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Injury/ischemia-induced stem cells: up-to-date knowledge and future perspectives for neural regeneration

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Neural Regeneration Research 2025年第3期20卷 797-798页

作者： takayuki Nakagomi Institute for Advanced Medical Sciences Hyogo Medical UniversityNishinomiyaJapan Department of Therapeutic Progress in Brain Diseases Hyogo Medical UniversityNishinomiyaJapan

Brain injuries like ischemic stroke induce endogenous stem cell production. Although the precise traits of stem cells in pathological brains remain unclear, we previously demonstrated that injury/ischemia-induced stem... 详细信息

关键词： ischemia injuries

Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli Guo takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli Guo Chikako Harada takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

Phase transition in Pd_(40)Ni_(10)Cu_(30)P_(20) bulk metallic glass under HP & HT

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Science China(Physics,Mechanics & Astronomy) 2005年第6期48卷 716-722页

作者： utsumi Wataru Okada Taku Synchrotron Radiation Research Center Japan Atomic Energy Research Institute 1-1-1 Kout Mikasuki Sayo Hyogo 679-5148 Japan

The phase transitions in Pd40Ni10Cu30P20 bulk metallic glass (BMG) have been studied under high pressure and high temperature (HP & HT) by X-ray diffraction measurements with synchrotron radiation source. We found that the BMG underwent a phase transitions of amorphous-crystalline-amorphous at 10 GPa upon heating. The parallel experiments were carried out at 7 GPa, while we did not observe the amorphous-crystalline-amorphous transitions by increasing temperature. Quenching the melted BMG at 7 GPa, it was found that the phase crystallized from the melt differed from the primary phase crystallized from the starting amorphous solid upon heating, suggesting there existed a distinct mechanism in two cases.

关键词： phase transition, Pd40Ni10Cu30P20, high pressure and high temperature.

APPLICABILITY OF CREEP CONSTITUTIVE EQUATIONS TOCREEP CURVES UNDER CONSTANT LOAD

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Acta Metallurgica Sinica(English Letters) 1998年第6期11卷 397-404页

作者： Y.Kurata H.utsumi Japan Atomic Energy Research Inst Ibaraki-ken Japan

Applicability of the following creep constitutive equations was investigated for normal type creep curves of Ni-18.5Cr alloy and tertiary creep dominant curves of Ni-18.5Cr16W alloy under constant load: the θ projection method describing a creep curse by a sum of two exponential terms, modified θ method describing a primary creep stage by an exponential term and a tertiary creep stage by a logarithmic term, modified Ω method describing a creep curve by a sum of two logarithmic term, 2θ method with only a tertiary creep component and Ω method. The θ, modified θ and modified Ω methods can describe normal type and tertiary creep dominant curves. Tertiary creep dominant curves of Ni-18.5Cr-16W alloy at 900℃ are also described using 2θ and Ω methods. Applicability of the modified θ and modified Ω methods is superior for constant load creep curves because they can predict creep curves up to rupture and rupture life accurately and conservatively.

关键词： creep equation θ projection method Ω method Ni-18.5Cr alloy,Ni-18.5Cr-16W alloy

Surface modification and characterization of F-Co doped spinel LiMn_2O_4

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Rare Metals 2006年第Z1期25卷 33-38页

作者： WATANABE takayuki Department of Environmental Chemistry and Engineering Tokyo Institute of Technology 4259 Nagatsuta Yokomaha 226-8502 Japan

Spinel LiCo0.09Mn1.91O3.92F0.08 as cathode material was modified with LiCoO2 by the sol-gel method, and the crystal structure, morphology and electrochemical performance were characterized with XRD, SEM, EDS, AAS and charge-discharge test in this paper. The results show that a good clad coated on parent material can be synthesized by the sol-gel method, and the materials with modification have perfect spinel structure. LiCo0.09Mn1.91O3.92F0.08 materials coated by LiCoO2 improve the stability of crystal structure and decrease the dissolution of Mn into electrolyte. With the LiCoO2 content increasing, the specific capacity and cycle performance of samples are improved. The capacity loss is also suppressed distinctly even at 55 ℃.

