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小麦胚芽活性肽通过AMPK/SIRT1改善大鼠肝脏衰老损伤的作用机制研究

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中国科学：生命科学 2024年第3期54卷 537-547页

作者：汪芳罗涛陈烩铃 Kiyoshi itagaki 宋海昭熊玲王銮凤沈新春南京财经大学食品科学与工程学院江苏省现代粮食流通与安全协同创新中心江苏高校粮油质量安全控制及深加工重点实验室南京210023 Harvard Medical School Boston 02115USA

小麦胚芽作为小麦面粉加工过程中产生的副产品,资源极为丰富,但一直以来未能得到充分合理的利用.本研究以课题组前期获得的麦胚活性肽ADWGGPLPH(ADW)为对象,以自然增龄的SD大鼠作为肝脏老化损伤的动物模型,9月龄大鼠作为对照,用麦胚源... 详细信息

小麦胚芽作为小麦面粉加工过程中产生的副产品,资源极为丰富,但一直以来未能得到充分合理的利用.本研究以课题组前期获得的麦胚活性肽ADWGGPLPH(ADW)为对象,以自然增龄的SD大鼠作为肝脏老化损伤的动物模型,9月龄大鼠作为对照,用麦胚源活性肽持续灌胃干预至21月龄,研究麦胚源活性肽对自然增龄大鼠肝脏老化损伤的影响,并结合H2O2诱导衰老HepG2细胞模型初步探明其分子机制.结果表明,麦胚源活性肽ADW能够增加大鼠血清及肝脏中SOD,T-AOC,GSH-Px,CAT等抗氧化酶活性,同时降低MDA水平,改善大鼠肝脏中氧化应激水平;降低血清及肝脏中IL-6,IL-1β,MMP3,TNF-α水平,并且增加抗炎因子IL-10分泌,改善增龄大鼠肝脏中炎症环境;麦胚源活性肽干预后肝脏结构明显好转、脂肪空泡减少、细胞排列整齐,ALT以AST水平均显著下降.麦胚源活性肽能够有效地改善老化肝脏中细胞的结构及生长状态异常,减少增龄过程中肝脏质量损失,降低了衰老标志蛋白P53和P21的表达量,减轻肝脏老化损伤程度并减缓了肝脏的老化进程.通过加入抑制剂、激活剂、siRNA等手段,初步阐明麦胚源活性肽能够通过激活AMPK/Sirt1信号通路以调控衰老相关进程.本研究对于开发健康老龄化膳食结构以及麦胚资源的精深利用具有十分重大的意义.

关键词：小麦胚芽活性肽衰老 AMPK 肝脏

Activities of liquid Fe-As and Fe-Sb alloys saturated with carbon

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Rare Metals 2006年第5期25卷 488-491页

作者： Leandro Voisin Kimio itagaki Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan

A solid iron base alloy of the so-called furnace residue is often formed as a by-product in reduction smelting of lead sinter and scraps with high contents of arsenic and antimony. The use of phase separation into a liquid iron-rich alloy and a liquid lead-rich alloy in lead-iron-arsenic and lead-iron-antimony systems saturated with carbon at relatively low temperatures of about 1200~C was proposed in a new process for treating the fumace residue to recover valuable elements into the lead-rich alloy and fLx toxic arsenic into the iron-rich alloy. As a fundamental study for the proposed process, the activity coefficients and interaction parameters of the Fe-As and Fe-Sb systems saturated with carbon at 1200℃ were derived in this study, based on the determined phase relations in the Fe-Pb-As and Fe-Pb-Sb systems saturated with carbon.

关键词： activity coefficient phase relations Pb-Fe-As-C system Pb-Fe-Sb-C system lead-smelting lead-recycling

Stability of the linear chain structure for 12C in covariant density functional theory on a 3D lattice

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Science China(Physics,Mechanics & Astronomy) 2019年第11期62卷 6-13页

作者： ZhengXue Ren ShuangQuan Zhang PengWei Zhao Naoyuki itagaki Joachim AMaruhn Jie Meng State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Yukawa Institute for Theoretical Physics Kyoto UniversityKyoto 606-8502Japan Institut fur Theoretische Physik Goethe-UniversitatMax-von-Laue-Str.160438 Frankfurt am MainGermany Department of Physics University of StellenboschStellenbosch 7600South Africa

