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Open Journal of Anesthesiology 2016年第6期6卷 85-90页

作者： Toru Goyagi Takehito Sato takashi horiguchi Toshiaki Nishikawa Department of Anesthesia and Intensive Care Medicine Akita University Graduate School of Medicine Akita Japan

Introduction: Although inhalational anesthesia and nitrousoxide (N2O) are known to affect the intraocular pressure (IOP), little is known about the effect of nitrousoxide on the IOP during sevoflurane and remifentanil anesthesia. In the present study, we examined the effect of balanced anesthesia on the IOP. Materials and Methods: After obtaining informed consent, the patients undergoing abdominal surgery under general anesthesia were divided into two groups: N2O group (n = 10) and control group (n = 12). General anesthesia was maintained with remifentanil (0.05 - 0.3 μg/kg/min), 33% O2 and 1.2% sevoflurane to keep ETCO2 of 35 - 40 mmHg following tracheal intubation. After baseline measurement of IOP (T0, 20 minutes after injection of anesthesia), the patients in the N2O group received 67% nitrousoxide, and the patients in the control group received air, with O2 and 1.2% sevoflurane. Then, IOP was measured at 1 hour (T1), 2 hours (T2), and 3 hours (T3) after anesthesia induction in the supineposition. Blood pressure and heart rate were recorded at the same time interval. Results: There was no significant difference in the IOP at any period between the two groups. In both groups, the IOP at the T3 was significantly higher than that at T0. Conclusion: These results suggest that N2O does not affect the IOP in patients undergoing abdominal surgery under sevoflurane and remifentanil anesthesia.

关键词： Intraocular Pressure Nitrous Oxide Balanced Anesthesia

Clipping versus Coiling in Ruptured Aneurysms of the Anterior Cerebral Circulation

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Open Journal of Modern Neurosurgery 2020年第1期10卷 88-104页

作者： Farrag Mohammad takashi horiguchi Katsuhiro Mizutani Kazunari Yoshida Department of Neurosurgery Keio University School of Medicine Tokyo Japan Department of Neurosurgery Faculty of Medicine Assiut University Assiut Egypt

Objective: To evaluate and compare the outcomes of microsurgical clipping and endovascular coiling of ruptured anterior cerebral circulation aneurysms. Methods: The current study retrospectively included 61 patients presented with subarachnoid hemorrhage (SAH), treated by clipping or coiling for ruptured aneurysms located in anterior circulation. Anatomic outcome and post-operative ischemic events were evaluated. The primary clinical outcomes were evaluated as operative complications while the secondary clinical outcome was evaluated by modified Rankin scale (mRS) at discharge. Results: Of 61 ruptured aneurysms, 47 and 14 were treated by surgery and coiling, respectively. The average follow-up duration was 19.1 ± 18.6 months for clipping and 21.7 ± 14.8 months for coiling. Complete occlusion was greater in surgery group (80.8%) than endovascular group (21.4%). Re-growth occurred in 2 cases of the coiling group only. Ischemic events were encountered in both groups;silent ones were higher in coiling group (21.4%) than in clipping group (6.3%), while symptomatic ones were higher in the clipping group (49%). Good outcome (mRS 0 - 2) was 51% and 71.4% after clipping and coiling respectively. Postoperative hospital period was longer after clipping (P = 0.04). Conclusions: For anterior circulation ruptured aneurysms, both treatments are feasible, coiling showed lower rate of morbidity while clipping results were better regarding durability and recurrence. Coil embolization may be preferred, which is the current point proved by the RCT like ISAT, but if you choose the patients carefully and find out the optimal candidate for the clipping, the clipping is still enough feasible as a mainstream.

关键词： Anterior Circulation SAH Clipping Coiling Ruptured Aneurysms

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彩色反转片RT500和RT125

感光材料 1981年第4期 55-58页

作者： takashi horiguchi 彭长久

1974年富士胶片公司曾提供了适用于专业摄影的16毫米富士彩色电视反转片 RT400(8425型)和 RT100(8426型)。这些胶片由于在乳剂中采用了超坚膜技术,所以在加工过程中省去了予坚工序,使反转片开始实现高温加工。在此基础上,该公司研究部... 详细信息

1974年富士胶片公司曾提供了适用于专业摄影的16毫米富士彩色电视反转片 RT400(8425型)和 RT100(8426型)。这些胶片由于在乳剂中采用了超坚膜技术,所以在加工过程中省去了予坚工序,使反转片开始实现高温加工。在此基础上,该公司研究部门进一步致力于提高产品质量,增加感光度、缩短显影时间、实现无氰漂白加工,降低能源消耗和设计新片种等方面的研究。因此,又研制了两种用于专业电影和电视拍摄的新型16毫

关键词： RT500 富士 MCR 光谱感光度乳剂层片种

糖尿病和肥胖症动物模型肌肉及脂肪组织的葡萄糖摄取:利用18F-FDG评价胰岛素和β3受体激动剂的作用

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中华核医学与分子影像杂志 2018年第1期38卷 73-73页

