompromised patients, and patients with UC. Stool samples were collected from the recto-sigmoid region of the colon by endoscopy. The samples were qualitatively analyzed for bacterial and viral enteropathogens with a multiplex PCR assay using a Seeplex® Kit. Additional clinical and laboratory data were collected from the medical records. RESULTS: A multiplex PCR assay detected 397 pathogens(191 bacteria and 206 viruses) in 215 samples(71.7%). The most frequently detected bacteria were Escherichia coli H7, 85(28.3%); followed by Aeromonas spp., 43(14.3%); and Clostridium perfringens, 36(12.0%) samples. The most prevalent viruses were Epstein-Barr virus(EBV), 90(30.0%); followed by human herpes virus-6(HHV-6), 53(17.7%); and cytomegalovirus(CMV), 37(12.3%) samples. The prevalence rate of CMV infection was significantly higher in the immunocompromised group than in the immunocompetent group(P < 0.01). CMV infection was more common in patients with UC(26/71; 36.6%)than in the immunocompetent patients excluding UC(6/188; 3.2%)(P < 0.01). CMV infection was more prevalent in UC active patients(25/58; 43.1%) than in UC inactive patients(1/13; 7.7%)(P < 0.05). Among 4 groups which defined by the UC activity and immunosuppressive drugs, the prevalence rate of CMV infection was highest in the UC active patients with immunosuppressive drugs(19/34; 55.8%). EpsteinBarr virus(EBV) infection was more common in the immunocompromised patients excluding UC(18/41; 43.9%) than in the immunocompetent patients excluding UC(47/188; 25.0%)(P < 0.05). The simultaneous presence of CMV and EBV and/or HHV6 in UC active patients(14/58; 24.1%) was greater than in immunocompromised patients excluding UC(5/41; 12.2%)(P < 0.05). CONCLUSION: The mult

关键词： Polymerase chain reaction Ulcerativecolitis Cytome

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亚洲东部森林的小气候特征：1.辐射和能量的平衡

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植物生态学报 2015年第6期39卷 541-553页

作者：谭正洪于贵瑞周国逸韩士杰夏禹九前田高尚小杉绿子山野井克己李胜功太田岳史平田竜一安田幸生中野隆志小南裕志北村兼三溝口康子廖志勇赵俊福杨廉雁中国科学院西双版纳热带植物园热带森林生态学重点实验室中国昆明650223 中国科学院地理科学与资源研究所中国北京100101 中国科学院华南植物园中国广州510650 中国科学院沈阳应用生态研究所中国沈阳110016 华大学环境学院中国台湾花莲97401 日本产业技术综合研究所环境管理技术研究部门日本筑波305-8569 京都大学农学研究科日本京都606-8501 日本森林综合研究所北海道支所日本札幌062-8516 名古屋大学生命农学研究科日本名古屋464-8601 日本国立环境研究所地球环境研究中心日本筑波305-8506 日本森林综合研究所东北支所日本岩手020-0123 日本森林综合研究所气象环境研究领域日本筑波305-8687 日本森林综合研究所关西支所日本京都612-0855 日本森林综合研究所九州支所日本熊本860-0862

森林小气候是森林植被与区域气候相互作用所形成的局地环境系统。森林小气候的研究,不仅是一项关于森林生态系统运行机理的理论研究工作,对农林业生产也具有现实的指导意义,在全球变化形势下其重要性又进一步凸显。辐射的收支、能量的... 详细信息

森林小气候是森林植被与区域气候相互作用所形成的局地环境系统。森林小气候的研究,不仅是一项关于森林生态系统运行机理的理论研究工作,对农林业生产也具有现实的指导意义,在全球变化形势下其重要性又进一步凸显。辐射的收支、能量的平衡与分配是小气候特征形成的基础。对森林辐射收支和能量分配的研究,过去主要以单站点为主,系统的区域分析十分匮乏。该文采用亚洲东部17个森林站点的实测数据,分析了生态系统的辐射收支和能量平衡,探讨了区域尺度上辐射特征量的纬度变异性及其预测关系式,建立了亚洲东部森林带典型森林生态系统的辐射和能量收支模式。所选站点以水平地带性为主,为区域分析奠定了基础。研究发现,辐射特征量具有明显的纬度依赖性,辐射特征量和纬度二者的关系可以用于相应的预测。比如,太阳辐射随着纬度的变化关系为:y=6205–42.15x(p<0.01),即纬度每上升1°,太阳辐射年总量下降42 MJ,理论最大值为6 205 MJ。净辐射的纬度趋势更加显著(r=–0.89,p<0.000 1),其线性回归关系为:y=4340–45.60x。亚洲东部森林蒸散比(EF)与降水量(P)之间的定量关系为:EF=0.7098(1–exp(–0.0026P))。通过对比不同森林带的辐射和能量模式,发现亚热带森林在辐射收支上与温带森林相近,波文比既高于温带森林,也高于热带森林,表明更多的净辐射能用于显热交换。关于亚热带森林在小气候和物质代谢方面的特殊性,值得进一步分析研究。

关键词：亚热带森林纬度地带性蒸散比太阳辐射能量分配

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