The stability of the linear chain structure of three α clusters for 12C against the bending and fission is investigated in the cranking covariant density functional theory, in which the equation of motion is solved on a 3D lattice with the inverse Hamiltonian and the Fourier spectral methods. Starting from a twisted three α initial configuration, it is found that the linear chain structure is stable when the rotational frequency is within the range of ~2.0-~2.5 MeV. Beyond this range, the final states are not stable against fission. By examining the density distributions and the occupation of single-particle levels, however, these fissions are found to arise from the occupation of unphysical continuum with large angular momenta. To properly remove these unphysical continuum, a damping function for the cranking term is introduced. Eventually, the stable linear chain structure could survive up to the rotational frequency ~3.5 MeV, but the fission still occurs when the rotational frequency approaches ~4.0 MeV.

关键词： covariant density functional theory cranking model 3D lattice space linear chain structure alpha-cluster structure collective rotation 12C

Heat generation properties in AC magnetic field for composite powder material of the Y3Fe5O12-nSiC system prepared by reverse coprecipitation method

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Journal of Advanced Ceramics 2016年第3期5卷 262-268页

作者： Hiromichi AONO Yuhi YAMANO Takashi NAOHARA Yoshiteru itagaki Tsunehiro MAEHARA Hideyuki HIRAZAWA Graduate School of Science and Engineering Ehime University Matsuyama 790-8577 Japan National Institute of Technology Niihama College Niihama 792-8580 Japan

Composite powder material of the Y3Fe5O12–nSiC system was synthesized by a reverse coprecipitation method to study its heat generation property in an AC magnetic field. For Y3Fe5O12 (n = 0), the maximum heat generation ability of 0.45 W·g−1 in an AC magnetic field (370 kHz, 1.77 kA·m−1) was obtained for the sample calcined at 1100 °C. The SiC addition helped to suppress the particle growth for Y3Fe5O12 at the calcination temperature. The heat generation ability was improved by the addition of the SiC powder, and the maximum value of 0.93 W·g−1 was obtained for the n = 0.3 sample calcined at 1250 °C. The heat generation ability and the hysteresis loss value were proportional to the cube of the magnetic field (H 3). The heat generation ability (W·g−1) of the Y3Fe5O12–0.3SiC sample calcined at 1250 °C could be expressed by the equation 4.5×10−4 · f · H 3 using the frequency f (kHz) and the magnetic field H (kA·m−1).

关键词： magnetic materials composite material Y3Fe5O12 SiC heat generation ability AC magnetic field

Alcohol,postprandial plasma glucose,and prognosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第1期19卷 78-85页

作者： Hiroshi Abe Yuta Aida Haruya Ishiguro Kai Yoshizawa Tamihiro Miyazaki Munenori itagaki Satoshi Sutoh Yoshio Aizawa Division of Gastroenterology and Hepatology Department of Internal MedicineJikei University School of Medicine Katsushika Medical CenterTokyo 125-8506Japan

AIM:To identify factors associated with prognosis of hepatocellular carcinoma(HCC) after initial ***:A total of 377 HCC patients who were newly treated at Katsushika Medical Center,Japan from January 2000 to December 2009 and followed up for > 2 years,or died during follow-up,were *** factors related to survival were first analyzed in 377 patients with HCC tumor stage T1-T4 using multivariate Cox proportional hazards regression analysis.A similar analysis was performed in 282 patients with tumor stage ***,factors associated with the period between initial and subsequent therapy were examined in 144 patients who did not show local ***,214 HCC stage T1-T3 patients who died during the observation period were classified into four groups according to their alcohol consumption and postprandial glucose levels,and differences in their causes of death were ***:On multivariate Cox proportional hazards regression analysis,the following were significantly associated with survival:underlying liver disease stage [non-cirrhosis/Child-Pugh A vs B/C,hazard ratio(HR):0.603,95% CI:0.417-0.874,P = 0.0079],HCC stage(T1/T2 vs T3/T4,HR:0.447,95% CI:0.347-0.576,P < 0.0001),and mean postprandial plasma glucose after initial therapy(< 200 vs ≥ 200 mg/dL,HR:0.181,95% CI:0.067-0.488,P = 0.0008).In T1-T3 patients,uninterrupted alcohol consumption after initial therapy(no vs yes,HR:0.641,95% CI:0.469-0.877,P = 0.0055) was significant in addition to underlying liver disease stage(non-cirrhosis/Child-Pugh A vs B/C,HR:0649,95% CI:0.476-0.885,P = 0.0068),HCC stage(T1 vs T2/T3,HR:0.788,95% CI:0.653-0.945,P = 0.0108),and mean postprandial plasma glucose after initial therapy(< 200 mg/dL vs ≥ 200 mg/dL,HR:0.502,95% CI:0.337-0.747,P = 0.0005).In patients without local recurrence,time from initial to subsequent therapy for newly emerging HCC was significantly longer in the "postprandial glucose within 200 mg/dL group" than the "postprandial