作者：唐军 Seigo Ishino Taku Sugita Yusuke Kondo Mika Okai Kazue Tsuchimori Masanori Watanabe Ikuo Mori Masaki Hosoya takashi horiguchi Hidenori Kamiguchi 上海交通大学医学院附属苏州九龙医院核医学科 Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited

目的糖尿病和肥胖症的主要原因是胰岛素功能不足导致肌肉和脂肪组织内的糖摄取、糖代谢异常。因此,许多药物的研发都是基于促进肌肉和脂肪组织对葡萄糖的摄取。现已可通过测定血液相关参数来评价上述组织糖代谢的增加,但这仅仅反映了用... 详细信息

目的糖尿病和肥胖症的主要原因是胰岛素功能不足导致肌肉和脂肪组织内的糖摄取、糖代谢异常。因此,许多药物的研发都是基于促进肌肉和脂肪组织对葡萄糖的摄取。现已可通过测定血液相关参数来评价上述组织糖代谢的增加,但这仅仅反映了用药后的全身反应。课题组进行了数项研究来调查药理实验中疾病动物模型的不同肌肉和脂肪组织葡萄糖摄取测定的实用性。方法对肥胖大鼠模型(2型糖尿病模型)、饮食诱导的肥胖鼠模型(肥胖模型)和相应的对照组模型分别注射18F-脱氧葡萄糖(FDG),各模型肌肉和脂肪组织(白色和棕色脂肪)的基础葡萄糖摄取通过生物分布法进行比较。另外,可促进肌肉和脂肪组织葡萄糖摄取的胰岛素和β3受体激动剂(CL316,243)亦用于各模型来评价两者的作用。18F-FDG在各组织的摄取通过测量各组织放射性的方法进行,而18F-FDG的分布采用放射自显影的方法来分析。结果2型糖尿病模型与对照组(瘦大鼠)相比,所有组织的测量结果均显示其基础葡萄糖摄取水平降低。肥胖模型的白色脂肪组织也有相同表现,但肥胖模型棕色脂肪组织的基础葡萄糖摄取水平增加。胰岛素可促进2型糖尿病模型和瘦大鼠模型的葡萄糖摄取,尽管前者的葡萄糖摄取增加有所抑制。同样的现象也存在于对照组,但使用胰岛素后肥胖模型的肌肉和棕色脂肪组织没有观察到葡萄糖摄取的明显增加。2型糖尿病模型与瘦大鼠使用β3受体激动剂后可观察到与使用胰岛素后一样的反应,但前者脂肪组织的葡萄糖摄取增加受抑。结论通过18F-FDG监测组织葡萄糖摄取水平能够观察到疾病动物模型和相应对照模型间葡萄糖摄取的差别,同时可识别各组织对胰岛素和β3受体激动剂的反应。总之,18F-FDG生物分布法可在疾病动物模型上用于抗糖尿病和抗肥胖药物的评价研究。

关键词： 18F-FDG 肥胖大鼠模型饮食诱导的肥胖鼠模型胰岛素 β3受体激动剂

Overexpression of NK2 inhibits liver regeneration after partial hepatectomy in mice

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World Journal of Gastroenterology 2005年第47期11卷 7444-7449页

作者： Toshiyuki Otsuka Norio horiguchi Daisuke Kanda takashi Kosone Yuichi Yamazaki Kazuhisa Yuasa Naondo Sohara Satoru Kakizaki Ken Sato Hitoshi Takagi Glenn Merlino Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of Medicine3-39-15 ShowaMaebashiGunma 371-8511Japan Laboratory of Cell Regulation and Carinogenesis National Cancer InstituteBuilding 37Room 5002BethesdaMD 20892-4264United States

AIM： To investigate the in vivo effects of NK2 on liver regeneration after partial hepatectomy （PH）. METHODS： Survival after PH was observed with 21 NK2 transgenic mice and 23 wild-type （WT） mice over 10 d. Liver regeneration was analyzed using histology and immunohistochemistry. Expressions of genes were analyzed using Northern blot analysis, immunoprecipitation and immunoblotting, and reverse transcriptase polymerase chain reaction assay. Kaplan Meier method and the log-rank test were used for analyzing the survival after PH. Differences in the results of immunohistochemistry and percentage of liver regeneration was determined by the Student＇s t-test. RESULTS： More than half of NK2 transgenic mice died within 48 h after PH. After PH, increased deposition of small lipid droplets in hepatocytes was evident and hepatic proliferation was inhibited in NK2 transgenic mice. The hepatic expression and kinase activity of HGF receptor, c-Met, were unchanged among WT mice and NK2 transgenic mice after PH. The expression of tumor necrosis factor-co （TNF-c0 and interleukin-6 （IL-6） in liver tissues were prolonged in NK2 transgenic mice that died after PH. CONCLUSION： Our findings indicate that overexpression of NK2 inhibits liver regeneration after PH.