关键词： lithium ion batteries spinel LiMn2O4 ion doping surface coating

Prevention of recurrence after surgery for Crohn's disease: Efficacy of infliximab

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World Journal of Gastroenterology 2010年第43期16卷 5405-5410页

作者： takayuki Yamamoto Inflammatory Bowel Disease Center and Department of Surgery Yokkaichi Social Insurance Hospital

After surgery for Crohn's disease (CD), early endoscopic lesions are frequently observed despite no symptomatic recurrence. The severity of lesions found at postoperative endoscopy is reported to be a strong predictive factor for future clinical recurrence. If endoscopic lesions in the early postoperative period can be reduced with medications, symptomatic recurrence will likely be delayed and decreased. Before the introduction of biologic therapies, various medications were used for the maintenance of clinical remission after surgery; however, few demonstrated consistent efficacy. Infliximab is a recombinant anti-tumor necrosis factor-α antibody. Although infliximab is one of the most effective medications in the management of CD, its efficacy for early endoscopic lesions after surgery has not yet been assessed. The author and colleagues recently conducted a prospective study in order to investigate the impact of infliximab on early endoscopic lesions after resection for CD. We found that infliximab therapy showed clear suppressive effects on clinical and endoscopic disease activity in patients with early endoscopic lesions after resection.

关键词： Crohn’s disease Postoperative recurrence Endoscopic lesion Infliximab

Factors affecting recurrence after surgery for Crohn's disease

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World Journal of Gastroenterology 2005年第26期11卷 3971-3979页

作者： takayuki Yamamoto Inflammatory Bowel Disease Center and Department of Surgery Yokkaichi Social Insurance Hospital YokkaichiMie 510-0016Japan

Although in Crohn's disease post-operative recurrence is common, the determinants of disease recurrence remain speculative. The aim of this study was to examine factors affecting post-operative recurrence of Crohn's disease. A Medline-based literature review was carried out. The following factors were investigated: age at onset of disease, sex, family history of Crohn's disease,smoking, duration of Crohn's disease before surgery,prophylactic medical treatment (corticosteroids, 5-amino salicylic acid [5-ASA] and immunosuppressants),anatomical site of involvement, indication for surgery (perforating or non-perforating disease), length of resected bowel, anast-omotic technique, presence of granuloma in the specimen, involvement of disease at the resection margin, blood transfusions and postoperative complications. Smoking significantly increases the risk of recurrence (risk is approximately twice as high), especially in women and heavy smokers. Quitting smoking reduces the post-operative recurrence rate. A number of studies have shown a higher risk when the duration of the disease before surgery was short. There were, however, different definitions of 'short' among the studies. Prophylactic cortic-osteroids therapy is not effective in reducing the post-operative recurrence. A number of randomized controlled trials offered evidence of the efficacy of 5-ASA (mesalazine) in reducing post-operative recurrence. Recently, the thera-peutic efficacy of immunosuppressive drugs (azathioprine and 6-mercaptopurine) in the prevention of post-operative recurrence has been investigated and several studies have reported that these drugs might help prevent the recurrence. Further clinical trials would be necessary to evaluate the prophylactic efficacy of *** studies showed a higher recurrence rate in patients with perforating disease than in those with non-perforating disease. However, evidence for differing recurrence rates in perforating and non-perforating dis

关键词： Crohn's disease Post-operative recurrence Predictive factors Resection Surgery

Decomposition of Glycerine by Water Plasmas at Atmospheric Pressure

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Plasma Science and Technology 2013年第4期15卷 357-361页

作者： takayuki WATANABE NARENGERILE Department of Environmental Chemistry and Engineering Tokyo Institute of Technology 4259 NagatsutaYokohama 226-8502 Japan

High concentration of aqueous glycerine was decomposed using a direct current （DC） plasma torch at atmospheric pressure. The torch can generate the plasma with water as the plasma-supporting gas in the absence of any additionM gas supply system and cooling devices. The results indicated that 5 mol% glycerine was completely decomposed by water plasmas at arc powers of 0.55~1.05 kW. The major products in the effluent gas were H2 （68.9%~71.1%）, CO2 （18.9%~23.0%）, and CO （0.2%~0.6%）. However, trace levels of formic acid （HCOOH） and formaldehyde （HCHO） were observed in the liquid effluent. The results indicated that the water plasma waste treatment process is capable of being an alternative green technology for organic waste decomposition.

关键词： thermal plasma water plasma glycerine decomposition