关键词： Hepatocellular carcinoma Prognosis Alcohol consumption Diabetes mellitus Postprandial plasma glucose level Initial therapy Local recurrence Survival

Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C

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World Journal of Gastroenterology 2008年第14期14卷 2200-2207页

作者： Ying Yuan Ichiro Shimizu Mi Shen Eriko Aoyagi Hidetaka Takenaka Tatuzo itagaki Mari Urata Katsutaka Sannomiya Nao Kohno Katsuyoshi Tamaki Masayuki Shono Tetsuji Takayama Jiangsu Key Laboratory of Neuroregeneration Nantong University Nantong 226001 Jiangsu Province China Department of Digestive and Cardiovascular Medicine Institute of Health Biosciences Tokushima 7708503 Japan Support Center for Advanced Medical Sciences University of Tokushima Graduate School Tokushima 7708503 Japan

AIM:To investigate the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stressstimulated production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, and macrophage chemotactic protein (MCP)-1 by peripheral blood mononuclear cells (PBMCs) from patients with chronic hepatitis C and healthy controls. METHODS:The PBMCs were separated from agematched 72 males and 71 females with and without chronic hepatitis C, who were divided into two groups based on a mean menopausal age of 50 years. Oxidative stress was induced by hydrogen peroxide in the cells incubated in serum-free media. Cytokines in the culture supernatant were measured by an enzyme-linked immunosorbent assay. RESULTS:The highest levels of the spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by the unstimulated PBMCs were in the older male patients with chronic hepatitis C and the lowest levels were in the premenopausal female healthy controls. E2 inhibited the cytokine production by the unstimulated PBMCs from the older male and post-menopausal female patients, which was further stimulated by progesterone. The exposure to hydrogen peroxide in the PBMCs from the younger male and pre-menopausal female healthy subjects induced the production of cytokines. The change rates of the hydrogen peroxide-stimulated cytokine production were suppressed by E2 and enhanced by progesterone. CONCLUSION:These findings suggest that E2 may play a favorable role in the course of persistent liver injury by preventing the accumulation of monocytes-macrophages and by inhibiting proinflammatory cytokine production, whereas progesterone may counteract the favorable E2 effects.

关键词： Estradiol Progesterone Mononuclear cell Proinflammatory cytokine Chemokine

Hepatitis C virus G1b infection decreases the number of small low-density lipoprotein particles

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World Journal of Gastroenterology 2016年第29期22卷 6716-6725页

作者： Chika Kinoshita Tomohisa Nagano Nobuyoshi Seki Yoichi Tomita Tomonori Sugita Yuta Aida Munenori itagaki Kenichi Satoh Satoshi Sutoh Hiroshi Abe Akihito Tsubota Yoshio Aizawa Department of Gastroenterology and Hepatology Internal Medicine of Jikei University Katsushika Medical Center Tokyo 125-8506 Japan Core Research Facilities for Basic Science Research Center for Medical Science Jikei University School of Medicine Tokyo 105-8461 Japan

