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A durable complete response resulting from treatment with nivolumab plus ipilimumab for metastatic collecting duct carcinoma of the kidney

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Asian Journal of Urology 2023年第3期10卷 376-378页

作者： Keisuke Funajima Sei Naito takanobu kabasawa Hayato Nishida Tomoyuki Kato Mitsuru Futakuchi Norihiko Tsuchiya Department of Urology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan Department of Pathology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan

Dear Editor,Collecting duct carcinoma(CDC)or Bellini carcinoma originates in the distal collecting *** is a markedly aggressive subtype of renal cell carcinoma and accounts for less than 1%of all renal cell carcinomas[1].We described a patient with CDC and psoriasis,who showed complete response(CR)after being treated with combination therapy of nivolumab and ipilimumab(NI).The study was conducted in accordance with and approved by the Ethics Committee of Yamagata University Faculty of Medicine(approval no.2019-35).The need for patient consent was waived by the same institutional review board;all the patients provided written informed consents.

关键词： markedly nivolumab approval

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Not Follicular but Dermal Melanocyte Precursors Are Histopathologically Retained in Vitiligo

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第1期13卷 38-44页

作者： Atsushi Tanemura Ryoko Kawabe Yuka Sudo Kazunori Yokoi takanobu kabasawa Mitsuru Futakuchi Tamio Suzuki Manabu Fujimoto Department of Dermatology School of Medicine Osaka University Graduate Suita Osaka Japan Department of Pathology Faculty of Medicine Yamagata University Yamagata Japan Department of Dermatology Faculty of Medicine Yamagata University Yamagata Japan

Although perifollicular repigmentation in the vitiligo lesions is owing to activation of follicular melanocyte stem cells and/or precursor cells followed by supplying matured melanocytes, the underlying mechanism of diffuse repigmentation on the whole vitiligo surface remains still unknown. In addition to the presence of remaining melanocytes, it is conceivable that dermal melanocyte precursor cells contribute to induce diffuse repigmentation after treatment. Therefore, we investigated here whether dermal and follicular melanocyte precursor cells were reduced or not in vitiligo lesions. We performed an immunostaining for Nestin and p75NGFR as dermal melanocyte precursor cells and MITF/Fzd4 as follicular melanocyte precursor cells and compared the positive cells number between lesions and non-lesions (n = 11). Although MITF+/Fzd4+ cells in the hair follicle were significantly decreased in number in the lesions, Nestin+ and p75NGFR+ cells were not. This result indicates that dermal precursor cells could be retained in the vitiligo lesions but be disturbed to differentiate into matured melanocytes.

关键词： Melanocyte Precursor Cells p75NGFR Nestin Frizzled4 Vitiligo

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