关键词： Hepatocyte growth factor NK2 Transgenic mice Partial hepatectomy Liver regeneration

Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling

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World Journal of Hepatology 2020年第7期12卷 350-362页

作者： Takayoshi Suga Ken Sato Tatsuya Ohyama Sho Matsui Takeshi Kobayashi Hiroki Tojima Norio horiguchi Yuichi Yamazaki Satoru Kakizaki Ayaka Nishikido takashi Okamura Masanobu Yamada TadahiroKitamura Toshio Uraoka Department of Gastroenterology and Hepatology Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan Metabolic Signal Research Center Institute for Molecular and Cellular RegulationGunma UniversityMaebashi 371-8512GunmaJapan Department of Medicine and Molecular Science Gunma Graduate School of MedicineMaebashi 371-8511GunmaJapan

BACKGROUND Sodium glucose cotransporter 2(SGLT2)inhibitors are newly developed oral antidiabetic ***2 is primarily expressed in the kidneys and reabsorbs approximately 90%of the glucose filtered by the renal ***2 inhibitors lower glucose levels independently of insulin action by facilitating urinary glucose *** SGLT2 inhibitor ipragliflozin has reportedly improved liver steatosis in animal models and clinical ***,the mechanisms by which SGLT2 inhibitors improve liver steatosis are not fully *** To investigate the ameliorative effects of ipragliflozin on liver steatosis and the mechanisms of these effects in obese *** We analyzed 8-wk-old male obese(ob/ob)mice that were randomly divided into a group receiving a normal chow diet and a group receiving a normal chow diet supplemented with ipragliflozin(3 mg/kg or 10 mg/kg)for 4 *** also analyzed their lean sex-matched littermates receiving a normal chow diet as another control group. Body weight and liver weight were evaluated, and liverhistology, immunoblotting, and reverse transcription-polymerase chain reactionanalyses were *** lipid accumulation was significantly ameliorated in ob/ob mice treatedwith 10 mg/kg ipragliflozin compared to untreated ob/ob mice irrespective ofbody weight changes. Ipragliflozin had no appreciable effects on hepatic oxidativestress-related gene expression levels or macrophage infiltration, but significantlyreduced hepatic interleukin-1β (IL-1β) mRNA expression levels. Ipragliflozinincreased both the mRNA and protein expression levels of sirtuin 1 (SIRT1) in theliver. The hepatic mRNA levels of peroxisome proliferator-activated receptor γcoactivator 1α (PGC-1α), peroxisome proliferator-activated receptor α (PPARα),and fibroblast growth factor-21 (FGF21) were also significantly higher inipragliflozin-treated ob/ob mice than in untreated ob/ob *** study suggests that the liver steatosis-ameliorati

关键词： Selective sodium glucose cotransporter 2 Nonalcoholic fatty liver disease Sirtuin 1 Peroxisome proliferator-activated receptorγcoactivator 1α Peroxisome proliferator-activated receptorα Fibroblast growth factor-21

Late-onset non-islet cell tumor hypoglycemia: A case report

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World Journal of Clinical Cases 2021年第1期9卷 163-169页

作者： Shunichi Matsumoto Eijiro Yamada Yasuyo Nakajima Naoki Yamaguchi takashi Okamura Toshiki Yajima Satoshi Yoshino Kazuhiko horiguchi Emi Ishida Masashi Yoshikawa Jun Nagaoka Sho Sekiguchi Mai Sue Shuichi Okada Izumi Fukuda Ken Shirabe Masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan Division of General Thoracic Surgery Integrative Center of General SurgeryGunma University HospitalMaebashi 371-8511GunmaJapan Department of Endocrinology Diabetes and MetabolismGraduate School of Medicine Nippon Medical SchoolTokyo 1138602Japan

BACKGROUND Hypoglycemia due to non-insulin-producing tumors is referred to as non-islet cell tumor hypoglycemia(NICTH).As NICTH is a rare lesion,the natural course of NICTH is not well *** report a case of NICTH that was observed 30 years before the onset of *** SUMMARY A 50-year-old man was diagnosed with an abnormal right chest shadow during a routine X-ray examination,but no further examination was undertaken because the lesion appeared *** years after the tumor discovery,the patient was admitted to the hospital with symptoms of severe hypoglycemia,which was diagnosed as NICTH based on a complete *** tumor was resected and found to be a solitary fibrous mass(15.6 cm×13.7 cm×10.4 cm);thereafter,the patient’s blood glucose levels normalized and he completely *** NICTH can have an acute onset,even if the tumor has been present and asymptomatic over a long time period.

关键词： Hypoglycemia Non-islet cell tumor hypoglycemia Blood glucose Solitary tumor Late onset Case report Insulin-like growth factor II