AIM: To investigate how hepatitis C virus (HCV) G1b infection influences the particle number of ***: The numbers of lipoprotein particles in fasting sera from 173 Japanese subjects, 82 with active HCV G1b infection (active HCV group) and 91 with cleared HCV infection (SVR group), were examined. Serum lipoprotein was fractionated by high-performance liquid chromatography into twenty fractions. The cholesterol and triglyceride concentrations in each fraction were measured using LipoSEARCH. The number of lipoprotein particles in each fraction was calculated using a newly developed algorithm, and the relationship between chronic HCV G1b infection and the lipoprotein particle number was determined by multiple linear regression ***: The median number of low-density lipoprotein (LDL) particles was significantly lower in the active HCV group [1182 nmol/L, interquartile range (IQR): 444 nmol/L] than in the SVR group (1363 nmol/L, IQR: 472 nmol/L, P < 0.001), as was that of high-density lipoprotein (HDL) particles (14168 nmol/L vs 15054 nmol/L, IQR: 4114 nmol/L vs 3385 nmol/L, P = 0.042). The number of very low-density lipoprotein (VLDL) particles was similar between the two groups. Among the four LDL sub-fractions, the number of large LDL particles was similar between the two groups. However, the numbers of medium (median: 533.0 nmol/L, IQR: 214.7 nmol/L vs median: 633.5 nmol/L, IQR: 229.6 nmol/L, P < 0.001), small (median: 190.9 nmol/L, IQR: 152.4 nmol/L vs median: 263.2 nmol/L, IQR: 159.9 nmol/L; P < 0.001), and very small LDL particles (median: 103.5 nmol/L, IQR: 66.8 nmol/L vs median: 139.3 nmol/L, IQR: 67.3 nmol/L, P < 0.001) were significantly lower in the active HCV group than in the SVR group, respectively. Multiple linear regression analysis indicated an association between HCV G1b infection and the decreased numbers of medium, small, and very small LDL particles. However, active HCV infection did not aff

关键词： Chronic hepatitis C Lipoprotein particles Low-density lipoproteins Very low-density lipoproteins Triglycerides Cholesterol Regression analysis

High level of serum cholesteryl ester transfer protein inactive hepatitis C virus infection

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World Journal of Hepatology 2016年第5期8卷 291-300页

作者： Kenichi Satoh Tomohisa Nagano Nobuyoshi Seki Yoichi Tomita Yuta Aida Tomonori Sugita Munenori itagaki Satoshi Sutoh Hiroshi Abe Yoshio Aizawa Department of Gastroenterology and Hepatology Internal Medicine of Jikei University Katsushika Medical CenterKatsushikakuTokyo 125-8506Japan

AIM: To determine the significance of cholesteryl ester transfer protein(CETP) in lipoprotein abnormalities in chronic hepatitis C virus(HCV) ***: We evaluated the significance of the serum concentration of CETP in 110 Japanese patients with chronic HCV infection. Fifty-five patients had active HCV infection, and HCV eradication had been achieved in 55. The role of CETP in serum lipoprotein abnormalities, specifically, in triglyceride(TG) concentrations in the four major classes of lipoproteins, was investigated using Pearson correlations in conjunction with multiple regression analysis and compared them between those with active HCV infection and those in whom eradication had been achieved. RESULTS: The serum CETP levels of patients with active HCV infection were significantly higher than those of patients in whom HCV eradication was achieved(mean ± SD, 2.84 ± 0.69 μg/m L vs 2.40 ± 1.00 μg/m L, P = 0.008). In multiple regression analysis, HCV infection status(active or eradicated) was an independent factor significantly associated with the serum CETP level. TG concentrations in low-density lipoprotein(mean ± SD, 36.25 ± 15.28 μg/m L vs 28.14 ± 9.94 μg/m L, P = 0.001) and high-density lipoprotein(HDL)(mean ± SD, 25.9 ± 7.34 μg/m L vs 17.17 ± 4.82 μg/m L, P < 0.001) were significantly higher in patientswith active HCV infection than in those in whom HCV eradication was achieved. The CETP level was strongly correlated with HDL-TG in patients with active HCV infection(R = 0.557, P < 0.001), whereas CETP was not correlated with HDL-TG in patients in whom HCV eradication was achieved(R =-0.079, P = 0.56). CONCLUSION: Our results indicate that CETP plays a role in abnormalities of lipoprotein metabolism in patients with chronic HCV infection.

关键词： Hepatitis C virus Cholesteryl ester transferprotein High-density lipoprotein triglyceride Casecontrol study Lipoprotein metabolism

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应对多标准无线电基站发射机测试的挑战

电子设计技术 EDN CHINA 2012年第6期19卷 55-56页

作者： Moto itagaki 安捷伦科技公司

下一代基站发射机和接收机将会支持更宽的带宽,不仅包括采用单一无线制式的多载波（MC）,还包括在单一发射机路径中的多种制式。例如,GSM、W-CDMA和LTE多载波可以同时从一个多标准无线（MSR）基站单元进行传输。蜂窝网络可以支持多种制式,

关键词：多标准无线电基站发射机安捷伦